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Items: 37


The Novel Perspectives of Adipokines on Brain Health.

Lee TH, Cheng KK, Hoo RL, Siu PM, Yau SY.

Int J Mol Sci. 2019 Nov 11;20(22). pii: E5638. doi: 10.3390/ijms20225638. Review.


CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.

Wong TL, Ng KY, Tan KV, Chan LH, Zhou L, Che N, Hoo RL, Lee TK, Richard S, Lo CM, Man K, Khong PL, Ma S.

Hepatology. 2019 Aug 30. doi: 10.1002/hep.30923. [Epub ahead of print]


Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation.

Pan Y, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, Wang Y, Lam KSL, Xu A.

J Clin Invest. 2019 Feb 1;129(2):834-849. doi: 10.1172/JCI123069. Epub 2019 Jan 22.


A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.

Shu L, Hoo RL, Wu X, Pan Y, Lee IP, Cheong LY, Bornstein SR, Rong X, Guo J, Xu A.

Nat Commun. 2017 Jan 27;8:14147. doi: 10.1038/ncomms14147.


Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.

Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL, Hoo RL, Chung SK, Xu A, Lam KS, Chan KH.

Mol Neurodegener. 2016 Nov 25;11(1):71.


Erratum. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4A Signaling Pathway. Diabetes 2010;59:2949-2959.

Chang J, Li Y, Huang Y, Lam KS, Hoo RL, Wong WT, Cheng KK, Wang Y, Vanhoutte PM, Xu A.

Diabetes. 2016 Oct;65(10):3219. doi: 10.2337/db16-er10b. No abstract available.


Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice.

Kwok KHM, Cheng KKY, Hoo RLC, Ye D, Xu A, Lam KSL.

Clin Sci (Lond). 2016 Nov 1;130(22):2087-2100. doi: 10.1042/CS20160465. Epub 2016 Aug 10.


The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells.

Li X, Cheng KKY, Liu Z, Yang JK, Wang B, Jiang X, Zhou Y, Hallenborg P, Hoo RLC, Lam KSL, Ikeda Y, Gao X, Xu A.

Nat Commun. 2016 Jun 6;7:11740. doi: 10.1038/ncomms11740.


Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction.

Zhou M, Bao Y, Li H, Pan Y, Shu L, Xia Z, Wu D, Lam KS, Vanhoutte PM, Xu A, Jia W, Hoo RL.

Clin Sci (Lond). 2015 Oct;129(7):547-59. doi: 10.1042/CS20150073. Epub 2015 Jun 11.


Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action.

Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo RL, Isserlin R, Bader GD, Tungtrongchitr R, Deshaies Y, Xu A, Sweeney G.

Biochem J. 2015 Jul 1;469(1):71-82. doi: 10.1042/BJ20141455. Epub 2015 Apr 27.


Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin.

Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A, So KF.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15810-5. doi: 10.1073/pnas.1415219111. Epub 2014 Oct 20.


TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.

Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A.

Biochem J. 2013 Oct 15;455(2):207-16. doi: 10.1042/BJ20130760.


Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone.

Ye H, Zhang HJ, Xu A, Hoo RL.

PLoS One. 2013 Jun 12;8(6):e65543. doi: 10.1371/journal.pone.0065543. Print 2013.


Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice.

Hoo RL, Lee IP, Zhou M, Wong JY, Hui X, Xu A, Lam KS.

J Hepatol. 2013 Feb;58(2):358-64. doi: 10.1016/j.jhep.2012.10.022. Epub 2012 Oct 26.


APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice.

Cheng KK, Lam KS, Wu D, Wang Y, Sweeney G, Hoo RL, Zhang J, Xu A.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8919-24. doi: 10.1073/pnas.1202435109. Epub 2012 May 7.


Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes.

Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A.

J Biol Chem. 2011 Oct 7;286(40):34559-66. doi: 10.1074/jbc.M111.285965. Epub 2011 Aug 17.


Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice.

Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VW, Lam KS, Vanhoutte PM, Huang Y.

