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Items: 1 to 50 of 63

1.

Compounds isolation and biological activities of Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) roots.

Mbosso Teinkela JE, Noundou XS, Zeh Mimba JE, Meyer F, Tabouguia OM, Assob Nguedia JC, Hoppe HC, Maçedo Krause RW, Wintjens R, Blaise Azebaze GA.

J Ethnopharmacol. 2020 Mar 6:112716. doi: 10.1016/j.jep.2020.112716. [Epub ahead of print]

PMID:
32151754
2.

Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay.

Swart T, Khan FD, Ntlantsana A, Laming D, Veale CGL, Przyborski JM, Edkins AL, Hoppe HC.

Sci Rep. 2020 Mar 6;10(1):4193. doi: 10.1038/s41598-020-61101-3.

3.

Synthesis and biological evaluation of bis-N2,N2'-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides.

Manyeruke MH, Tshiwawa T, Hoppe HC, Isaacs M, Seldon R, Warner DF, Krause RWM, Kaye PT.

Bioorg Med Chem Lett. 2020 Mar 1;30(5):126911. doi: 10.1016/j.bmcl.2019.126911. Epub 2019 Dec 19.

PMID:
31952962
4.

A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae: their antitrypanosomal and antiplasmodial evaluation.

Christopher R, Mgani QA, Nyandoro SS, Rousseau AL, Isaacs M, Hoppe HC.

Nat Prod Res. 2020 Jan 5:1-8. doi: 10.1080/14786419.2019.1710705. [Epub ahead of print]

PMID:
31903791
5.

Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives.

Mbaba M, Dingle LMK, Cash D, Mare JA, Laming D, Taylor D, Hoppe HC, Edkins AL, Khanye SD.

Eur J Med Chem. 2020 Feb 1;187:111924. doi: 10.1016/j.ejmech.2019.111924. Epub 2019 Dec 2.

PMID:
31855792
6.

Exploring the Antiplasmodial 2-Aminopyridines as Potential Antitrypanosomal Agents.

Veale CGL, Laming D, Swart T, Chibale K, Hoppe HC.

ChemMedChem. 2019 Dec 17;14(24):2034-2041. doi: 10.1002/cmdc.201900492. Epub 2019 Nov 12.

PMID:
31670464
7.

Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities.

Mbosso Teinkela JE, Siwe Noundou X, Fannang S, Mbem Song A, Assob Nguedia JC, Hoppe HC, Krause RWM.

Nat Prod Res. 2019 Aug 6:1-10. doi: 10.1080/14786419.2019.1647425. [Epub ahead of print]

PMID:
31385525
8.

Preparation and antiplasmodial activity of 3',4'-dihydro-1'H-spiro(indoline-3,2'-quinolin)-2-ones.

Mathebula B, Butsi KR, van Zyl RL, Jansen van Vuuren NC, Hoppe HC, Michael JP, de Koning CB, Rousseau AL.

Chem Biol Drug Des. 2019 Oct;94(4):1849-1858. doi: 10.1111/cbdd.13598. Epub 2019 Aug 27.

PMID:
31361393
9.

Anti-Trypanosomal and Antimalarial Properties of Tetralone Derivatives and Structurally Related Benzocycloalkanones.

Beteck RM, Legoabe LJ, Isaacs M, Khanye SD, Laming D, Hoppe HC.

Medicina (Kaunas). 2019 May 24;55(5). pii: E206. doi: 10.3390/medicina55050206.

10.

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis.

Beteck RM, Seldon R, Jordaan A, Warner DF, Hoppe HC, Laming D, Khanye SD.

Molecules. 2019 May 4;24(9). pii: E1740. doi: 10.3390/molecules24091740.

11.

Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation.

Beteck RM, Seldon R, Jordaan A, Warner DF, Hoppe HC, Laming D, Legoabe LJ, Khanye SD.

Medchemcomm. 2019 Jan 11;10(2):326-331. doi: 10.1039/c8md00480c. eCollection 2019 Feb 1.

12.

Evaluation of novel N'-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors.

