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Items: 1 to 50 of 120

1.

Metal coordination-based inhibitors of adenylyl cyclase: novel potent P-site antagonists.

Levy DE, Bao M, Cherbavaz DB, Tomlinson JE, Sedlock DM, Homcy CJ, Scarborough RM.

J Med Chem. 2003 May 22;46(11):2177-86.

PMID:
12747789
2.

Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.

Hardt SE, Geng YJ, Montagne O, Asai K, Hong C, Yang GP, Bishop SP, Kim SJ, Vatner DE, Seidman CE, Seidman JG, Homcy CJ, Vatner SF.

Circulation. 2002 Feb 5;105(5):614-20.

PMID:
11827928
3.

Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms.

Onda T, Hashimoto Y, Nagai M, Kuramochi H, Saito S, Yamazaki H, Toya Y, Sakai I, Homcy CJ, Nishikawa K, Ishikawa Y.

J Biol Chem. 2001 Dec 21;276(51):47785-93. Epub 2001 Oct 15.

4.

Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha.

Vatner DE, Yang GP, Geng YJ, Asai K, Yun JS, Wagner TE, Ishikawa Y, Bishop SP, Homcy CJ, Vatner SF.

Circ Res. 2000 Apr 14;86(7):802-6.

PMID:
10764415
5.

Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart.

Vatner DE, Asai K, Iwase M, Ishikawa Y, Shannon RP, Homcy CJ, Vatner SF.

Am J Cardiol. 1999 Jun 17;83(12A):80H-85H. Review.

PMID:
10750593
7.

Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse.

Asai K, Yang GP, Geng YJ, Takagi G, Bishop S, Ishikawa Y, Shannon RP, Wagner TE, Vatner DE, Homcy CJ, Vatner SF.

J Clin Invest. 1999 Sep;104(5):551-8.

8.

Differential regulation of inotropy and lusitropy in overexpressed Gsalpha myocytes through cAMP and Ca2+ channel pathways.

Kim SJ, Yatani A, Vatner DE, Yamamoto S, Ishikawa Y, Wagner TE, Shannon RP, Kim YK, Takagi G, Asai K, Homcy CJ, Vatner SF.

J Clin Invest. 1999 Apr;103(7):1089-97.

9.

Apoptosis of cardiac myocytes in Gsalpha transgenic mice.

Geng YJ, Ishikawa Y, Vatner DE, Wagner TE, Bishop SP, Vatner SF, Homcy CJ.

Circ Res. 1999 Jan 8-22;84(1):34-42.

PMID:
9915772
10.

Cardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway.

Lader AS, Xiao YF, Ishikawa Y, Cui Y, Vatner DE, Vatner SF, Homcy CJ, Cantiello HF.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9669-74.

11.

Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

Vatner DE, Asai K, Iwase M, Ishikawa Y, Wagner TE, Shannon RP, Homcy CJ, Vatner SF.

J Clin Invest. 1998 May 1;101(9):1916-22.

12.

Signaling hypertrophy: how many switches, how many wires.

Homcy CJ.

Circulation. 1998 May 19;97(19):1890-2. Review. No abstract available.

PMID:
9609078
13.

Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha.

Uechi M, Asai K, Osaka M, Smith A, Sato N, Wagner TE, Ishikawa Y, Hayakawa H, Vatner DE, Shannon RP, Homcy CJ, Vatner SF.

Circ Res. 1998 Mar 9;82(4):416-23.

PMID:
9506701
14.

Localisation of cardiac GS alpha in transgenic mice overexpressing GS alpha.

Muntz KH, Ishikawa Y, Wagner T, Homcy CJ, Vatner SF, Vatner DE.

J Mol Cell Cardiol. 1997 Jun;29(6):1649-53.

PMID:
9220350
15.

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C.

Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, Ishikawa Y.

J Cell Biochem. 1997 Mar 1;64(3):492-8.

PMID:
9057106
16.

The adenylyl cyclases as integrators of transmembrane signal transduction.

Ishikawa Y, Homcy CJ.

Circ Res. 1997 Mar;80(3):297-304. Review. No abstract available.

PMID:
9048648
17.

Cardiomyopathy induced by cardiac Gs alpha overexpression.

Iwase M, Uechi M, Vatner DE, Asai K, Shannon RP, Kudej RK, Wagner TE, Wight DC, Patrick TA, Ishikawa Y, Homcy CJ, Vatner SF.

Am J Physiol. 1997 Jan;272(1 Pt 2):H585-9.

PMID:
9038982
18.

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.

Reiss K, Cheng W, Ferber A, Kajstura J, Li P, Li B, Olivetti G, Homcy CJ, Baserga R, Anversa P.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8630-5.

19.

Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression.

Iwase M, Bishop SP, Uechi M, Vatner DE, Shannon RP, Kudej RK, Wight DC, Wagner TE, Ishikawa Y, Homcy CJ, Vatner SF.

Circ Res. 1996 Apr;78(4):517-24.

PMID:
8635208
20.

Regulation of adenylyl cyclase by protein kinase A.

Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y.

J Biol Chem. 1995 May 26;270(21):12481-4.

21.

Multiplicity in type V adenylylcyclase: type V-a and type V-b.

Iwami G, Akanuma M, Kawabe J, Cannon PJ, Homcy CJ, Ishikawa Y.

Mol Cell Endocrinol. 1995 Apr 28;110(1-2):43-7. Erratum in: Mol Cell Endocrinol 1996 Aug 30;122(1):111-2.

PMID:
7672452
22.

Overexpression of Gs alpha protein in the hearts of transgenic mice.

Gaudin C, Ishikawa Y, Wight DC, Mahdavi V, Nadal-Ginard B, Wagner TE, Vatner DE, Homcy CJ.

