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Items: 42


Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538.

Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ.

Toxicol Rep. 2017 Dec 30;5:207-208. doi: 10.1016/j.toxrep.2017.12.023. eCollection 2018. No abstract available.


Assessment of immunotoxicity in female Fischer 344/N and Sprague Dawley rats and female B6C3F1 mice exposed to hexavalent chromium via the drinking water.

Shipkowski KA, Sheth CM, Smith MJ, Hooth MJ, White KL Jr, Germolec DR.

J Immunotoxicol. 2017 Dec;14(1):215-227. doi: 10.1080/1547691X.2017.1394932.


14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure.

Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ.

Toxicol Rep. 2016;3:531-538. doi: 10.1016/j.toxrep.2016.05.001. Epub 2016 May 12.


Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies.

Mutlu E, Cristy T, Graves SW, Hooth MJ, Waidyanatha S.

Environ Sci Pollut Res Int. 2017 Jan;24(1):405-416. doi: 10.1007/s11356-016-7803-x. Epub 2016 Oct 10.


Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water.

Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR.

J Immunotoxicol. 2016 Sep;13(5):666-75. doi: 10.3109/1547691X.2016.1154118. Epub 2016 May 25.


Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

Bhusari S, Pandiri AR, Nagai H, Wang Y, Foley J, Hong HH, Ton TV, DeVito M, Shockley KR, Peddada SD, Gerrish KE, Malarkey DE, Hooth MJ, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Dec;43(8):1114-26. doi: 10.1177/0192623315599853. Epub 2015 Aug 18.


Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal.

Hong HH, Hoenerhoff MJ, Ton TV, Herbert RA, Kissling GE, Hooth MJ, Behl M, Witt KL, Smith-Roe SL, Sills RC, Pandiri AR.

Toxicol Pathol. 2015 Aug;43(6):872-82. doi: 10.1177/0192623315581192. Epub 2015 Jun 9.


Developmental neurotoxicity of 3,3',4,4'-tetrachloroazobenzene with thyroxine deficit: Sensitivity of glia and dentate granule neurons in the absence of behavioral changes.

Harry GJ, Hooth MJ, Vallant M, Behl M, Travlos GS, Howard JL, Price CJ, McBride S, Mervis R, Mouton PR.

Toxics. 2014 Sep;2(3):496-532.


Comparative toxicity and carcinogenicity of soluble and insoluble cobalt compounds.

Behl M, Stout MD, Herbert RA, Dill JA, Baker GL, Hayden BK, Roycroft JH, Bucher JR, Hooth MJ.

Toxicology. 2015 Jul 3;333:195-205. doi: 10.1016/j.tox.2015.04.008. Epub 2015 Apr 17.


F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation.

Harvey JB, Hong HH, Bhusari S, Ton TV, Wang Y, Foley JF, Peddada SD, Hooth M, DeVito M, Nyska A, Pandiri AR, Hoenerhoff MJ.

Vet Pathol. 2016 Jan;53(1):170-81. doi: 10.1177/0300985815571680. Epub 2015 Mar 2.


Evaluation of propargyl alcohol toxicity and carcinogenicity in F344/N rats and B6C3F1/N mice following whole-body inhalation exposure.

Thakur SA, Flake GP, Travlos GS, Dill JA, Grumbein SL, Harbo SJ, Hooth MJ.

Toxicology. 2013 Dec 6;314(1):100-11. doi: 10.1016/j.tox.2013.09.002. Epub 2013 Sep 10.


Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene.

Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth MJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014;42(3):555-64. doi: 10.1177/0192623313491169. Epub 2013 May 23.


Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice.

Waidyanatha S, Johnson JD, Hong SP, Robinson VG, Gibbs S, Graves SW, Hooth MJ, Smith CS.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):216-28. doi: 10.1016/j.taap.2013.05.001. Epub 2013 May 10.


Mechanistic insights from the NTP studies of chromium.

Witt KL, Stout MD, Herbert RA, Travlos GS, Kissling GE, Collins BJ, Hooth MJ.

Toxicol Pathol. 2013 Feb;41(2):326-42. doi: 10.1177/0192623312469856. Epub 2013 Jan 18.


Pyrogallol-associated dermal toxicity and carcinogenicity in F344/N rats and B6C3F1/N mice.

Mercado-Feliciano M, Herbert RA, Wyde ME, Gerken DK, Hejtmancik MR, Hooth MJ.

Cutan Ocul Toxicol. 2013 Sep;32(3):234-40. doi: 10.3109/15569527.2012.746358. Epub 2012 Dec 11.


Immunohistochemical features of 3,3',4,4'-tetrachloroazobenzene-induced rat gingival lesions.

Ramot Y, Vered M, Malarkey DE, Hooth MJ, Painter JT, Dayan D, Clayton N, Masinde T, Nyska A.

Toxicol Pathol. 2012 Jun;40(4):577-92. doi: 10.1177/0192623311436185. Epub 2012 Feb 7.


Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo.

Cheng Y, Martinez-Guerrero LJ, Wright SH, Kuester RK, Hooth MJ, Sipes IG.

Drug Metab Dispos. 2011 Sep;39(9):1755-61. doi: 10.1124/dmd.110.035865. Epub 2011 Jun 6.


Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice.

Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Walden R, Abdo K, Pritchard JB, Fernando RA, Burka LT, Hooth MJ.