Jesumoroti OJ, Faridoon, Mnkandhla D, Isaacs M, Hoppe HC, Klein R.

Medchemcomm. 2018 Dec 10;10(1):80-88. doi: 10.1039/c8md00328a. eCollection 2019 Jan 1.

13.

Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery.

Veale CGL, Hoppe HC.

Medchemcomm. 2018 Oct 26;9(12):2037-2044. doi: 10.1039/c8md00319j. eCollection 2018 Dec 1.

14.

Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays.

Kimuda MP, Laming D, Hoppe HC, Tastan Bishop Ö.

Molecules. 2019 Jan 1;24(1). pii: E142. doi: 10.3390/molecules24010142.

15.

Isolation, Chemical Profile and Antimalarial Activities of Bioactive Compounds from Rauvolfia caffra Sond.

Tlhapi DB, Ramaite IDI, Van Ree T, Anokwuru CP, Orazio TS, Hoppe HC.

Molecules. 2018 Dec 21;24(1). pii: E39. doi: 10.3390/molecules24010039.

16.

Novobiocin-ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.

Mbaba M, de la Mare JA, Sterrenberg JN, Kajewole D, Maharaj S, Edkins AL, Isaacs M, Hoppe HC, Khanye SD.

J Biol Inorg Chem. 2019 Mar;24(2):139-149. doi: 10.1007/s00775-018-1634-9. Epub 2018 Dec 12.

PMID:
30542925
17.

In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones.

Beteck RM, Legoabe LJ, Isaacs M, Hoppe HC.

Drug Res (Stuttg). 2019 Jun;69(6):337-341. doi: 10.1055/a-0775-0737. Epub 2018 Nov 16.

PMID:
30452077
18.

Design, synthesis, and antiplasmodial evaluation of a series of novel sulfoximine analogues of carbohydrate-based thiochromans.

Chizema M, Mabasa TF, Hoppe HC, Kinfe HH.

Chem Biol Drug Des. 2019 Mar;93(3):254-261. doi: 10.1111/cbdd.13408. Epub 2018 Nov 19.

PMID:
30264436
19.

Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity.

Gumbo M, Beteck RM, Mandizvo T, Seldon R, Warner DF, Hoppe HC, Isaacs M, Laming D, Tam CC, Cheng LW, Liu N, Land KM, Khanye SD.

Molecules. 2018 Aug 15;23(8). pii: E2038. doi: 10.3390/molecules23082038.

20.

Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers.

Lunga MJ, Chisango RL, Weyers C, Isaacs M, Taylor D, Edkins AL, Khanye SD, Hoppe HC, Veale CGL.

ChemMedChem. 2018 Jul 6;13(13):1353-1362. doi: 10.1002/cmdc.201800235. Epub 2018 Jun 7.

PMID:
29756273
21.

Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors.

Faridoon, Mnkandhla D, Isaacs M, Hoppe HC, Kaye PT.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1067-1070. doi: 10.1016/j.bmcl.2018.02.020. Epub 2018 Feb 12.

PMID:
29482943
22.

Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: An antimalarial, antitrypanosomal and cytotoxity evaluation.

Mbosso Teinkela JE, Siwe Noundou X, Nguemfo EL, Meyer F, Wintjens R, Isaacs M, Mpondo Mpondo AE, Hoppe HC, Krause RWM, Azebaze AGB.

Saudi J Biol Sci. 2018 Jan;25(1):117-122. doi: 10.1016/j.sjbs.2017.07.002. Epub 2017 Jul 20.

23.

Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors.

Sekgota KC, Majumder S, Isaacs M, Mnkandhla D, Hoppe HC, Khanye SD, Kriel FH, Coates J, Kaye PT.

Bioorg Chem. 2017 Dec;75:310-316. doi: 10.1016/j.bioorg.2017.09.015. Epub 2017 Sep 22.

PMID:
29080495
24.

Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity.

Mbaba M, Mabhula AN, Boel N, Edkins AL, Isaacs M, Hoppe HC, Khanye SD.

