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Marine Drugs Acting as Autophagy Modulators.

Dyshlovoy SA, Honecker F.

Mar Drugs. 2020 Jan 14;18(1). pii: E53. doi: 10.3390/md18010053.


Marine Compounds and Cancer: The First Two Decades of XXI Century.

Dyshlovoy SA, Honecker F.

Mar Drugs. 2019 Dec 26;18(1). pii: E20. doi: 10.3390/md18010020.


Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.

Bremmer F, Bohnenberger H, Küffer S, Oellerich T, Serve H, Urlaub H, Strauss A, Maatoug Y, Behnes CL, Oing C, Radzun HJ, Ströbel P, Balabanov S, Honecker F.

Dis Markers. 2019 Sep 3;2019:8298524. doi: 10.1155/2019/8298524. eCollection 2019.


5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells.

Oing C, Verem I, Mansour WY, Bokemeyer C, Dyshlovoy S, Honecker F.

Int J Mol Sci. 2018 Dec 21;20(1). pii: E21. doi: 10.3390/ijms20010021.


Palliative treatment of germ cell cancer.

Oing C, Giannatempo P, Honecker F, Oechsle K, Bokemeyer C, Beyer J.

Cancer Treat Rev. 2018 Dec;71:102-107. doi: 10.1016/j.ctrv.2018.10.007. Epub 2018 Oct 22. Review.


Everolimus in patients with multiply relapsed or cisplatin refractory germ cell tumors: results of a phase II, single-arm, open-label multicenter trial (RADIT) of the German Testicular Cancer Study Group.

Fenner M, Oing C, Dieing A, Gauler T, Oechsle K, Lorch A, Hentrich M, Kopp HG, Bokemeyer C, Honecker F.

J Cancer Res Clin Oncol. 2019 Mar;145(3):717-723. doi: 10.1007/s00432-018-2752-z. Epub 2018 Sep 19.


ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up.

Honecker F, Aparicio J, Berney D, Beyer J, Bokemeyer C, Cathomas R, Clarke N, Cohn-Cedermark G, Daugaard G, Dieckmann KP, Fizazi K, Fosså S, Germa-Lluch JR, Giannatempo P, Gietema JA, Gillessen S, Haugnes HS, Heidenreich A, Hemminki K, Huddart R, Jewett MAS, Joly F, Lauritsen J, Lorch A, Necchi A, Nicolai N, Oing C, Oldenburg J, Ondruš D, Papachristofilou A, Powles T, Sohaib A, Ståhl O, Tandstad T, Toner G, Horwich A.

Ann Oncol. 2018 Aug 1;29(8):1658-1686. doi: 10.1093/annonc/mdy217.


Marine Compounds and Autophagy: Beginning of a New Era.

Dyshlovoy SA, Honecker F.

Mar Drugs. 2018 Jul 31;16(8). pii: E260. doi: 10.3390/md16080260. No abstract available.


[Prediction of unplanned discontinuation of treatment in patients with castration-resistant prostate cancer-results from the IBuTu study].

Honecker F, Wedding U, Kallischnigg G, Schroeder A, Klier J, Frangenheim T, Weißbach L.

Urologe A. 2018 Aug;57(8):909-918. doi: 10.1007/s00120-018-0704-5. Review. German. No abstract available.


Marine Compounds and Cancer: 2017 Updates.

Dyshlovoy SA, Honecker F.

Mar Drugs. 2018 Jan 24;16(2). pii: E41. doi: 10.3390/md16020041.


Risk factors for unplanned discontinuation of scheduled treatment in elderly patients with castration-resistant prostate cancer: results of the IBuTu study.

Honecker F, Wedding U, Kallischnigg G, Schroeder A, Klier J, Frangenheim T, Weißbach L.

J Cancer Res Clin Oncol. 2018 Mar;144(3):571-577. doi: 10.1007/s00432-017-2577-1. Epub 2018 Jan 4.


Geriatric assessment and biomarkers in patients with metastatic breast cancer receiving first-line mono-chemotherapy: Results from the randomized phase III PELICAN trial.

