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S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation of endothelial calcium signaling.

Haldar B, Hamilton CL, Solodushko V, Abney KA, Alexeyev M, Honkanen RE, Scammell JG, Cioffi DL.

FASEB J. 2020 Feb;34(2):3179-3196. doi: 10.1096/fj.201901777R. Epub 2020 Jan 9.


Targeting phosphatases in cancer: suppression of many versus the ablation of one.

D'Arcy BM, Prakash A, Honkanen RE.

Oncotarget. 2019 Nov 12;10(61):6543-6545. doi: 10.18632/oncotarget.27201. eCollection 2019 Nov 12. No abstract available.


Development of a Synthetic 3-ketosteroid Δ1-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells.

D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE.

Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8.


The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.

D'Arcy BM, Swingle MR, Papke CM, Abney KA, Bouska ES, Prakash A, Honkanen RE.

Mol Cancer Ther. 2019 Mar;18(3):556-566. doi: 10.1158/1535-7163.MCT-17-1143. Epub 2019 Jan 24.


Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development.

Swingle MR, Honkanen RE.

Curr Med Chem. 2019;26(15):2634-2660. doi: 10.2174/0929867325666180508095242. Review.


Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C-FKBP51 axis.

Hamilton CL, Abney KA, Vasauskas AA, Alexeyev M, Li N, Honkanen RE, Scammell JG, Cioffi DL.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217753156. doi: 10.1177/2045893217753156. Epub 2017 Dec 28.


PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.

Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W.

J Am Chem Soc. 2017 Dec 13;139(49):17703-17706. doi: 10.1021/jacs.7b09368. Epub 2017 Nov 28.


An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C).

Swingle M, Volmar CH, Saldanha SA, Chase P, Eberhart C, Salter EA, D'Arcy B, Schroeder CE, Golden JE, Wierzbicki A, Hodder P, Honkanen RE.

SLAS Discov. 2017 Jan;22(1):21-31. doi: 10.1177/1087057116668852. Epub 2016 Sep 27.


Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.

Chattopadhyay D, Swingle MR, Salter EA, Wood E, D'Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, Banerjee S, Forbes D, Wierzbicki A, Honkanen RE.

Biochem Pharmacol. 2016 Jun 1;109:14-26. doi: 10.1016/j.bcp.2016.03.011. Epub 2016 Mar 23.


Modeling the antiferromagnetic MnIIMnII system within the protein phosphatase-5 catalytic site.

Salter EA, Honkanen RE, Wierzbicki A.

J Mol Model. 2015 Jan;21(1):14. doi: 10.1007/s00894-014-2556-2. Epub 2015 Jan 24.


Protein phosphatases in pancreatic islets.

Ortsäter H, Grankvist N, Honkanen RE, Sjöholm Å.

J Endocrinol. 2014 Jun;221(3):R121-44. doi: 10.1530/JOE-14-0002. Epub 2014 Mar 28. Review.


Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.

Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE.

J Biol Chem. 2014 Feb 14;289(7):4219-32. doi: 10.1074/jbc.M113.518514. Epub 2013 Dec 26.


Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and β-cells.

Fransson L, Rosengren V, Saha TK, Grankvist N, Islam T, Honkanen RE, Sjöholm Å, Ortsäter H.

Mol Cell Endocrinol. 2014 Mar 5;383(1-2):126-36. doi: 10.1016/j.mce.2013.12.010. Epub 2013 Dec 20.


Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain.

Grankvist N, Honkanen RE, Sjöholm Å, Ortsäter H.

FEBS Lett. 2013 Nov 29;587(23):3869-74. doi: 10.1016/j.febslet.2013.10.022. Epub 2013 Oct 26.


Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.

Theobald B, Bonness K, Musiyenko A, Andrews JF, Urban G, Huang X, Dean NM, Honkanen RE.

Mol Cancer Res. 2013 Aug;11(8):845-55. doi: 10.1158/1541-7786.MCR-13-0032. Epub 2013 May 13.


Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.

Henesy MB, Britain AL, Zhu B, Amable L, Honkanen RE, Corbin JD, Francis SH, Rich TC.

PLoS One. 2012;7(8):e41711. doi: 10.1371/journal.pone.0041711. Epub 2012 Aug 2.


Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases.

Bouazza B, Krytska K, Debba-Pavard M, Amrani Y, Honkanen RE, Tran J, Tliba O.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):464-73. doi: 10.1165/rcmb.2011-0364OC. Epub 2012 May 16.


Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells.

Grankvist N, Amable L, Honkanen RE, Sjöholm A, Ortsäter H.

Diabetologia. 2012 Jul;55(7):2005-15. doi: 10.1007/s00125-012-2541-1. Epub 2012 Apr 12.


DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.

Oncogene. 2012 Oct 11;31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23.


Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).

Amable L, Grankvist N, Largen JW, Ortsäter H, Sjöholm Å, Honkanen RE.

J Biol Chem. 2011 Nov 25;286(47):40413-22. doi: 10.1074/jbc.M111.244053. Epub 2011 Sep 15.


Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity.

