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Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy.

Noordam L, Kaijen MEH, Bezemer K, Cornelissen R, Maat LAPWM, Hoogsteden HC, Aerts JGJV, Hendriks RW, Hegmans JPJJ, Vroman H.

Oncoimmunology. 2018 Jul 30;7(12):e1474318. doi: 10.1080/2162402X.2018.1474318. eCollection 2018.


Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes.

Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M.

Eur Respir J. 2018 Mar 1;51(3). pii: 1701124. doi: 10.1183/13993003.01124-2017. Print 2018 Mar.


Daily home spirometry to detect early steroid treatment effects in newly treated pulmonary sarcoidosis.

Broos CE, Wapenaar M, Looman CWN, In 't Veen JCCM, van den Toorn LM, Overbeek MJ, Grootenboers MJJH, Heller R, Mostard RL, Poell LHC, Hoogsteden HC, Kool M, Wijsenbeek MS, van den Blink B.

Eur Respir J. 2018 Jan 18;51(1). pii: 1702089. doi: 10.1183/13993003.02089-2017. Print 2018 Jan. No abstract available.


Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human.

Aerts JGJV, de Goeje PL, Cornelissen R, Kaijen-Lambers MEH, Bezemer K, van der Leest CH, Mahaweni NM, Kunert A, Eskens FALM, Waasdorp C, Braakman E, van der Holt B, Vulto AG, Hendriks RW, Hegmans JPJJ, Hoogsteden HC.

Clin Cancer Res. 2018 Feb 15;24(4):766-776. doi: 10.1158/1078-0432.CCR-17-2522. Epub 2017 Dec 12.


No evidence found for an association between prednisone dose and FVC change in newly-treated pulmonary sarcoidosis.

Broos CE, Poell LHC, Looman CWN, In 't Veen JCCM, Grootenboers MJJH, Heller R, van den Toorn LM, Wapenaar M, Hoogsteden HC, Kool M, Wijsenbeek MS, van den Blink B.

Respir Med. 2018 May;138S:S31-S37. doi: 10.1016/j.rmed.2017.10.022. Epub 2017 Oct 31.


The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma.

KleinJan A, Tindemans I, Montgomery JE, Lukkes M, de Bruijn MJW, van Nimwegen M, Bergen I, Moellering RE, Hoogsteden HC, Boon L, Amsen D, Hendriks RW.

J Allergy Clin Immunol. 2018 Jul;142(1):76-85.e8. doi: 10.1016/j.jaci.2017.08.042. Epub 2017 Oct 27.


Patient and partner empowerment programme for idiopathic pulmonary fibrosis.

van Manen MJG, van 't Spijker A, Tak NC, Baars CT, Jongenotter SM, van Roon LR, Kraan J, Hoogsteden HC, Wijsenbeek MS.

Eur Respir J. 2017 Apr 26;49(4). pii: 1601596. doi: 10.1183/13993003.01596-2016. Print 2017 Apr. No abstract available.


What patients with pulmonary fibrosis and their partners think: a live, educative survey in the Netherlands and Germany.

van Manen MJ, Kreuter M, van den Blink B, Oltmanns U, Palmowski K, Brunnemer E, Hummler S, Tak NC, van den Toorn L, Miedema J, Hoogsteden HC, Wijsenbeek MS.

ERJ Open Res. 2017 Feb 14;3(1). pii: 00065-2016. doi: 10.1183/23120541.00065-2016. eCollection 2017 Jan.


Efficacy of Tumor Vaccines and Cellular Immunotherapies in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Dammeijer F, Lievense LA, Veerman GD, Hoogsteden HC, Hegmans JP, Arends LR, Aerts JG.

J Clin Oncol. 2016 Sep 10;34(26):3204-12. doi: 10.1200/JCO.2015.66.3955. Epub 2016 Jul 18. Review.


T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice.

Li BW, de Bruijn MJ, Tindemans I, Lukkes M, KleinJan A, Hoogsteden HC, Hendriks RW.

Eur J Immunol. 2016 Jun;46(6):1392-403. doi: 10.1002/eji.201546119. Epub 2016 May 12.


Extended Tumor Control after Dendritic Cell Vaccination with Low-Dose Cyclophosphamide as Adjuvant Treatment in Patients with Malignant Pleural Mesothelioma.

Cornelissen R, Hegmans JP, Maat AP, Kaijen-Lambers ME, Bezemer K, Hendriks RW, Hoogsteden HC, Aerts JG.

Am J Respir Crit Care Med. 2016 May 1;193(9):1023-31. doi: 10.1164/rccm.201508-1573OC.


