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Items: 1 to 50 of 54

1.

Interaction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells.

Schillemans M, Karampini E, Hoogendijk AJ, Wahedi M, van Alphen FPJ, van den Biggelaar M, Voorberg J, Bierings R.

J Proteomics. 2019 Jun 13;205:103417. doi: 10.1016/j.jprot.2019.103417. [Epub ahead of print]

2.

Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans.

van der Meer AJ, Kroeze A, Hoogendijk AJ, Soussan AA, Ellen van der Schoot C, Wuillemin WA, Voermans C, van der Poll T, Zeerleder S.

Blood Adv. 2019 Mar 12;3(5):724-728. doi: 10.1182/bloodadvances.2018018895. No abstract available.

3.

Kinase activity is impaired in neutrophils of sepsis patients.

Hoogendijk AJ, van Vught LA, Wiewel MA, Fuhler GM, Belkasim-Bohoudi H, Horn J, Schultz MJ, Scicluna BP, Peppelenbosch MP, van 't Veer C, de Vos AF, van der Poll T.

Haematologica. 2019 Jun;104(6):e233-e235. doi: 10.3324/haematol.2018.201913. Epub 2018 Dec 4. No abstract available.

4.

Neutrophils mitigate the systemic host response during endotoxemia in mice.

van der Meer AJ, Ding C, Hoogendijk AJ, de Vos AF, Boon L, Zeerleder SS, van der Poll T.

Immunology. 2019 Mar;156(3):277-281. doi: 10.1111/imm.13026. Epub 2018 Dec 18.

5.

Integrated proteomic analysis of tumor necrosis factor α and interleukin 1β-induced endothelial inflammation.

Béguin EP, van den Eshof BL, Hoogendijk AJ, Nota B, Mertens K, Meijer AB, van den Biggelaar M.

J Proteomics. 2019 Feb 10;192:89-101. doi: 10.1016/j.jprot.2018.08.011. Epub 2018 Aug 25.

PMID:
30153514
6.

The host response in critically ill sepsis patients on statin therapy: a prospective observational study.

Wiewel MA, Scicluna BP, van Vught LA, Hoogendijk AJ, Zwinderman AH, Lutter R, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T.

Ann Intensive Care. 2018 Jan 18;8(1):9. doi: 10.1186/s13613-017-0349-3.

7.

Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis upon ICU Admission.

Scicluna BP, Wiewel MA, van Vught LA, Hoogendijk AJ, Klarenbeek AM, Franitza M, Toliat MR, Nürnberg P, Horn J, Bonten MJ, Schultz MJ, Cremer OL, van der Poll T.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1070-1073. doi: 10.1164/rccm.201707-1339LE. No abstract available.

PMID:
28972859
8.

Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics.

van den Eshof BL, Hoogendijk AJ, Simpson PJ, van Alphen FPJ, Zanivan S, Mertens K, Meijer AB, van den Biggelaar M.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1891-1902. doi: 10.1161/ATVBAHA.117.309926. Epub 2017 Aug 17.

PMID:
28818855
9.

Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.

van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PMC, Ong DSY, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Bonten MMJ, Schultz MJ, van der Poll T; MARS Consortium.

Crit Care Med. 2017 Nov;45(11):1854-1862. doi: 10.1097/CCM.0000000000002649.

PMID:
28806220
10.

Expression of intra- and extracellular granzymes in patients with typhoid fever.

de Jong HK, Garcia-Laorden MI, Hoogendijk AJ, Parry CM, Maude RR, Dondorp AM, Faiz MA, van der Poll T, Wiersinga WJ.

PLoS Negl Trop Dis. 2017 Jul 27;11(7):e0005823. doi: 10.1371/journal.pntd.0005823. eCollection 2017 Jul.

11.

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis.

Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, Artigas A, Martin-Loeches I, Hoogendijk AJ, van der Poll T, Horn J, Juffermans N, Calfee CS, Schultz MJ; MARS consortium.

Thorax. 2017 Oct;72(10):876-883. doi: 10.1136/thoraxjnl-2016-209719. Epub 2017 Apr 27.

12.

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Hoogendijk AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, Belkasim-Bohoudi H, Duitman J, Horn J, Schultz MJ, Scicluna BP, van 't Veer C, de Vos AF, van der Poll T.

Crit Care Med. 2017 May;45(5):e524-e531. doi: 10.1097/CCM.0000000000002294.

PMID:
28240686
13.

