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Items: 1 to 50 of 309

1.

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

Jarosz-Griffiths HH, Corbett NJ, Rowland HA, Fisher K, Jones AC, Baron J, Howell GJ, Cowley SA, Chintawar S, Cader MZ, Kellett KAB, Hooper NM.

J Biol Chem. 2019 Apr 26;294(17):7085-7097. doi: 10.1074/jbc.RA118.005364. Epub 2019 Mar 14.

2.

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y; Alzheimer Disease Genetics Consortium (ADGC),; European Alzheimer’s Disease Initiative (EADI),; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),; Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),, Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O'Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA.

Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. Epub 2019 Feb 28.

PMID:
30820047
3.

Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms.

Andrew RJ, Fisher K, Heesom KJ, Kellett KAB, Hooper NM.

J Neurochem. 2019 May;149(3):399-412. doi: 10.1111/jnc.14666. Epub 2019 Feb 14.

PMID:
30664241
4.

Soluble Amyloid Precursor Protein α: Friend or Foe?

Corbett NJ, Hooper NM.

Adv Exp Med Biol. 2018;1112:177-183. doi: 10.1007/978-981-13-3065-0_13.

PMID:
30637698
5.

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data.

Kramarz B, Roncaglia P, Meldal BHM, Huntley RP, Martin MJ, Orchard S, Parkinson H, Brough D, Bandopadhyay R, Hooper NM, Lovering RC.

Genes (Basel). 2018 Nov 29;9(12). pii: E593. doi: 10.3390/genes9120593.

6.

Modelling Sporadic Alzheimer's Disease Using Induced Pluripotent Stem Cells.

Rowland HA, Hooper NM, Kellett KAB.

Neurochem Res. 2018 Dec;43(12):2179-2198. doi: 10.1007/s11064-018-2663-z. Epub 2018 Nov 1. Review.

7.

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.

Quinn JP, Corbett NJ, Kellett KAB, Hooper NM.

J Alzheimers Dis. 2018;63(1):13-33. doi: 10.3233/JAD-170959.

8.

Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

Xu J, Church SJ, Patassini S, Begley P, Kellett KAB, Vardy ERLC, Unwin RD, Hooper NM, Cooper GJS.

Biometals. 2018 Apr;31(2):267-276. doi: 10.1007/s10534-018-0089-3. Epub 2018 Mar 7.

9.

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.

Potjewyd G, Moxon S, Wang T, Domingos M, Hooper NM.

Trends Biotechnol. 2018 Apr;36(4):457-472. doi: 10.1016/j.tibtech.2018.01.003. Epub 2018 Feb 6. Review.

PMID:
29422410
10.

Hemorrhagic Shock.

Hooper N, Armstrong TJ.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 May 6.

11.

Tau Diagnostics and Clinical Studies.

Gozes I, Höglinger G, Quinn JP, Hooper NM, Höglund K.

J Mol Neurosci. 2017 Oct;63(2):123-130. doi: 10.1007/s12031-017-0983-0.

PMID:
29082468
12.

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil.

Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo AI, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, Morin P, Hooper NM, Porter R, Preston J, Al-Shawi R, Baillie G, Lovestone S, Cuadrado A, Harte M, Simons P, Srivastava DP, Killick R.

Alzheimers Dement. 2018 Mar;14(3):306-317. doi: 10.1016/j.jalz.2017.09.008. Epub 2017 Oct 19.

13.

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?

Doig AJ, Del Castillo-Frias MP, Berthoumieu O, Tarus B, Nasica-Labouze J, Sterpone F, Nguyen PH, Hooper NM, Faller P, Derreumaux P.

ACS Chem Neurosci. 2017 Jul 19;8(7):1435-1437. doi: 10.1021/acschemneuro.7b00188. Epub 2017 Jun 6.

PMID:
28586203
14.

Open-source mobile digital platform for clinical trial data collection in low-resource settings.

van Dam J, Omondi Onyango K, Midamba B, Groosman N, Hooper N, Spector J, Pillai GC, Ogutu B.

BMJ Innov. 2017 Feb;3(1):26-31. doi: 10.1136/bmjinnov-2016-000164. Epub 2017 Jan 6.

15.

A step-by-step translation of evidence into a psychosocial intervention for everyday activities in dementia: a focus group study.

Giebel CM, Challis D, Hooper NM, Ferris S.

Aging Ment Health. 2018 Mar;22(3):323-329. doi: 10.1080/13607863.2016.1262819. Epub 2016 Dec 12.

PMID:
27936875
16.

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.

Andrew RJ, Kellett KA, Thinakaran G, Hooper NM.

