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Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure.

Johnson KA, Liput DJ, Homanics GE, Lovinger DM.

Alcohol. 2019 Jun 21. pii: S0741-8329(19)30118-1. doi: 10.1016/j.alcohol.2019.06.003. [Epub ahead of print]


Identification of a Functional Non-coding Variant in the GABA A Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.

Mulligan MK, Abreo T, Neuner SM, Parks C, Watkins CE, Houseal MT, Shapaker TM, Hook M, Tan H, Wang X, Ingels J, Peng J, Lu L, Kaczorowski CC, Bryant CD, Homanics GE, Williams RW.

Front Genet. 2019 Mar 29;10:188. doi: 10.3389/fgene.2019.00188. eCollection 2019.


Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.

Harmon DB, Mandler WK, Sipula IJ, Dedousis N, Lewis SE, Eckels JT, Du J, Wang Y, Huckestein BR, Pagano PJ, Cifuentes-Pagano E, Homanics GE, Van't Erve TJ, Stefanovic-Racic M, Jurczak MJ, O'Doherty RM, Kelley EE.

Diabetes. 2019 Jun;68(6):1221-1229. doi: 10.2337/db18-1198. Epub 2019 Apr 1.


Intergenerational Effects of Alcohol: A Review of Paternal Preconception Ethanol Exposure Studies and Epigenetic Mechanisms in the Male Germline.

Rompala GR, Homanics GE.

Alcohol Clin Exp Res. 2019 Jun;43(6):1032-1045. doi: 10.1111/acer.14029. Epub 2019 Apr 26. Review.


Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference.

Muñoz B, Gallegos S, Peters C, Murath P, Lovinger DM, Homanics GE, Aguayo LG.

Addict Biol. 2019 Mar 18. doi: 10.1111/adb.12726. [Epub ahead of print]


Paternal Preconception Every-Other-Day Ethanol Drinking Alters Behavior and Ethanol Consumption in Offspring.

Beeler E, Nobile ZL, Homanics GE.

Brain Sci. 2019 Mar 6;9(3). pii: E56. doi: 10.3390/brainsci9030056.


Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.

Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA.

Genes Brain Behav. 2019 Jul;18(6):e12562. doi: 10.1111/gbb.12562. Epub 2019 May 2.


Gene-edited CRISPy Critters for alcohol research.

Homanics GE.

Alcohol. 2019 Feb;74:11-19. doi: 10.1016/j.alcohol.2018.03.001. Epub 2018 Mar 7. Review.


Paternal Preconception Chronic Variable Stress Confers Attenuated Ethanol Drinking Behavior Selectively to Male Offspring in a Pre-Stress Environment Dependent Manner.

Rompala GR, Simons A, Kihle B, Homanics GE.

Front Behav Neurosci. 2018 Nov 2;12:257. doi: 10.3389/fnbeh.2018.00257. eCollection 2018.


Heavy Chronic Intermittent Ethanol Exposure Alters Small Noncoding RNAs in Mouse Sperm and Epididymosomes.

Rompala GR, Mounier A, Wolfe CM, Lin Q, Lefterov I, Homanics GE.

Front Genet. 2018 Feb 8;9:32. doi: 10.3389/fgene.2018.00032. eCollection 2018.


Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia.

Lu J, Fan S, Zou G, Hou Y, Pan T, Guo W, Yao L, Du F, Homanics GE, Liu D, Zhang L, Xiong W.

Neuropharmacology. 2018 May 1;133:224-232. doi: 10.1016/j.neuropharm.2018.01.041. Epub 2018 Feb 1.


Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit.

Zamudio-Bulcock PA, Homanics GE, Woodward JJ.

Alcohol Clin Exp Res. 2018 Apr;42(4):698-705. doi: 10.1111/acer.13597. Epub 2018 Feb 9.


Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress.

Varodayan FP, Khom S, Patel RR, Steinman MQ, Hedges DM, Oleata CS, Homanics GE, Roberto M, Bajo M.

Alcohol Alcohol. 2018 Nov 1;53(6):642-649. doi: 10.1093/alcalc/agx114.


Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum.

Pratt CP, Kuljis DA, Homanics GE, He J, Kolodieznyi D, Dudem S, Hollywood MA, Barth AL, Bruchez MP.

Front Cell Neurosci. 2017 Oct 31;11:337. doi: 10.3389/fncel.2017.00337. eCollection 2017.


Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring.

Hill SY, Rompala G, Homanics GE, Zezza N.

Epigenomics. 2017 Sep;9(9):1189-1203. doi: 10.2217/epi-2017-0052. Epub 2017 Aug 11.


Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.

Blednov YA, Borghese CM, Ruiz CI, Cullins MA, Da Costa A, Osterndorff-Kahanek EA, Homanics GE, Harris RA.

Neuropharmacology. 2017 Sep 1;123:201-209. doi: 10.1016/j.neuropharm.2017.06.013. Epub 2017 Jun 13.


GABAA receptor α4-subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model.

Yocum GT, Turner DL, Danielsson J, Barajas MB, Zhang Y, Xu D, Harrison NL, Homanics GE, Farber DL, Emala CW.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L406-L415. doi: 10.1152/ajplung.00107.2017. Epub 2017 May 4.


Epigenetic mediators and consequences of excessive alcohol consumption.

Mahnke AH, Miranda RC, Homanics GE.

Alcohol. 2017 May;60:1-6. doi: 10.1016/j.alcohol.2017.02.357. Epub 2017 Mar 11. Review. No abstract available.


Effects of Repeated Ethanol Exposures on NMDA Receptor Expression and Locomotor Sensitization in Mice Expressing Ethanol Resistant NMDA Receptors.

den Hartog CR, Gilstrap M, Eaton B, Lench DH, Mulholland PJ, Homanics GE, Woodward JJ.

Front Neurosci. 2017 Feb 21;11:84. doi: 10.3389/fnins.2017.00084. eCollection 2017.


The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons.

Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE.

Front Cell Neurosci. 2017 Feb 13;11:17. doi: 10.3389/fncel.2017.00017. eCollection 2017.


Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.


Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background.

Rompala GR, Finegersh A, Slater M, Homanics GE.

Alcohol. 2017 May;60:169-177. doi: 10.1016/j.alcohol.2016.11.001. Epub 2016 Nov 5.


Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice.

Rompala GR, Finegersh A, Homanics GE.

Alcohol. 2016 Jun;53:19-25. doi: 10.1016/j.alcohol.2016.03.006. Epub 2016 Apr 22.


APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C, Homanics GE, Cao G, Bennett MV, Chen J.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3558-67. doi: 10.1073/pnas.1606226113. Epub 2016 Jun 6.


Chromatin immunoprecipitation and gene expression analysis of neuronal subtypes after fluorescence activated cell sorting.

Finegersh A, Homanics GE.

J Neurosci Methods. 2016 Apr 1;263:81-8. doi: 10.1016/j.jneumeth.2016.02.006. Epub 2016 Feb 8.


Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling.

Cai X, Huang H, Kuzirian MS, Snyder LM, Matsushita M, Lee MC, Ferguson C, Homanics GE, Barth AL, Ross SE.

Genesis. 2016 Jan;54(1):29-37. doi: 10.1002/dvg.22910. Epub 2015 Dec 18.


Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region.

Finegersh A, Ferguson C, Maxwell S, Mazariegos D, Farrell D, Homanics GE.

Front Mol Neurosci. 2015 Aug 5;8:39. doi: 10.3389/fnmol.2015.00039. eCollection 2015.


Brains, genes, and primates.

Izpisua Belmonte JC, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F.

Neuron. 2015 May 6;86(3):617-31. doi: 10.1016/j.neuron.2015.03.021. Review. Erratum in: Neuron. 2015 Aug 5;87(3):671.


Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.

Jaiswal MK, Keros S, Zhao M, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA.

Front Cell Neurosci. 2015 Apr 9;9:127. doi: 10.3389/fncel.2015.00127. eCollection 2015.


Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations.