The Host Response in Patients with Sepsis Developing Intensive Care Unit-acquired Secondary Infections.

van Vught LA, Wiewel MA, Hoogendijk AJ, Frencken JF, Scicluna BP, Klein Klouwenberg PMC, Zwinderman AH, Lutter R, Horn J, Schultz MJ, Bonten MMJ, Cremer OL, van der Poll T.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):458-470. doi: 10.1164/rccm.201606-1225OC.

PMID:
28107024
14.

Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis: A Prospective Observational Study.

Wiewel MA, van Vught LA, Scicluna BP, Hoogendijk AJ, Frencken JF, Zwinderman AH, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium.

Crit Care Med. 2017 Mar;45(3):454-463. doi: 10.1097/CCM.0000000000002236.

PMID:
28079604
15.

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016.

Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, González-Quevedo N, Rajas O, Briones M, Rodríguez de Castro F, Rodríguez Gallego C, Esen F, Orhun G, Ergin Ozcan P, Senturk E, Ugur Yilmaz C, Orhan N, Arican N, Kaya M, Kucukerden M, Giris M, Akcan U, Bilgic Gazioglu S, Tuzun E, Riff R, Naamani O, Douvdevani A, Takegawa R, Yoshida H, Hirose T, Yamamoto N, Hagiya H, Ojima M, Akeda Y, Tasaki O, Tomono K, Shimazu T, Ono S, Kubo T, Suda S, Ueno T, Ikeda T, Hirose T, Ogura H, Takahashi H, Ojima M, Kang J, Nakamura Y, Kojima T, Shimazu T, Ikeda T, Suda S, Izutani Y, Ueno T, Ono S, Taniguchi T, O M, Dinter C, Lotz J, Eilers B, Wissmann C, Lott R, Meili MM, Schuetz PS, Hawa H, Sharshir M, Aburageila M, Salahuddin N, Chantziara V, Georgiou S, Tsimogianni A, Alexandropoulos P, Vassi A, Lagiou F, Valta M, Micha G, Chinou E, Michaloudis G, Kodaira A, Ikeda T, Ono S, Ueno T, Suda S, Izutani Y, Imaizumi H, De la Torre-Prados MV, Garcia-De la Torre A, Enguix-Armada A, Puerto-Morlan A, Perez-Valero V, Garcia-Alcantara A, Bolton N, Dudziak J, Bonney S, Tridente A, Nee P, Nicolaes G, Wiewel M, Schultz M, Wildhagen K, Horn J, Schrijver R, Van der Poll T, Reutelingsperger C, Pillai S, Davies G, Mills G, Aubrey R, Morris K, Williams P, Evans P, Gayat EG, Struck J, Cariou A, Deye N, Guidet B, Jabert S, Launay J, Legrand M, Léone M, Resche-Rigon M, Vicaut E, Vieillard-Baron A, Mebazaa A, Arnold R, Capan M, Linder A, Akesson P, Popescu M, Tomescu D, Sprung CL, Calderon Morales R, Munteanu G, Orenbuch-Harroch E, Levin P, Kasdan H, Reiter A, Volker T, Himmel Y, Cohen Y, Meissonnier J, Girard L, Rebeaud F, Herrmann I, Delwarde B, Peronnet E, Cerrato E, Venet F, Lepape A, Rimmelé T, Monneret G, Textoris J, Beloborodova N, Moroz V, Osipov A, Bedova A, Sarshor Y, Pautova A, Sergeev A, Chernevskaya E, Odermatt J, Bolliger R, Hersberger L, Ottiger M, Christ-Crain M, Mueller B, Schuetz P, Sharma NK, Tashima AK, Brunialti MK, Machado FR, Assuncao M, Rigato O, Salomao R, Cajander SC, Rasmussen G, Tina E, Söderquist B, Källman J, Strålin K, Lange AL, Sundén-Cullberg JS, Magnuson AM, Hultgren OH, Davies G, Pillai S, Mills G, Aubrey R, Morris K, Williams P, Evans P, Pillai S, Davies G, Mills G, Aubrey R, Morris K, Williams P, Evans P, Pillai S, Davies G, Mills G, Aubrey R, Morris K, Williams P, Evans P, Van der Geest P, Mohseni M, Linssen J, De Jonge R, Duran S, Groeneveld J, Miller R 3rd, Lopansri BK, McHugh