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Separate vmPFC ensembles control cocaine self-administration versus extinction in rats.

Warren BL, Kane L, Venniro M, Selvam P, Quintana-Feliciano R, Mendoza MP, Madangopal R, Komer L, Whitaker LR, Rubio FJ, Bossert JM, Caprioli D, Shaham Y, Hope BT.

J Neurosci. 2019 Jul 22. pii: 0918-19. doi: 10.1523/JNEUROSCI.0918-19.2019. [Epub ahead of print]


Discriminative stimuli are sufficient for incubation of cocaine craving.

Madangopal R, Tunstall BJ, Komer LE, Weber SJ, Hoots JK, Lennon VA, Bossert JM, Epstein DH, Shaham Y, Hope BT.

Elife. 2019 Feb 25;8. pii: e44427. doi: 10.7554/eLife.44427.


Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats.

Bäck S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, Lupica CR, Underhill SM, Amara SG, Domanskyi A, Anttila JE, Airavaara M, Hope BT, Hamra FK, Richie CT, Harvey BK.

Neuron. 2019 Apr 3;102(1):105-119.e8. doi: 10.1016/j.neuron.2019.01.035. Epub 2019 Feb 18.


Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking.

Pardo-Garcia TR, Garcia-Keller C, Penaloza T, Richie CT, Pickel J, Hope BT, Harvey BK, Kalivas PW, Heinsbroek JA.

J Neurosci. 2019 Mar 13;39(11):2041-2051. doi: 10.1523/JNEUROSCI.2822-18.2018. Epub 2019 Jan 8.


Improved methods for marking active neuron populations.

Moeyaert B, Holt G, Madangopal R, Perez-Alvarez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eickholt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, Schreiter ER.

Nat Commun. 2018 Oct 25;9(1):4440. doi: 10.1038/s41467-018-06935-2.


Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in a polydrug self-administration rat model.

Rubio FJ, Quintana-Feliciano R, Warren BL, Li X, Witonsky KFR, Valle FSD, Selvam PV, Caprioli D, Venniro M, Bossert JM, Shaham Y, Hope BT.

Eur J Neurosci. 2019 Jan;49(2):165-178. doi: 10.1111/ejn.14203. Epub 2018 Nov 9.


Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.

Whitaker LR, Hope BT.

Learn Mem. 2018 Aug 16;25(9):455-460. doi: 10.1101/lm.046698.117. Print 2018 Sep. Review.


Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning.

Whitaker LR, Warren BL, Venniro M, Harte TC, McPherson KB, Beidel J, Bossert JM, Shaham Y, Bonci A, Hope BT.

J Neurosci. 2017 Sep 6;37(36):8845-8856. doi: 10.1523/JNEUROSCI.3761-16.2017. Epub 2017 Aug 4.


Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse.

Xue YX, Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L.

Biol Psychiatry. 2017 Dec 1;82(11):781-793. doi: 10.1016/j.biopsych.2017.04.017. Epub 2017 May 11.


Mechanistic Resolution Required to Mediate Operant Learned Behaviors: Insights from Neuronal Ensemble-Specific Inactivation.

Warren BL, Suto N, Hope BT.

Front Neural Circuits. 2017 Apr 24;11:28. doi: 10.3389/fncir.2017.00028. eCollection 2017.


Cortical and amygdalar neuronal ensembles in alcohol seeking, drinking and withdrawal.

George O, Hope BT.

Neuropharmacology. 2017 Aug 1;122:107-114. doi: 10.1016/j.neuropharm.2017.04.031. Epub 2017 Apr 20. Review.


Near-infrared fluorescent protein iRFP713 as a reporter protein for optogenetic vectors, a transgenic Cre-reporter rat, and other neuronal studies.

Richie CT, Whitaker LR, Whitaker KW, Necarsulmer J, Baldwin HA, Zhang Y, Fortuno L, Hinkle JJ, Koivula P, Henderson MJ, Sun W, Wang K, Smith JC, Pickel J, Ji N, Hope BT, Harvey BK.

