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Association between UGT1A1 gene polymorphism and safety and efficacy of irinotecan monotherapy as the third-line treatment for advanced gastric cancer.

Yamaguchi T, Iwasa S, Shoji H, Honma Y, Takashima A, Kato K, Hamaguchi T, Higuchi K, Boku N.

Gastric Cancer. 2019 Jan 2. doi: 10.1007/s10120-018-00917-5. [Epub ahead of print]


Randomized phase III trial of post-operative chemotherapy for patients with stage I/II/III small bowel adenocarcinoma (JCOG1502C, J-BALLAD).

Kitahara H, Honma Y, Ueno M, Kanemitsu Y, Ohkawa S, Mizusawa J, Furuse J, Shimada Y; Colorectal Cancer Study Group and Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group.

Jpn J Clin Oncol. 2018 Dec 24. doi: 10.1093/jjco/hyy188. [Epub ahead of print]


Hyperammonemia in a Woman with Late-onset Ornithine Transcarbamylase Deficiency.

Koya Y, Shibata M, Senju M, Honma Y, Hiura M, Ishii M, Matsumoto S, Harada M.

Intern Med. 2018 Nov 19. doi: 10.2169/internalmedicine.1851-18. [Epub ahead of print]


[Surgery for chronic constipation].

Mimura T, Honma Y, Horie H.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(11):967-976. doi: 10.11405/nisshoshi.115.967. Japanese. No abstract available.


Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages.

Shibata S, Hayashi R, Okubo T, Kudo Y, Katayama T, Ishikawa Y, Toga J, Yagi E, Honma Y, Quantock AJ, Sekiguchi K, Nishida K.

Cell Rep. 2018 Nov 6;25(6):1668-1679.e5. doi: 10.1016/j.celrep.2018.10.032.


TORC1 signaling regulates DNA replication via DNA replication protein levels.

Yamamoto K, Makino N, Nagai M, Honma Y, Araki H, Ushimaru T.

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1128-1133. doi: 10.1016/j.bbrc.2018.10.018. Epub 2018 Oct 11.


A Young Adult Patient with Nonalcoholic Steatohepatitis Developed Severe Gastroesophageal Varices Associated with Severe Obesity and Diabetes Mellitus.

Honma Y, Sumida K, Ogino N, Kusanaga M, Minami S, Kumei S, Matsuoka H, Watanabe T, Hiura M, Abe S, Shibata M, Harada M.

Case Rep Gastroenterol. 2018 Aug 23;12(2):487-496. doi: 10.1159/000492423. eCollection 2018 May-Aug.


Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs: a retrospective study.

Ida H, Honma Y, Hirano H, Shoji H, Iwasa S, Okita N, Takashima A, Kato K, Fukuda T, Boku N.

Invest New Drugs. 2018 Sep 28. doi: 10.1007/s10637-018-0669-7. [Epub ahead of print]


An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions.

Hashimoto K, Sano T, Honma Y, Ida M, Tominaga H, Sawada A, Abe T, Takahashi H, Shimada Y, Masaki T, Kamata M, Naito S, Aoyama T, Takeuchi Y, Akiya M, Inukai M, Nakata N.

CEN Case Rep. 2019 Feb;8(1):48-54. doi: 10.1007/s13730-018-0363-9. Epub 2018 Sep 22.


Retrospective Analyses of Systemic Chemotherapy and Cytoreductive Surgery for Patients with Ovarian Metastases from Colorectal Cancer: A Single-Center Experience.

Sekine K, Hamaguchi T, Shoji H, Takashima A, Honma Y, Iwasa S, Kato K, Takahashi K, Kato T, Kanemitsu Y, Boku N.

Oncology. 2018;95(4):220-228. doi: 10.1159/000489665. Epub 2018 Jul 20.


Imaging peritoneal metastasis of gastric cancer with 18F-fluorothymidine positron emission tomography/computed tomography: a proof-of-concept study.

Honma Y, Terauchi T, Tateishi U, Kano D, Nagashima K, Shoji H, Iwasa S, Takashima A, Kato K, Hamaguchi T, Boku N, Shimada Y, Yamada Y.