LC, Seldon A, Burke JP, Johnston J, Reece-Anthony R, Bond A, Molokhia A, Mcgrath C, Nsutebu E, Bank Pedersen P, Pilsgaard Henriksen D, Mikkelsen S, Touborg Lassen A, Tincu R, Cobilinschi C, Tomescu D, Ghiorghiu Z, Macovei R, Wiewel MA, Harmon MB, Van Vught LA, Scicluna BP, Hoogendijk AJ, Horn J, Zwinderman AH, Cremer OL, Bonten MJ, Schultz MJ, Van der Poll T, Juffermans NP, Wiersinga WJ, Eren G, Tekdos Y, Dogan M, Acicbe O, Kaya E, Hergunsel O, Alsolamy S, Ghamdi G, Alswaidan L, Alharbi S, Alenezi F, Arabi Y, Heaton J, Boyce A, Nolan L, Johnston J, Dukoff-Gordon A, Dean A, Molokhia A, Mann Ben Yehudah T, Fleischmann C, Thomas-Rueddel D, Haas C, Dennler U, Reinhart K, Suntornlohanakul O, Khwannimit B, Breckenridge F, Puxty A, Szturz P, Folwarzcny P, Svancara J, Kula R, Sevcik P, Caneva L, Casazza A, Bellazzi E, Marra S, Pagani L, Vetere M, Vanzino R, Ciprandi D, Preda R, Boschi R, Carnevale L, Lopez V, Aguilar Arzapalo M, Barradas L, Escalante A, Gongora J, Cetina M, Adamik B, Jakubczyk D, Kübler A, Radford A, Lee T, Singer J, Boyd J, Fineberg D, Williams M, Russell J, Scarlatescu E, Tomescu D, Droc G, Arama S, Müller M, Straat M, Zeerleder SS, Juffermans NP, Fuchs CF, Scheer CS, Wauschkuhn SW, Vollmer MV, Meissner KM, Kuhn SK, Hahnenkamp KH, Rehberg SR, Gründling MG, Yamamoto N, Ojima M, Hamaguchi S, Hirose T, Akeda Y, Takegawa R, Tasaki O, Shimazu T, Tomono K, Gómez-Sánchez E, Heredia-Rodríguez M, Álvarez-Fuente E, Lorenzo-López M, Gómez-Pesquera E, Aragón-Camino M, Liu-Zhu P, Sánchez-López A, Hernández-Lozano A, Peláez-Jareño MT, Tamayo E, Thomas-Rüddel DO, Fleischmann C, Haas C, Dennler U, Reinhart K, Adora V, Kar A, Chakraborty A, Roy S, Bandyopadhyay A, Das M, Mann Ben Yehudah T, BenYehudah G, Salim M, Kumar N, Arabi L, Burger T, Lephart P, Toth-Martin E, Valencia C, Hammami N, Blot S, Vincent JL, Lambert ML, Brunke J, Riemann T, Roschke I, Tincu R, Cobilinschi C, Tomescu D, Ghiorghiu Z, Macovei R, Nimitvilai S, Jintanapramote K, Jarupongprapa S, Adukauskiene D, Valanciene D, Bose G, Lostarakos V, Carr B, Khedher S, Maaoui A, Ezzamouri A, Salem M, Chen J, Cranendonk DR, Van Vught LA, Wiewel MA, Cremer OL, Horn J, Bonten MJ, Schultz MJ, Van der Poll T, Wiersinga WJ, Day M, Penrice G, Roy K, Robertson P, Godbole G, Jones B, Booth M, Donaldson L, Kawano Y, Ishikura H, Al-Dorzi H, Almutairi M, Alhamadi B, Crizaldo Toledo A, Khan R, Al Raiy B, Arabi Y, Talaie H, Van Oers JA, Harts A, Nieuwkoop E, Vos P, Boussarsar Y, Boutouta F, Kamoun S, Mezghani I, Koubaji S, Ben Souissi A, Riahi A, Mebazaa MS, Giamarellos-Bourboulis E, Tziolos N, Routsi C, Katsenos C, Tsangaris I, Pneumatikos I, Vlachogiannis G, Theodorou V, Prekates A, Antypa E, Koulouras V, Kapravelos N, Gogos C, Antoniadou E, Mandragos K, Armaganidis A, Robles Caballero AR, Civantos B, Figueira JC, López J, Silva-Pinto A, Ceia F, Sarmento A, Santos L, Almekhlafi G, Sakr Y, Al-Dorzi H, Khan R, Baharoon S, Aldawood A, Matroud A, Alchin J, Al Johani S, Balkhy H, Arabi Y, Alsolamy S, Yousif SY, Alotabi BO, Alsaawi AS, Ang J, Curran MD, Enoch D, Navapurkar V, Morris A, Sharvill R, Astin J, Heredia-Rodríguez M, Gómez-Sánchez E, Peláez-Jareño MT, Gómez-Pesquera E, Lorenzo-López M, Liu-Zhu P, Aragón-Camino