J Neurosci Methods. 2017 Jun 1;284:1-14. doi: 10.1016/j.jneumeth.2017.03.020. Epub 2017 Apr 2.


Neurons Internalize Functionalized Micron-Sized Silicon Dioxide Microspheres.

Wallace VJ, Cimbro R, Rubio FJ, Fortuno LV, Necarsulmer JC, Koivula PP, Henderson MJ, DeBiase LM, Warren BL, Harvey BK, Hope BT.

Cell Mol Neurobiol. 2017 Nov;37(8):1487-1499. doi: 10.1007/s10571-017-0479-z. Epub 2017 Mar 4.


Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence.

Caprioli D, Venniro M, Zhang M, Bossert JM, Warren BL, Hope BT, Shaham Y.

J Neurosci. 2017 Jan 25;37(4):1014-1027. doi: 10.1523/JNEUROSCI.3091-16.2016.


Distinct memory engrams in the infralimbic cortex of rats control opposing environmental actions on a learned behavior.

Suto N, Laque A, De Ness GL, Wagner GE, Watry D, Kerr T, Koya E, Mayford MR, Hope BT, Weiss F.

Elife. 2016 Dec 10;5. pii: e21920. doi: 10.7554/eLife.21920.


Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence.

de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O.

J Neurosci. 2016 Sep 7;36(36):9446-53. doi: 10.1523/JNEUROSCI.1395-16.2016.


Role of Central Amygdala Neuronal Ensembles in Incubation of Nicotine Craving.

Funk D, Coen K, Tamadon S, Hope BT, Shaham Y, Lê AD.

J Neurosci. 2016 Aug 17;36(33):8612-23. doi: 10.1523/JNEUROSCI.1505-16.2016.


Daun02 Inactivation of Behaviorally Activated Fos-Expressing Neuronal Ensembles.

Koya E, Margetts-Smith G, Hope BT.

Curr Protoc Neurosci. 2016 Jul 1;76:8.36.1-8.36.17. doi: 10.1002/cpns.2.


Distinct Fos-Expressing Neuronal Ensembles in the Ventromedial Prefrontal Cortex Mediate Food Reward and Extinction Memories.

Warren BL, Mendoza MP, Cruz FC, Leao RM, Caprioli D, Rubio FJ, Whitaker LR, McPherson KB, Bossert JM, Shaham Y, Hope BT.

J Neurosci. 2016 Jun 22;36(25):6691-703. doi: 10.1523/JNEUROSCI.0140-16.2016.


Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence.

Marchant NJ, Campbell EJ, Whitaker LR, Harvey BK, Kaganovsky K, Adhikary S, Hope BT, Heins RC, Prisinzano TE, Vardy E, Bonci A, Bossert JM, Shaham Y.

J Neurosci. 2016 Mar 16;36(11):3281-94. doi: 10.1523/JNEUROSCI.4299-15.2016.


Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons.

Liberini CG, Boyle CN, Cifani C, Venniro M, Hope BT, Lutz TA.

Eur J Neurosci. 2016 Mar;43(5):653-61. doi: 10.1111/ejn.13163. Epub 2016 Feb 5.


Associative Learning Drives the Formation of Silent Synapses in Neuronal Ensembles of the Nucleus Accumbens.

Whitaker LR, Carneiro de Oliveira PE, McPherson KB, Fallon RV, Planeta CS, Bonci A, Hope BT.

Biol Psychiatry. 2016 Aug 1;80(3):246-56. doi: 10.1016/j.biopsych.2015.08.006. Epub 2015 Aug 14.


Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex.

Pfarr S, Meinhardt MW, Klee ML, Hansson AC, Vengeliene V, Schönig K, Bartsch D, Hope BT, Spanagel R, Sommer WH.

J Neurosci. 2015 Jul 29;35(30):10750-61. doi: 10.1523/JNEUROSCI.0684-15.2015.


Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons.

Li X, Rubio FJ, Zeric T, Bossert JM, Kambhampati S, Cates HM, Kennedy PJ, Liu QR, Cimbro R, Hope BT, Nestler EJ, Shaham Y.