Br J Radiol. 2018 Sep;91(1089):20180259. doi: 10.1259/bjr.20180259. Epub 2018 Jun 27.


Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient.

Morino K, Honma Y, Kumei S, Watanabe T, Kume K, Yoshikawa I, Harada M.

Intern Med. 2018 Nov 1;57(21):3079-3085. doi: 10.2169/internalmedicine.0633-17. Epub 2018 Jun 6.


A fertility-restoring genotype of beet (Beta vulgaris L.) is composed of a weak restorer-of-fertility gene and a modifier gene tightly linked to the Rf1 locus.

Arakawa T, Uchiyama D, Ohgami T, Ohgami R, Murata T, Honma Y, Hamada H, Kuroda Y, Taguchi K, Kitazaki K, Kubo T.

PLoS One. 2018 Jun 1;13(6):e0198409. doi: 10.1371/journal.pone.0198409. eCollection 2018.


Use of homeobox gene expression patterns to determine anatomical regions of origin for body surface tissues derived from adult mice.

Okubo T, Hayashi R, Shibata S, Kudo Y, Honma Y, Nishida K.

J Tissue Eng Regen Med. 2018 Jun;12(6):1412-1419. doi: 10.1002/term.2673. Epub 2018 May 10.


Cotylenin A and tyrosine kinase inhibitors synergistically inhibit the growth of chronic myeloid leukemia cells.

Ikejiri F, Honma Y, Okada T, Urano T, Suzumiya J.

Int J Oncol. 2018 Jun;52(6):2061-2068. doi: 10.3892/ijo.2018.4350. Epub 2018 Apr 2.


Functional domains of the FSHD-associated DUX4 protein.

Mitsuhashi H, Ishimaru S, Homma S, Yu B, Honma Y, Beermann ML, Miller JB.

Biol Open. 2018 Apr 26;7(4). pii: bio033977. doi: 10.1242/bio.033977.


How Important is a Discharge Diagnosis of Critical Illness Polyneuromyopathy?

Taito S, Honma Y, Nojima T.

Crit Care Med. 2018 Apr;46(4):e346-e347. doi: 10.1097/CCM.0000000000002940. No abstract available.


Type of second primary malignancy after achieving complete response by definitive chemoradiation therapy in patients with esophageal squamous cell carcinoma.

Yamaguchi T, Kato K, Nagashima K, Iwasa S, Honma Y, Takashima A, Hamaguchi T, Ito Y, Itami J, Boku N, Higuchi K.

Int J Clin Oncol. 2018 Aug;23(4):652-658. doi: 10.1007/s10147-018-1258-7. Epub 2018 Mar 8.


TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate-induced growth inhibition in pancreatic cancer cells.

Ikejiri F, Honma Y, Kasukabe T, Urano T, Suzumiya J.

Oncol Lett. 2018 Mar;15(3):3240-3244. doi: 10.3892/ol.2017.7713. Epub 2017 Dec 29.


The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: A case report.

Yanase T, Morii D, Kamio S, Nishimura A, Fukao E, Inose Y, Honma Y, Kitahara N, Yokozawa T, Chang B, Oda T.

J Infect Chemother. 2018 Aug;24(8):669-673. doi: 10.1016/j.jiac.2018.01.009. Epub 2018 Feb 9.


Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A.

Inoue T, Higuchi Y, Yoneyama T, Lin B, Nunomura K, Honma Y, Kato N.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):646-650. doi: 10.1016/j.bmcl.2018.01.030.


A retrospective analysis of 5-fluorouracil plus cisplatin as first-line chemotherapy in the recent treatment strategy for patients with metastatic or recurrent esophageal squamous cell carcinoma.

Hiramoto S, Kato K, Shoji H, Okita N, Takashima A, Honma Y, Iwasa S, Hamaguchi T, Yamada Y, Shimada Y, Boku N.

Int J Clin Oncol. 2018 Jun;23(3):466-472. doi: 10.1007/s10147-018-1239-x. Epub 2018 Jan 20.


Measuring Liquid-Level Utilizing Wedge Wave.

Matsuya I, Honma Y, Mori M, Ihara I.

Sensors (Basel). 2017 Dec 21;18(1). pii: E2. doi: 10.3390/s18010002.