M, Hernández-Lozano A, Sánchez-López A, Álvarez-Fuente E, Tamayo E, Patel J, Kruger C, O'Neal J, Rhodes H, Jancik J, François B, Laterre PF, Eggimann P, Torres A, Sánchez M, Dequin PF, Bassi GL, Chastre J, Jafri HS, Ben Romdhane M, Douira Z, Kamoun S, Bousselmi M, Ben Souissi A, Boussarsar Y, Riahi A, Mebazaa MS, Vakalos A, Avramidis V, Craven TH, Wojcik G, Kefala K, McCoubrey J, Reilly J, Paterson R, Inverarity D, Laurenson I, Walsh TS, Mongodi S, Bouhemad B, Orlando A, Stella A, Via G, Iotti G, Braschi A, Mojoli F, Haliloglu M, Bilgili B, Kasapoglu U, Sayan I, Süzer Aslan M, Yalcin A, Cinel I, Vakalos A, Avramidis V, Ellis HE, Bauchmuller K, Miller D, Temple A, Chastre J, François B, Torres A, Luyt CE, Sánchez M, Singer M, Jafri HS, Nassar Y, Ayad MS, Trifi A, Abdellatif S, Daly F, Nasri R, Ben Lakhal S, Bilgili B, Haliloglu M, Gul F, Cinel I, Kuzovlev A, Shabanov A, Polovnikov S, Moroz V, Kadrichu N, Dang T, Corkery K, Challoner P, Bassi GL, Aguilera E, Chiurazzi C, Travierso C, Motos A, Fernandez L, Amaro R, Senussi T, Idone F, Bobi J, Rigol M, Torres A, Hodiamont CJ, Juffermans NP, Janssen JM, Bouman CS, Mathôt RA, De Jong MD, Van Hest RM, Payne L, Fraser GL, Tudor B, Lahner M, Roth G, Krenn C, Talaie H, Jault P, Gabard J, Leclerc T, Jennes S, Que Y, Rousseau A, Ravat F, Al-Dorzi H, Eissa A, Al-Harbi S, Aldabbagh T, Khan R, Arabi Y, Trifi A, Abdellatif S, Daly F, Nasri R, Ben Lakhal S, Paramba F, Purayil N, Naushad V, Mohammad O, Negi V, Chandra P, Kleinsasser A, Witrz MR, Buchner-Doeven JF, Tuip-de Boer AM, Goslings JC, Juffermans NP, Van Hezel M, Straat M, Boing A, Van Bruggen R, Juffermans N, Markopoulou D, Venetsanou K, Kaldis V, Koutete D, Chroni D, Alamanos I, Koch L, Jancik J, Rhodes H, Walter E, Maekawa K, Hayakawa M, Kushimoto S, Shiraishi A, Kato H, Sasaki J, Ogura H, Matauoka T, Uejima T, Morimura N, Ishikura H, Hagiwara A, Takeda M, Tarabrin O, Shcherbakow S, Gavrychenko D, Mazurenko G, Ivanova V, Chystikov O, Plourde C, Lessard J, Chauny J, Daoust R, Shcherbakow S, Tarabrin O, Gavrychenko D, Mazurenko G, Chystikov O, Vakalos A, Avramidis V, Kropman L, In Het Panhuis L, Konings J, Huskens D, Schurgers E, Roest M, De Laat B, Lance M, Durila M, Lukas P, Astraverkhava M, Jonas J, Budnik I, Shenkman B, Hayami H, Koide Y, Goto T, Iqbal R, Alhamdi Y, Venugopal N, Abrams S, Downey C, Toh CH, Welters ID, Bombay VB, Chauny JM, Daoust RD, Lessard JL, Marquis MM, Paquet JP, Siemens K, Sangaran D, Hunt BJ, Durward A, Nyman A, Murdoch IA, Tibby SM, Ampatzidou F, Moisidou D, Dalampini E, Nastou M, Vasilarou E, Kalaizi V, Chatzikostenoglou H, Drossos G, Spadaro S, Fogagnolo A, Fiore T, Schiavi A, Fontana V, Taccone F, Volta C, Chochliourou E, Volakli E, Violaki A, Samkinidou E, Evlavis G, Panagiotidou V, Sdougka M, Mothukuri R, Battle C, Guy K, Mills G, Evans P, Wijesuriya J, Keogh S, Docherty A, O'Donnell R, Brunskill S, Trivella M, Doree C, Holst L, Parker M, Gregersen M, Almeida J, Walsh T, Stanworth S, Moravcova S, Mansell J, Rogers A, Smith RA, Hamilton-Davies C, Omar A, Allam M, Bilala O, Kindawi A, Ewila H, Ampatzidou F, Moisidou D, Nastou M, Dalampini E, Malamas A, Vasilarou E, Drossos G, Ferreira G, Caldas J, Fukushima J, Osawa