J Inorg Biochem. 2017 Jul;172:88-93. doi: 10.1016/j.jinorgbio.2017.04.014. Epub 2017 Apr 13.

PMID:
28441548
25.

Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives.

Adeyemi CM, Faridoon, Isaacs M, Mnkandhla D, Hoppe HC, Krause RW, Kaye PT.

Bioorg Med Chem. 2016 Dec 1;24(23):6131-6138. doi: 10.1016/j.bmc.2016.04.021. Epub 2016 Apr 9.

PMID:
27773366
26.

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates.

Lourens AC, Gravestock D, van Zyl RL, Hoppe HC, Kolesnikova N, Taweechai S, Yuthavong Y, Kamchonwongpaisan S, Rousseau AL.

Org Biomol Chem. 2016 Aug 16;14(33):7899-911. doi: 10.1039/c6ob01350c.

PMID:
27477595
27.

Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors.

Faridoon, Edkins AL, Isaacs M, Mnkandhla D, Hoppe HC, Kaye PT.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3810-2. doi: 10.1016/j.bmcl.2016.05.023. Epub 2016 May 9.

PMID:
27317645
28.

Indolyl-3-ethanone-α-thioethers: A promising new class of non-toxic antimalarial agents.

Svogie AL, Isaacs M, Hoppe HC, Khanye SD, Veale CG.

Eur J Med Chem. 2016 May 23;114:79-88. doi: 10.1016/j.ejmech.2016.02.056. Epub 2016 Mar 3.

PMID:
26974377
29.

Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester–AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors.

Manyeruke MH, Olomola TO, Majumder S, Abrahams S, Isaacs M, Mautsa N, Mosebi S, Mnkandhla D, Hewer R, Hoppe HC, Klein R, Kaye PT.

Bioorg Med Chem. 2015 Dec 15;23(24):7521-8.

PMID:
26775541
30.

Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3-L1.

Kramer AH, Edkins AL, Hoppe HC, Prinsloo E.

J Cell Biochem. 2015 Jul;116(7):1232-40. doi: 10.1002/jcb.25076.

PMID:
25565605
31.

ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum.

Khan T, van Brummelen AC, Parkinson CJ, Hoppe HC.

Malar J. 2012 Nov 7;11:369. doi: 10.1186/1475-2875-11-369.

32.

Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells.

Deponte M, Hoppe HC, Lee MC, Maier AG, Richard D, Rug M, Spielmann T, Przyborski JM.

Mol Biochem Parasitol. 2012 Dec;186(2):95-116. doi: 10.1016/j.molbiopara.2012.09.007. Epub 2012 Oct 5. Review.

PMID:
23043991
33.

Insights into the role of heme in the mechanism of action of antimalarials.

Combrinck JM, Mabotha TE, Ncokazi KK, Ambele MA, Taylor D, Smith PJ, Hoppe HC, Egan TJ.

ACS Chem Biol. 2013 Jan 18;8(1):133-7. doi: 10.1021/cb300454t. Epub 2012 Oct 11.

34.

New frontiers in ethnomedicine: exploring the Angolan indigenous pharmacopeia for novel antimalarial drugs.

Rangel Campos W, Catarino PP, Hoppe HC.

Drug Discov Today. 2012 Jul;17(13-14):651-3. doi: 10.1016/j.drudis.2012.05.015. Epub 2012 Jun 2. No abstract available.

PMID:
22668824
35.

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors.

Bode ML, Gravestock D, Moleele SS, van der Westhuyzen CW, Pelly SC, Steenkamp PA, Hoppe HC, Khan T, Nkabinde LA.

Bioorg Med Chem. 2011 Jul 15;19(14):4227-37. doi: 10.1016/j.bmc.2011.05.062. Epub 2011 Jun 21.

PMID:
21700466
36.

Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum.

Feng TS, Guantai EM, Nell M, van Rensburg CE, Ncokazi K, Egan TJ, Hoppe HC, Chibale K.

Biochem Pharmacol. 2011 Aug 1;82(3):236-47. doi: 10.1016/j.bcp.2011.04.018. Epub 2011 May 8.