J Neurosci. 2015 May 27;35(21):8232-44. doi: 10.1523/JNEUROSCI.1022-15.2015.


Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.

Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y.

Neuropsychopharmacology. 2016 Jan;41(2):402-9. doi: 10.1038/npp.2015.149. Epub 2015 May 28.


Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking.

Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O.

J Neurosci. 2015 Apr 15;35(15):6241-53. doi: 10.1523/JNEUROSCI.3302-14.2015. Erratum in: J Neurosci. 2015 Aug 5;35(31):11169.


Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.

Rubio FJ, Liu QR, Li X, Cruz FC, Leão RM, Warren BL, Kambhampati S, Babin KR, McPherson KB, Cimbro R, Bossert JM, Shaham Y, Hope BT.

J Neurosci. 2015 Apr 8;35(14):5625-39. doi: 10.1523/JNEUROSCI.4997-14.2015.


Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction.

Cruz FC, Javier Rubio F, Hope BT.

Brain Res. 2015 Dec 2;1628(Pt A):157-73. doi: 10.1016/j.brainres.2014.11.005. Epub 2014 Nov 11. Review.


Role of nucleus accumbens shell neuronal ensembles in context-induced reinstatement of cocaine-seeking.

Cruz FC, Babin KR, Leao RM, Goldart EM, Bossert JM, Shaham Y, Hope BT.

J Neurosci. 2014 May 28;34(22):7437-46. doi: 10.1523/JNEUROSCI.0238-14.2014.


New technologies for examining the role of neuronal ensembles in drug addiction and fear.

Cruz FC, Koya E, Guez-Barber DH, Bossert JM, Lupica CR, Shaham Y, Hope BT.

Nat Rev Neurosci. 2013 Nov;14(11):743-54. doi: 10.1038/nrn3597. Epub 2013 Oct 3. Review.


Detection of molecular alterations in methamphetamine-activated Fos-expressing neurons from a single rat dorsal striatum using fluorescence-activated cell sorting (FACS).

Liu QR, Rubio FJ, Bossert JM, Marchant NJ, Fanous S, Hou X, Shaham Y, Hope BT.

J Neurochem. 2014 Jan;128(1):173-85. doi: 10.1111/jnc.12381. Epub 2013 Aug 21.


Exploring the epigenetics of cocaine resistance.

Hope BT, Skinner MK, Kenny PJ, Akbarian S.

Nat Med. 2013 Feb;19(2):136-7. doi: 10.1038/nm.3091. No abstract available.


Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats.

Calu DJ, Kawa AB, Marchant NJ, Navarre BM, Henderson MJ, Chen B, Yau HJ, Bossert JM, Schoenbaum G, Deisseroth K, Harvey BK, Hope BT, Shaham Y.

J Neurosci. 2013 Jan 2;33(1):214-26. doi: 10.1523/JNEUROSCI.2016-12.2013.


Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking.

Fanous S, Guez-Barber DH, Goldart EM, Schrama R, Theberge FR, Shaham Y, Hope BT.

J Neurochem. 2013 Jan;124(1):100-8. doi: 10.1111/jnc.12074. Epub 2012 Nov 21.


Silent synapses in selectively activated nucleus accumbens neurons following cocaine sensitization.

Koya E, Cruz FC, Ator R, Golden SA, Hoffman AF, Lupica CR, Hope BT.

Nat Neurosci. 2012 Nov;15(11):1556-62. doi: 10.1038/nn.3232. Epub 2012 Sep 30.


Role of orbitofrontal cortex neuronal ensembles in the expression of incubation of heroin craving.

Fanous S, Goldart EM, Theberge FR, Bossert JM, Shaham Y, Hope BT.

J Neurosci. 2012 Aug 22;32(34):11600-9. doi: 10.1523/JNEUROSCI.1914-12.2012.


Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving.

Theberge FR, Pickens CL, Goldart E, Fanous S, Hope BT, Liu QR, Shaham Y.

Psychopharmacology (Berl). 2012 Dec;224(4):559-71. doi: 10.1007/s00213-012-2784-z. Epub 2012 Jul 12.