EA, Arita E, Camara L, Zeferino S, Jardim J, Gaioto F, Dallan L, Jatene FB, Kalil Filho R, Galas F, Hajjar LA, Mitaka C, Ohnuma T, Murayama T, Kunimoto F, Nagashima M, Takei T, Tomita M, Omar A, Mahmoud K, Hanoura S, Sudarsanan S, Sivadasan P, Othamn H, Shouman Y, Singh R, Al Khulaifi A, Mandel I, Mikheev S, Suhodolo I, Kiselev V, Svirko Y, Podoksenov Y, Jenkins SA, Griffin R, Tovar Doncel MS, Lima A, Aldecoa C, Ince C, Taha A, Shafie A, Mostafa M, Syed N, Hon H, Righetti F, Colombaroli E, Castellano G, Righetti F, Colombaroli E, Hravnak M, Chen LC, Dubrawski AD, Clermont GC, Pinsky MR, Gonzalez S, Macias D, Acosta J, Jimenez P, Loza A, Lesmes A, Lucena F, Leon C, Tovar Doncel MS, Ince C, Aldecoa C, Lima A, Bastide M, Richecoeur J, Frenoy E, Lemaire C, Sauneuf B, Tamion F, Nseir S, Du Cheyron D, Dupont H, Maizel J, Shaban M, Kolko R, Salahuddin N, Sharshir M, AbuRageila M, AlHussain A, Mercado P, Maizel J, Kontar L, Titeca D, Brazier F, Riviere A, Joris M, Soupison T, De Cagny B, Slama M, Wagner J, Körner A, Kubik M, Kluge S, Reuter D, Saugel B, Colombaroli E, Righetti F, Castellano G, Tran T, De Bels D, Cudia A, Strachinaru M, Ghottignies P, Devriendt J, Pierrakos C, Martínez González Ó, Blancas R, Luján J, Ballesteros D, Martínez Díaz C, Núñez A, Martín Parra C, López Matamala B, Alonso Fernández M, Chana M, Huber W, Eckmann M, Elkmann F, Gruber A, Klein I, Schmid RM, Lahmer T, Moller PW, Sondergaard S, Jakob SM, Takala J, Berger D, Bastoni D, Aya H, Toscani L, Pigozzi L, Rhodes A, Cecconi M, Ostrowska C, Aya H, Abbas A, Mellinghoff J, Ryan C, Dawson D, Rhodes A, Cecconi M, Cronhjort M, Wall O, Nyberg E, Zeng R, Svensen C, Mårtensson J, Joelsson-Alm E, Aguilar Arzapalo M, Barradas L, Lopez V, Cetina M, Parenti N, Palazzi C, Amidei LA, Borrelli FB, Campanale SC, Tagliazucchi FT, Sedoni GS, Lucchesi DL, Carella EC, Luciani AL, Mackovic M, Maric N, Bakula M, Aya H, Rhodes A, Grounds RM, Fletcher N, Cecconi M, Avard B, Zhang P, Mezidi M, Charbit J, Ould-Chikh M, Deras P, Maury C, Martinez O, Capdevila X, Hou P, Linde-Zwirble WZ, Douglas ID, Shapiro NS, Ben Souissi A, Mezghani I, Ben Aicha Y, Kamoun S, Laribi B, Jeribi B, Riahi A, Mebazaa MS, Pereira C, Marinho R, Antunes R, Marinho A, Crivits M, Raes M, Decruyenaere J, Hoste E, Bagin V, Rudnov V, Savitsky A, Astafyeva M, Korobko I, Vein V, Kampmeier T, Arnemann P, Hessler M, Wald A, Bockbreder K, Morelli A, Van Aken H, Rehberg S, Ertmer C, Arnemann P, Hessler M, Kampmeier T, Rehberg S, Van Aken H, Ince C, Ertmer C, Reddy S, Bailey M, Beasley R, Bellomo R, Mackle D, Psirides A, Young P, Reddy S, Bailey M, Beasley R, Bellomo R, Mackle D, Young P, Venkatesh H, Ramachandran S, Basu A, Nair H, Egan S, Bates J, Oliveira S, Rangel Neto NR, Reis FQ, Lee CP, Lin XL, Choong C, Eu KM, Sim WY, Tee KS, Pau J, Abisheganaden J, Maas K, De Geus H, Lafuente E, Marinho R, Moura J, Antunes R, Marinho A, Doris TE, Monkhouse D, Shipley T, Kardasz S, Gonzalez I, Stads S, Groeneveld AJ, Elsayed I, Ward N, Tridente A, Raithatha A, Steuber A, Pelletier C, Schroeder S, Michael E, Slowinski T, 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Crit Care. 2016 Oct 24;20:347. doi: 10.1186/s13054-016-1358-6. eCollection 2016.

