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Items: 1 to 50 of 104

1.

18F-Flortaucipir in TDP-43 associated frontotemporal dementia.

Smith R, Santillo AF, Waldö ML, Strandberg O, Berron D, Vestberg S, van Westen D, van Swieten J, Honer M, Hansson O.

Sci Rep. 2019 Apr 15;9(1):6082. doi: 10.1038/s41598-019-42625-9.

2.

Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain.

Kuwabara H, Comley RA, Borroni E, Honer M, Kitmiller K, Roberts J, Gapasin L, Mathur A, Klein G, Wong DF.

J Nucl Med. 2018 Dec;59(12):1877-1884. doi: 10.2967/jnumed.118.214437. Epub 2018 Aug 10.

3.

Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects.

Wong DF, Comley RA, Kuwabara H, Rosenberg PB, Resnick SM, Ostrowitzki S, Vozzi C, Boess F, Oh E, Lyketsos CG, Honer M, Gobbi L, Klein G, George N, Gapasin L, Kitzmiller K, Roberts J, Sevigny J, Nandi A, Brasic J, Mishra C, Thambisetty M, Mogekar A, Mathur A, Albert M, Dannals RF, Borroni E.

J Nucl Med. 2018 Dec;59(12):1869-1876. doi: 10.2967/jnumed.118.209916. Epub 2018 May 4. Erratum in: J Nucl Med. 2019 Jan;60(1):141.

4.

Periodic microstructures on bioactive glass surfaces enhance osteogenic differentiation of human mesenchymal stromal cells and promote osteoclastogenesis in vitro.

Höner M, Lauria I, Dabhi C, Kant S, Leube RE, Fischer H.

J Biomed Mater Res A. 2018 Jul;106(7):1965-1978. doi: 10.1002/jbm.a.36399. Epub 2018 Apr 10.

PMID:
29569421
5.

mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex.

Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M.

Neuropsychopharmacology. 2018 May;43(6):1457-1465. doi: 10.1038/npp.2017.295. Epub 2017 Dec 5.

6.

Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.

Honer M, Gobbi L, Knust H, Kuwabara H, Muri D, Koerner M, Valentine H, Dannals RF, Wong DF, Borroni E.

J Nucl Med. 2018 Apr;59(4):675-681. doi: 10.2967/jnumed.117.196741. Epub 2017 Sep 28.

7.

Response of umbilical cord mesenchymal stromal cells to varying titanium topographical signals.

Lauria I, Höner M, Kant S, Davtalab R, Weik T, Sternberg K, Fischer H.

J Biomed Mater Res A. 2018 Jan;106(1):180-191. doi: 10.1002/jbm.a.36229. Epub 2017 Sep 26.

PMID:
28884523
8.

Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

Gobbi LC, Knust H, Körner M, Honer M, Czech C, Belli S, Muri D, Edelmann MR, Hartung T, Erbsmehl I, Grall-Ulsemer S, Koblet A, Rueher M, Steiner S, Ravert HT, Mathews WB, Holt DP, Kuwabara H, Valentine H, Dannals RF, Wong DF, Borroni E.

J Med Chem. 2017 Sep 14;60(17):7350-7370. doi: 10.1021/acs.jmedchem.7b00632. Epub 2017 Jul 12.

PMID:
28654263
9.

Mimicking physiological flow conditions to study alterations of bioactive glass surfaces in vitro.

Höner M, Böke F, Weber M, Fischer H.

J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):228-236. doi: 10.1002/jbm.b.33847. Epub 2017 Jan 27.

PMID:
28130877
10.

Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy.

Smith R, Schöll M, Honer M, Nilsson CF, Englund E, Hansson O.

Acta Neuropathol. 2017 Jan;133(1):149-151. doi: 10.1007/s00401-016-1650-1. Epub 2016 Nov 29. No abstract available.

11.

Increased basal ganglia binding of 18 F-AV-1451 in patients with progressive supranuclear palsy.

Smith R, Schain M, Nilsson C, Strandberg O, Olsson T, Hägerström D, Jögi J, Borroni E, Schöll M, Honer M, Hansson O.

Mov Disord. 2017 Jan;32(1):108-114. doi: 10.1002/mds.26813. Epub 2016 Oct 6.

12.

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers.

Smith R, Puschmann A, Schöll M, Ohlsson T, van Swieten J, Honer M, Englund E, Hansson O.

