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A novel NMDA receptor-based intervention to suppress compulsion-like alcohol drinking.

Wegner SA, Hu B, De Oliveira Sergio T, Darevsky D, Kwok CC, Lei K, Hopf FW.

Neuropharmacology. 2019 Oct;157:107681. doi: 10.1016/j.neuropharm.2019.107681. Epub 2019 Jun 25.


Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals.

Lei K, Kwok C, Darevsky D, Wegner SA, Yu J, Nakayama L, Pedrozo V, Anderson L, Ghotra S, Fouad M, Hopf FW.

Front Neurosci. 2019 Feb 13;13:88. doi: 10.3389/fnins.2019.00088. eCollection 2019.


In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness.

Yamaguchi H, Hopf FW, Li SB, de Lecea L.

Nat Commun. 2018 Dec 6;9(1):5211. doi: 10.1038/s41467-018-07566-3.


A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety.

Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti SM, Lei K, Morikawa H, Hopf FW, Messing RO.

J Neurosci. 2019 Feb 6;39(6):1030-1043. doi: 10.1523/JNEUROSCI.2143-18.2018. Epub 2018 Dec 10.


Advances in behavioral animal models of alcohol use disorder.

Goltseker K, Hopf FW, Barak S.

Alcohol. 2019 Feb;74:73-82. doi: 10.1016/j.alcohol.2018.05.014. Epub 2018 Jun 1. Review.


Drinking despite adversity: behavioral evidence for a head down and push strategy of conflict-resistant alcohol drinking in rats.

Darevsky D, Gill TM, Vitale KR, Hu B, Wegner SA, Hopf FW.

Addict Biol. 2019 May;24(3):426-437. doi: 10.1111/adb.12608. Epub 2018 Mar 8.


Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice.

Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW.

Alcohol Clin Exp Res. 2017 Feb;41(2):345-358. doi: 10.1111/acer.13303. Epub 2017 Jan 19.


A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice.

Lei K, Wegner SA, Yu JH, Simms JA, Hopf FW.

Alcohol. 2016 Sep;55:9-16. doi: 10.1016/j.alcohol.2016.07.008. Epub 2016 Aug 20.


Do specific NMDA receptor subunits act as gateways for addictive behaviors?

Hopf FW.

Genes Brain Behav. 2017 Jan;16(1):118-138. doi: 10.1111/gbb.12348. Epub 2016 Nov 18. Review.


Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking.

Lei K, Wegner SA, Yu JH, Mototake A, Hu B, Hopf FW.

Front Neurosci. 2016 Aug 30;10:400. doi: 10.3389/fnins.2016.00400. eCollection 2016.


Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms.

Zuo W, Xiao C, Gao M, Hopf FW, Krnjević K, McIntosh JM, Fu R, Wu J, Bekker A, Ye JH.

Sci Rep. 2016 Sep 6;6:32937. doi: 10.1038/srep32937.


Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice.

Lei K, Wegner SA, Yu JH, Hopf FW.

Neuropharmacology. 2016 Nov;110(Pt A):431-437. doi: 10.1016/j.neuropharm.2016.08.008. Epub 2016 Aug 11.


A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.

Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO.

Front Neurosci. 2015 Dec 24;9:487. doi: 10.3389/fnins.2015.00487. eCollection 2015.


Commentary: alcohol depletion of magnesium: a new mechanism for tolerance to alcohol activation of BK channels?

Hopf FW.

Alcohol Clin Exp Res. 2015 Nov;39(11):2095-6. doi: 10.1111/acer.12857. Epub 2015 Sep 1. Review. No abstract available.


Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons.

Zuo W, Fu R, Hopf FW, Xie G, Krnjević K, Li J, Ye JH.

Addict Biol. 2017 Jan;22(1):103-116. doi: 10.1111/adb.12298. Epub 2015 Aug 18.


D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats.

Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW.

Neuropsychopharmacology. 2015 Sep;40(10):2357-67. doi: 10.1038/npp.2015.84. Epub 2015 Mar 24.


Rodent models for compulsive alcohol intake.

Hopf FW, Lesscher HM.

Alcohol. 2014 May;48(3):253-64. doi: 10.1016/j.alcohol.2014.03.001. Epub 2014 Mar 27. Review.


The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area.

Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE.

PLoS One. 2013 Jul 15;8(7):e68300. doi: 10.1371/journal.pone.0068300. Print 2013.


Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.

Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW.

Nat Neurosci. 2013 Aug;16(8):1094-100. doi: 10.1038/nn.3445. Epub 2013 Jun 30.


Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area.

Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A.

Alcohol Clin Exp Res. 2013 Oct;37(10):1680-7. doi: 10.1111/acer.12153. Epub 2013 Jun 13.


MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro.

Hopf FW, Seif T, Chung S, Civelli O.

PeerJ. 2013 Apr 9;1:e61. doi: 10.7717/peerj.61. Print 2013.


Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking.

Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A.

Nature. 2013 Apr 18;496(7445):359-62. doi: 10.1038/nature12024. Epub 2013 Apr 3.


The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration.

Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE.

PLoS One. 2012;7(9):e44726. doi: 10.1371/journal.pone.0044726. Epub 2012 Sep 21.


Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.

Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E.

J Neurosci. 2012 Jun 27;32(26):9023-34. doi: 10.1523/JNEUROSCI.0918-12.2012.


Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation.

