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Items: 40


Development and application of a LC-MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum.

Hurst EA, Homer NZ, Denham SG, MacFarlane E, Campbell S, Boswinkel M, Mellanby RJ.

J Steroid Biochem Mol Biol. 2020 Jan 17:105598. doi: 10.1016/j.jsbmb.2020.105598. [Epub ahead of print]


Estrogens and glucocorticoids in mammary adipose tissue: Relationships with body mass index and breast cancer features.

Laforest S, Pelletier M, Denver N, Poirier B, Nguyen S, Walker BR, Durocher F, Homer NZM, Diorio C, Andrew R, Tchernof A.

J Clin Endocrinol Metab. 2019 Dec 19. pii: dgz268. doi: 10.1210/clinem/dgz268. [Epub ahead of print]


Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography triple quadrupole mass spectrometry.

Verma M, Sooy K, Just G, Nixon M, Morgan R, Andrew R, Chapman KE, Homer NZM.

Rapid Commun Mass Spectrom. 2019 Nov 2. doi: 10.1002/rcm.8610. [Epub ahead of print]


Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry.

Laforest S, Pelletier M, Denver N, Poirier B, Nguyen S, Walker BR, Durocher F, Homer NZM, Diorio C, Tchernof A, Andrew R.

J Steroid Biochem Mol Biol. 2019 Dec;195:105476. doi: 10.1016/j.jsbmb.2019.105476. Epub 2019 Sep 24.


Positive adaptation of HPA axis function in women during 44 weeks of infantry-based military training.

Gifford RM, O'Leary TJ, Double RL, Wardle SL, Wilson K, Boyle LD, Homer NZM, Kirschbaum C, Greeves JP, Woods DR, Reynolds RM.

Psychoneuroendocrinology. 2019 Dec;110:104432. doi: 10.1016/j.psyneuen.2019.104432. Epub 2019 Sep 5.


Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry.

Denver N, Khan S, Stasinopoulos I, Church C, Homer NZM, MacLean MR, Andrew R.

Data Brief. 2019 Mar 8;23:103740. doi: 10.1016/j.dib.2019.103740. eCollection 2019 Apr.


Current strategies for quantification of estrogens in clinical research.

Denver N, Khan S, Homer NZM, MacLean MR, Andrew R.

J Steroid Biochem Mol Biol. 2019 Sep;192:105373. doi: 10.1016/j.jsbmb.2019.04.022. Epub 2019 May 18. Review.


Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.

Agnew EJ, Garcia-Burgos A, Richardson RV, Manos H, Thomson AJW, Sooy K, Just G, Homer NZM, Moran CM, Brunton PJ, Gray GA, Chapman KE.

J Endocrinol. 2019 Jun 1;241(3):279-292. doi: 10.1530/JOE-18-0666.


Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors.

Gibb FW, Dixon JM, Clarke C, Homer NZ, Faqehi AMM, Andrew R, Walker BR.

J Clin Endocrinol Metab. 2019 Sep 1;104(9):3670-3678. doi: 10.1210/jc.2018-02339.


Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry.

Denver N, Khan S, Stasinopoulos I, Church C, Homer NZ, MacLean MR, Andrew R.

Anal Chim Acta. 2019 Apr 25;1054:84-94. doi: 10.1016/j.aca.2018.12.023. Epub 2018 Dec 21.


Androgens modulate glucocorticoid receptor activity in adipose tissue and liver.

Spaanderman DCE, Nixon M, Buurstede JC, Sips HC, Schilperoort M, Kuipers EN, Backer EA, Kooijman S, Rensen PCN, Homer NZM, Walker BR, Meijer OC, Kroon J.

J Endocrinol. 2018 Oct 1. pii: JOE-18-0503.R1. doi: 10.1530/JOE-18-0503. [Epub ahead of print]


Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease.

Taylor AHM, Rankin AJ, McQuarrie EP, Freel EM, Homer NZM, Andrew R, Jardine AG, Mark PB.

Clin Sci (Lond). 2018 Jan 25;132(2):285-294. doi: 10.1042/CS20171603. Print 2018 Jan 31.


Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.

Stirrat LI, Walker JJ, Stryjakowska K, Jones N, Homer NZM, Andrew R, Norman JE, Lightman SL, Reynolds RM.

Clin Endocrinol (Oxf). 2018 Apr;88(4):592-600. doi: 10.1111/cen.13548. Epub 2018 Jan 29.


11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.

Verma M, Kipari TMJ, Zhang Z, Man TY, Forster T, Homer NZM, Seckl JR, Holmes MC, Chapman KE.

Brain Behav Immun. 2018 Mar;69:223-234. doi: 10.1016/j.bbi.2017.11.015. Epub 2017 Nov 21.


Transfer and Metabolism of Cortisol by the Isolated Perfused Human Placenta.

Stirrat LI, Sengers BG, Norman JE, Homer NZM, Andrew R, Lewis RM, Reynolds RM.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):640-648. doi: 10.1210/jc.2017-02140.


Detecting drug-target binding in cells using fluorescence-activated cell sorting coupled with mass spectrometry analysis.

Wilson K, Webster SP, Iredale JP, Zheng X, Homer NZ, Pham NT, Auer M, Mole DJ.

Methods Appl Fluoresc. 2017 Dec 15;6(1):015002. doi: 10.1088/2050-6120/aa8c60.


Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR.

Sci Rep. 2017 Sep 6;7(1):10633. doi: 10.1038/s41598-017-10410-1.


Glucocorticoids are lower at delivery in maternal, but not cord blood of obese pregnancies.

Stirrat LI, Just G, Homer NZM, Andrew R, Norman JE, Reynolds RM.