Honecker F, Harbeck N, Schnabel C, Wedding U, Waldenmaier D, Saupe S, Jäger E, Schmidt M, Kreienberg R, Müller L, Otremba B, Dorn J, Warm M, Al-Batran SE, de Wit M; PELICAN investigators.

J Geriatr Oncol. 2018 Mar;9(2):163-169. doi: 10.1016/j.jgo.2017.09.009. Epub 2017 Oct 18.


Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells.

Dyshlovoy SA, Rast S, Hauschild J, Otte K, Alsdorf WH, Madanchi R, Kalinin VI, Silchenko AS, Avilov SA, Dierlamm J, Honecker F, Stonik VA, Bokemeyer C, von Amsberg G.

Leuk Lymphoma. 2017 Dec;58(12):2905-2915. doi: 10.1080/10428194.2017.1317091. Epub 2017 May 16.


Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin.

Dyshlovoy SA, Otte K, Venz S, Hauschild J, Junker H, Makarieva TN, Balabanov S, Alsdorf WH, Madanchi R, Honecker F, Bokemeyer C, Stonik VA, von Amsberg G.

Proteomics. 2017 Jun;17(11). doi: 10.1002/pmic.201700048.


The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells.

Dyshlovoy SA, Madanchi R, Hauschild J, Otte K, Alsdorf WH, Schumacher U, Kalinin VI, Silchenko AS, Avilov SA, Honecker F, Stonik VA, Bokemeyer C, von Amsberg G.

BMC Cancer. 2017 Feb 1;17(1):93. doi: 10.1186/s12885-017-3085-z.


The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.

Jostes S, Nettersheim D, Fellermeyer M, Schneider S, Hafezi F, Honecker F, Schumacher V, Geyer M, Kristiansen G, Schorle H.

J Cell Mol Med. 2017 Jul;21(7):1300-1314. doi: 10.1111/jcmm.13059. Epub 2016 Dec 27.


Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues.

Fedorov SN, Stonik VA, Honecker F, Dyshlovoy SA.

Curr Med Chem. 2017;24(42):4779-4799. doi: 10.2174/0929867324666161121115404. Review.


Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer.

Dyshlovoy SA, Otte K, Alsdorf WH, Hauschild J, Lange T, Venz S, Bauer CK, Bähring R, Amann K, Mandanchi R, Schumacher U, Schröder-Schwarz J, Makarieva TN, Guzii AG, Tabakmakher KM, Fedorov SN, Shubina LK, Kasheverov IE, Ehmke H, Steuber T, Stonik VA, Bokemeyer C, Honecker F, von Amsberg G.

Oncotarget. 2016 Oct 25;7(43):69703-69717. doi: 10.18632/oncotarget.11941.


A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment.

Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, Kristiansen G, Schorle H.

Oncotarget. 2016 Nov 15;7(46):74931-74946. doi: 10.18632/oncotarget.11647.


Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro.

Dyshlovoy SA, Tabakmakher KM, Hauschild J, Shchekaleva RK, Otte K, Guzii AG, Makarieva TN, Kudryashova EK, Fedorov SN, Shubina LK, Bokemeyer C, Honecker F, Stonik VA, von Amsberg G.

Mar Drugs. 2016 Jul 15;14(7). pii: E133. doi: 10.3390/md14070133.


Cabazitaxel overcomes cisplatin resistance in germ cell tumour cells.

Gerwing M, Jacobsen C, Dyshlovoy S, Hauschild J, Rohlfing T, Oing C, Venz S, Oldenburg J, Oechsle K, Bokemeyer C, von Amsberg G, Honecker F.

J Cancer Res Clin Oncol. 2016 Sep;142(9):1979-94. doi: 10.1007/s00432-016-2204-6. Epub 2016 Jul 16.


Anti-migratory activity of marine alkaloid monanchocidin A - proteomics-based discovery and confirmation.

Dyshlovoy SA, Venz S, Hauschild J, Tabakmakher KM, Otte K, Madanchi R, Walther R, Guzii AG, Makarieva TN, Shubina LK, Fedorov SN, Stonik VA, Bokemeyer C, Balabanov S, Honecker F, V Amsberg G.

