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Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells.

Laksitorini MD, Yathindranath V, Xiong W, Hombach-Klonisch S, Miller DW.

Sci Rep. 2019 Dec 23;9(1):19718. doi: 10.1038/s41598-019-56075-w.


Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes.

Shojaei S, Koleini N, Samiei E, Aghaei M, Cole LK, Alizadeh J, Islam MI, Vosoughi AR, Albokashy M, Butterfield Y, Marzban H, Xu F, Thliveris J, Kardami E, Hatch GM, Eftekharpour E, Akbari M, Hombach-Klonisch S, Klonisch T, Ghavami S.

FEBS J. 2019 Sep 23. doi: 10.1111/febs.15069. [Epub ahead of print]


Emerging roles for the relaxin/RXFP1 system in cancer therapy.

Thanasupawat T, Glogowska A, Nivedita-Krishnan S, Wilson B, Klonisch T, Hombach-Klonisch S.

Mol Cell Endocrinol. 2019 May 1;487:85-93. doi: 10.1016/j.mce.2019.02.001. Epub 2019 Feb 11. Review.


Unlocking bone for proteomic analysis and FISH.

Mueller C, Gambarotti M, Benini S, Picci P, Righi A, Stevanin M, Hombach-Klonisch S, Henderson D, Liotta L, Espina V.

Lab Invest. 2019 May;99(5):708-721. doi: 10.1038/s41374-018-0168-7. Epub 2019 Jan 18.


Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.

Blanchard AA, Ma X, Wang N, Hombach-Klonisch S, Penner C, Ozturk A, Klonisch T, Pitz M, Murphy L, Leygue E, Myal Y.

Transl Oncol. 2019 Mar;12(3):561-575. doi: 10.1016/j.tranon.2018.12.011. Epub 2019 Jan 15.


A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control.

Wu J, Kumar-Kanojia A, Hombach-Klonisch S, Klonisch T, Lin F.

Lab Chip. 2018 Dec 4;18(24):3855-3864. doi: 10.1039/c8lc00981c.


Statins: a new approach to combat temozolomide chemoresistance in glioblastoma.

Shojaei S, Alizadeh J, Thliveris J, Koleini N, Kardami E, Hatch GM, Xu F, Hombach-Klonisch S, Klonisch T, Ghavami S.

J Investig Med. 2018 Dec;66(8):1083-1087. doi: 10.1136/jim-2018-000874. Epub 2018 Oct 27. Review.


Maternal smoking and high BMI disrupt thyroid gland development.

Filis P, Hombach-Klonisch S, Ayotte P, Nagrath N, Soffientini U, Klonisch T, O'Shaughnessy P, Fowler PA.

BMC Med. 2018 Oct 23;16(1):194. doi: 10.1186/s12916-018-1183-7.


HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.

Hombach-Klonisch S, Kalantari F, Medapati MR, Natarajan S, Krishnan SN, Kumar-Kanojia A, Thanasupawat T, Begum F, Xu FY, Hatch GM, Los M, Klonisch T.

Mol Oncol. 2019 Feb;13(2):153-170. doi: 10.1002/1878-0261.12390. Epub 2018 Nov 28.


C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.

Thanasupawat T, Glogowska A, Burg M, Krcek J, Beiko J, Pitz M, Zhang GJ, Hombach-Klonisch S, Klonisch T.

Mol Oncol. 2018 Sep;12(9):1464-1479. doi: 10.1002/1878-0261.12349. Epub 2018 Aug 2.


Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells.

Alizadeh J, Glogowska A, Thliveris J, Kalantari F, Shojaei S, Hombach-Klonisch S, Klonisch T, Ghavami S.

Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):749-768. doi: 10.1016/j.bbamcr.2018.02.007. Epub 2018 Feb 24.


Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.

Hombach-Klonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, Likus W, Wiechec E, Toyota BD, Hoshyar R, Seyfoori A, Sepehri Z, Ande SR, Khadem F, Akbari M, Gorman AM, Samali A, Klonisch T, Ghavami S.

Pharmacol Ther. 2018 Apr;184:13-41. doi: 10.1016/j.pharmthera.2017.10.017. Epub 2017 Nov 8. Review.


Dovitinib enhances temozolomide efficacy in glioblastoma cells.