Impaired survival of regulatory T cells in pulmonary sarcoidosis.

Broos CE, van Nimwegen M, Kleinjan A, ten Berge B, Muskens F, in 't Veen JC, Annema JT, Lambrecht BN, Hoogsteden HC, Hendriks RW, Kool M, van den Blink B.

Respir Res. 2015 Sep 16;16:108. doi: 10.1186/s12931-015-0265-8.


Decreased Cytotoxic T-Lymphocyte Antigen 4 Expression on Regulatory T Cells and Th17 Cells in Sarcoidosis: Double Trouble?

Broos CE, van Nimwegen M, In 't Veen JC, Hoogsteden HC, Hendriks RW, van den Blink B, Kool M.

Am J Respir Crit Care Med. 2015 Sep 15;192(6):763-5. doi: 10.1164/rccm.201503-0635LE. No abstract available.


[Surgical management of bronchiectasis].

Pieters AL, Maat A, Hoogsteden HC, van der Eerden MM.

Ned Tijdschr Geneeskd. 2015;159:A8928. Review. Dutch.


Immunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer.

de Goeje PL, Bezemer K, Heuvers ME, Dingemans AC, Groen HJ, Smit EF, Hoogsteden HC, Hendriks RW, Aerts JG, Hegmans JP.

Oncoimmunology. 2015 Mar 19;4(7):e1014242. eCollection 2015 Jul.


Intratumoral macrophage phenotype and CD8+ T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma.

Cornelissen R, Lievense LA, Robertus JL, Hendriks RW, Hoogsteden HC, Hegmans JP, Aerts JG.

Lung Cancer. 2015 Jun;88(3):332-7. doi: 10.1016/j.lungcan.2015.03.013. Epub 2015 Mar 21.


Immunotherapy prospects in the treatment of lung cancer and mesothelioma.

Aerts JG, Lievense LA, Hoogsteden HC, Hegmans JP.

Transl Lung Cancer Res. 2014 Feb;3(1):34-45. doi: 10.3978/j.issn.2218-6751.2013.11.04. Review.


Occurrence of virus-induced COPD exacerbations during four seasons.

Djamin RS, Uzun S, Snelders E, Kluytmans JJ, Hoogsteden HC, Aerts JG, Van Der Eerden MM.

Infect Dis (Lond). 2015 Feb;47(2):96-100. doi: 10.3109/00365548.2014.968866. Epub 2014 Nov 26.


Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma.

Cornelissen R, Lievense LA, Maat AP, Hendriks RW, Hoogsteden HC, Bogers AJ, Hegmans JP, Aerts JG.

PLoS One. 2014 Sep 5;9(9):e106742. doi: 10.1371/journal.pone.0106742. eCollection 2014.


Peptides from the variable region of specific antibodies are shared among lung cancer patients.

de Costa D, Broodman I, Calame W, Stingl C, Dekker LJ, Vernhout RM, de Koning HJ, Hoogsteden HC, Sillevis Smitt PA, van Klaveren RJ, Luider TM, Vanduijn MM.

PLoS One. 2014 May 1;9(5):e96029. doi: 10.1371/journal.pone.0096029. eCollection 2014.


Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial.

Uzun S, Djamin RS, Kluytmans JA, Mulder PG, van't Veer NE, Ermens AA, Pelle AJ, Hoogsteden HC, Aerts JG, van der Eerden MM.

Lancet Respir Med. 2014 May;2(5):361-8. doi: 10.1016/S2213-2600(14)70019-0. Epub 2014 Apr 15.


[Contemporary interpretation of lung function test results].

Quanjer P, Stam H, Mertens FW, de Jongste JC, Chavannes NH, Hoogsteden HC.

Ned Tijdschr Geneeskd. 2014;158:A7031. Dutch.


Enforced expression of Gata3 in T cells and group 2 innate lymphoid cells increases susceptibility to allergic airway inflammation in mice.

KleinJan A, Klein Wolterink RG, Levani Y, de Bruijn MJ, Hoogsteden HC, van Nimwegen M, Hendriks RW.

J Immunol. 2014 Feb 15;192(4):1385-94. doi: 10.4049/jimmunol.1301888. Epub 2014 Jan 10.


Granuloma formation in pulmonary sarcoidosis.

Broos CE, van Nimwegen M, Hoogsteden HC, Hendriks RW, Kool M, van den Blink B.

Front Immunol. 2013 Dec 10;4:437. doi: 10.3389/fimmu.2013.00437. Review.