Brain. 2016 Sep;139(Pt 9):2372-9. doi: 10.1093/brain/aww163. Epub 2016 Jun 29.

13.

Estimation of Drug Binding to Brain Tissue: Methodology and in Vivo Application of a Distribution Assay in Brain Polar Lipids.

Belli S, Assmus F, Wagner B, Honer M, Fischer H, Schuler F, Alvarez-Sánchez R.

Mol Pharm. 2015 Dec 7;12(12):4529-41. doi: 10.1021/acs.molpharmaceut.5b00717. Epub 2015 Nov 23.

PMID:
26560069
14.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

PMID:
25665805
15.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, Honer M, Huwyler J, Kuratli M, Niederhauser U, Pähler A, Peters JU, Petersen A, Prinssen E, Ricci A, Rueher D, Rueher M, Schneider M, Spurr P, Stoll T, Tännler D, Wichmann J, Porter RH, Wettstein JG, Lindemann L.

J Med Chem. 2015 Feb 12;58(3):1358-71. doi: 10.1021/jm501642c. Epub 2015 Feb 2.

PMID:
25565255
16.

Radioligand development for molecular imaging of the central nervous system with positron emission tomography.

Honer M, Gobbi L, Martarello L, Comley RA.

Drug Discov Today. 2014 Dec;19(12):1936-44. doi: 10.1016/j.drudis.2014.08.012. Epub 2014 Aug 27. Review.

PMID:
25173703
17.

Open randomised prospective comparative multi-centre intervention study of patients with cystic fibrosis and early diagnosed diabetes mellitus.

Ballmann M, Hubert D, Assael BM, Kronfeld K, Honer M, Holl RW; CFRD Study group.

BMC Pediatr. 2014 Mar 11;14:70. doi: 10.1186/1471-2431-14-70.

18.

Incidence and transmission patterns of tuberculosis among indigenous populations in Brazil.

Cunha EA, Ferrazoli L, Riley LW, Basta PC, Honer MR, Maia R, Costa IP.

Mem Inst Oswaldo Cruz. 2014 Feb;109(1):108-13. doi: 10.1590/0074-0276130082. Epub 2013 Nov 4.

19.

Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice.

Michalon A, Bruns A, Risterucci C, Honer M, Ballard TM, Ozmen L, Jaeschke G, Wettstein JG, von Kienlin M, Künnecke B, Lindemann L.

Biol Psychiatry. 2014 Feb 1;75(3):189-97. doi: 10.1016/j.biopsych.2013.05.038. Epub 2013 Jul 30.

PMID:
23910948
20.

Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models.

Campanile C, Arlt MJ, Krämer SD, Honer M, Gvozdenovic A, Brennecke P, Fischer CR, Sabile AA, Müller A, Ametamey SM, Born W, Schibli R, Fuchs B.

J Nucl Med. 2013 Aug;54(8):1362-8. doi: 10.2967/jnumed.112.115527. Epub 2013 Jun 25.

21.

Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial.

Griese M, Kappler M, Eismann C, Ballmann M, Junge S, Rietschel E, van Koningsbruggen-Rietschel S, Staab D, Rolinck-Werninghaus C, Mellies U, Köhnlein T, Wagner T, König S, Teschler H, Heuer HE, Kopp M, Heyder S, Hammermann J, Küster P, Honer M, Mansmann U, Beck-Speier I, Hartl D, Fuchs C; Glutathione Study Group, Hector A.

Am J Respir Crit Care Med. 2013 Jul 1;188(1):83-9. doi: 10.1164/rccm.201303-0427OC.

PMID:
23631796
22.

Renal histopathological findings in dogs with visceral leishmaniasis.

Rigo RS, Carvalho CM, Honer MR, Andrade GB, Silva IS, Rigo L, Figueiredo HR, Barreto WT.

Rev Inst Med Trop Sao Paulo. 2013 Mar-Apr;55(2):113-6.

23.

Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

Martínez-Cué C, Martínez P, Rueda N, Vidal R, García S, Vidal V, Corrales A, Montero JA, Pazos Á, Flórez J, Gasser R, Thomas AW, Honer M, Knoflach F, Trejo JL, Wettstein JG, Hernández MC.

J Neurosci. 2013 Feb 27;33(9):3953-66. doi: 10.1523/JNEUROSCI.1203-12.2013.

24.

