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Items: 18

1.

PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors.

Hone AJ, Fisher F, Christensen S, Gajewiak J, Larkin D, Whiteaker P, McIntosh JM.

J Med Chem. 2019 Jul 11;62(13):6262-6275. doi: 10.1021/acs.jmedchem.9b00566. Epub 2019 Jun 27.

PMID:
31194549
2.

Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes.

Grau V, Richter K, Hone AJ, McIntosh JM.

Front Pharmacol. 2019 Jan 7;9:1499. doi: 10.3389/fphar.2018.01499. eCollection 2018.

3.

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors.

Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh JM.

J Biol Chem. 2018 Nov 16;293(46):17838-17852. doi: 10.1074/jbc.RA118.005649. Epub 2018 Sep 24.

PMID:
30249616
4.

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.

Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V.

Front Immunol. 2018 Jul 30;9:1604. doi: 10.3389/fimmu.2018.01604. eCollection 2018.

5.

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.

Hone AJ, McIntosh JM.

FEBS Lett. 2018 Apr;592(7):1045-1062. doi: 10.1002/1873-3468.12884. Epub 2017 Oct 27. Review.

6.

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.

Christensen SB, Hone AJ, Roux I, Kniazeff J, Pin JP, Upert G, Servent D, Glowatzki E, McIntosh JM.

Front Cell Neurosci. 2017 Jul 21;11:219. doi: 10.3389/fncel.2017.00219. eCollection 2017.

7.

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10.

Zakrzewicz A, Richter K, Agné A, Wilker S, Siebers K, Fink B, Krasteva-Christ G, Althaus M, Padberg W, Hone AJ, McIntosh JM, Grau V.

Front Cell Neurosci. 2017 Jul 5;11:189. doi: 10.3389/fncel.2017.00189. eCollection 2017.

8.

α9-containing nicotinic acetylcholine receptors and the modulation of pain.

Hone AJ, Servent D, McIntosh JM.

Br J Pharmacol. 2018 Jun;175(11):1915-1927. doi: 10.1111/bph.13931. Epub 2017 Jul 30. Review.

9.

Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells.

Hone AJ, Michael McIntosh J, Rueda-Ruzafa L, Passas J, de Castro-Guerín C, Blázquez J, González-Enguita C, Albillos A.

J Neurochem. 2017 Jan;140(1):37-52. doi: 10.1111/jnc.13883. Epub 2016 Dec 9.

10.

Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.

Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V.

Sci Rep. 2016 Jun 28;6:28660. doi: 10.1038/srep28660.

11.

α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells.

Hone AJ, McIntosh JM, Azam L, Lindstrom J, Lucero L, Whiteaker P, Passas J, Blázquez J, Albillos A.

Mol Pharmacol. 2015 Nov;88(5):881-93. doi: 10.1124/mol.115.100982. Epub 2015 Sep 1. Erratum in: Mol Pharmacol. 2016 Feb;89(2):322.

12.

Monkey adrenal chromaffin cells express α6β4* nicotinic acetylcholine receptors.

Hernández-Vivanco A, Hone AJ, Scadden ML, Carmona-Hidalgo B, McIntosh JM, Albillos A.

PLoS One. 2014 Apr 11;9(4):e94142. doi: 10.1371/journal.pone.0094142. eCollection 2014.

13.

Comparative functional expression of nAChR subtypes in rodent DRG neurons.

Smith NJ, Hone AJ, Memon T, Bossi S, Smith TE, McIntosh JM, Olivera BM, Teichert RW.

Front Cell Neurosci. 2013 Nov 28;7:225. doi: 10.3389/fncel.2013.00225. eCollection 2013.

14.

Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.

Hone AJ, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, McIntosh JM.

J Biol Chem. 2013 Aug 30;288(35):25428-39. doi: 10.1074/jbc.M113.482059. Epub 2013 Jul 11.

15.

α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors.

Hone AJ, Scadden M, Gajewiak J, Christensen S, Lindstrom J, McIntosh JM.

Mol Pharmacol. 2012 Nov;82(5):972-82. doi: 10.1124/mol.112.080853. Epub 2012 Aug 22.

16.

Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4* subtype.

Hone AJ, Meyer EL, McIntyre M, McIntosh JM.

FASEB J. 2012 Feb;26(2):917-26. doi: 10.1096/fj.11-195883. Epub 2011 Oct 24.

17.

Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptors.

Hone AJ, Whiteaker P, Mohn JL, Jacob MH, McIntosh JM.

J Neurochem. 2010 Aug;114(4):994-1006. doi: 10.1111/j.1471-4159.2010.06819.x. Epub 2010 May 18.

18.

A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors.

Hone AJ, Whiteaker P, Christensen S, Xiao Y, Meyer EL, McIntosh JM.

J Neurochem. 2009 Oct;111(1):80-9. doi: 10.1111/j.1471-4159.2009.06299.x. Epub 2009 Jul 23.

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