Thanasupawat T, Natarajan S, Rommel A, Glogowska A, Bergen H, Krcek J, Pitz M, Beiko J, Krawitz S, Verma IM, Ghavami S, Klonisch T, Hombach-Klonisch S.

Mol Oncol. 2017 Aug;11(8):1078-1098. doi: 10.1002/1878-0261.12076. Epub 2017 Jun 5.


Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.

Alizadeh J, Zeki AA, Mirzaei N, Tewary S, Rezaei Moghadam A, Glogowska A, Nagakannan P, Eftekharpour E, Wiechec E, Gordon JW, Xu FY, Field JT, Yoneda KY, Kenyon NJ, Hashemi M, Hatch GM, Hombach-Klonisch S, Klonisch T, Ghavami S.

Sci Rep. 2017 Mar 27;7:44841. doi: 10.1038/srep44841.


Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada.

Hammond E, Shu E, Sawchuk K, Myal Y, Raouf A, Klonisch T, Hombach-Klonisch S, Leygue E, Kung S, Safneck J, Mowat M, Xu W, Murphy L, Pitz M.

Cancer Epidemiol. 2016 Dec;45:82-90. doi: 10.1016/j.canep.2016.10.006. Epub 2016 Oct 19.


Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells.

Klonisch T, Glogowska A, Thanasupawat T, Burg M, Krcek J, Pitz M, Jaggupilli A, Chelikani P, Wong GW, Hombach-Klonisch S.

Br J Pharmacol. 2017 May;174(10):1025-1033. doi: 10.1111/bph.13559. Epub 2016 Aug 11. Review.


Biodistribution of negatively charged iron oxide nanoparticles (IONPs) in mice and enhanced brain delivery using lysophosphatidic acid (LPA).

Sun Z, Worden M, Thliveris JA, Hombach-Klonisch S, Klonisch T, van Lierop J, Hegmann T, Miller DW.

Nanomedicine. 2016 Oct;12(7):1775-1784. doi: 10.1016/j.nano.2016.04.008. Epub 2016 Apr 25.


High Mobility Group A2 protects cancer cells against telomere dysfunction.

Natarajan S, Begum F, Gim J, Wark L, Henderson D, Davie JR, Hombach-Klonisch S, Klonisch T.

Oncotarget. 2016 Mar 15;7(11):12761-82. doi: 10.18632/oncotarget.6938.


RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.

Thanasupawat T, Glogowska A, Burg M, Wong GW, Hoang-Vu C, Hombach-Klonisch S, Klonisch T.

Front Endocrinol (Lausanne). 2015 Aug 13;6:127. doi: 10.3389/fendo.2015.00127. eCollection 2015. Review.


RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells.

Medapati MR, Dahlmann M, Ghavami S, Pathak KA, Lucman L, Klonisch T, Hoang-Vu C, Stein U, Hombach-Klonisch S.

Thyroid. 2015 May;25(5):514-27. doi: 10.1089/thy.2014.0257. Epub 2015 Apr 3.


Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells.

Thanasupawat T, Bergen H, Hombach-Klonisch S, Krcek J, Ghavami S, Del Bigio MR, Krawitz S, Stelmack G, Halayko A, McDougall M, Meier M, Stetefeld J, Klonisch T.

Nanomedicine. 2015 May;11(4):913-25. doi: 10.1016/j.nano.2015.01.014. Epub 2015 Feb 11.


Gesture-controlled interactive three dimensional anatomy: a novel teaching tool in head and neck surgery.

Hochman JB, Unger B, Kraut J, Pisa J, Hombach-Klonisch S.

J Otolaryngol Head Neck Surg. 2014 Oct 7;43:38. doi: 10.1186/s40463-014-0038-2. eCollection 2014.


Reproduction Symposium: does grazing on biosolids-treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

Evans NP, Bellingham M, Sharpe RM, Cotinot C, Rhind SM, Kyle C, Erhard H, Hombach-Klonisch S, Lind PM, Fowler PA.

J Anim Sci. 2014 Aug;92(8):3185-98. doi: 10.2527/jas.2014-7763. Epub 2014 Jun 19. Review.


Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells.

Hombach-Klonisch S, Natarajan S, Thanasupawat T, Medapati M, Pathak A, Ghavami S, Klonisch T.