The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy.

Shoji H, Tada K, Kitano S, Nishimura T, Shimada Y, Nagashima K, Aoki K, Hiraoka N, Honma Y, Iwasa S, Takashima A, Kato K, Boku N, Honda K, Yamada T, Heike Y, Hamaguchi T.

Oncotarget. 2017 May 30;8(56):95083-95094. doi: 10.18632/oncotarget.18297. eCollection 2017 Nov 10.


A Prospective, Multicenter Phase II Study of the Efficacy and Feasibility of 15-minute Panitumumab Infusion Plus Irinotecan for Oxaliplatin- and Irinotecan-refractory, KRAS Wild-type Metastatic Colorectal Cancer (Short Infusion of Panitumumab Trial).

Akiyoshi K, Hamaguchi T, Yoshimura K, Takahashi N, Honma Y, Iwasa S, Takashima A, Kato K, Yamada Y, Onodera H, Takeshita S, Yasui H, Sakai G, Akatsuka S, Ogawa K, Horita Y, Nagai Y, Shimada Y.

Clin Colorectal Cancer. 2018 Mar;17(1):e83-e89. doi: 10.1016/j.clcc.2017.10.004. Epub 2017 Oct 16.


Longitudinal acquisition of endotracheal intubation skills in novice physicians.

Takeuchi S, Shiga T, Koyama Y, Nakanishi T, Honma Y, Morita H, Goto T.

PLoS One. 2017 Nov 14;12(11):e0188224. doi: 10.1371/journal.pone.0188224. eCollection 2017.


Patterns of Relapse after Definitive Chemoradiotherapy in Stage II/III (Non-T4) Esophageal Squamous Cell Carcinoma.

Sudo K, Kato K, Kuwabara H, Sasaki Y, Takahashi N, Shoji H, Iwasa S, Honma Y, Okita NT, Takashima A, Hamaguchi T, Yamada Y, Ito Y, Itami J, Fukuda T, Tobinai K, Boku N.

Oncology. 2018;94(1):47-54. doi: 10.1159/000480515. Epub 2017 Oct 28.


Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids.

Miyashima Y, Shibata M, Honma Y, Matsuoka H, Hiura M, Abe S, Harada M.

Intern Med. 2017 Dec 15;56(24):3293-3297. doi: 10.2169/internalmedicine.8767-16. Epub 2017 Oct 11.


Expression of thymidylate synthase predicts clinical outcomes of S-1-based chemotherapy in squamous cell lung cancer.

Honma Y, Togo S, Shimizu K, Tulafu M, Hayashi T, Uekusa T, Tominaga S, Kido K, Fujimoto Y, Nanba Y, Takamochi K, Oh S, Suzuki K, Takahashi K.

Oncol Lett. 2017 Sep;14(3):3319-3326. doi: 10.3892/ol.2017.6610. Epub 2017 Jul 19.


Bullous Pemphigoid Associated with the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin in a Patient with Liver Cirrhosis Complicated with Rapidly Progressive Hepatocellular Carcinoma.

Harada M, Yoneda A, Haruyama S, Yabuki K, Honma Y, Hiura M, Shibata M, Matsuoka H, Uchiwa Y.

Intern Med. 2017 Sep 15;56(18):2471-2474. doi: 10.2169/internalmedicine.8703-16. Epub 2017 Aug 21.


Reactivation of Occult Hepatitis B Virus Infection 27 Months after the End of Chemotherapy Including Rituximab for Malignant Lymphoma.

Muraishi J, Shibata M, Honma Y, Hiura M, Abe S, Harada M.

Intern Med. 2017;56(15):1967-1971. doi: 10.2169/internalmedicine.56.8233. Epub 2017 Aug 1.


A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer.

Sasaki Y, Iwasa S, Okazaki S, Goto M, Kojima Y, Naganuma A, Nagashima K, Nagai Y, Hirano H, Honma Y, Takashima A, Kato K, Hamaguchi T.

Gastric Cancer. 2018 May;21(3):439-445. doi: 10.1007/s10120-017-0753-2. Epub 2017 Aug 1.


Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.

Inoue M, Honma Y, Urano T, Suzumiya J.