Cell Metab. 2011 Jul 6;14(1):104-15. doi: 10.1016/j.cmet.2011.05.009.


Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway.

Chang J, Li Y, Huang Y, Lam KS, Hoo RL, Wong WT, Cheng KK, Wang Y, Vanhoutte PM, Xu A.

Diabetes. 2010 Nov;59(11):2949-59. doi: 10.2337/db10-0582. Epub 2010 Aug 29. Erratum in: Diabetes. 2016 Oct;65(10):3219.


Functional identification of an intronic promoter of the human glucose-dependent insulinotropic polypeptide gene.

Hoo RL, Chu JY, Yuan Y, Yeung CM, Chan KY, Chow BK.

Gene. 2010 Sep 1;463(1-2):29-40. doi: 10.1016/j.gene.2010.04.017. Epub 2010 May 7.


Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice.

Xu A, Wang H, Hoo RL, Sweeney G, Vanhoutte PM, Wang Y, Wu D, Chu W, Qin G, Lam KS.

Endocrinology. 2009 Feb;150(2):625-33. doi: 10.1210/en.2008-0999. Epub 2008 Oct 16.


Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury.

Zhou M, Xu A, Tam PK, Lam KS, Chan L, Hoo RL, Liu J, Chow KH, Wang Y.

Hepatology. 2008 Oct;48(4):1087-96. doi: 10.1002/hep.22444.


Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid-binding protein.

Hoo RL, Yeung DC, Lam KS, Xu A.

Expert Rev Endocrinol Metab. 2008 Jan;3(1):29-41. doi: 10.1586/17446651.3.1.29.


Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production.

Hoo RL, Chow WS, Yau MH, Xu A, Tso AW, Tse HF, Fong CH, Tam S, Chan L, Lam KS.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2777-82. Epub 2007 Oct 11.


Thiazolidinedione increases serum soluble receptor for advanced glycation end-products in type 2 diabetes.

Tan KCB, Chow WS, Tso AWK, Xu A, Tse HF, Hoo RLC, Betteridge DJ, Lam KSL.

Diabetologia. 2007 Sep;50(9):1819-1825. doi: 10.1007/s00125-007-0759-0. Epub 2007 Jul 18.


Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene.

Hoo RL, Chan KY, Leung FK, Lee LT, Leung PC, Chow BK.

FEBS J. 2007 Jun;274(11):2695-706. Epub 2007 Apr 20.


Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, Wu D, Cooper GJ, Xu A.

Cancer Res. 2006 Dec 1;66(23):11462-70.


Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.

Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A.

Clin Chem. 2007 Jan;53(1):34-41. Epub 2006 Oct 13.


Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes.

Chen B, Lam KS, Wang Y, Wu D, Lam MC, Shen J, Wong L, Hoo RL, Zhang J, Xu A.

Biochem Biophys Res Commun. 2006 Mar 10;341(2):549-56. Epub 2006 Jan 13.


Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.

Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6086-91. Epub 2005 Apr 18.


Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes.

Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Lam KS.

J Biol Chem. 2005 May 6;280(18):18073-80. Epub 2005 Mar 9.


Identification and characterization of a glucagon receptor from the goldfish Carassius auratus: implications for the evolution of the ligand specificity of glucagon receptors in vertebrates.

Chow BK, Moon TW, Hoo RL, Yeung CM, Müller M, Christos PJ, Mojsov S.

Endocrinology. 2004 Jul;145(7):3273-88. Epub 2004 Mar 19.


Oct-1 is involved in the transcriptional repression of the gonadotropin-releasing hormone receptor gene.

Cheng CK, Yeung CM, Hoo RL, Chow BK, Leung PC.

Endocrinology. 2002 Dec;143(12):4693-701.


Structural and functional identification of the pituitary adenylate cyclase-activating polypeptide receptor VPAC2 from the frog Rana tigrina rugulosa.

Hoo RL, Alexandre D, Chan SM, Anouar Y, Pang RT, Vaudry H, Chow BK.

J Mol Endocrinol. 2001 Oct;27(2):229-38.


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