Front Endocrinol (Lausanne). 2014 Mar 25;5:37. doi: 10.3389/fendo.2014.00037. eCollection 2014. Review.


Elevated urinary CCL2: Cr at 6 months is associated with renal allograft interstitial fibrosis and inflammation at 24 months.

Ho J, Wiebe C, Gibson IW, Hombach-Klonisch S, Gao A, Rigatto C, Karpinski M, Storsley L, Nickerson PW, Rush DN.

Transplantation. 2014 Jul 15;98(1):39-46. doi: 10.1097/01.TP.0000442776.40295.73.


C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells.

Glogowska A, Kunanuvat U, Stetefeld J, Patel TR, Thanasupawat T, Krcek J, Weber E, Wong GW, Del Bigio MR, Hoang-Vu C, Hombach-Klonisch S, Klonisch T.

J Pathol. 2013 Dec;231(4):466-79. doi: 10.1002/path.4257.


Three-dimensional telomere dynamics in follicular thyroid cancer.

Wark L, Danescu A, Natarajan S, Zhu X, Cheng SY, Hombach-Klonisch S, Mai S, Klonisch T.

Thyroid. 2014 Feb;24(2):296-304. doi: 10.1089/thy.2013.0118. Epub 2013 Sep 4.


Three-dimensional nuclear telomere architecture changes during endometrial carcinoma development.

Danescu A, Herrero Gonzalez S, Di Cristofano A, Mai S, Hombach-Klonisch S.

Genes Chromosomes Cancer. 2013 Aug;52(8):716-32. doi: 10.1002/gcc.22067. Epub 2013 Apr 30.


HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.

Natarajan S, Hombach-Klonisch S, Dröge P, Klonisch T.

Neoplasia. 2013 Mar;15(3):263-80.


Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep.

Hombach-Klonisch S, Danescu A, Begum F, Amezaga MR, Rhind SM, Sharpe RM, Evans NP, Bellingham M, Cotinot C, Mandon-Pepin B, Fowler PA, Klonisch T.

Mol Cell Endocrinol. 2013 Mar 10;367(1-2):98-108. doi: 10.1016/j.mce.2012.12.022. Epub 2013 Jan 4.


Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction.

Chowdhury B, Hemming R, Hombach-Klonisch S, Flamion B, Triggs-Raine B.

J Biol Chem. 2013 Jan 4;288(1):520-8. doi: 10.1074/jbc.M112.393629. Epub 2012 Nov 21.


INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours.

Thanasupawat T, Hammje K, Adham I, Ghia JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T, Hombach-Klonisch S.

Oncol Rep. 2013 Jan;29(1):149-54. doi: 10.3892/or.2012.2119. Epub 2012 Oct 31.


Characterisation of an in vitro system to study maternal communication with spermatozoa.

Aldarmahi A, Elliott S, Russell J, Klonisch T, Hombach-Klonisch S, Fazeli A.

Reprod Fertil Dev. 2012;24(7):988-98. doi: 10.1071/RD11268.


INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility.

Burnicka-Turek O, Mohamed BA, Shirneshan K, Thanasupawat T, Hombach-Klonisch S, Klonisch T, Adham IM.

Endocrinology. 2012 Oct;153(10):4655-65. Epub 2012 Jul 20.


Relaxin enhances the collagenolytic activity and in vitro invasiveness by upregulating matrix metalloproteinases in human thyroid carcinoma cells.

Bialek J, Kunanuvat U, Hombach-Klonisch S, Spens A, Stetefeld J, Sunley K, Lippert D, Wilkins JA, Hoang-Vu C, Klonisch T.

Mol Cancer Res. 2011 Jun;9(6):673-87. doi: 10.1158/1541-7786.MCR-10-0411. Epub 2011 Apr 14.


Estrogen-independent actions of environmentally relevant AhR-agonists in human endometrial epithelial cells.

Willing C, Peich M, Danescu A, Kehlen A, Fowler PA, Hombach-Klonisch S.

Mol Hum Reprod. 2011 Feb;17(2):115-26. doi: 10.1093/molehr/gaq081. Epub 2010 Sep 27. Erratum in: Mol Hum Reprod. 2013 Jul;19(7):473.


Nuclear imaging in three dimensions: a unique tool in cancer research.

Klonisch T, Wark L, Hombach-Klonisch S, Mai S.