J Biol Chem. 2016 Sep 9;291(37):19235-44. doi: 10.1074/jbc.R116.746032. Epub 2016 Jul 29. Review.

17.

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

Whitehouse IJ, Brown D, Baybutt H, Diack AB, Kellett KA, Piccardo P, Manson JC, Hooper NM.

PLoS One. 2016 Jul 22;11(7):e0159119. doi: 10.1371/journal.pone.0159119. eCollection 2016.

18.

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ.

Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524.

19.

Mindfulness reduces the correspondence bias.

Hopthrow T, Hooper N, Mahmood L, Meier BP, Weger U.

Q J Exp Psychol (Hove). 2017 Mar;70(3):351-360. Epub 2016 Mar 31.

PMID:
27030310
20.

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein.

Jarosz-Griffiths HH, Noble E, Rushworth JV, Hooper NM.

J Biol Chem. 2016 Feb 12;291(7):3174-83. doi: 10.1074/jbc.R115.702704. Epub 2015 Dec 30. Review.

21.

Using Brief Cognitive Restructuring and Cognitive Defusion Techniques to Cope With Negative Thoughts.

Larsson A, Hooper N, Osborne LA, Bennett P, McHugh L.

Behav Modif. 2016 May;40(3):452-82. doi: 10.1177/0145445515621488. Epub 2015 Dec 18.

PMID:
26685210
22.

The five-year radiological results of the uncemented Oxford medial compartment knee arthroplasty.

Hooper N, Snell D, Hooper G, Maxwell R, Frampton C.

Bone Joint J. 2015 Oct;97-B(10):1358-63. doi: 10.1302/0301-620X.97B10.35668.

PMID:
26430010
23.

Does a titanium-coated polyethylene press-fit cup give reliable midterm results?

Hooper N, Sargeant H, Frampton C, Hooper G.

Clin Orthop Relat Res. 2015 Dec;473(12):3806-10. doi: 10.1007/s11999-015-4556-7.

24.

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Lewis V, Johanssen VA, Crouch PJ, Klug GM, Hooper NM, Collins SJ.

Cell Mol Life Sci. 2016 Feb;73(3):667-83. doi: 10.1007/s00018-015-2022-z. Epub 2015 Aug 23.

PMID:
26298290
25.

The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α.

O'Sullivan J, Comerford E, Rachidi W, Scott M, Hooper NM, McMahon HE.

Biochim Biophys Acta. 2015 Nov;1850(11):2213-21. doi: 10.1016/j.bbagen.2015.08.010. Epub 2015 Aug 20.

PMID:
26297964
26.

The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus.

Kellett KA, Hooper NM.

Subcell Biochem. 2015;76:363-74. doi: 10.1007/978-94-017-7197-9_17.

PMID:
26219720
27.

Heme oxygenase-1 protects against Alzheimer's amyloid-β(1-42)-induced toxicity via carbon monoxide production.

Hettiarachchi N, Dallas M, Al-Owais M, Griffiths H, Hooper N, Scragg J, Boyle J, Peers C.

Cell Death Dis. 2014 Dec 11;5:e1569. doi: 10.1038/cddis.2014.529.

28.

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease.

Watt NT, Griffiths HH, Hooper NM.

Front Cell Dev Biol. 2014 Aug 20;2:41. doi: 10.3389/fcell.2014.00041. eCollection 2014.

29.

Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421.

Lambert DW, Lambert LA, Clarke NE, Hooper NM, Porter KE, Turner AJ.

Clin Sci (Lond). 2014 Aug;127(4):243-9. doi: 10.1042/CS20130420.

PMID:
24564768
30.

A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers.

Rushworth JV, Ahmed A, Griffiths HH, Pollock NM, Hooper NM, Millner PA.

Biosens Bioelectron. 2014 Jun 15;56:83-90. doi: 10.1016/j.bios.2013.12.036. Epub 2013 Dec 24.

PMID:
24480125
31.

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging.

Glennon EB, Whitehouse IJ, Miners JS, Kehoe PG, Love S, Kellett KA, Hooper NM.

PLoS One. 2013 Oct 21;8(10):e78806. doi: 10.1371/journal.pone.0078806. eCollection 2013.

32.
33.

The outcome of bone substitute wedges in medial opening high tibial osteotomy.

Hooper NM, Schouten R, Hooper GJ.

Open Orthop J. 2013 Sep 6;7:373-7. doi: 10.2174/1874325001307010373. eCollection 2013.

34.

The effects of repeated thought suppression attempts on thought occurrence.

Hooper N, McHugh L.

Am J Psychol. 2013 Fall;126(3):315-22.

