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Items: 1 to 50 of 161

1.

Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.

Jansma M, Linke-Winnebeck C, Eustermann S, Lammens K, Kostrewa D, Stakyte K, Litz C, Kessler B, Hopfner KP.

Structure. 2019 Nov 6. pii: S0969-2126(19)30354-5. doi: 10.1016/j.str.2019.10.013. [Epub ahead of print]

PMID:
31740028
2.

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.

Sustmann C, Dickopf S, Regula JT, Kettenberger H, Mølhøj M, Gassner C, Weininger D, Fenn S, Manigold T, Kling L, Künkele KP, Schwaiger M, Bossenmaier B, Griese JJ, Hopfner KP, Graff-Meyer A, Stahlberg H, Ringler P, Lauer ME, Brinkmann U, Schaefer W, Klein C.

MAbs. 2019 Nov-Dec;11(8):1402-1414. doi: 10.1080/19420862.2019.1661736. Epub 2019 Sep 17.

3.

Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.

Käshammer L, Saathoff JH, Lammens K, Gut F, Bartho J, Alt A, Kessler B, Hopfner KP.

Mol Cell. 2019 Nov 7;76(3):382-394.e6. doi: 10.1016/j.molcel.2019.07.035. Epub 2019 Sep 3.

PMID:
31492634
4.

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.

Turunen SP, von Nandelstadh P, Öhman T, Gucciardo E, Seashore-Ludlow B, Martins B, Rantanen V, Li H, Höpfner K, Östling P, Varjosalo M, Lehti K.

Cell Death Differ. 2019 Dec;26(12):2577-2593. doi: 10.1038/s41418-019-0321-x. Epub 2019 Mar 22.

PMID:
30903103
5.

A Click-Chemistry Linked 2'3'-cGAMP Analogue.

Dialer CR, Stazzoni S, Drexler DJ, Müller FM, Veth S, Pichler A, Okamura H, Witte G, Hopfner KP, Carell T.

Chemistry. 2019 Feb 6;25(8):2089-2095. doi: 10.1002/chem.201805409. Epub 2019 Jan 17.

PMID:
30536650
6.

Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state.

Butryn A, Woike S, Shetty SJ, Auble DT, Hopfner KP.

Elife. 2018 Oct 5;7. pii: e37774. doi: 10.7554/eLife.37774.

7.

Molecular architecture and regulation of BCL10-MALT1 filaments.

Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner KP, Gutsche I, Krappmann D, Lammens K.

Nat Commun. 2018 Oct 2;9(1):4041. doi: 10.1038/s41467-018-06573-8.

8.

The bacterial Mre11-Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions.

Saathoff JH, Käshammer L, Lammens K, Byrne RT, Hopfner KP.

Nucleic Acids Res. 2018 Nov 30;46(21):11303-11314. doi: 10.1093/nar/gky878.

9.

Bifunctional PD-1 × αCD3 × αCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.

Herrmann M, Krupka C, Deiser K, Brauchle B, Marcinek A, Ogrinc Wagner A, Rataj F, Mocikat R, Metzeler KH, Spiekermann K, Kobold S, Fenn NC, Hopfner KP, Subklewe M.

Blood. 2018 Dec 6;132(23):2484-2494. doi: 10.1182/blood-2018-05-849802. Epub 2018 Oct 1.

PMID:
30275109
10.

Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells.

Braciak TA, Roskopf CC, Wildenhain S, Fenn NC, Schiller CB, Schubert IA, Jacob U, Honegger A, Krupka C, Subklewe M, Spiekermann K, Hopfner KP, Fey GH, Aigner M, Krause S, Mackensen A, Oduncu FS.

Oncoimmunology. 2018 Jul 30;7(9):e1472195. doi: 10.1080/2162402X.2018.1472195. eCollection 2018.

11.

The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.

Knoll KR, Eustermann S, Niebauer V, Oberbeckmann E, Stoehr G, Schall K, Tosi A, Schwarz M, Buchfellner A, Korber P, Hopfner KP.

Nat Struct Mol Biol. 2018 Sep;25(9):823-832. doi: 10.1038/s41594-018-0115-8. Epub 2018 Sep 3.

