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Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.

Lee SH, McIntyre D, Honess D, Hulikova A, Pacheco-Torres J, Cerdán S, Swietach P, Harris AL, Griffiths JR.

Br J Cancer. 2018 Aug;119(5):622-630. doi: 10.1038/s41416-018-0216-5. Epub 2018 Sep 12.


Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using 18F-ICMT-11 and 18F-FLT PET.

Heinzmann K, Nguyen QD, Honess D, Smith DM, Stribbling S, Brickute D, Barnes C, Griffiths J, Aboagye E.

J Nucl Med. 2018 Oct;59(10):1558-1565. doi: 10.2967/jnumed.118.209304. Epub 2018 May 24.


Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.

Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith DM, Fricke IB, Just N, Doblas S, Sinkus R, Döring C, Schäfers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH.

J Nucl Med. 2018 Jul;59(7):1063-1069. doi: 10.2967/jnumed.117.206250. Epub 2018 Feb 23.


Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2017 Dec 15;7(1):99. doi: 10.1186/s13550-017-0349-1.


3'-Deoxy-3'-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.

Schelhaas S, Heinzmann K, Honess DJ, Smith DM, Keen H, Heskamp S, Witney TH, Besret L, Doblas S, Griffiths JR, Aboagye EO, Jacobs AH.

Mol Imaging Biol. 2018 Apr;20(2):194-199. doi: 10.1007/s11307-017-1125-3.


The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox.

Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR.

Cancer Metab. 2017 Feb 28;5:4. doi: 10.1186/s40170-017-0166-z. eCollection 2017.


Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.

Heskamp S, Heijmen L, Gerrits D, Molkenboer-Kuenen JDM, Ter Voert EGW, Heinzmann K, Honess DJ, Smith DM, Griffiths JR, Doblas S, Sinkus R, Laverman P, Oyen WJG, Heerschap A, Boerman OC.

Mol Imaging Biol. 2017 Aug;19(4):540-549. doi: 10.1007/s11307-016-1021-2.


Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

Schelhaas S, Held A, Wachsmuth L, Hermann S, Honess DJ, Heinzmann K, Smith DM, Griffiths JR, Faber C, Jacobs AH.

Cancer Res. 2016 Dec 15;76(24):7096-7105. Epub 2016 Oct 26.


The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2016 Dec;6(1):63. doi: 10.1186/s13550-016-0218-3. Epub 2016 Aug 11. Erratum in: EJNMMI Res. 2017 Dec 15;7(1):99.


Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.

Ainsworth NL, McLean MA, McIntyre DJO, Honess DJ, Brown AM, Harden SV, Griffiths JR.

Magn Reson Med. 2017 May;77(5):1987-1995. doi: 10.1002/mrm.26257. Epub 2016 Jun 9.


Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

Gallagher FA, Sladen H, Kettunen MI, Serrao EM, Rodrigues TB, Wright A, Gill AB, McGuire S, Booth TC, Boren J, McIntyre A, Miller JL, Lee SH, Honess D, Day SE, Hu DE, Howat WJ, Harris AL, Brindle KM.

Cancer Res. 2015 Oct 1;75(19):4109-18. doi: 10.1158/0008-5472.CAN-15-0857. Epub 2015 Aug 6.


Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-¹⁸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.

Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith DM, Hermann S, Wagner S, Kuhlmann MT, Müller-Tidow C, Kopka K, Schober O, Schäfers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH.

J Nucl Med. 2014 Jun;55(6):983-8. doi: 10.2967/jnumed.113.133348. Epub 2014 Apr 28.


[(18)F]FLT: an imaging biomarker of tumour proliferation for assessment of tumour response to treatment.

Soloviev D, Lewis D, Honess D, Aboagye E.

Eur J Cancer. 2012 Mar;48(4):416-24. doi: 10.1016/j.ejca.2011.11.035. Epub 2011 Dec 29. Review.


Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA.

Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.


In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging.

Bayly SR, King RC, Honess DJ, Barnard PJ, Betts HM, Holland JP, Hueting R, Bonnitcha PD, Dilworth JR, Aigbirhio FI, Christlieb M.

J Nucl Med. 2008 Nov;49(11):1862-8. doi: 10.2967/jnumed.108.054015. Epub 2008 Oct 16.


Norman Bleehen.

Honess D.

Br J Cancer. 2008 Sep 2;99(5):681-2. doi: 10.1038/sj.bjc.6604542. No abstract available.


Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.

Tozer GM, Akerman S, Cross NA, Barber PR, Björndahl MA, Greco O, Harris S, Hill SA, Honess DJ, Ireson CR, Pettyjohn KL, Prise VE, Reyes-Aldasoro CC, Ruhrberg C, Shima DT, Kanthou C.

Cancer Res. 2008 Apr 1;68(7):2301-11. doi: 10.1158/0008-5472.CAN-07-2011.


Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1.

Williams KJ, Telfer BA, Xenaki D, Sheridan MR, Desbaillets I, Peters HJ, Honess D, Harris AL, Dachs GU, van der Kogel A, Stratford IJ.