Ann Anat. 2010 Sep 20;192(5):292-301. doi: 10.1016/j.aanat.2010.07.007. Epub 2010 Aug 6. Review.


Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts.

Radestock Y, Willing C, Kehlen A, Hoang-Vu C, Hombach-Klonisch S.

Mol Cancer Res. 2010 Apr;8(4):494-506. doi: 10.1158/1541-7786.MCR-09-0307. Epub 2010 Mar 23.


Thyroid stem cells and cancer.

Klonisch T, Hoang-Vu C, Hombach-Klonisch S.

Thyroid. 2009 Dec;19(12):1303-15. doi: 10.1089/thy.2009.1604. Review.


Expression and function of Toll-like receptors in human endometrial epithelial cell lines.

Aboussahoud W, Aflatoonian R, Bruce C, Elliott S, Ward J, Newton S, Hombach-Klonisch S, Klonisch T, Fazeli A.

J Reprod Immunol. 2010 Jan;84(1):41-51. doi: 10.1016/j.jri.2009.09.008. Epub 2009 Dec 2.


INSL3 has tumor-promoting activity in thyroid cancer.

Hombach-Klonisch S, Bialek J, Radestock Y, Truong A, Agoulnik AI, Fiebig B, Willing C, Weber E, Hoang-Vu C, Klonisch T.

Int J Cancer. 2010 Aug 1;127(3):521-31. doi: 10.1002/ijc.25068.


TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions.

Seifert A, Taubert H, Hombach-Klonisch S, Fischer B, Navarrete Santos A.

Int J Oncol. 2009 Aug;35(2):417-24.


Estrogen and TCDD influence RLN2 gene activity in estrogen receptor-positive human breast cancer cells.

Kietz S, Feng S, Agoulnik A, Hombach-Klonisch S.

Ann N Y Acad Sci. 2009 Apr;1160:367-73. doi: 10.1111/j.1749-6632.2009.03836.x.


Lysosomal acid hydrolases of the cathepsin family are novel targets of INSL3 in human thyroid carcinoma cells.

Bialek J, Hombach-Klonisch S, Fiebig B, Weber E, Hoang-Vu C, Klonisch T.

Ann N Y Acad Sci. 2009 Apr;1160:361-6. doi: 10.1111/j.1749-6632.2009.03832.x.


Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation.

King AE, Horne AW, Hombach-Klonisch S, Mason JI, Critchley HO.

Mol Hum Reprod. 2009 May;15(5):311-9. doi: 10.1093/molehr/gap020. Epub 2009 Mar 8.


Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines.

Trojanowicz B, Winkler A, Hammje K, Chen Z, Sekulla C, Glanz D, Schmutzler C, Mentrup B, Hombach-Klonisch S, Klonisch T, Finke R, Köhrle J, Dralle H, Hoang-Vu C.

J Mol Endocrinol. 2009 Mar;42(3):249-60. doi: 10.1677/JME-08-0118. Epub 2008 Dec 5.


Cancer stem cell markers in common cancers - therapeutic implications.

Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M.

Trends Mol Med. 2008 Oct;14(10):450-60. doi: 10.1016/j.molmed.2008.08.003. Epub 2008 Sep 3. Review.


Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells.

Radestock Y, Hoang-Vu C, Hombach-Klonisch S.

Breast Cancer Res. 2008;10(4):R71. doi: 10.1186/bcr2136. Epub 2008 Aug 21.


Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications.

Hombach-Klonisch S, Panigrahi S, Rashedi I, Seifert A, Alberti E, Pocar P, Kurpisz M, Schulze-Osthoff K, Mackiewicz A, Los M.

J Mol Med (Berl). 2008 Dec;86(12):1301-14. doi: 10.1007/s00109-008-0383-6. Epub 2008 Jul 16. Review.


Cancer stem cells as targets for cancer therapy: selected cancers as examples.

Hombach-Klonisch S, Paranjothy T, Wiechec E, Pocar P, Mustafa T, Seifert A, Zahl C, Gerlach KL, Biermann K, Steger K, Hoang-Vu C, Schulze-Osthoff K, Los M.

Arch Immunol Ther Exp (Warsz). 2008 May-Jun;56(3):165-80. doi: 10.1007/s00005-008-0023-4. Epub 2008 May 30. Review.

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