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Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE.

Cell Host Microbe. 2018 Apr 11;23(4):570. doi: 10.1016/j.chom.2018.03.013. No abstract available.


Secretory autophagy of lysozyme in Paneth cells.

Bel S, Hooper LV.

Autophagy. 2018;14(4):719-721. doi: 10.1080/15548627.2018.1430462. Epub 2018 Mar 8.


Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation.

Burger E, Araujo A, López-Yglesias A, Rajala MW, Geng L, Levine B, Hooper LV, Burstein E, Yarovinsky F.

Cell Host Microbe. 2018 Feb 14;23(2):177-190.e4. doi: 10.1016/j.chom.2018.01.001. Epub 2018 Jan 18.


Precision editing of the gut microbiota ameliorates colitis.

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE.

Nature. 2018 Jan 11;553(7687):208-211. doi: 10.1038/nature25172. Epub 2018 Jan 3.


Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE.

Cell Host Microbe. 2018 Jan 10;23(1):54-64.e6. doi: 10.1016/j.chom.2017.11.006. Epub 2017 Dec 21. Erratum in: Cell Host Microbe. 2018 Apr 11;23 (4):570.


Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.

Propheter DC, Chara AL, Harris TA, Ruhn KA, Hooper LV.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11027-11033. doi: 10.1073/pnas.1711395114. Epub 2017 Sep 25.


The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.

Wang Y, Kuang Z, Yu X, Ruhn KA, Kubo M, Hooper LV.

Science. 2017 Sep 1;357(6354):912-916. doi: 10.1126/science.aan0677.


An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, Behrendt CL, Kim J, Chessa D, Andrews-Polymenis HL, Beiting DP, Santos RL, Hooper LV, Winter SE.

Cell Host Microbe. 2017 Sep 13;22(3):291-301.e6. doi: 10.1016/j.chom.2017.07.018. Epub 2017 Aug 24.


Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.

Bel S, Pendse M, Wang Y, Li Y, Ruhn KA, Hassell B, Leal T, Winter SE, Xavier RJ, Hooper LV.

Science. 2017 Sep 8;357(6355):1047-1052. doi: 10.1126/science.aal4677. Epub 2017 Jul 27.


NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.

Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH.

Cell Rep. 2017 Jun 27;19(13):2756-2770. doi: 10.1016/j.celrep.2017.05.084.


Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.

Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE.

Cell Host Microbe. 2017 Feb 8;21(2):208-219. doi: 10.1016/j.chom.2017.01.005.


IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.

Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1196-E1204. doi: 10.1073/pnas.1621258114. Epub 2017 Jan 30.


Molecular Basis for Lytic Bacteriophage Resistance in Enterococci.

Duerkop BA, Huo W, Bhardwaj P, Palmer KL, Hooper LV.

MBio. 2016 Aug 30;7(4). pii: e01304-16. doi: 10.1128/mBio.01304-16.


Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome.

McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK.

J Immunol. 2016 Jul 1;197(1):97-107. doi: 10.4049/jimmunol.1502566. Epub 2016 May 23.


Immunology: Mum's microbes boost baby's immunity.

Pendse M, Hooper LV.

Nature. 2016 May 5;533(7601):42-3. doi: 10.1038/nature17895. Epub 2016 Apr 27. No abstract available.


Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.

Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B.

Cell Host Microbe. 2016 Feb 10;19(2):227-39. doi: 10.1016/j.chom.2016.01.003.


The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH.

Cell Rep. 2015 Dec 1;13(9):1922-36. doi: 10.1016/j.celrep.2015.10.040. Epub 2015 Nov 19.


Immunology: A bacterial nudge to T-cell function.

Bel S, Hooper LV.

Nature. 2015 Oct 15;526(7573):328-30. doi: 10.1038/526328a. No abstract available.


Bacteria Come into Focus: New Tools for Visualizing the Microbiota.

Propheter DC, Hooper LV.

Cell Host Microbe. 2015 Oct 14;18(4):392-4. doi: 10.1016/j.chom.2015.10.004.


Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis.

Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY.

PLoS Pathog. 2015 Aug 27;11(8):e1005129. doi: 10.1371/journal.ppat.1005129. eCollection 2015 Aug.


Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.

Fan D, Coughlin LA, Neubauer MM, Kim J, Kim MS, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY.

Nat Med. 2015 Jul;21(7):808-14. doi: 10.1038/nm.3871. Epub 2015 Jun 8.


Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells.

Sturge CR, Burger E, Raetz M, Hooper LV, Yarovinsky F.

J Immunol. 2015 Jul 1;195(1):36-40. doi: 10.4049/jimmunol.1500366. Epub 2015 May 29.


Epithelial cell contributions to intestinal immunity.

Hooper LV.

Adv Immunol. 2015;126:129-72. doi: 10.1016/ Epub 2015 Feb 7. Review.


Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes.

Kleiner M, Hooper LV, Duerkop BA.

BMC Genomics. 2015 Jan 22;16:7. doi: 10.1186/s12864-014-1207-4.


Antimicrobial defense of the intestine.

Mukherjee S, Hooper LV.

Immunity. 2015 Jan 20;42(1):28-39. doi: 10.1016/j.immuni.2014.12.028. Epub 2015 Jan 1. Review.