Oncol Lett. 2017 Jul;14(1):792-800. doi: 10.3892/ol.2017.6219. Epub 2017 May 19.


Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility.

Yanagihara K, Watanabe A, Aoki N, Matsumoto T, Yoshida M, Sato J, Wakamura T, Sunakawa K, Kadota J, Kiyota H, Iwata S, Kaku M, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Takeuchi K, Takeda H, Ikeda H, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Morino E, Takasaki J, Mezaki K, Chonabayashi N, Tanaka C, Sugiura H, Goto H, Saraya T, Kurai D, Katono Y, Inose R, Niki Y, Takuma T, Kudo M, Ehara S, Sato Y, Tsukada H, Watabe N, Honma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Seki M, Hamaguchi S, Toyokawa M, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Nakamura T, Mikasa K, Kasahara K, Ui K, Fukuda S, Nakamura A, Morimura M, Yamashita M, Takesue Y, Wada Y, Sugimoto K, Kusano N, Nose M, Mihara E, Kuwabara M, Doi M, Watanabe Y, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Ota T, Fujita M, Honda J, Hiramatsu K, Aoki Y, Fukuoka M, Magarifuchi H, Nagasawa Z, Kaku N, Fujita J, Higa F, Tateyama M.

J Infect Chemother. 2017 Sep;23(9):587-597. doi: 10.1016/j.jiac.2017.05.010. Epub 2017 Jun 29.


Clinical Outcomes of Resectable Esophageal Cancer with Supraclavicular Lymph Node Metastases Treated with Curative Intent.

Honma Y, Hokamura N, Nagashima K, Sudo K, Shoji H, Iwasa S, Takashima A, Kato K, Hamaguchi T, Boku N, Umezawa R, Ito Y, Itami J, Koyanagi K, Igaki H, Tachimori Y.

Anticancer Res. 2017 Jul;37(7):3741-3749.


Esophageal Metastasis from Rectal Cancer Successfully Treated with Fluorouracil-Based Chemotherapy with Bevacizumab: A Case Report and Review of the Literature.

Watanabe S, Takashima A, Taniguchi H, Tanaka Y, Nakamura S, Okita N, Honma Y, Iwasa S, Kato K, Hamaguchi T, Boku N.

Case Rep Oncol. 2017 May 5;10(2):407-415. doi: 10.1159/000474939. eCollection 2017 May-Aug.


Phase II study of lanreotide autogel in Japanese patients with unresectable or metastatic well-differentiated neuroendocrine tumors.

Ito T, Honma Y, Hijioka S, Kudo A, Fukutomi A, Nozaki A, Kimura Y, Motoi F, Isayama H, Komoto I, Hisamatsu S, Nakajima A, Shimatsu A.

Invest New Drugs. 2017 Aug;35(4):499-508. doi: 10.1007/s10637-017-0466-8. Epub 2017 May 3.


Trehalose activates autophagy and decreases proteasome inhibitor-induced endoplasmic reticulum stress and oxidative stress-mediated cytotoxicity in hepatocytes.

Honma Y, Sato-Morita M, Katsuki Y, Mihara H, Baba R, Harada M.

Hepatol Res. 2018 Jan;48(1):94-105. doi: 10.1111/hepr.12892. Epub 2017 May 4.


[Comparison of Response to Chemotherapy between Ovarian and Extraovarian Metastasis of Gastric Cancer].

Ishimoto U, Nakamura S, Sasaki Y, Takahashi N, Iwasa S, Honma Y, Okita N, Takashima A, Kato K, Hamaguchi T, Boku N.

Gan To Kagaku Ryoho. 2017 Mar;44(3):233-237. Japanese.


A Japanese male with a novel ANO5 mutation with minimal muscle weakness and muscle pain till his late fifties.

Kadoya M, Ogata K, Suzuki M, Honma Y, Momma K, Yatabe K, Tamura T, Kaida K, Miyata N, Nishino I, Nonaka I, Kawai M.

Neuromuscul Disord. 2017 May;27(5):477-480. doi: 10.1016/j.nmd.2017.01.012. Epub 2017 Jan 18.