Proteomics. 2016 May;16(10):1590-603. doi: 10.1002/pmic.201500334. Epub 2016 Apr 27.


The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.

Dyshlovoy SA, Menchinskaya ES, Venz S, Rast S, Amann K, Hauschild J, Otte K, Kalinin VI, Silchenko AS, Avilov SA, Alsdorf W, Madanchi R, Bokemeyer C, Schumacher U, Walther R, Aminin DL, Fedorov SN, Shubina LK, Stonik VA, Balabanov S, Honecker F, von Amsberg G.

Int J Cancer. 2016 May 15;138(10):2450-65. doi: 10.1002/ijc.29977. Epub 2016 Jan 23.


Marine Compounds and Cancer: Where Do We Stand?

Dyshlovoy SA, Honecker F.

Mar Drugs. 2015 Sep;13(9):5657-65. Epub 2015 Sep 2. No abstract available.


Activity of nintedanib in germ cell tumors.

Steinemann G, Jacobsen C, Gerwing M, Hauschild J, von Amsberg G, Höpfner M, Nitzsche B, Honecker F.

Anticancer Drugs. 2016 Feb;27(2):89-98. doi: 10.1097/CAD.0000000000000305.


Role of N-cadherin in proliferation, migration, and invasion of germ cell tumours.

Bremmer F, Schallenberg S, Jarry H, Küffer S, Kaulfuss S, Burfeind P, Strauß A, Thelen P, Radzun HJ, Ströbel P, Honecker F, Behnes CL.

Oncotarget. 2015 Oct 20;6(32):33426-37. doi: 10.18632/oncotarget.5288.


Emerging Therapeutic Targets for Male Germ Cell Tumors.

Fankhauser CD, Honecker F, Beyer J, Bode PK.

Curr Oncol Rep. 2015 Dec;17(12):54. doi: 10.1007/s11912-015-0479-4. Review.


Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: Results of the CLL9 trial of the German CLL study group.

Goede V, Bahlo J, Chataline V, Eichhorst B, Dürig J, Stilgenbauer S, Kolb G, Honecker F, Wedding U, Hallek M.

Leuk Lymphoma. 2016;57(4):789-96. doi: 10.3109/10428194.2015.1091933. Epub 2015 Oct 13.


Regulation of tissue factor in NT2 germ cell tumor cells by cisplatin chemotherapy.

Jacobsen C, Oechsle K, Hauschild J, Steinemann G, Spath B, Bokemeyer C, Ruf W, Honecker F, Langer F.

Thromb Res. 2015 Sep;136(3):673-81. doi: 10.1016/j.thromres.2015.07.002. Epub 2015 Jul 14.


Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization.

Dyshlovoy SA, Hauschild J, Amann K, Tabakmakher KM, Venz S, Walther R, Guzii AG, Makarieva TN, Shubina LK, Fedorov SN, Stonik VA, Bokemeyer C, Balabanov S, Honecker F, von Amsberg G.

Oncotarget. 2015 Jul 10;6(19):17328-41.


Second-Line Treatment of Advanced Urothelial Cancer with Paclitaxel and Everolimus in a German Phase II Trial (AUO Trial AB 35/09).

Niegisch G, Retz M, Thalgott M, Balabanov S, Honecker F, Ohlmann CH, Stöckle M, Bögemann M, Vom Dorp F, Gschwend J, Hartmann A, Ohmann C, Albers P.

Oncology. 2015;89(2):70-8. doi: 10.1159/000376551. Epub 2015 Mar 11.


Cisplatin resistance in germ cell tumours: models and mechanisms.

Jacobsen C, Honecker F.

Andrology. 2015 Jan;3(1):111-21. doi: 10.1111/andr.299. Epub 2014 Dec 29. Review.


First salvage treatment of germ cell tumor patients with bone metastases: retrospective analysis of a large international database.

Oing C, Lorch A, Bokemeyer C, Honecker F, Beyer J, Berger LA, Oechsle K.