Sci Rep. 2017 Aug 31;7(1):10263. doi: 10.1038/s41598-017-10266-5.


Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.

Vliegenthart A, Kimmitt RA, Seymour JH, Homer NZ, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW.

Clin Pharmacol Ther. 2017 Apr;101(4):531-540. doi: 10.1002/cpt.541. Epub 2016 Nov 30.


Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.

Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L, Hayes AJ, Tsoumanis A, Lyster D, Parks RW, Garden OJ, Iredale JP, Uings IJ, Liddle J, Wright WL, Dukes G, Webster SP, Mole DJ.

Sci Rep. 2016 Sep 27;6:33951. doi: 10.1038/srep33951.


ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy.

Nixon M, Mackenzie SD, Taylor AI, Homer NZ, Livingstone DE, Mouras R, Morgan RA, Mole DJ, Stimson RH, Reynolds RM, Elfick AP, Andrew R, Walker BR.

Sci Transl Med. 2016 Aug 17;8(352):352ra109. doi: 10.1126/scitranslmed.aaf9074.


Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus.

Anderson AJ, Andrew R, Homer NZ, Jones GC, Smith K, Livingstone DE, Walker BR, Stimson RH.

J Clin Endocrinol Metab. 2016 Oct;101(10):3787-3793. Epub 2016 Jul 26.


Mass spectrometry and its evolving role in assessing tissue specific steroid metabolism.

Andrew R, Homer NZ.

Biochem Soc Trans. 2016 Apr 15;44(2):645-51. doi: 10.1042/BST20150234. Review.


Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men.

Gibb FW, Homer NZ, Faqehi AM, Upreti R, Livingstone DE, McInnes KJ, Andrew R, Walker BR.

J Clin Endocrinol Metab. 2016 May;101(5):2040-6. doi: 10.1210/jc.2015-4146. Epub 2016 Mar 11.


Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry.

Faqehi AMM, Cobice DF, Naredo G, Mak TCS, Upreti R, Gibb FW, Beckett GJ, Walker BR, Homer NZM, Andrew R.

Talanta. 2016 May 1;151:148-156. doi: 10.1016/j.talanta.2015.12.062. Epub 2015 Dec 29.


Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.

Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.


Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.

van den Driesche S, Macdonald J, Anderson RA, Johnston ZC, Chetty T, Smith LB, Mckinnell C, Dean A, Homer NZ, Jorgensen A, Camacho-Moll ME, Sharpe RM, Mitchell RT.

Sci Transl Med. 2015 May 20;7(288):288ra80. doi: 10.1126/scitranslmed.aaa4097.


A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.

Wilson K, Mole DJ, Homer NZ, Iredale JP, Auer M, Webster SP.

J Biomol Screen. 2015 Feb;20(2):292-8. doi: 10.1177/1087057114554171. Epub 2014 Oct 8.


Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry.

Upreti R, Naredo G, Faqehi AM, Hughes KA, Stewart LH, Walker BR, Homer NZ, Andrew R.

Talanta. 2015 Jan;131:728-35. doi: 10.1016/j.talanta.2014.07.087. Epub 2014 Aug 14.


Acute inhibition of NCC does not activate distal electrogenic Na+ reabsorption or kaliuresis.

Hunter RW, Craigie E, Homer NZ, Mullins JJ, Bailey MA.

Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F457-67. doi: 10.1152/ajprenal.00339.2013. Epub 2014 Jan 8.


Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.

Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP.

Protein Expr Purif. 2014 Mar;95:96-103. doi: 10.1016/j.pep.2013.11.015. Epub 2013 Dec 4.


Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry.

Upreti R, Homer NZ, Naredo G, Cobice DF, Hughes KA, Stewart LH, Walker BR, Andrew R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:121-8. doi: 10.1016/j.jchromb.2013.04.020. Epub 2013 Apr 19.


Quantitative analysis of RU38486 (mifepristone) by HPLC triple quadrupole mass spectrometry.

Homer NZ, Reynolds RM, Mattsson C, Bailey MA, Walker BR, Andrew R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):497-501. doi: 10.1016/j.jchromb.2008.12.051. Epub 2008 Dec 27.


Preparation of 99m Tc-MAG3: the effect on radiochemical purity of using sodium chloride injection from plastic ampoules that have been exposed to light.

Beattie LA, O'Brien LM, Waight CC, Homer NZ, Andrew R, Millar AM.

Nucl Med Commun. 2008 Jul;29(7):649-53. doi: 10.1097/MNM.0b013e3282f63552.


Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.

Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR.

J Clin Endocrinol Metab. 2007 Nov;92(11):4480-4. Epub 2007 Sep 4.


Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.

Wake DJ, Stimson RH, Tan GD, Homer NZ, Andrew R, Karpe F, Walker BR.

J Clin Endocrinol Metab. 2007 May;92(5):1848-56. Epub 2007 Feb 27.


Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans.

Wake DJ, Homer NZ, Andrew R, Walker BR.

J Clin Endocrinol Metab. 2006 Nov;91(11):4682-8. Epub 2006 Sep 5.


Dimethylsulfoxide oxidizes glutathione in vitro and in human erythrocytes: kinetic analysis by 1H NMR.

Homer NZ, Reglinski J, Sowden R, Spickett CM, Wilson R, Walker JJ.

Cryobiology. 2005 Jun;50(3):317-24.


The interaction of sodium chlorite with phospholipids and glutathione: a comparison of effects in vitro, in mammalian and in microbial cells.

Ingram PR, Homer NZ, Smith RA, Pitt AR, Wilson CG, Olejnik O, Spickett CM.

Arch Biochem Biophys. 2003 Feb 1;410(1):121-33.


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