16.

Risk factors, host response and outcome of hypothermic sepsis.

Wiewel MA, Harmon MB, van Vught LA, Scicluna BP, Hoogendijk AJ, Horn J, Zwinderman AH, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T, Juffermans NP, Wiersinga WJ.

Crit Care. 2016 Oct 14;20(1):328.

17.

Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study.

Wiewel MA, Huson MA, van Vught LA, Hoogendijk AJ, Klein Klouwenberg PM, Horn J, Lutter R, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T; MARS Consortium.

Crit Care. 2016 Oct 10;20(1):322.

18.

Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients.

van Vught LA, Scicluna BP, Hoogendijk AJ, Wiewel MA, Klein Klouwenberg PM, Cremer OL, Horn J, Nürnberg P, Bonten MM, Schultz MJ, van der Poll T.

Crit Care. 2016 Aug 6;20(1):252. doi: 10.1186/s13054-016-1429-8.

19.

Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy Adults.

Lankelma JM, Belzer C, Hoogendijk AJ, de Vos AF, de Vos WM, van der Poll T, Wiersinga WJ.

Clin Transl Gastroenterol. 2016 Aug 4;7(8):e186. doi: 10.1038/ctg.2016.43.

20.

Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients.

van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PM, Franitza M, Toliat MR, Nürnberg P, Cremer OL, Horn J, Schultz MJ, Bonten MM, van der Poll T.

Am J Respir Crit Care Med. 2016 Dec 1;194(11):1366-1374.

PMID:
27267747
21.

The impact of HIV infection on blood leukocyte responsiveness to bacterial stimulation in asymptomatic patients and patients with bloodstream infection.

Huson MA, Hoogendijk AJ, de Vos AF, Grobusch MP, van der Poll T.

J Int AIDS Soc. 2016 May 16;19(1):20759. doi: 10.7448/IAS.19.1.20759. eCollection 2016.

22.

Impact of HIV infection on the haemostatic response during sepsis and malaria.

Huson MA, Kalkman R, Hoogendijk AJ, Alabi AS, van 't Veer C, Grobusch MP, Meijers JC, van der Poll T.

Br J Haematol. 2016 Jun;173(6):918-26. doi: 10.1111/bjh.14006. Epub 2016 Mar 11.

PMID:
26970408
23.

Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response.

van Vught LA, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Scicluna BP, Ong DS, Cremer OL, Horn J, Bonten MM, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.

Crit Care Med. 2016 Jul;44(7):1338-46. doi: 10.1097/CCM.0000000000001650.

PMID:
26958752
24.

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients.

Claushuis TA, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Ong DS, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Zwinderman AH, Bonten MJ, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.

Blood. 2016 Jun 16;127(24):3062-72. doi: 10.1182/blood-2015-11-680744. Epub 2016 Mar 8.

25.

The Impact of HIV Co-Infection on the Genomic Response to Sepsis.

Huson MA, Scicluna BP, van Vught LA, Wiewel MA, Hoogendijk AJ, Cremer OL, Bonten MJ, Schultz MJ, Franitza M, Toliat MR, Nürnberg P, Grobusch MP, van der Poll T.

PLoS One. 2016 Feb 12;11(2):e0148955. doi: 10.1371/journal.pone.0148955. eCollection 2016.

26.

Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis.

Wiewel MA, de Stoppelaar SF, van Vught LA, Frencken JF, Hoogendijk AJ, Klein Klouwenberg PMC, Horn J, Bonten MJ, Zwinderman AH, Cremer OL, Schultz MJ, van der Poll T; MARS Consortium.

Intensive Care Med. 2016 Mar;42(3):352-360. doi: 10.1007/s00134-015-4171-9. Epub 2016 Jan 14.

27.

Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients.