J Cancer Res Clin Oncol. 2015 May;141(5):923-31. doi: 10.1007/s00432-014-1876-z. Epub 2014 Nov 14.


Personalizing, not patronizing: the case for patient autonomy by unbiased presentation of management options in stage I testicular cancer.

Oldenburg J, Aparicio J, Beyer J, Cohn-Cedermark G, Cullen M, Gilligan T, De Giorgi U, De Santis M, de Wit R, Fosså SD, Germà-Lluch JR, Gillessen S, Haugnes HS, Honecker F, Horwich A, Lorch A, Ondruš D, Rosti G, Stephenson AJ, Tandstad T; On behalf of: SWENOTECA (Swedish Norwegian Testicular Cancer group), the Italian Germ Cell Cancer Group (IGG), Spanish Germ Cell Cancer Group (SGCCG).

Ann Oncol. 2015 May;26(5):833-8. doi: 10.1093/annonc/mdu514. Epub 2014 Nov 6. Review.


Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-κB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells.

Dyshlovoy SA, Fedorov SN, Shubina LK, Kuzmich AS, Bokemeyer C, Keller-von Amsberg G, Honecker F.

Biomed Res Int. 2014;2014:469309. doi: 10.1155/2014/469309. Epub 2014 Jul 23.


First salvage treatment in patients with advanced germ cell cancer after cisplatin-based chemotherapy: analysis of a registry of the German Testicular Cancer Study Group (GTCSG).

Berger LA, Bokemeyer C, Lorch A, Hentrich M, Kopp HG, Gauler TC, Beyer J, de Wit M, Mayer F, Boehlke I, Oing C, Honecker F, Oechsle K.

J Cancer Res Clin Oncol. 2014 Jul;140(7):1211-20. doi: 10.1007/s00432-014-1661-z. Epub 2014 Apr 3.


Circulating tumor cells in patients with testicular germ cell tumors.

Nastały P, Ruf C, Becker P, Bednarz-Knoll N, Stoupiec M, Kavsur R, Isbarn H, Matthies C, Wagner W, Höppner D, Fisch M, Bokemeyer C, Ahyai S, Honecker F, Riethdorf S, Pantel K.

Clin Cancer Res. 2014 Jul 15;20(14):3830-41. doi: 10.1158/1078-0432.CCR-13-2819. Epub 2014 Mar 14.


Quinone-carbohydrate nonglucoside conjugates as a new type of cytotoxic agents: synthesis and determination of in vitro activity.

Pelageev DN, Dyshlovoy SA, Pokhilo ND, Denisenko VA, Borisova KL, Keller-von Amsberg G, Bokemeyer C, Fedorov SN, Honecker F, Anufriev VP.

Eur J Med Chem. 2014 Apr 22;77:139-44. doi: 10.1016/j.ejmech.2014.03.006. Epub 2014 Mar 5.


Nodal, pulmonary and pleural gliomatosis in a 42-year-old-male with non-seminomatous testicular germ cell cancer.

Oing C, Wagner R, Bokemeyer C, Honecker F.

Histopathology. 2014 Jul;65(1):142-3. doi: 10.1111/his.12374. Epub 2014 Mar 14. No abstract available.


Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

Nettersheim D, Heukamp LC, Fronhoffs F, Grewe MJ, Haas N, Waha A, Honecker F, Waha A, Kristiansen G, Schorle H.

PLoS One. 2013 Dec 26;8(12):e82881. doi: 10.1371/journal.pone.0082881. eCollection 2013.


Proteome analysis of the effects of all-trans retinoic acid on human germ cell tumor cell lines.

Honecker F, Rohlfing T, Harder S, Braig M, Gillis AJ, Glaesener S, Barett C, Bokemeyer C, Buck F, Brümmendorf TH, Looijenga LH, Balabanov S.

J Proteomics. 2014 Jan 16;96:300-13. doi: 10.1016/j.jprot.2013.11.010. Epub 2013 Nov 22.


Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer.

Dyshlovoy SA, Venz S, Shubina LK, Fedorov SN, Walther R, Jacobsen C, Stonik VA, Bokemeyer C, Balabanov S, Honecker F.