Addolorato G, Leggio L, Hopf FW, Diana M, Bonci A.

Neuropsychopharmacology. 2012 Jan;37(1):163-77. doi: 10.1038/npp.2011.216. Epub 2011 Oct 26. Review.


The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing.

Seif T, Makriyannis A, Kunos G, Bonci A, Hopf FW.

Neuroscience. 2011 Oct 13;193:21-33. doi: 10.1016/j.neuroscience.2011.07.055. Epub 2011 Jul 27.


Endocytosis promotes rapid dopaminergic signaling.

Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M.

Neuron. 2011 Jul 28;71(2):278-90. doi: 10.1016/j.neuron.2011.05.036.


The SK channel as a novel target for treating alcohol use disorders.

Hopf FW, Seif T, Bonci A.

Channels (Austin). 2011 Jul-Aug;5(4):289-92. doi: 10.4161/chan.5.4.16577. Epub 2011 Jul 1.


Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats.

Hopf FW, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A.

Biol Psychiatry. 2011 Apr 1;69(7):618-24. doi: 10.1016/j.biopsych.2010.11.011. Epub 2010 Dec 31.


Translational models of interactions between stress and alcohol consumption: strengths and limitations.

Hopf FW, Sparta DR, Bonci A.

ILAR J. 2011;52(3):239-50. doi: 10.1093/ilar.52.3.239.


Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.

Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A.

Curr Top Behav Neurosci. 2010;3:3-27. doi: 10.1007/7854_2009_23. Review.


Dnmt3a: addiction's molecular forget-me-not?

Hopf FW, Bonci A.

Nat Neurosci. 2010 Sep;13(9):1041-3. doi: 10.1038/nn0910-1041.


Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity.

Kapfhamer D, Berger KH, Hopf FW, Seif T, Kharazia V, Bonci A, Heberlein U.

J Neurosci. 2010 Jun 30;30(26):8830-40. doi: 10.1523/JNEUROSCI.1292-10.2010.


Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration.

Hopf FW, Chang SJ, Sparta DR, Bowers MS, Bonci A.

Alcohol Clin Exp Res. 2010 Sep 1;34(9):1565-73. doi: 10.1111/j.1530-0277.2010.01241.x. Epub 2010 Jun 25.


The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum.

Hopf FW, Seif T, Mohamedi ML, Chen BT, Bonci A.

Eur J Neurosci. 2010 Jun;31(11):1946-59. doi: 10.1111/j.1460-9568.2010.07231.x. Epub 2010 May 24.


Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.

Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A.

Neuron. 2010 Mar 11;65(5):682-94. doi: 10.1016/j.neuron.2010.02.015.


Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse.

Chen BT, Hopf FW, Bonci A.

Ann N Y Acad Sci. 2010 Feb;1187:129-39. doi: 10.1111/j.1749-6632.2009.05154.x. Review.


Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.

Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH.

J Neurosci. 2009 Jun 24;29(25):8156-65. doi: 10.1523/JNEUROSCI.3905-08.2009.


Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels.

Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ.

Alcohol Clin Exp Res. 2009 Jul;33(7):1125-35. doi: 10.1111/j.1530-0277.2009.00936.x. Epub 2009 Apr 9. Review.


The melanin-concentrating hormone system modulates cocaine reward.

Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6772-7. doi: 10.1073/pnas.0811331106. Epub 2009 Apr 2.


Striatal-enriched protein-tyrosine-phosphatase, synaptic plasticity, and psychostimulant-induced stereotypies.

Hopf FW, Bonci A.

Biol Psychiatry. 2009 Apr 15;65(8):635-6. doi: 10.1016/j.biopsych.2009.02.008. No abstract available.


Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure.

Wanat MJ, Sparta DR, Hopf FW, Bowers MS, Melis M, Bonci A.

Biol Psychiatry. 2009 Apr 15;65(8):646-53. doi: 10.1016/j.biopsych.2008.10.042. Epub 2008 Dec 31.


Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.

Bowers MS, Hopf FW, Chou JK, Guillory AM, Chang SJ, Janak PH, Bonci A, Diamond I.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12533-8. doi: 10.1073/pnas.0706999105. Epub 2008 Aug 21.


Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA.

Chen BT, Bowers MS, Martin M, Hopf FW, Guillory AM, Carelli RM, Chou JK, Bonci A.

Neuron. 2008 Jul 31;59(2):288-97. doi: 10.1016/j.neuron.2008.05.024.


Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area.

Stuber GD, Hopf FW, Hahn J, Cho SL, Guillory A, Bonci A.

Alcohol Clin Exp Res. 2008 Oct;32(10):1714-20. doi: 10.1111/j.1530-0277.2008.00749.x. Epub 2008 Jul 8.


Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih.

Wanat MJ, Hopf FW, Stuber GD, Phillips PE, Bonci A.

J Physiol. 2008 Apr 15;586(8):2157-70. doi: 10.1113/jphysiol.2007.150078. Epub 2008 Feb 28.


Calcium misregulation and the pathogenesis of muscular dystrophy.

Hopf FW, Turner PR, Steinhardt RA.

Subcell Biochem. 2007;45:429-64. Review.


Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro.

Hopf FW, Martin M, Chen BT, Bowers MS, Mohamedi MM, Bonci A.

J Neurophysiol. 2007 Oct;98(4):2297-310. Epub 2007 Aug 15.


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