Hoogendijk AJ, Wiewel MA, van Vught LA, Scicluna BP, Belkasim-Bohoudi H, Horn J, Zwinderman AH, Klein Klouwenberg PM, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T; MARS consortium.

Crit Care. 2015 Nov 25;19:412. doi: 10.1186/s13054-015-1125-0.

28.

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

Schuijt TJ, Lankelma JM, Scicluna BP, de Sousa e Melo F, Roelofs JJ, de Boer JD, Hoogendijk AJ, de Beer R, de Vos A, Belzer C, de Vos WM, van der Poll T, Wiersinga WJ.

Gut. 2016 Apr;65(4):575-83. doi: 10.1136/gutjnl-2015-309728. Epub 2015 Oct 28.

29.

Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis.

Hoogendijk AJ, Blok DC, Garcia Laorden MI, Kager LM, Lede IO, Rahman W, Afroz R, Bresser P, van der Zee JS, Ghose A, Visser CE, de Jong MD, Zahed AS, Husain MA, Alam KM, Barua PC, Hassan M, Hossain A, Tayab MA, Lutter R, Day N, Dondorp AM, Van't Veer C, de Vos AF, van der Poll T.

J Infect. 2015 Dec;71(6):706-9. doi: 10.1016/j.jinf.2015.09.002. Epub 2015 Sep 15. No abstract available.

PMID:
26384438
30.

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia.

Anas AA, de Vos AF, Hoogendijk AJ, van Lieshout MH, van Heijst JW, Florquin S, Li Z, van 't Veer C, van der Poll T.

J Pathol. 2016 Jan;238(1):74-84. doi: 10.1002/path.4637. Epub 2015 Oct 19.

31.

Increased intra- and extracellular granzyme expression in patients with tuberculosis.

Garcia-Laorden MI, Blok DC, Kager LM, Hoogendijk AJ, van Mierlo GJ, Lede IO, Rahman W, Afroz R, Ghose A, Visser CE, Md Zahed AS, Husain MA, Alam KM, Chandra Barua P, Hassan M, Hossain A, Tayab MA, Day N, Dondorp AM, de Vos AF, van der Poll T.

Tuberculosis (Edinb). 2015 Sep;95(5):575-80. doi: 10.1016/j.tube.2015.05.016. Epub 2015 Jun 20.

PMID:
26156785
32.

A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission.

Scicluna BP, Klein Klouwenberg PM, van Vught LA, Wiewel MA, Ong DS, Zwinderman AH, Franitza M, Toliat MR, Nürnberg P, Hoogendijk AJ, Horn J, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):826-35. doi: 10.1164/rccm.201502-0355OC.

PMID:
26121490
33.

Reduced Responsiveness of Blood Leukocytes to Lipopolysaccharide Does not Predict Nosocomial Infections in Critically Ill Patients.

van Vught LA, Wiewel MA, Hoogendijk AJ, Scicluna BP, Belkasim-Bohoudi H, Horn J, Schultz MJ, van der Poll T.

Shock. 2015 Aug;44(2):110-4. doi: 10.1097/SHK.0000000000000391.

PMID:
25895151
34.

Expression of inhibitory regulators of innate immunity in patients with active tuberculosis.

Blok DC, Kager LM, Hoogendijk AJ, Lede IO, Rahman W, Afroz R, Bresser P, van der Zee JS, Ghose A, Visser CE, de Jong MD, Zahed AS, Husain MA, Alam KM, Barua PC, Hassan M, Hossain A, Tayab MA, Lutter R, Day N, Dondorp AM, de Vos AF, van 't Veer C, van der Poll T.

BMC Infect Dis. 2015 Feb 26;15:98. doi: 10.1186/s12879-015-0833-z.

35.

Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis.

de Stoppelaar SF, Van't Veer C, Roelofs JJ, Claushuis TA, de Boer OJ, Tanck MW, Hoogendijk AJ, van der Poll T.

J Thromb Haemost. 2015 Jun;13(6):1128-38. doi: 10.1111/jth.12893. Epub 2015 Apr 23.

36.

DNAX-activating protein of 12 kDa impairs host defense in pneumococcal pneumonia.

Hommes TJ, Hoogendijk AJ, Dessing MC, Van't Veer C, Florquin S, de Vos AF, van der Poll T.

Crit Care Med. 2014 Dec;42(12):e783-90. doi: 10.1097/CCM.0000000000000686.

PMID:
25402298
37.

Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia.

Hommes TJ, Hoogendijk AJ, Dessing MC, Van't Veer C, Florquin S, Colonna M, de Vos AF, van der Poll T.