Leflunomide as part of the treatment for multidrug-resistant cytomegalovirus disease after lung transplantation: case report and review of the literature.

Verkaik NJ, Hoek RA, van Bergeijk H, van Hal PT, Schipper ME, Pas SD, Beersma MF, Boucher CA, Jedema I, Falkenburg F, Hoogsteden HC, van den Blink B, Murk JL.

Transpl Infect Dis. 2013 Dec;15(6):E243-9. doi: 10.1111/tid.12156. Epub 2013 Oct 23. Review.


Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients.

Heuvers ME, Muskens F, Bezemer K, Lambers M, Dingemans AC, Groen HJM, Smit EF, Hoogsteden HC, Hegmans JPJJ, Aerts JGJV.

Lung Cancer. 2013 Sep;81(3):468-474. doi: 10.1016/j.lungcan.2013.06.005. Epub 2013 Jul 11.


Cytokines in nasal lavages and plasma and their correlation with clinical parameters in cystic fibrosis.

Paats MS, Bergen IM, Bakker M, Hoek RA, Nietzman-Lammering KJ, Hoogsteden HC, Hendriks RW, van der Eerden MM.

J Cyst Fibros. 2013 Dec;12(6):623-9. doi: 10.1016/j.jcf.2013.05.002. Epub 2013 Jun 14.


The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.

Gloudemans AK, Plantinga M, Guilliams M, Willart MA, Ozir-Fazalalikhan A, van der Ham A, Boon L, Harris NL, Hammad H, Hoogsteden HC, Yazdanbakhsh M, Hendriks RW, Lambrecht BN, Smits HH.

PLoS One. 2013;8(3):e59822. doi: 10.1371/journal.pone.0059822. Epub 2013 Mar 20.


Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis.

Dillingh MR, van den Blink B, Moerland M, van Dongen MG, Levi M, Kleinjan A, Wijsenbeek MS, Lupher ML Jr, Harper DM, Getsy JA, Hoogsteden HC, Burggraaf J.

Pulm Pharmacol Ther. 2013 Dec;26(6):672-6. doi: 10.1016/j.pupt.2013.01.008. Epub 2013 Feb 4.


T helper 17 cells are involved in the local and systemic inflammatory response in community-acquired pneumonia.

Paats MS, Bergen IM, Hanselaar WE, van Zoelen EC, Verbrugh HA, Hoogsteden HC, van den Blink B, Hendriks RW, van der Eerden MM.

Thorax. 2013 May;68(5):468-74. doi: 10.1136/thoraxjnl-2012-202168. Epub 2013 Jan 12.


Local and systemic cytokine profiles in nonsevere and severe community-acquired pneumonia.

Paats MS, Bergen IM, Hanselaar WE, Groeninx van Zoelen EC, Hoogsteden HC, Hendriks RW, van der Eerden MM.

Eur Respir J. 2013 Jun;41(6):1378-85. doi: 10.1183/09031936.00060112. Epub 2012 Dec 20.


Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model.

Kleinjan A, van Nimwegen M, Leman K, Hoogsteden HC, Lambrecht BN.

Allergy. 2013 Feb;68(2):204-12. doi: 10.1111/all.12082. Epub 2012 Dec 18.


Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment.

Heuvers ME, Aerts JG, Cornelissen R, Groen H, Hoogsteden HC, Hegmans JP.

BMC Cancer. 2012 Dec 5;12:580. doi: 10.1186/1471-2407-12-580. Review.


Dendritic cell-based immunotherapy in mesothelioma.

Cornelissen R, Lievense LA, Heuvers ME, Maat AP, Hendriks RW, Hoogsteden HC, Hegmans JP, Aerts JG.

Immunotherapy. 2012 Oct;4(10):1011-22. doi: 10.2217/imt.12.108. Review.


Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor.

Willart MA, van Nimwegen M, Grefhorst A, Hammad H, Moons L, Hoogsteden HC, Lambrecht BN, Kleinjan A.

Allergy. 2012 Dec;67(12):1501-10. doi: 10.1111/all.12019. Epub 2012 Sep 25.


Incidence of viral respiratory pathogens causing exacerbations in adult cystic fibrosis patients.

Hoek RA, Paats MS, Pas SD, Bakker M, Hoogsteden HC, Boucher CA, van der Eerden MM.

Scand J Infect Dis. 2013 Jan;45(1):65-9. doi: 10.3109/00365548.2012.708942. Epub 2012 Sep 19.


New roads open up for implementing immunotherapy in mesothelioma.

Cornelissen R, Heuvers ME, Maat AP, Hendriks RW, Hoogsteden HC, Aerts JG, Hegmans JP.