J Clin Invest. 1995 Apr;95(4):1676-83.

23.

Mammalian adenylyl cyclase family members are randomly located on different chromosomes.

Gaudin C, Homcy CJ, Ishikawa Y.

Hum Genet. 1994 Nov;94(5):527-9.

PMID:
7959689
24.

A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity.

Kawabe J, Ebina T, Ismail S, Kitchen DB, Homcy CJ, Ishikawa Y.

J Biol Chem. 1994 Oct 7;269(40):24906-11.

25.

Differential activation of adenylyl cyclase by protein kinase C isoenzymes.

Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y.

J Biol Chem. 1994 Jun 17;269(24):16554-8. Erratum in: J Biol Chem 1994 Sep 9;269(36):22912.

26.

Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.

Ishikawa Y, Sorota S, Kiuchi K, Shannon RP, Komamura K, Katsushika S, Vatner DE, Vatner SF, Homcy CJ.

J Clin Invest. 1994 May;93(5):2224-9.

27.

Changes in type VI adenylyl cyclase isoform expression correlate with a decreased capacity for cAMP generation in the aging ventricle.

Tobise K, Ishikawa Y, Holmer SR, Im MJ, Newell JB, Yoshie H, Fujita M, Susannie EE, Homcy CJ.

Circ Res. 1994 Apr;74(4):596-603.

PMID:
8137496
29.

Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats.

Meggs LG, Coupet J, Huang H, Cheng W, Li P, Capasso JM, Homcy CJ, Anversa P.

Circ Res. 1993 Jun;72(6):1149-62.

PMID:
8495545
30.

Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.

Kiuchi K, Shannon RP, Komamura K, Cohen DJ, Bianchi C, Homcy CJ, Vatner SF, Vatner DE.

J Clin Invest. 1993 Mar;91(3):907-14.

31.

In vivo generation of an adenylylcyclase isoform with a half-molecule motif.

Katsushika S, Kawabe J, Homcy CJ, Ishikawa Y.

J Biol Chem. 1993 Feb 5;268(4):2273-6.

32.

Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.

Katsushika S, Chen L, Kawabe J, Nilakantan R, Halnon NJ, Homcy CJ, Ishikawa Y.

Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8774-8.

33.

High efficiency gene transfer into mammalian cells by a double transfection protocol.

Ishikawa Y, Homcy CJ.

Nucleic Acids Res. 1992 Aug 25;20(16):4367. No abstract available.

34.

Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J, Homcy CJ.

J Biol Chem. 1992 Jul 5;267(19):13553-7.

36.

G proteins in the heart. A redundant and diverse transmembrane signaling network.

Holmer SR, Homcy CJ.

Circulation. 1991 Nov;84(5):1891-902. Review. No abstract available.

PMID:
1934366
37.
38.

The beta-adrenergic signaling pathway in the heart.

Homcy CJ.

Hosp Pract (Off Ed). 1991 May 15;26(5):43-50.

PMID:
1851499
39.

Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension.

Shannon RP, Gelpi RJ, Hittinger L, Vatner DE, Homcy CJ, Graham RM, Vatner SF.

Circ Res. 1991 Feb;68(2):543-54.

PMID:
1671344
41.

Beta-adrenergic receptor regulation in the heart in pathophysiologic states: abnormal adrenergic responsiveness in cardiac disease.

Homcy CJ, Vatner SF, Vatner DE.

Annu Rev Physiol. 1991;53:137-59. Review. No abstract available.

PMID:
1645945
42.

Role of intact cardiac nerves and reflex mechanisms in desensitization to catecholamines in conscious dogs.

Nejima J, Uemura N, Vatner DE, Homcy CJ, Hintze TH, Vatner SF.

J Clin Invest. 1990 Dec;86(6):2046-53.

43.

Phosphorylation state of pro-atrial natriuretic factor in rat atrial secretory granules.

Wildey GM, Fischman AJ, Margolies MN, Graham RM, Homcy CJ.

Endocrinology. 1990 Dec;127(6):2839-48.

PMID:
2174336
44.

Alternative promoter and 5' exon generate a novel Gs alpha mRNA.

Ishikawa Y, Bianchi C, Nadal-Ginard B, Homcy CJ.

J Biol Chem. 1990 May 25;265(15):8458-62.

45.
46.

Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.

Vatner DE, Vatner SF, Nejima J, Uemura N, Susanni EE, Hintze TH, Homcy CJ.

J Clin Invest. 1989 Dec;84(6):1741-8.

47.

One hour of myocardial ischemia decreases the activity of the stimulatory guanine-nucleotide regulatory protein Gs.

Susanni EE, Manders WT, Knight DR, Vatner DE, Vatner SF, Homcy CJ.

Circ Res. 1989 Oct;65(4):1145-50.

PMID:
2551529
48.

Tissue- and species-specific expression of inhibitory guanine nucleotide-binding proteins. Cloning of a full-length complementary DNA from canine heart.

Holmer SR, Stevens S, Homcy CJ.

Circ Res. 1989 Oct;65(4):1136-40. Erratum in: Circ Res 1989 Dec;65(6):1810.

PMID:
2477170
49.

Morphologic and functional correlates of plasma membrane injury during oxidant exposure.

Scott JA, Fischman AJ, Homcy CJ, Fallon JT, Khaw BA, Peto CA, Rabito CA.

Free Radic Biol Med. 1989;6(4):361-7.

PMID:
2707620
50.

Alpha-adrenergic vasoconstriction and receptor subtypes in large coronary arteries of calves.

Young MA, Vatner DE, Knight DR, Graham RM, Homcy CJ, Vatner SF.

Am J Physiol. 1988 Dec;255(6 Pt 2):H1452-9.

PMID:
2904772

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