Profile and geographic distribution of reported cases of visceral leishmaniasis in Campo Grande, State of Mato Grosso do Sul, Brazil, from 2002 to 2009.

Brazuna JC, Silva EA, Brazuna JM, Domingos IH, Chaves N, Honer MR, van Onselen VJ, Oliveira AL.

Rev Soc Bras Med Trop. 2012 Oct;45(5):601-6.

25.

Evolution of bombesin conjugates for targeted PET imaging of tumors.

Zhang H, Abiraj K, Thorek DL, Waser B, Smith-Jones PM, Honer M, Reubi JC, Maecke HR.

PLoS One. 2012;7(9):e44046. Epub 2012 Sep 14.

26.

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).

Vats D, Wang H, Esterhazy D, Dikaiou K, Danzer C, Honer M, Stuker F, Matile H, Migliorini C, Fischer E, Ripoll J, Keist R, Krek W, Schibli R, Stoffel M, Rudin M.

Diabetologia. 2012 Sep;55(9):2407-16. doi: 10.1007/s00125-012-2605-2. Epub 2012 Jul 13.

27.

Impact of inherent variability and experimental parameters on the reliability of small animal PET data.

Martic-Kehl MI, Ametamey SM, Alf MF, Schubiger PA, Honer M.

EJNMMI Res. 2012 Jun 9;2(1):26. doi: 10.1186/2191-219X-2-26.

28.

Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation.

Selivanova SV, Honer M, Combe F, Isensee K, Stark H, Krämer SD, Schubiger PA, Ametamey SM.

Bioorg Med Chem. 2012 May 1;20(9):2889-96. doi: 10.1016/j.bmc.2012.03.024. Epub 2012 Mar 17.

PMID:
22483590
29.

CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.

Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG.

J Pharmacol Exp Ther. 2011 Nov;339(2):474-86. doi: 10.1124/jpet.111.185660. Epub 2011 Aug 17.

PMID:
21849627
30.

Anti-VEGF antibody treatment accelerates polycystic kidney disease.

Raina S, Honer M, Krämer SD, Liu Y, Wang X, Segerer S, Wüthrich RP, Serra AL.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F773-83. doi: 10.1152/ajprenal.00058.2011. Epub 2011 Jun 15.

31.

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5).

Wanger-Baumann CA, Mu L, Honer M, Belli S, Alf MF, Schubiger PA, Krämer SD, Ametamey SM.

Neuroimage. 2011 Jun 1;56(3):984-91. doi: 10.1016/j.neuroimage.2011.03.024. Epub 2011 Mar 21.

PMID:
21406237
32.

Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice.

Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4471-6. doi: 10.1073/pnas.1012456108. Epub 2011 Feb 28.

33.

18F-labeled bombesin analog for specific and effective targeting of prostate tumors expressing gastrin-releasing peptide receptors.

Honer M, Mu L, Stellfeld T, Graham K, Martic M, Fischer CR, Lehmann L, Schubiger PA, Ametamey SM, Dinkelborg L, Srinivasan A, Borkowski S.

J Nucl Med. 2011 Feb;52(2):270-8. doi: 10.2967/jnumed.110.081620. Epub 2011 Jan 13.

34.

Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase.

Jeger S, Zimmermann K, Blanc A, Grünberg J, Honer M, Hunziker P, Struthers H, Schibli R.

Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9995-7. doi: 10.1002/anie.201004243. No abstract available.

PMID:
21110357
35.

In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography.

Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, Banziger-Tobler NE, Schibli R, Neri D, Detmar M.

Cancer Res. 2010 Nov 1;70(21):8842-51. doi: 10.1158/0008-5472.CAN-10-0896. Epub 2010 Oct 26.

36.

A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors.

Ross TL, Honer M, Müller C, Groehn V, Schibli R, Ametamey SM.

J Nucl Med. 2010 Nov;51(11):1756-62. doi: 10.2967/jnumed.110.079756. Epub 2010 Oct 18.

37.

In vitro and in vivo characterization of novel 18F-labeled bombesin analogues for targeting GRPR-positive tumors.

Mu L, Honer M, Becaud J, Martic M, Schubiger PA, Ametamey SM, Stellfeld T, Graham K, Borkowski S, Lehmann L, Dinkelborg L, Srinivasan A.

Bioconjug Chem. 2010 Oct 20;21(10):1864-71. doi: 10.1021/bc100222u.