PMID:
24027945
35.

Neuronal zinc regulation and the prion protein.

Watt NT, Griffiths HH, Hooper NM.

Prion. 2013 May-Jun;7(3):203-8. doi: 10.4161/pri.24503. Review.

36.

Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage.

Whitehouse IJ, Miners JS, Glennon EB, Kehoe PG, Love S, Kellett KA, Hooper NM.

PLoS One. 2013;8(4):e59554. doi: 10.1371/journal.pone.0059554. Epub 2013 Apr 5.

37.

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1.

Rushworth JV, Griffiths HH, Watt NT, Hooper NM.

J Biol Chem. 2013 Mar 29;288(13):8935-51. doi: 10.1074/jbc.M112.400358. Epub 2013 Feb 5.

38.

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

Mok NY, Chadwick J, Kellett KA, Casas-Arce E, Hooper NM, Johnson AP, Fishwick CW.

J Med Chem. 2013 Mar 14;56(5):1843-52. doi: 10.1021/jm301127x. Epub 2013 Feb 22.

39.

Prion protein facilitates uptake of zinc into neuronal cells.

Watt NT, Taylor DR, Kerrigan TL, Griffiths HH, Rushworth JV, Whitehouse IJ, Hooper NM.

Nat Commun. 2012;3:1134. doi: 10.1038/ncomms2135.

40.

The relationship between the American Society Of Anesthesiologists physical rating and outcome following total hip and knee arthroplasty: an analysis of theNew Zealand Joint Registry.

Hooper GJ, Rothwell AG, Hooper NM, Frampton C.

J Bone Joint Surg Am. 2012 Jun 20;94(12):1065-70. doi: 10.2106/JBJS.J.01681.

PMID:
22717825
41.

Regulation of amyloid-β production by the prion protein.

Griffiths HH, Whitehouse IJ, Hooper NM.

Prion. 2012 Jul 1;6(3):217-22. doi: 10.4161/pri.18988. Epub 2012 Jul 1.

42.

Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.

Lewis V, Whitehouse IJ, Baybutt H, Manson JC, Collins SJ, Hooper NM.

PLoS One. 2012;7(2):e31754. doi: 10.1371/journal.pone.0031754. Epub 2012 Feb 21.

43.

Comparing thought suppression and acceptance as coping techniques for food cravings.

Hooper N, Sandoz EK, Ashton J, Clarke A, McHugh L.

Eat Behav. 2012 Jan;13(1):62-4. doi: 10.1016/j.eatbeh.2011.10.002. Epub 2011 Oct 19.

PMID:
22177399
44.

Mindful maths: reducing the impact of stereotype threat through a mindfulness exercise.

Weger UW, Hooper N, Meier BP, Hopthrow T.

Conscious Cogn. 2012 Mar;21(1):471-5. doi: 10.1016/j.concog.2011.10.011. Epub 2011 Nov 15.

PMID:
22088808
45.

Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease.

Vardy ER, Kellett KA, Cocklin SL, Hooper NM.

Neurodegener Dis. 2012;9(1):31-7. doi: 10.1159/000329722. Epub 2011 Oct 20.

PMID:
22024719
46.

A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.

Cilia La Corte AL, Carter AM, Rice GI, Duan QL, Rouleau GA, Adam A, Grant PJ, Hooper NM.

Hum Mutat. 2011 Nov;32(11):1326-31. doi: 10.1002/humu.21579. Epub 2011 Sep 12.

PMID:
21898657
47.

Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.

Griffiths HH, Whitehouse IJ, Baybutt H, Brown D, Kellett KA, Jackson CD, Turner AJ, Piccardo P, Manson JC, Hooper NM.

J Biol Chem. 2011 Sep 23;286(38):33489-500. doi: 10.1074/jbc.M111.278556. Epub 2011 Jul 27.

48.

Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function.

Kellett KA, Williams J, Vardy ER, Smith AD, Hooper NM.

Int J Mol Epidemiol Genet. 2011;2(2):114-21. Epub 2011 Feb 10.

49.

Comparing thought suppression and mindfulness as coping techniques for spider fear.

Hooper N, Davies N, Davies L, McHugh L.

Conscious Cogn. 2011 Dec;20(4):1824-30. doi: 10.1016/j.concog.2011.05.013. Epub 2011 Jun 11.

PMID:
21658971
50.

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC; Alzheimer's Disease Neuroimaging Initiative, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S; CHARGE consortium, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M; EADI1 consortium, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J.

Nat Genet. 2011 May;43(5):429-35. doi: 10.1038/ng.803. Epub 2011 Apr 3.

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