Radiother Oncol. 2005 Apr;75(1):89-98. Epub 2005 Apr 18.


Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.

Seddon BM, Maxwell RJ, Honess DJ, Grimshaw R, Raynaud F, Tozer GM, Workman P.

Clin Cancer Res. 2002 Jul;8(7):2323-35.


Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours.

Patterson AV, Williams KJ, Cowen RL, Jaffar M, Telfer BA, Saunders M, Airley R, Honess D, van der Kogel AJ, Wolf CR, Stratford IJ.

Gene Ther. 2002 Jul;9(14):946-54.


Measurement of tumor oxygenation: in vivo comparison of a luminescence fiber-optic sensor and a polarographic electrode in the p22 tumor.

Seddon BM, Honess DJ, Vojnovic B, Tozer GM, Workman P.

Radiat Res. 2001 Jun;155(6):837-46.


Simultaneous evaluation of the effects of RF hyperthermia on the intra- and extracellular tumor pH.

Jayasundar R, Honess D, Hall LD, Bleehen NM.

Magn Reson Med. 2000 Jan;43(1):1-8.


Changes in oxygenation during radiotherapy in carcinoma of the cervix.

Cooper RA, West CM, Logue JP, Davidson SE, Miller A, Roberts S, Statford IJ, Honess DJ, Hunter RD.

Int J Radiat Oncol Biol Phys. 1999 Aug 1;45(1):119-26.


Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (Prognox) in murine and xenograft systems in vivo.

Honess DJ, Hill SA, Collingridge DR, Edwards B, Brauers G, Powell NA, Chaplin DJ.

Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):731-5.


Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice.

Honess DJ, Dennis IF, Bleehen NM.

Radiother Oncol. 1993 Sep;28(3):208-18.


Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy.

Horsman MR, Høyer M, Honess DJ, Dennis IF, Overgaard J.

Radiother Oncol. 1993 May;27(2):131-9.


Tumour concentrations of flavone acetic acid (FAA) in human melanoma: comparison with mouse data.

Maughan TS, Ward R, Dennis I, Honess DJ, Workman P, Bleehen NM.

Br J Cancer. 1992 Sep;66(3):579-82.


Effects of calcium channel blockers on renal function in mice.

Honess DJ, Bleehen NM.

Int J Radiat Oncol Biol Phys. 1992;22(3):443-6.


Comparative effects of hydralazine on perfusion of KHT tumor, kidney and liver and on renal function in mice.

Honess DJ, Bleehen NM.

Int J Radiat Oncol Biol Phys. 1992;22(5):953-61.


A study of the mechanism of hydralazine enhancement of thermal damage in the KHT tumour.

Honess DJ, Hu DE, Bleehen NM.

Int J Hyperthermia. 1991 Jul-Aug;7(4):667-79.


Effects of two tumor blood flow modifiers, hydralazine and flavone acetic acid, on KHT tumours and normal tissues in mice.

Honess DJ, Bleehen NM.

Int J Radiat Biol. 1991 Jul-Aug;60(1-2):249-53. No abstract available.


Effect of the manipulation of oxyhemoglobin status by BW12C on tumor thermosensitivity and on blood flow in tumor and normal tissues in mice.

Honess DJ, White RD, Nethersell AB, Bleehen NM.

Int J Radiat Oncol Biol Phys. 1989 May;16(5):1187-90.


Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system.

Honess DJ, Wasserman TH, Workman P, Ward R, Bleehen NM.

Int J Radiat Oncol Biol Phys. 1988 Sep;15(3):671-5.


Thermal enhancement of drug cytotoxicity in vivo and in vitro.

Honess DJ, Bleehen NM.

Recent Results Cancer Res. 1988;109:161-9. No abstract available.


Does initial haemoglobin level modify the efficacy of radiosensitizers? An analysis of the MRC misonidazole studies in head and neck cancer and cervix cancer.

Freedman LS, Honess DJ, Bleehen NM, Adams GE, Dische S, Henk JM.

Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Dec;52(6):965-7. No abstract available.


The effect of systemic hyperthermia on melphalan pharmacokinetics in mice.

Honess DJ, Donaldson J, Workman P, Bleehen NM.

Br J Cancer. 1985 Jan;51(1):77-84.


Potentiation of melphalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumours.

Honess DJ, Bleehen NM.

Int J Hyperthermia. 1985 Jan-Mar;1(1):57-68.


The dielectric properties of normal and tumour mouse tissue between 50 MHz and 10 GHz.

Rogers JA, Sheppard RJ, Grant EH, Bleehen NM, Honess DJ.

Br J Radiol. 1983 May;56(665):335-8.


Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.

Honess DJ, Workman P, Morgan JE, Bleehen NM.

Br J Cancer. 1980 Apr;41(4):529-40.


The interaction of thermal tolerance with drug cytotoxicity in vitro.

Morgan JE, Honess DJ, Bleehen NM.

Br J Cancer. 1979 Apr;39(4):422-8.

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