The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor.

Yu X, Wang Y, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV.

Elife. 2014 Oct 13;3. doi: 10.7554/eLife.04406.


Immunology. Innate lymphoid cells sweeten the pot.

Hooper LV.

Science. 2014 Sep 12;345(6202):1248-9. doi: 10.1126/science.1259808. No abstract available.


Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.

Derebe MG, Zlatkov CM, Gattu S, Ruhn KA, Vaishnava S, Diehl GE, MacMillan JB, Williams NS, Hooper LV.

Elife. 2014 Jul 29;3:e03206. doi: 10.7554/eLife.03206.


Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.

Mirpuri J, Raetz M, Sturge CR, Wilhelm CL, Benson A, Savani RC, Hooper LV, Yarovinsky F.

Gut Microbes. 2014 Jan-Feb;5(1):28-39. doi: 10.4161/gmic.26489. Epub 2013 Sep 25.


Antibacterial membrane attack by a pore-forming intestinal C-type lectin.

Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV.

Nature. 2014 Jan 2;505(7481):103-7. doi: 10.1038/nature12729. Epub 2013 Nov 20.


TH17 cell differentiation is regulated by the circadian clock.

Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV.

Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884.


Resident viruses and their interactions with the immune system.

Duerkop BA, Hooper LV.

Nat Immunol. 2013 Jul;14(7):654-9. doi: 10.1038/ni.2614.


Intestinal epithelial autophagy is essential for host defense against invasive bacteria.

Benjamin JL, Sumpter R Jr, Levine B, Hooper LV.

Cell Host Microbe. 2013 Jun 12;13(6):723-34. doi: 10.1016/j.chom.2013.05.004.


Understanding the microbiota in the midst of Renaissance architecture and olive groves.

Guarner F, Hooper LV, Núñez G.

Nat Immunol. 2013 Feb;14(2):101-5. doi: 10.1038/ni.2512.


Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells.

Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F.

Nat Immunol. 2013 Feb;14(2):136-42. doi: 10.1038/ni.2508. Epub 2012 Dec 23.


A composite bacteriophage alters colonization by an intestinal commensal bacterium.

Duerkop BA, Clements CV, Rollins D, Rodrigues JL, Hooper LV.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17621-6. doi: 10.1073/pnas.1206136109. Epub 2012 Oct 8.


Epithelial antimicrobial defence of the skin and intestine.

Gallo RL, Hooper LV.

Nat Rev Immunol. 2012 Jun 25;12(7):503-16. doi: 10.1038/nri3228. Review.


Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.

Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y.

Genes Dev. 2012 Jun 15;26(12):1306-11. doi: 10.1101/gad.191031.112.


Interactions between the microbiota and the immune system.

Hooper LV, Littman DR, Macpherson AJ.

Science. 2012 Jun 8;336(6086):1268-73. doi: 10.1126/science.1223490. Epub 2012 Jun 6. Review.


You AhR what you eat: linking diet and immunity.

Hooper LV.

Cell. 2011 Oct 28;147(3):489-91. doi: 10.1016/j.cell.2011.10.004.


The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV.

Science. 2011 Oct 14;334(6053):255-8. doi: 10.1126/science.1209791.


Intestinal microbiota promote enteric virus replication and systemic pathogenesis.

Kuss SK, Best GT, Etheredge CA, Pruijssers AJ, Frierson JM, Hooper LV, Dermody TS, Pfeiffer JK.

Science. 2011 Oct 14;334(6053):249-52. doi: 10.1126/science.1211057.


Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis.

Li XD, Chiu YH, Ismail AS, Behrendt CL, Wight-Carter M, Hooper LV, Chen ZJ.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17390-5. doi: 10.1073/pnas.1107114108. Epub 2011 Sep 29.


Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.

Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8743-8. doi: 10.1073/pnas.1019574108. Epub 2011 May 9.


Eat your carrots! T cells are RARing to go.

Vaishnava S, Hooper LV.

Immunity. 2011 Mar 25;34(3):290-2. doi: 10.1016/j.immuni.2011.03.007.


Cardiac sarcoidosis and sudden death. The heart may look normal or mimic other cardiomyopathies.

Bagwan IN, Hooper LV, Sheppard MN.

Virchows Arch. 2011 Jun;458(6):671-8. doi: 10.1007/s00428-010-1003-8. Epub 2011 Feb 5.


Molecular basis for peptidoglycan recognition by a bactericidal lectin.

Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7722-7. doi: 10.1073/pnas.0909449107. Epub 2010 Apr 9.


Immune adaptations that maintain homeostasis with the intestinal microbiota.

Hooper LV, Macpherson AJ.

Nat Rev Immunol. 2010 Mar;10(3):159-69. doi: 10.1038/nri2710. Review.


Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.

Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL.

Nat Med. 2009 Dec;15(12):1377-82. doi: 10.1038/nm.2062. Epub 2009 Nov 22.


Immune responses to the microbiota at the intestinal mucosal surface.

Duerkop BA, Vaishnava S, Hooper LV.

Immunity. 2009 Sep 18;31(3):368-76. doi: 10.1016/j.immuni.2009.08.009. Review.

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