Daclatasvir and Asunaprevir Combination Therapy-induced Hepatitis and Cholecystitis with Coagulation Disorder due to Hypersensitivity Reactions.

Miyashima Y, Honma Y, Miyagawa K, Oe S, Senju M, Shibata M, Hiura M, Abe S, Harada M.

Intern Med. 2016;55(24):3595-3601. Epub 2016 Dec 15.


Irinotecan monotherapy as third-line treatment for advanced gastric cancer refractory to fluoropyrimidines, platinum, and taxanes.

Nishimura T, Iwasa S, Nagashima K, Okita N, Takashima A, Honma Y, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Boku N.

Gastric Cancer. 2017 Jul;20(4):655-662. doi: 10.1007/s10120-016-0670-9. Epub 2016 Nov 17.


Pollen tube contents initiate ovule enlargement and enhance seed coat development without fertilization.

Kasahara RD, Notaguchi M, Nagahara S, Suzuki T, Susaki D, Honma Y, Maruyama D, Higashiyama T.

Sci Adv. 2016 Oct 28;2(10):e1600554. eCollection 2016 Oct.


Recognition of infection, status of outpatient treatment, and treatment history before carcinogenesis in patients with viral hepatitis-associated liver cancer.

Shibata M, Minami S, Oe S, Miyagawa K, Honma Y, Onitsuka R, Senju M, Hiura M, Harada R, Abe S, Tabaru A, Harada M.

Nihon Shokakibyo Gakkai Zasshi. 2016;113(10):1734-1742. Japanese.


Evaluation of Resistance-Associated Substitutions in NS5A Using Direct Sequence and Cycleave Method and Treatment Outcome with Daclatasvir and Asunaprevir for Chronic Hepatitis C Genotype 1.

Ide T, Eguchi Y, Harada M, Ishii K, Morita M, Morita Y, Sugiyama G, Fukushima H, Yano Y, Noguchi K, Nakamura H, Hisatomi J, Kumemura H, Shirachi M, Iwane S, Okada M, Honma Y, Arinaga-Hino T, Miyajima I, Ogata K, Kuwahara R, Amano K, Kawaguchi T, Kuromatsu R, Torimura T; DAAs Multicenter Study Group.

PLoS One. 2016 Sep 29;11(9):e0163884. doi: 10.1371/journal.pone.0163884. eCollection 2016.


Hepatectomy for Colorectal Cancer Liver Metastases in the Era of Modern Preoperative Chemotherapy: Evaluation of Postoperative Complications.

Fukuoka K, Nara S, Honma Y, Kishi Y, Esaki M, Shimada K.

World J Surg. 2017 Apr;41(4):1073-1081. doi: 10.1007/s00268-016-3724-6.


Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease.

Oe S, Miyagawa K, Honma Y, Harada M.

Exp Cell Res. 2016 Sep 10;347(1):192-200. doi: 10.1016/j.yexcr.2016.08.003. Epub 2016 Aug 5.


A phase I study of the combination of panitumumab and bevacizumab in KRAS wild-type colorectal cancer patients previously treated with fluoropyrimidine, oxaliplatin, irinotecan and bevacizumab.

Takahashi N, Iwasa S, Fukahori M, Sudo K, Sasaki Y, Shoji H, Honma Y, Okita NT, Takashima A, Hamaguchi T, Boku N, Shimada Y, Honda K, Yamada T, Yamada Y.

Cancer Chemother Pharmacol. 2016 Sep;78(3):567-75. doi: 10.1007/s00280-016-3111-x. Epub 2016 Jul 20.


Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells.

Kasukabe T, Honma Y, Okabe-Kado J, Higuchi Y, Kato N, Kumakura S.

Oncol Rep. 2016 Aug;36(2):968-76. doi: 10.3892/or.2016.4867. Epub 2016 Jun 10.


Comparison of Panitumumab Plus Irinotecan and Cetuximab Plus Irinotecan for KRAS Wild-type Metastatic Colorectal Cancer.

Yamaguchi T, Iwasa S, Nagashima K, Ikezawa N, Hamaguchi T, Shoji H, Honma Y, Takashima A, Okita N, Kato K, Yamada Y, Shimada Y.

Anticancer Res. 2016 Jul;36(7):3531-6.


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