Yang X, Liu Y, Yang XM, Hu F, Cui L, Swingle MR, Honkanen RE, Soltani P, Tissier R, Cohen MV, Downey JM.

Basic Res Cardiol. 2011 May;106(3):421-30. doi: 10.1007/s00395-011-0165-0. Epub 2011 Mar 12.


Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications.

Bhardwaj A, Singh S, Srivastava SK, Honkanen RE, Reed E, Singh AP.

Mol Cancer Ther. 2011 May;10(5):720-31. doi: 10.1158/1535-7163.MCT-10-1096. Epub 2011 Mar 10.


Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.

Skarra DV, Goudreault M, Choi H, Mullin M, Nesvizhskii AI, Gingras AC, Honkanen RE.

Proteomics. 2011 Apr;11(8):1508-16. doi: 10.1002/pmic.201000770. Epub 2011 Feb 25.


Total synthesis and evaluation of phostriecin and key structural analogues.

Burke CP, Swingle MR, Honkanen RE, Boger DL.

J Org Chem. 2010 Nov 19;75(22):7505-13. doi: 10.1021/jo1010203. Epub 2010 Jul 29.


Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.

Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE.

J Pharmacol Exp Ther. 2009 Oct;331(1):45-53. doi: 10.1124/jpet.109.155630. Epub 2009 Jul 10.


Human DNA polymerase eta activity and translocation is regulated by phosphorylation.

Chen YW, Cleaver JE, Hatahet Z, Honkanen RE, Chang JY, Yen Y, Chou KM.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16578-83. doi: 10.1073/pnas.0808589105. Epub 2008 Oct 22.


Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.

Golden T, Aragon IV, Rutland B, Tucker JA, Shevde LA, Samant RS, Zhou G, Amable L, Skarra D, Honkanen RE.

Biochim Biophys Acta. 2008 Apr;1782(4):259-70. doi: 10.1016/j.bbadis.2008.01.004. Epub 2008 Jan 26.


The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer.

Golden T, Swingle M, Honkanen RE.

Cancer Metastasis Rev. 2008 Jun;27(2):169-78. doi: 10.1007/s10555-008-9125-z. Review.


Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.

Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL.

J Am Chem Soc. 2006 Dec 27;128(51):16720-32.


Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells.

Lehtihet M, Webb DL, Honkanen RE, Sjöholm A.

Biochem Biophys Res Commun. 2005 Mar 11;328(2):601-7. Erratum in: Biochem Biophys Res Commun. 2013 Nov 8;441(1):273. Webb, Dominic-Luc [added].


Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice.

Golden T, Aragon IV, Zhou G, Cooper SR, Dean NM, Honkanen RE.

Cancer Lett. 2004 Nov 8;215(1):95-100.


Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade.

Zhou G, Golden T, Aragon IV, Honkanen RE.

J Biol Chem. 2004 Nov 5;279(45):46595-605. Epub 2004 Aug 24.


Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.

Swingle MR, Honkanen RE, Ciszak EM.

J Biol Chem. 2004 Aug 6;279(32):33992-9. Epub 2004 May 23.


Inositol hexakisphosphate and sulfonylureas regulate beta-cell protein phosphatases.

Lehtihet M, Honkanen RE, Sjöholm A.

Biochem Biophys Res Commun. 2004 Apr 9;316(3):893-7.


Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.

Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL.

J Am Chem Soc. 2003 Dec 24;125(51):15694-5.


Regulating the expression of protein phosphatase type 5.

Golden TA, Honkanen RE.

Methods Enzymol. 2003;366:372-90. No abstract available.


Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression.

Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE.

J Biol Chem. 2003 Mar 14;278(11):9747-53. Epub 2003 Jan 7.


Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells.

Sjöholm A, Lehtihet M, Efanov AM, Zaitsev SV, Berggren PO, Honkanen RE.

Endocrinology. 2002 Dec;143(12):4592-8.


Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

Honkanen RE, Golden T.

Curr Med Chem. 2002 Nov;9(22):2055-75. Review.


Use of antisense oligonucleotides: advantages, controls, and cardiovascular tissue.

Golden T, Dean NM, Honkanen RE.

Microcirculation. 2002 Jan;9(1):51-64. Review.


Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling.

Dean DA, Urban G, Aragon IV, Swingle M, Miller B, Rusconi S, Bueno M, Dean NM, Honkanen RE.

BMC Cell Biol. 2001;2:6. Epub 2001 May 17.


Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively.

Urban G, Golden T, Aragon IV, Scammell JG, Dean NM, Honkanen RE.

J Biol Chem. 2001 Jul 20;276(29):27638-46. Epub 2001 Apr 30.


Effects of second messengers on serine/threonine protein phosphatases in insulin-secreting cells.

Sjöholm A, Berggren PO, Honkanen RE.

Biochem Biophys Res Commun. 2001 May 4;283(2):364-8.


Photoreceptor serine/threonine protein phosphatase type 7: cloning, expression, and functional analysis.

Huang X, Swingle MR, Honkanen RE.

Methods Enzymol. 2000;315:579-93. No abstract available.


Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.

Sjöholm A, Honkanen RE.

Pancreas. 2000 Jan;20(1):32-7.


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