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Items: 26


Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer.

Hopkins BD, Goncalves MD, Cantley LC.

Nat Rev Endocrinol. 2020 Mar 3. doi: 10.1038/s41574-020-0329-9. [Epub ahead of print] Review.


PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC.

Cell Rep. 2019 May 14;27(7):1991-2001.e5. doi: 10.1016/j.celrep.2019.04.070.


Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.

Hodakoski C, Hopkins BD, Zhang G, Su T, Cheng Z, Morris R, Rhee KY, Goncalves MD, Cantley LC.

Cancers (Basel). 2019 Jan 2;11(1). pii: E37. doi: 10.3390/cancers11010037.


Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.

Goncalves MD, Hopkins BD, Cantley LC.

N Engl J Med. 2018 Nov 22;379(21):2052-2062. doi: 10.1056/NEJMra1704560. Review. No abstract available.


Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC.

Nature. 2018 Nov;563(7731):E24. doi: 10.1038/s41586-018-0506-3.


Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC.

Nature. 2018 Aug;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4. Erratum in: Nature. 2018 Aug 29;:.


Cancer metabolism gets physical.

DelNero P, Hopkins BD, Cantley LC, Fischbach C.

Sci Transl Med. 2018 May 23;10(442). pii: eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Review.


Fenofibrate prevents skeletal muscle loss in mice with lung cancer.

Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. doi: 10.1073/pnas.1714703115. Epub 2018 Jan 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Feb 20;:.


Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity.

Riquelme SA, Hopkins BD, Wolfe AL, DiMango E, Kitur K, Parsons R, Prince A.

Immunity. 2017 Dec 19;47(6):1169-1181.e7. doi: 10.1016/j.immuni.2017.11.010. Epub 2017 Dec 12.


The PI3K Pathway in Human Disease.

Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT.

Cell. 2017 Aug 10;170(4):605-635. doi: 10.1016/j.cell.2017.07.029. Review.


Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.

Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, Rao R, Mosquera JM, Robinson B, Faltas BM, Emerling BE, Gadi VK, Bernard B, Elemento O, Beltran H, Demichelis F, Kemp CJ, Grandori C, Cantley LC, Rubin MA.

Cancer Discov. 2017 May;7(5):462-477. doi: 10.1158/2159-8290.CD-16-1154. Epub 2017 Mar 22.


Obesity and Cancer Mechanisms: Cancer Metabolism.

Hopkins BD, Goncalves MD, Cantley LC.

J Clin Oncol. 2016 Dec 10;34(35):4277-4283. Epub 2016 Nov 7. Review.


Under Construction: One State's Approach to Creating Health Homes for Individuals with Serious Mental Illness.

Auxier AM, Hopkins BD, Reins AE.

AIMS Public Health. 2015 Apr 22;2(2):163-182. doi: 10.3934/publichealth.2015.2.163. eCollection 2015.


PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.

Mense SM, Barrows D, Hodakoski C, Steinbach N, Schoenfeld D, Su W, Hopkins BD, Su T, Fine B, Hibshoosh H, Parsons R.

Sci Signal. 2015 Mar 31;8(370):ra32. doi: 10.1126/scisignal.2005840.


Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy.

Hopkins BD, Parsons RE.

Clin Cancer Res. 2014 Nov 1;20(21):5379-83. doi: 10.1158/1078-0432.CCR-13-2661. Review.


PTEN function: the long and the short of it.

Hopkins BD, Hodakoski C, Barrows D, Mense SM, Parsons RE.

Trends Biochem Sci. 2014 Apr;39(4):183-90. doi: 10.1016/j.tibs.2014.02.006. Epub 2014 Mar 18. Review.


Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.

Hodakoski C, Hopkins BD, Barrows D, Mense SM, Keniry M, Anderson KE, Kern PA, Hawkins PT, Stephens LR, Parsons R.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):155-60. doi: 10.1073/pnas.1213773111. Epub 2013 Dec 23.


A secreted PTEN phosphatase that enters cells to alter signaling and survival.

Hopkins BD, Fine B, Steinbach N, Dendy M, Rapp Z, Shaw J, Pappas K, Yu JS, Hodakoski C, Mense S, Klein J, Pegno S, Sulis ML, Goldstein H, Amendolara B, Lei L, Maurer M, Bruce J, Canoll P, Hibshoosh H, Parsons R.

Science. 2013 Jul 26;341(6144):399-402. doi: 10.1126/science.1234907. Epub 2013 Jun 6.


Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.

Pires MM, Hopkins BD, Saal LH, Parsons RE.

Cancer Biol Ther. 2013 Mar;14(3):246-53. doi: 10.4161/cbt.23297. Epub 2013 Jan 4.


3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.

Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R.

Cancer Res. 2009 Aug 1;69(15):6299-306. doi: 10.1158/0008-5472.CAN-09-0820. Epub 2009 Jul 14.


Gab2-mediated signaling promotes melanoma metastasis.

Horst B, Gruvberger-Saal SK, Hopkins BD, Bordone L, Yang Y, Chernoff KA, Uzoma I, Schwipper V, Liebau J, Nowak NJ, Brunner G, Owens D, Rimm DL, Parsons R, Celebi JT.

Am J Pathol. 2009 Apr;174(4):1524-33. doi: 10.2353/ajpath.2009.080543.


Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.

Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1344-51. doi: 10.1152/ajpheart.01246.2008. Epub 2009 Mar 20.


Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.

Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME.

Blood. 2007 Feb 15;109(4):1524-32. Epub 2006 Oct 5.


An amphibian model to test the effects of xenobiotic chemicals on development of the hematopoietic system.

Rollins-Smith LA, Hopkins BD, Reinert LK.

Environ Toxicol Chem. 2004 Dec;23(12):2863-7.


Introduction of Kex2 cleavage sites in fusion proteins for monitoring localization and transport in yeast secretory pathway.

Hopkins BD, Sato K, Nakano A, Graham TR.

Methods Enzymol. 2000;327:107-18. No abstract available.


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