PMID:
21596024
37.

Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction.

Feng TS, Guantai EM, Nell MJ, van Rensburg CE, Hoppe HC, Chibale K.

Bioorg Med Chem Lett. 2011 May 15;21(10):2882-6. doi: 10.1016/j.bmcl.2011.03.090. Epub 2011 Mar 30.

PMID:
21489789
38.

Novel N-heterocyclic ylideneamine gold(I) complexes: synthesis, characterisation and screening for antitumour and antimalarial activity.

Coetzee J, Cronje S, Dobrzańska L, Raubenheimer HG, Jooné G, Nell MJ, Hoppe HC.

Dalton Trans. 2011 Feb 21;40(7):1471-83. doi: 10.1039/c0dt01312a. Epub 2011 Jan 12.

PMID:
21225079
39.

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock.

Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL.

Cell Stress Chaperones. 2011 Jul;16(4):389-401. doi: 10.1007/s12192-010-0250-6. Epub 2010 Dec 30.

40.

PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking.

Vaid A, Ranjan R, Smythe WA, Hoppe HC, Sharma P.

Blood. 2010 Mar 25;115(12):2500-7. doi: 10.1182/blood-2009-08-238972. Epub 2010 Jan 21.

41.

Genomes2Drugs: identifies target proteins and lead drugs from proteome data.

Toomey D, Hoppe HC, Brennan MP, Nolan KB, Chubb AJ.

PLoS One. 2009 Jul 10;4(7):e6195. doi: 10.1371/journal.pone.0006195.

42.

Heterologous expression of plasmodial proteins for structural studies and functional annotation.

Birkholtz LM, Blatch G, Coetzer TL, Hoppe HC, Human E, Morris EJ, Ngcete Z, Oldfield L, Roth R, Shonhai A, Stephens L, Louw AI.

Malar J. 2008 Oct 1;7:197. doi: 10.1186/1475-2875-7-197. Review.

43.

The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns.

Pesce ER, Acharya P, Tatu U, Nicoll WS, Shonhai A, Hoppe HC, Blatch GL.

Int J Biochem Cell Biol. 2008;40(12):2914-26. doi: 10.1016/j.biocel.2008.06.011. Epub 2008 Jul 12.

PMID:
18674634
44.

Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.

Roberts L, Egan TJ, Joiner KA, Hoppe HC.

Antimicrob Agents Chemother. 2008 May;52(5):1840-2. doi: 10.1128/AAC.01478-07. Epub 2008 Mar 3.

45.

Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum.

Smythe WA, Joiner KA, Hoppe HC.

Cell Microbiol. 2008 Feb;10(2):452-64. Epub 2007 Oct 18.

PMID:
17944961
46.

Transformations of manool. tri- and tetracyclic norditerpenoids with in vitro activity against Plasmodium falciparum.

van Wyk AW, Lobb KA, Caira MR, Hoppe HC, Davies-Coleman MT.

J Nat Prod. 2007 Aug;70(8):1253-8. Epub 2007 Jul 11.

PMID:
17625894
47.

Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis.

Rautenbach M, Vlok NM, Stander M, Hoppe HC.

Biochim Biophys Acta. 2007 Jun;1768(6):1488-97. Epub 2007 Jan 26.

48.

Selective lysis of erythrocytes infected with the trophozoite stage of Plasmodium falciparum by polyene macrolide antibiotics.

Wiehart UI, Rautenbach M, Hoppe HC.

Biochem Pharmacol. 2006 Mar 14;71(6):779-90. Epub 2006 Jan 24.

PMID:
16436272
49.

The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation.

Yang M, Coppens I, Wormsley S, Baevova P, Hoppe HC, Joiner KA.

J Cell Sci. 2004 Aug 1;117(Pt 17):3831-8. Epub 2004 Jul 13.

50.

Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum.

Hoppe HC, van Schalkwyk DA, Wiehart UI, Meredith SA, Egan J, Weber BW.

Antimicrob Agents Chemother. 2004 Jul;48(7):2370-8.

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