Finegersh A, Rompala GR, Martin DI, Homanics GE.

Alcohol. 2015 Aug;49(5):461-70. doi: 10.1016/j.alcohol.2015.02.008. Epub 2015 Mar 30. Review.


Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol.

Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL.

Neuroscience. 2015 Jun 25;297:68-77. doi: 10.1016/j.neuroscience.2015.03.034. Epub 2015 Mar 28.


Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.

Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL.

Mol Pharmacol. 2014 Dec;86(6):635-46. doi: 10.1124/mol.114.093773. Epub 2014 Sep 22.


Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.

Cramer JM, Zimmerman MW, Thompson T, Homanics GE, Lazo JS, Lagasse E.

Stem Cell Res. 2014 Jul;13(1):164-171. doi: 10.1016/j.scr.2014.05.004. Epub 2014 May 27.


Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex.

Finegersh A, Homanics GE.

Alcohol Clin Exp Res. 2014 Jul;38(7):1865-73. doi: 10.1111/acer.12465. Epub 2014 Jun 18.


Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring.

Finegersh A, Homanics GE.

PLoS One. 2014 Jun 4;9(6):e99078. doi: 10.1371/journal.pone.0099078. eCollection 2014.


Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation.

Aguayo LG, Castro P, Mariqueo T, Muñoz B, Xiong W, Zhang L, Lovinger DM, Homanics GE.

Neuropsychopharmacology. 2014 Oct;39(11):2538-48. doi: 10.1038/npp.2014.100. Epub 2014 May 7.


Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons.

Mariqueo TA, Agurto A, Muñoz B, San Martin L, Coronado C, Fernández-Pérez EJ, Murath P, Sánchez A, Homanics GE, Aguayo LG.

J Neurophysiol. 2014 May;111(10):1940-8. doi: 10.1152/jn.00789.2013. Epub 2014 Feb 26.


Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting.

Horn CC, Wallisch WJ, Homanics GE, Williams JP.

Eur J Pharmacol. 2014 Jan 5;722:55-66. doi: 10.1016/j.ejphar.2013.10.037. Epub 2013 Oct 26. Review.


Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.

Zimmerman MW, McQueeney KE, Isenberg JS, Pitt BR, Wasserloos KA, Homanics GE, Lazo JS.

J Biol Chem. 2014 Feb 28;289(9):5904-13. doi: 10.1074/jbc.M113.480038. Epub 2014 Jan 8.


Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.

Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L.

Nat Neurosci. 2014 Feb;17(2):232-9. doi: 10.1038/nn.3615. Epub 2014 Jan 5.


Altered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout mice.

Peng Z, Zhang N, Chandra D, Homanics GE, Olsen RW, Houser CR.

Neurochem Res. 2014 Jun;39(6):1104-17. doi: 10.1007/s11064-013-1202-1. Epub 2013 Dec 19.


Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors.

den Hartog CR, Beckley JT, Smothers TC, Lench DH, Holseberg ZL, Fedarovich H, Gilstrap MJ, Homanics GE, Woodward JJ.

PLoS One. 2013 Nov 14;8(11):e80541. doi: 10.1371/journal.pone.0080541. eCollection 2013.


Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation.

Ferguson C, McKay M, Harris RA, Homanics GE.

Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.


Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.

Zimmerman MW, Homanics GE, Lazo JS.

PLoS One. 2013;8(3):e58300. doi: 10.1371/journal.pone.0058300. Epub 2013 Mar 28.


Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.

Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA.

Neuropharmacology. 2013 Apr;67:46-56. doi: 10.1016/j.neuropharm.2012.10.016. Epub 2012 Nov 9.


Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA.

Anesthesiology. 2012 Oct;117(4):765-71.


Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.

Sabaliauskas N, Shen H, Homanics GE, Smith SS, Aoki C.

Brain Res. 2012 Apr 23;1450:11-23. doi: 10.1016/j.brainres.2012.02.035. Epub 2012 Feb 22.


Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.

Blednov YA, Benavidez JM, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):317-29. doi: 10.1124/jpet.111.185124. Epub 2011 Oct 28.


Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28.

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