PMID:
20857927
38.

Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PET.

Honer M, Ebenhan T, Allegrini PR, Ametamey SM, Becquet M, Cannet C, Lane HA, O'Reilly TM, Schubiger PA, Sticker-Jantscheff M, Stumm M, McSheehy PM.

Transl Oncol. 2010 Aug 1;3(4):264-75.

39.

Syntheses and pharmacological characterization of novel thiazole derivatives as potential mGluR5 PET ligands.

Baumann CA, Mu L, Wertli N, Krämer SD, Honer M, Schubiger PA, Ametamey SM.

Bioorg Med Chem. 2010 Aug 15;18(16):6044-54. doi: 10.1016/j.bmc.2010.06.070. Epub 2010 Jun 25.

PMID:
20634080
41.

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events.

Lehmann S, Stiehl DP, Honer M, Dominietto M, Keist R, Kotevic I, Wollenick K, Ametamey S, Wenger RH, Rudin M.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14004-9. doi: 10.1073/pnas.0901194106. Epub 2009 Jul 31.

42.

Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5.

Lucatelli C, Honer M, Salazar JF, Ross TL, Schubiger PA, Ametamey SM.

Nucl Med Biol. 2009 Aug;36(6):613-22. doi: 10.1016/j.nucmedbio.2009.03.005.

PMID:
19647167
43.

Comparison of [18F]-tracers in various experimental tumor models by PET imaging and identification of an early response biomarker for the novel microtubule stabilizer patupilone.

Ebenhan T, Honer M, Ametamey SM, Schubiger PA, Becquet M, Ferretti S, Cannet C, Rausch M, McSheehy PM.

Mol Imaging Biol. 2009 Sep-Oct;11(5):308-21. doi: 10.1007/s11307-009-0216-1. Epub 2009 May 22. Erratum in: Mol Imaging Biol. 2009 Sep-Oct;11(5):379-80.

PMID:
19462209
44.

[Characterization of tuberculosis among HIV/AIDS patients at a referral center in Mato Grosso do Sul].

Cheade Mde F, Ivo ML, Siqueira PH, Sá RG, Honer MR.

Rev Soc Bras Med Trop. 2009 Mar-Apr;42(2):119-25. Portuguese.

45.

Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative.

Ross TL, Honer M, Lam PY, Mindt TL, Groehn V, Schibli R, Schubiger PA, Ametamey SM.

Bioconjug Chem. 2008 Dec;19(12):2462-70. doi: 10.1021/bc800356r.

PMID:
19053298
46.

Minimally invasive biomarkers for therapy monitoring.

McSheehy P, Allegrini P, Ametaby S, Becquet M, Ebenhan T, Honer M, Ferretti S, Lane H, Schubiger P, Schnell C, Stumm M, Wood J.

Ernst Schering Found Symp Proc. 2007;(4):153-88.

PMID:
18811057
47.

Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks.

Höhne A, Mu L, Honer M, Schubiger PA, Ametamey SM, Graham K, Stellfeld T, Borkowski S, Berndorff D, Klar U, Voigtmann U, Cyr JE, Friebe M, Dinkelborg L, Srinivasan A.

Bioconjug Chem. 2008 Sep;19(9):1871-9. doi: 10.1021/bc800157h. Epub 2008 Aug 28.

PMID:
18754574
48.

[Infant mortality and its preventability in Mato Grosso do Sul State, Brazil, 2000-2002].

Gastaud AL, Honer MR, Cunha RV.

Cad Saude Publica. 2008 Jul;24(7):1631-40. Portuguese.

49.

Molecular imaging with PET.

Ametamey SM, Honer M, Schubiger PA.

Chem Rev. 2008 May;108(5):1501-16. doi: 10.1021/cr0782426. Epub 2008 Apr 22. Review. No abstract available. Erratum in: Chem Rev. 2008 Sep;108(9):4036.

PMID:
18426240
50.

Identification of non-tuberculous mycobacteria from the Central Public Health Laboratory from Mato Grosso do Sul and analysis of clinical relevance.

de Souza Moraes PR, Chimara E, Telles MA, Ueki SY, Cunha EA, Honer MR, Leão SC.

Braz J Microbiol. 2008 Apr;39(2):268-72. doi: 10.1590/S1517-838220080002000013. Epub 2008 Jun 1.

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