Toxicol Sci. 2010 Dec;118(2):368-79. doi: 10.1093/toxsci/kfq263. Epub 2010 Sep 15.


Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB).

Singh BP, Nyska A, Kissling GE, Lieuallen W, Johansson SL, Malarkey DE, Hooth MJ.

Toxicol Pathol. 2010 Apr;38(3):372-81. doi: 10.1177/0192623310362708. Epub 2010 Mar 16.


Validation and application of a method for the determination of total chromium in rat tissues by inductively coupled plasma mass spectrometry.

Levine KE, Stout MD, Ross GT, Essader AS, Weber FX, Grohse PM, Fernando RA, Milstein LS, Hooth MJ, Collins BJ.

Arch Environ Contam Toxicol. 2010 Apr;58(3):883-91. doi: 10.1007/s00244-009-9397-5. Epub 2009 Oct 2.


Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed to 3,3',4,4'-tetrachloroazobenzene for 2 years.

Ramot Y, Nyska A, Lieuallen W, Maly A, Flake G, Kissling GE, Brix A, Malarkey DE, Hooth MJ.

Toxicology. 2009 Nov 9;265(1-2):1-9. doi: 10.1016/j.tox.2009.08.017. Epub 2009 Sep 6.


Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats.

Knudsen GA, Cheng Y, Kuester RK, Hooth MJ, Sipes IG.

Drug Metab Dispos. 2009 Nov;37(11):2171-7. doi: 10.1124/dmd.109.029082. Epub 2009 Aug 24.


Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.

Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Abdo KM, Malarkey DE, Hooth MJ.

Environ Health Perspect. 2009 May;117(5):716-22. doi: 10.1289/ehp.0800208. Epub 2008 Dec 31.


Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2.

Cheng Y, Wright SH, Hooth MJ, Sipes IG.

Drug Metab Dispos. 2009 Apr;37(4):909-16. doi: 10.1124/dmd.108.022681. Epub 2009 Jan 26.


Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years.

Stout MD, Nyska A, Collins BJ, Witt KL, Kissling GE, Malarkey DE, Hooth MJ.

Food Chem Toxicol. 2009 Apr;47(4):729-33. doi: 10.1016/j.fct.2009.01.006. Epub 2009 Jan 8.


Human Health Effects Workgroup report.

Azevedo SM, Chernoff N, Falconer IR, Gage M, Hilborn ED, Hooth MJ, Jensen K, MacPhail R, Rogers E, Shaw GR, Stewart I, Fournie JW.

Adv Exp Med Biol. 2008;619:579-606. No abstract available.


Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice.

Hooth MJ, Herbert RA, Haseman JK, Orzech DP, Johnson JD, Bucher JR.

Toxicology. 2004 Nov 15;204(2-3):123-40.


Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice.

Hooth MJ, Sills RC, Burka LT, Haseman JK, Witt KL, Orzech DP, Fuciarelli AF, Graves SW, Johnson JD, Bucher JR.

Food Chem Toxicol. 2004 Nov;42(11):1757-68.


Changes in cecal microbial metabolism of rats induced by individual and a mixture of drinking water disinfection by-products.

George SE, Wolf DC, Brooks LR, Bailey KC, Hooth MJ, Nelson GM.

Cancer Lett. 2004 Feb 10;204(1):15-21.


The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive.

Hooth MJ, McDorman KS, Hester SD, George MH, Brooks LR, Swank AE, Wolf DC.

Toxicol Sci. 2002 Oct;69(2):322-31.


Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors.

Shiao YH, Kamata SI, Li LM, Hooth MJ, DeAngelo AB, Anderson LM, Wolf DC.

Cancer Lett. 2002 Dec 10;187(1-2):207-14.


Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia.

Hooth MJ, Deangelo AB, George MH, Gaillard ET, Travlos GS, Boorman GA, Wolf DC.

Toxicol Pathol. 2001 Mar-Apr;29(2):250-9.


Telomere shortening, telomerase expression, and chromosome instability in rat hepatic epithelial stem-like cells.

Golubovskaya VM, Filatov LV, Behe CI, Presnell SC, Hooth MJ, Smith GJ, Kaufmann WK.

Mol Carcinog. 1999 Mar;24(3):209-17.


Spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells.

Hooth MJ, Coleman WB, Presnell SC, Borchert KM, Grisham JW, Smith GJ.

Am J Pathol. 1998 Dec;153(6):1913-21.


Establishment of a functional HGF/C-MET autocrine loop in spontaneous transformants of WB-F344 rat liver stem-like cells.

Presnell SC, Hooth MJ, Borchert KM, Coleman WB, Grisham JW, Smith GJ.

Hepatology. 1998 Nov;28(5):1253-9.


Expression of telomerase in normal and malignant rat hepatic epithelia.

Golubovskaya VM, Presnell SC, Hooth MJ, Smith GJ, Kaufmann WK.

Oncogene. 1997 Sep 4;15(10):1233-40.


Comparison of the effects of losulazine and reserpine on central aminergic neurons.

Pan JT, Hooth MJ, Lookingland KJ, Moore KE, Marks TA.

Toxicol Appl Pharmacol. 1993 Nov;123(1):26-33.


Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine.

Bronstein SM, Hooth MJ, Swenberg JA, Skopek TR.

Cancer Res. 1992 Jul 15;52(14):3851-6.

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