J Proteomics. 2014 Jan 16;96:223-39. doi: 10.1016/j.jprot.2013.11.009. Epub 2013 Nov 21.


Venous thromboembolic events in germ cell cancer patients undergoing platinum-based chemotherapy.

Honecker F, Koychev D, Luhmann AD, Langer F, Dieckmann KP, Bokemeyer C, Oechsle K.

Onkologie. 2013;36(11):663-8. doi: 10.1159/000355652. Epub 2013 Oct 14.


Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature.

Janjetovic S, Bokemeyer C, Fiedler W, Frenzel T, Calaminus G, Honecker F.

Onkologie. 2013;36(6):371-3. doi: 10.1159/000351255. Epub 2013 May 21. Review.


Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer.

Nitzsche B, Gloesenkamp C, Schrader M, Hoffmann B, Zengerling F, Balabanov S, Honecker F, Höpfner M.

Br J Cancer. 2012 Nov 20;107(11):1853-63. doi: 10.1038/bjc.2012.481.


Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer.

Beyer J, Albers P, Altena R, Aparicio J, Bokemeyer C, Busch J, Cathomas R, Cavallin-Stahl E, Clarke NW, Claßen J, Cohn-Cedermark G, Dahl AA, Daugaard G, De Giorgi U, De Santis M, De Wit M, De Wit R, Dieckmann KP, Fenner M, Fizazi K, Flechon A, Fossa SD, Germá Lluch JR, Gietema JA, Gillessen S, Giwercman A, Hartmann JT, Heidenreich A, Hentrich M, Honecker F, Horwich A, Huddart RA, Kliesch S, Kollmannsberger C, Krege S, Laguna MP, Looijenga LH, Lorch A, Lotz JP, Mayer F, Necchi A, Nicolai N, Nuver J, Oechsle K, Oldenburg J, Oosterhuis JW, Powles T, Rajpert-De Meyts E, Rick O, Rosti G, Salvioni R, Schrader M, Schweyer S, Sedlmayer F, Sohaib A, Souchon R, Tandstad T, Winter C, Wittekind C.

Ann Oncol. 2013 Apr;24(4):878-88. doi: 10.1093/annonc/mds579. Epub 2012 Nov 14.


Cabazitaxel plus prednisone for metastatic castration-resistant prostate cancer progressing after docetaxel: results from the German compassionate-use programme.

Heidenreich A, Scholz HJ, Rogenhofer S, Arsov C, Retz M, Müller SC, Albers P, Gschwend J, Wirth M, Steiner U, Miller K, Heinrich E, Trojan L, Volkmer B, Honecker F, Bokemeyer C, Keck B, Otremba B, Ecstein-Fraisse E, Pfister D.

Eur Urol. 2013 Jun;63(6):977-82. doi: 10.1016/j.eururo.2012.08.058. Epub 2012 Sep 3.


Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors.

Dyshlovoy SA, Fedorov SN, Kalinovsky AI, Shubina LK, Bokemeyer C, Stonik VA, Honecker F.

Mar Drugs. 2012 Jun;10(6):1212-24. doi: 10.3390/md10061212. Epub 2012 May 30.


Cisplatin resistance induced in germ cell tumour cells is due to reduced susceptibility towards cell death but not to altered DNA damage induction or repair.

Fenske AE, Glaesener S, Bokemeyer C, Thomale J, Dahm-Daphi J, Honecker F, Dartsch DC.

Cancer Lett. 2012 Nov 28;324(2):171-8. doi: 10.1016/j.canlet.2012.05.009. Epub 2012 May 19.


Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity.

Dyshlovoy SA, Naeth I, Venz S, Preukschas M, Sievert H, Jacobsen C, Shubina LK, Gesell Salazar M, Scharf C, Walther R, Krepstakies M, Priyadarshini P, Hauber J, Fedorov SN, Bokemeyer C, Stonik VA, Balabanov S, Honecker F.

J Proteome Res. 2012 Apr 6;11(4):2316-30. doi: 10.1021/pr300170p. Epub 2012 Mar 28.


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