Clin Dev Immunol. 2012;2012:927240. doi: 10.1155/2012/927240. Epub 2012 Jun 24. Review.


Optical detection of preneoplastic lesions of the central airways.

van der Leest C, Amelink A, van Klaveren RJ, Hoogsteden HC, Sterenborg HJ, Aerts JG.

ISRN Oncol. 2012;2012:957835. doi: 10.5402/2012/957835. Epub 2012 Mar 22.


Evidence for local dendritic cell activation in pulmonary sarcoidosis.

Ten Berge B, Kleinjan A, Muskens F, Hammad H, Hoogsteden HC, Hendriks RW, Lambrecht BN, Van den Blink B.

Respir Res. 2012 Apr 18;13:33. doi: 10.1186/1465-9921-13-33.


History of tuberculosis as an independent prognostic factor for lung cancer survival.

Heuvers ME, Aerts JG, Hegmans JP, Veltman JD, Uitterlinden AG, Ruiter R, Rodenburg EM, Hofman A, Bakker M, Hoogsteden HC, Stricker BH, van Klaveren RJ.

Lung Cancer. 2012 Jun;76(3):452-6. doi: 10.1016/j.lungcan.2011.12.008. Epub 2012 Jan 9.


Systemic CD4+ and CD8+ T-cell cytokine profiles correlate with GOLD stage in stable COPD.

Paats MS, Bergen IM, Hoogsteden HC, van der Eerden MM, Hendriks RW.

Eur Respir J. 2012 Aug;40(2):330-7. doi: 10.1183/09031936.00079611. Epub 2011 Dec 19.


Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy.

Hou J, Lambers M, den Hamer B, den Bakker MA, Hoogsteden HC, Grosveld F, Hegmans J, Aerts J, Philipsen S.

J Thorac Oncol. 2012 Jan;7(1):105-14. doi: 10.1097/JTO.0b013e3182352a45.


Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis.

Ten Berge B, Paats MS, Bergen IM, van den Blink B, Hoogsteden HC, Lambrecht BN, Hendriks RW, Kleinjan A.

Rheumatology (Oxford). 2012 Jan;51(1):37-46. doi: 10.1093/rheumatology/ker316. Epub 2011 Nov 10.


SUVmax during 18FDG-PET scanning in small cell lung cancer: similar information as in non-small cell lung cancer?

van der Leest C, Smit EF, Baas J, Versteijlen RJ, van Walree N, Hoogsteden HC, Aerts JG.

Lung Cancer. 2012 Apr;76(1):67-71. doi: 10.1016/j.lungcan.2011.09.007. Epub 2011 Oct 11.


Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs.

Kool M, Geurtsvankessel C, Muskens F, Madeira FB, van Nimwegen M, Kuipers H, Thielemans K, Hoogsteden HC, Hammad H, Lambrecht BN.

J Leukoc Biol. 2011 Dec;90(6):1177-90. doi: 10.1189/jlb.0610342. Epub 2011 Sep 20.


Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction.

van Riel D, Leijten LM, van der Eerden M, Hoogsteden HC, Boven LA, Lambrecht BN, Osterhaus AD, Kuiken T.

PLoS Pathog. 2011 Jun;7(6):e1002099. doi: 10.1371/journal.ppat.1002099. Epub 2011 Jun 23.


Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice.

van Rijt LS, Vos N, Willart M, Muskens F, Tak PP, van der Horst C, Hoogsteden HC, Lambrecht BN.

Am J Respir Crit Care Med. 2011 Aug 1;184(3):303-11. doi: 10.1164/rccm.201101-0019OC. Epub 2011 May 11.


COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function.

Veltman JD, Lambers ME, van Nimwegen M, Hendriks RW, Hoogsteden HC, Aerts JG, Hegmans JP.

BMC Cancer. 2010 Aug 30;10:464. doi: 10.1186/1471-2407-10-464.


Serum biomarkers in idiopathic pulmonary fibrosis.

van den Blink B, Wijsenbeek MS, Hoogsteden HC.

Pulm Pharmacol Ther. 2010 Dec;23(6):515-20. doi: 10.1016/j.pupt.2010.08.001. Epub 2010 Aug 12. Review.


Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma.

Veltman JD, Lambers ME, van Nimwegen M, Hendriks RW, Hoogsteden HC, Hegmans JP, Aerts JG.

Br J Cancer. 2010 Aug 24;103(5):629-41. doi: 10.1038/sj.bjc.6605814. Epub 2010 Jul 27.

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