PMID:
30177756
12.

Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.

Lässig C, Lammens K, Gorenflos López JL, Michalski S, Fettscher O, Hopfner KP.

Elife. 2018 Jul 26;7. pii: e38958. doi: 10.7554/eLife.38958.

13.

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.

Eustermann S, Schall K, Kostrewa D, Lakomek K, Strauss M, Moldt M, Hopfner KP.

Nature. 2018 Apr;556(7701):386-390. doi: 10.1038/s41586-018-0029-y. Epub 2018 Apr 11.

14.

Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.

Kotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C.

Nat Genet. 2018 Mar;50(3):344-348. doi: 10.1038/s41588-018-0063-6. Epub 2018 Feb 26.

15.

Single-molecule nucleosome remodeling by INO80 and effects of histone tails.

Schwarz M, Schall K, Kallis E, Eustermann S, Guariento M, Moldt M, Hopfner KP, Michaelis J.

FEBS Lett. 2018 Feb;592(3):318-331. doi: 10.1002/1873-3468.12973. Epub 2018 Jan 26.

16.

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

Chiang JJ, Sparrer KMJ, van Gent M, Lässig C, Huang T, Osterrieder N, Hopfner KP, Gack MU.

Nat Immunol. 2018 Jan;19(1):53-62. doi: 10.1038/s41590-017-0005-y. Epub 2017 Nov 27.

17.

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.

Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A.

Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. doi: 10.1093/nar/gkx890.

18.

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.

Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.

Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13.

PMID:
28902841
19.

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.

Lässig C, Hopfner KP.

J Biol Chem. 2017 Jun 2;292(22):9000-9009. doi: 10.1074/jbc.R117.788398. Epub 2017 Apr 14. Review.

20.

SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells.

Ponce LP, Fenn NC, Moritz N, Krupka C, Kozik JH, Lauber K, Subklewe M, Hopfner KP.

Oncotarget. 2017 Feb 14;8(7):11284-11301. doi: 10.18632/oncotarget.14500.

21.

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.

Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM.

Mol Cell. 2016 Dec 1;64(5):951-966. doi: 10.1016/j.molcel.2016.10.032. Epub 2016 Nov 23.

22.

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.

Schiller CB, Braciak TA, Fenn NC, Seidel UJ, Roskopf CC, Wildenhain S, Honegger A, Schubert IA, Schele A, Lämmermann K, Fey GH, Jacob U, Lang P, Hopfner KP, Oduncu FS.

Oncotarget. 2016 Dec 13;7(50):83392-83408. doi: 10.18632/oncotarget.13110.

23.

Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.

Stahl E, Praetorius F, de Oliveira Mann CC, Hopfner KP, Dietz H.

ACS Nano. 2016 Oct 25;10(10):9156-9164. doi: 10.1021/acsnano.6b04787. Epub 2016 Sep 7.

PMID:
27583560
24.

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.

de Oliveira Mann CC, Kiefersauer R, Witte G, Hopfner KP.

Sci Rep. 2016 Jun 8;6:27498. doi: 10.1038/srep27498.

25.

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA.

Nat Commun. 2016 Jun 2;7:11733. doi: 10.1038/ncomms11733.

26.

RIG-I-Like Receptors: One STrEP Forward.

Lässig C, Hopfner KP.

Trends Microbiol. 2016 Jul;24(7):517-519. doi: 10.1016/j.tim.2016.05.001. Epub 2016 May 25.

PMID:
27236860
27.

Invited review: Architectures and mechanisms of ATP binding cassette proteins.

Hopfner KP.

Biopolymers. 2016 Aug;105(8):492-504. doi: 10.1002/bip.22843. Review.

PMID:
27037766
28.

Editorial overview: Macromolecular machines and assemblies.

Barford D, Hopfner KP.

Curr Opin Struct Biol. 2016 Apr;37:vi-viii. doi: 10.1016/j.sbi.2016.03.002. Epub 2016 Mar 16. No abstract available.

PMID:
26994942
29.

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.

Roskopf CC, Braciak TA, Fenn NC, Kobold S, Fey GH, Hopfner KP, Oduncu FS.