J Pathol. 2014 Aug;233(4):357-67. doi: 10.1002/path.4361. Epub 2014 Jun 3.

PMID:
24752755
38.

Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by Streptococcus pneumoniae.

Blok DC, van Lieshout MH, Hoogendijk AJ, Florquin S, de Boer OJ, Garlanda C, Mantovani A, van't Veer C, de Vos AF, van der Poll T.

J Innate Immun. 2014;6(4):542-52. doi: 10.1159/000358239. Epub 2014 Feb 14.

39.

Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.

de Boer JD, Yang J, van den Boogaard FE, Hoogendijk AJ, de Beer R, van der Zee JS, Roelofs JJ, van 't Veer C, de Vos AF, van der Poll T.

J Innate Immun. 2014;6(2):219-26. doi: 10.1159/000354984. Epub 2013 Oct 18.

40.

Glyburide reduces bacterial dissemination in a mouse model of melioidosis.

Koh GC, Weehuizen TA, Breitbach K, Krause K, de Jong HK, Kager LM, Hoogendijk AJ, Bast A, Peacock SJ, van der Poll T, Steinmetz I, Wiersinga WJ.

PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2500. doi: 10.1371/journal.pntd.0002500. eCollection 2013.

41.

Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice.

de Stoppelaar SF, Van't Veer C, van den Boogaard FE, Nieuwland R, Hoogendijk AJ, de Boer OJ, Roelofs JJ, van der Poll T.

Thromb Haemost. 2013 Sep;110(3):582-92. doi: 10.1160/TH13-01-0052. Epub 2013 Jun 20.

PMID:
23783078
42.

CCAAT/enhancer-binding protein δ: multifaceted regulator in respiratory disease.

Duitman JW, Hoogendijk AJ, van der Poll T, Spek CA.

Am J Pathol. 2013 Apr;182(4):1459. doi: 10.1016/j.ajpath.2012.12.038.

PMID:
23499053
43.

AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) reduces lipoteichoic acid-induced lung inflammation.

Hoogendijk AJ, Pinhanços SS, van der Poll T, Wieland CW.

J Biol Chem. 2013 Mar 8;288(10):7047-52. doi: 10.1074/jbc.M112.413138. Epub 2013 Jan 15.

44.

Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.

Daan de Boer J, Roelofs JJ, de Vos AF, de Beer R, Schouten M, Hommes TJ, Hoogendijk AJ, de Boer OJ, Stroo I, van der Zee JS, Veer CV, van der Poll T.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):382-9. doi: 10.1165/rcmb.2012-0331OC. Epub 2012 Dec 13.

PMID:
23239494
45.

CCAAT-enhancer binding protein delta (C/EBPδ) protects against Klebsiella pneumoniae-induced pulmonary infection: potential role for macrophage migration.

Duitman J, Hoogendijk AJ, Groot AP, Ruela de Sousa RR, van der Poll T, Florquin S, Spek CA.

J Infect Dis. 2012 Dec 15;206(12):1826-35. doi: 10.1093/infdis/jis615. Epub 2012 Nov 12.

PMID:
23148291
46.

Cyclin-dependent kinase inhibition reduces lung damage in a mouse model of ventilator-induced lung injury.

Hoogendijk AJ, Kuipers MT, van der Poll T, Schultz MJ, Wieland CW.

Shock. 2012 Oct;38(4):375-80. doi: 10.1097/SHK.0b013e3182656e7b.

PMID:
22777120
47.

Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia.

Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van 't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.

Mol Med. 2012 Sep 25;18:1067-75. doi: 10.2119/molmed.2011.00450.

48.

Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation.

Hoogendijk AJ, Pinhanços SS, van der Poll T, Wieland CW.

Immunobiology. 2013 Apr;218(4):435-42. doi: 10.1016/j.imbio.2012.05.027. Epub 2012 Jun 6.

PMID:
22727776
49.

R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae.

Hoogendijk AJ, Roelofs JJ, Duitman J, van Lieshout MH, Blok DC, van der Poll T, Wieland CW.

Mol Med. 2012 Sep 25;18:1086-95. doi: 10.2119/molmed.2012.00033.

50.

Osteopontin impairs host defense during pneumococcal pneumonia.

van der Windt GJ, Hoogendijk AJ, Schouten M, Hommes TJ, de Vos AF, Florquin S, van der Poll T.

J Infect Dis. 2011 Jun 15;203(12):1850-8. doi: 10.1093/infdis/jir185.

PMID:
21606543

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