Medial prefrontal cortex neuronal activation and synaptic alterations after stress-induced reinstatement of palatable food seeking: a study using c-fos-GFP transgenic female rats.

Cifani C, Koya E, Navarre BM, Calu DJ, Baumann MH, Marchant NJ, Liu QR, Khuc T, Pickel J, Lupica CR, Shaham Y, Hope BT.

J Neurosci. 2012 Jun 20;32(25):8480-90. doi: 10.1523/JNEUROSCI.5895-11.2012.


FACS purification of immunolabeled cell types from adult rat brain.

Guez-Barber D, Fanous S, Harvey BK, Zhang Y, Lehrmann E, Becker KG, Picciotto MR, Hope BT.

J Neurosci Methods. 2012 Jan 15;203(1):10-8. doi: 10.1016/j.jneumeth.2011.08.045. Epub 2011 Sep 3.


Neurobiology of the incubation of drug craving.

Pickens CL, Airavaara M, Theberge F, Fanous S, Hope BT, Shaham Y.

Trends Neurosci. 2011 Aug;34(8):411-20. doi: 10.1016/j.tins.2011.06.001. Epub 2011 Jul 20. Review.


Cocaine and synaptic alterations in the nucleus accumbens.

Koya E, Hope BT.

Biol Psychiatry. 2011 Jun 1;69(11):1013-4. doi: 10.1016/j.biopsych.2011.04.001. No abstract available.


FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons.

Guez-Barber D, Fanous S, Golden SA, Schrama R, Koya E, Stern AL, Bossert JM, Harvey BK, Picciotto MR, Hope BT.

J Neurosci. 2011 Mar 16;31(11):4251-9. doi: 10.1523/JNEUROSCI.6195-10.2011.


Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin.

Bossert JM, Stern AL, Theberge FR, Cifani C, Koya E, Hope BT, Shaham Y.

Nat Neurosci. 2011 Apr;14(4):420-2. doi: 10.1038/nn.2758. Epub 2011 Feb 20.


Context-specific modulation of cocaine-induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens.

Marin MT, Berkow A, Golden SA, Koya E, Planeta CS, Hope BT.

Eur J Neurosci. 2009 Nov;30(10):1931-40. doi: 10.1111/j.1460-9568.2009.06982.x. Epub 2009 Nov 11.


Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization.

Koya E, Golden SA, Harvey BK, Guez-Barber DH, Berkow A, Simmons DE, Bossert JM, Nair SG, Uejima JL, Marin MT, Mitchell TB, Farquhar D, Ghosh SC, Mattson BJ, Hope BT.

Nat Neurosci. 2009 Aug;12(8):1069-73. doi: 10.1038/nn.2364. Epub 2009 Jul 20.


Role of ventral medial prefrontal cortex in incubation of cocaine craving.

Koya E, Uejima JL, Wihbey KA, Bossert JM, Hope BT, Shaham Y.

Neuropharmacology. 2009;56 Suppl 1:177-85. doi: 10.1016/j.neuropharm.2008.04.022. Epub 2008 May 8.


Context-specific sensitization of cocaine-induced locomotor activity and associated neuronal ensembles in rat nucleus accumbens.

Mattson BJ, Koya E, Simmons DE, Mitchell TB, Berkow A, Crombag HS, Hope BT.

Eur J Neurosci. 2008 Jan;27(1):202-12. Epub 2007 Dec 17.


Repeated amphetamine administration outside the home cage enhances drug-induced Fos expression in rat nucleus accumbens.

Mattson BJ, Crombag HS, Mitchell T, Simmons DE, Kreuter JD, Morales M, Hope BT.

Behav Brain Res. 2007 Dec 28;185(2):88-98. Epub 2007 Jul 21.


Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.

Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Müller C, Woods AS, Hope BT, Ciruela F, Casadó V, Canela EI, Lluis C, Goldberg SR, Moratalla R, Franco R, Ferré S.

Neuropsychopharmacology. 2007 Nov;32(11):2249-59. Epub 2007 Mar 14.

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