Oncotarget. 2016 Apr 19;7(16):22579-89. doi: 10.18632/oncotarget.8022.

30.

Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.

Chatzopoulou EI, Roskopf CC, Sekhavati F, Braciak TA, Fenn NC, Hopfner KP, Oduncu FS, Fey GH, Rädler JO.

Analyst. 2016 Apr 7;141(7):2284-95. doi: 10.1039/c5an02585k.

PMID:
26958659
31.

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.

Elife. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available.

32.

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.

Seifert FU, Lammens K, Stoehr G, Kessler B, Hopfner KP.

EMBO J. 2016 Apr 1;35(7):759-72. doi: 10.15252/embj.201592934. Epub 2016 Feb 19.

33.

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.

Genes Dev. 2016 Feb 1;30(3):337-54. doi: 10.1101/gad.273813.115. Epub 2016 Jan 21.

34.

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.

Elife. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954.

35.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.

Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7.

36.

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.

Butryn A, Schuller JM, Stoehr G, Runge-Wollmann P, Förster F, Auble DT, Hopfner KP.

Elife. 2015 Aug 10;4. doi: 10.7554/eLife.07432.

37.

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.

Seifert FU, Lammens K, Hopfner KP.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):752-7. doi: 10.1107/S2053230X15007566. Epub 2015 May 22.

38.

Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.

Müller M, Deimling T, Hopfner KP, Witte G.

Biochem J. 2015 Aug 1;469(3):367-74. doi: 10.1042/BJ20150373. Epub 2015 May 27.

PMID:
26014055
39.

Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans.

Butryn A, Stoehr G, Linke-Winnebeck C, Hopfner KP.

Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):471-6. doi: 10.1107/S2053230X15004902. Epub 2015 Mar 21.

40.

Structural basis for dodecameric assembly states and conformational plasticity of the full-length AAA+ ATPases Rvb1 · Rvb2.

Lakomek K, Stoehr G, Tosi A, Schmailzl M, Hopfner KP.

Structure. 2015 Mar 3;23(3):483-495. doi: 10.1016/j.str.2014.12.015. Epub 2015 Feb 5.

41.

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.

Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D.

Chem Biol. 2015 Jan 22;22(1):129-38. doi: 10.1016/j.chembiol.2014.10.021. Epub 2014 Dec 31.

42.

Molecular architecture of the HerA-NurA DNA double-strand break resection complex.

Byrne RT, Schuller JM, Unverdorben P, Förster F, Hopfner KP.

FEBS Lett. 2014 Dec 20;588(24):4637-44. doi: 10.1016/j.febslet.2014.10.035. Epub 2014 Nov 11.

43.

c-di-AMP recognition by Staphylococcus aureus PstA.

Müller M, Hopfner KP, Witte G.

FEBS Lett. 2015 Jan 2;589(1):45-51. doi: 10.1016/j.febslet.2014.11.022. Epub 2014 Nov 28.

44.

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.

Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V.

EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25.

45.

Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.

Rojowska A, Lammens K, Seifert FU, Direnberger C, Feldmann H, Hopfner KP.

EMBO J. 2014 Dec 1;33(23):2847-59. doi: 10.15252/embj.201488889. Epub 2014 Oct 27.

46.
47.

RIG-I holds the CARDs in a game of self versus nonself.

Hopfner KP.

Mol Cell. 2014 Aug 21;55(4):505-7. doi: 10.1016/j.molcel.2014.08.009.

48.

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.

Roskopf CC, Schiller CB, Braciak TA, Kobold S, Schubert IA, Fey GH, Hopfner KP, Oduncu FS.

Oncotarget. 2014 Aug 15;5(15):6466-83.

49.

Crystal and solution structure of the human RIG-I SF2 domain.

Deimling T, Cui S, Lammens K, Hopfner KP, Witte G.

Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):1027-31. doi: 10.1107/S2053230X14012230. Epub 2014 Jul 23.

50.

Structural studies of DNA end detection and resection in homologous recombination.

Schiller CB, Seifert FU, Linke-Winnebeck C, Hopfner KP.

Cold Spring Harb Perspect Biol. 2014 Jul 31;6(10):a017962. doi: 10.1101/cshperspect.a017962. Review.

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