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Items: 1 to 50 of 96


The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW.

Science. 2019 Apr 12;364(6436). pii: eaau8650. doi: 10.1126/science.aau8650.


A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro.

Xu JH, Jiang Z, Solania A, Chatterjee S, Suzuki B, Lietz CB, Hook VYH, O'Donoghue AJ, Wolan DW.

ACS Chem Biol. 2018 Sep 21;13(9):2513-2521. doi: 10.1021/acschembio.8b00420. Epub 2018 Aug 23.


Identification of novel loci affecting circulating chromogranins and related peptides.

Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT.

Hum Mol Genet. 2017 Jan 1;26(1):233-242. doi: 10.1093/hmg/ddw380.


Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms.

Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook VY, Mahata SK, Vaingankar S, O'Connor DT.

J Neurochem. 2014 Apr;129(1):48-59. doi: 10.1111/jnc.12527. Epub 2013 Nov 25.


Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure.

Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook VY, O'Connor DT.

J Hypertens. 2012 Oct;30(10):1961-9.


Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.

Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT.

Cell Mol Neurobiol. 2010 Nov;30(8):1395-400. doi: 10.1007/s10571-010-9600-2.


Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.

Hook VY, Kindy M, Reinheckel T, Peters C, Hook G.

Biochem Biophys Res Commun. 2009 Aug 21;386(2):284-8. doi: 10.1016/j.bbrc.2009.05.131. Epub 2009 Jun 6.


Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains.

Courel M, Vasquez MS, Hook VY, Mahata SK, Taupenot L.

J Biol Chem. 2008 Apr 25;283(17):11807-22. doi: 10.1074/jbc.M709832200. Epub 2008 Feb 25.


Primary culture of bovine chromaffin cells.

O'Connor DT, Mahata SK, Mahata M, Jiang Q, Hook VY, Taupenot L.

Nat Protoc. 2007;2(5):1248-53.


Multiple domains of endopin 2A for serpin cross-class inhibition of papain.

Hwang SR, Hook VY.

Arch Biochem Biophys. 2007 May 15;461(2):219-24. Epub 2007 Mar 21.


Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin.

Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT.

Diabetes Obes Metab. 2006 Nov;8(6):621-33. Review.


Protease pathways in peptide neurotransmission and neurodegenerative diseases.

Hook VY.

Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):449-69. Epub 2006 May 25. Review.


Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2.

Hwang SR, Garza CZ, Wegrzyn JL, Hook VY.

Biochem Biophys Res Commun. 2005 Feb 18;327(3):837-44.


Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B.

Hwang SR, Garza CZ, Wegrzyn J, Hook VY.

J Biol Chem. 2004 Aug 16. doi: 10.1074/jbc.M409166200. Epub 2004 Aug 16. Retraction in: J Biol Chem. 2015 Jul 31;290(31):19010.


Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice.

Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld MC, Hook VY.

J Neurochem. 2003 Aug;86(3):556-63.


Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells.

Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY.

Biochemistry. 2003 Jun 17;42(23):6938-46.


Agonist-stimulated neuropeptide and catecholamine release from bovine adrenal chromaffin cells.

Bundey RA, Toneff T, Pottenger J, Kennedy BP, Ziegler MG, Hook VY.

Ann N Y Acad Sci. 2002 Oct;971:338-40. No abstract available.


The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells.

Hwang SR, Steineckert B, Toneff T, Bundey R, Logvinova AV, Goldsmith P, Hook VY.

Biochemistry. 2002 Aug 20;41(33):10397-405.


Heredity and the autonomic nervous system in human hypertension.

O'Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ.

Curr Hypertens Rep. 2000 Feb;2(1):16-22. Review.


Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2.

Hwang SR, Ng SM, Steineckert B, Seidah NG, Hook VY.

DNA Cell Biol. 2000 Jul;19(7):409-19.


Detection of proteolytic activity by fluorescent zymogram in-gel assays.

Yasothornsrikul S, Hook VY.

Biotechniques. 2000 Jun;28(6):1166-8, 1170, 1172-3.


Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules.

Taylor CV, Taupenot L, Mahata SK, Mahata M, Wu H, Yasothornsrikul S, Toneff T, Caporale C, Jiang Q, Parmer RJ, Hook VY, O'Connor DT.

J Biol Chem. 2000 Jul 28;275(30):22905-15.


Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1.

Hwang SR, Steineckert B, Yasothornsrikul S, Sei CA, Toneff T, Rattan J, Hook VY.

J Biol Chem. 1999 Nov 26;274(48):34164-73.


Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells.

Hook VY, Noctor S, Sei CA, Toneff T, Yasothornsrikul S, Kang YH.

Endocrinology. 1999 Aug;140(8):3744-54.


Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles.

Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK.

J Neurochem. 1998 Dec;71(6):2365-72.


Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes.

Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK.

Biochemistry. 1998 Feb 3;37(5):1274-82.


High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing.

Hook VY, Moran K, Kannan R, Kohn A, Lively MO, Azaryan A, Schiller M, Miller K.

Protein Expr Purif. 1997 Jun;10(1):80-8.


Production of radiolabeled neuropeptide precursors by in vitro transcription and translation.

Hook VY, Schiller MR, Nguyen C, Yasothornsrikul S.

Pept Res. 1996 Jul-Aug;9(4):183-7.


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