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Items: 1 to 50 of 153

1.

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M.

J Hepatol. 2020 Jan 15. pii: S0168-8278(20)30010-6. doi: 10.1016/j.jhep.2019.12.019. [Epub ahead of print]

2.

Abnormal bone architecture in mice expressing MyD88 in cells of the osteoclast lineage.

Suren C, Lukashova L, Wischmann J, Wulsten D, Wildemann B, Von Eisenhart-Rothe R, Holzmann B, Mayer-Kuckuk P.

J Biol Regul Homeost Agents. 2019 Jul-Aug;33(4):1105-1111.

PMID:
31332987
3.

The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.

Jochheim LS, Odysseos G, Hidalgo-Sastre A, Zhong S, Staufer LM, Kroiss M, Kabacaoglu D, Lange S, Engleitner T, Hartmann D, Hüser N, Steiger K, Schmid RM, Holzmann B, von Figura G.

Pancreatology. 2019 Jun;19(4):541-547. doi: 10.1016/j.pan.2019.05.455. Epub 2019 May 11.

PMID:
31109903
4.

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M.

Nat Cell Biol. 2019 Jun;21(6):731-742. doi: 10.1038/s41556-019-0324-3. Epub 2019 May 13.

PMID:
31086261
5.

Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy.

Holtorf A, Conrad A, Holzmann B, Janssen KP.

Oncoimmunology. 2018 Jun 11;7(8):e1466770. doi: 10.1080/2162402X.2018.1466770. eCollection 2018.

6.

Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy.

Schulze S, Stöß C, Lu M, Wang B, Laschinger M, Steiger K, Altmayr F, Friess H, Hartmann D, Holzmann B, Hüser N.

Sci Rep. 2018 Aug 16;8(1):12271. doi: 10.1038/s41598-018-29924-3.

7.

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.

Friedrich C, Mamareli P, Thiemann S, Kruse F, Wang Z, Holzmann B, Strowig T, Sparwasser T, Lochner M.

PLoS Pathog. 2017 May 16;13(5):e1006357. doi: 10.1371/journal.ppat.1006357. eCollection 2017 May.

8.

Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling.

Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl AA, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T.

Cell Rep. 2016 Oct 18;17(4):1113-1127. doi: 10.1016/j.celrep.2016.09.055.

9.

Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice.

Didovic S, Opitz FV, Holzmann B, Förster I, Weighardt H.

Eur J Immunol. 2016 Apr;46(4):981-92. doi: 10.1002/eji.201545710. Epub 2016 Jan 18.

10.

Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.

Dudek M, Puttur F, Arnold-Schrauf C, Kühl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T.

Mucosal Immunol. 2016 Sep;9(5):1288-302. doi: 10.1038/mi.2015.128. Epub 2015 Dec 2.

11.

Procalcitonin ratio and on-demand relaparotomy for septic peritonitis: validation of the focus index (FI).

Assfalg V, Wolf P, Reim D, Hüser N, Hellbrügge G, Matevossian E, Friess H, Holzmann B, Emmanuel KL, Novotny AR.

Surg Today. 2016 May;46(5):603-12. doi: 10.1007/s00595-015-1226-z. Epub 2015 Jul 27.

PMID:
26212215
12.

The novel CGRP receptor antagonist BIBN4096BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus.

Glowka TR, Steinebach A, Stein K, Schwandt T, Lysson M, Holzmann B, Tsujikawa K, de Jonge WJ, Kalff JC, Wehner S.

Neurogastroenterol Motil. 2015 Jul;27(7):1038-49. doi: 10.1111/nmo.12584. Epub 2015 Apr 30.

PMID:
25929169
13.

Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4-stimulated macrophages.

Baliu-Piqué M, Jusek G, Holzmann B.

Eur J Immunol. 2014 Dec;44(12):3708-16. doi: 10.1002/eji.201444553. Epub 2014 Nov 10.

14.

Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection.

Arnold-Schrauf C, Dudek M, Dielmann A, Pace L, Swallow M, Kruse F, Kühl AA, Holzmann B, Berod L, Sparwasser T.

Cell Rep. 2014 Feb 27;6(4):698-708. doi: 10.1016/j.celrep.2014.01.023. Epub 2014 Feb 13.

15.

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.

Berod L, Stüve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini MV, Freitag J, Holzmann B, Sparwasser T.

Eur J Immunol. 2014 May;44(5):1399-409. doi: 10.1002/eji.201344039. Epub 2014 Feb 13.

16.

Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.

Wohn C, Ober-Blöbaum JL, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens EP, Clausen BE.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10723-8. doi: 10.1073/pnas.1307569110. Epub 2013 Jun 10.

17.

Antiinflammatory activities of CGRP modulating innate immune responses in health and disease.

Holzmann B.

Curr Protein Pept Sci. 2013 Jun;14(4):268-74. Review.

PMID:
23745695
18.

Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis.

Jusek G, Reim D, Tsujikawa K, Holzmann B.

Immunobiology. 2012 Aug;217(8):761-7. doi: 10.1016/j.imbio.2012.04.009. Epub 2012 May 4.

PMID:
22656887
19.

Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.

Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B.

J Immunol. 2012 Jun 15;188(12):5833-7. doi: 10.4049/jimmunol.1200038. Epub 2012 May 14.

20.

Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis.

Novotny AR, Reim D, Assfalg V, Altmayr F, Friess HM, Emmanuel K, Holzmann B.

Immunobiology. 2012 Jun;217(6):616-21. doi: 10.1016/j.imbio.2011.10.019. Epub 2011 Nov 3.

PMID:
22204813
21.

Modulation of immune responses by the neuropeptide CGRP.

Holzmann B.

Amino Acids. 2013 Jul;45(1):1-7. doi: 10.1007/s00726-011-1161-2. Epub 2011 Nov 24. Review.

PMID:
22113645
22.

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.

Schwandt T, Schumak B, Gielen GH, Jüngerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff JC, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze JL, Burgdorf S, den Haan JM, Knolle PA, Limmer A.

EMBO J. 2012 Jan 4;31(1):201-13. doi: 10.1038/emboj.2011.380. Epub 2011 Oct 28.

23.

The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.

Martini M, Gnann A, Scheikl D, Holzmann B, Janssen KP.

Int J Biochem Cell Biol. 2011 Nov;43(11):1630-40. doi: 10.1016/j.biocel.2011.07.012. Epub 2011 Jul 28.

PMID:
21820526
24.

Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response.

Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B.

J Leukoc Biol. 2011 Sep;90(3):613-20. doi: 10.1189/jlb.1110602. Epub 2011 May 31.

PMID:
21628330
25.

Interleukin-10 and -12 predict chemotherapy-associated toxicity in esophageal adenocarcinoma.

Schauer MC, Holzmann B, Peiper M, Friess H, Knoefel WT, Theisen J.

J Thorac Oncol. 2010 Nov;5(11):1849-54. doi: 10.1097/JTO.0b013e3181f19028.

26.

Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.

Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R.

Immunology. 2010 Nov;131(3):395-404. doi: 10.1111/j.1365-2567.2010.03313.x.

27.

LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming.

Balkow S, Heinz S, Schmidbauer P, Kolanus W, Holzmann B, Grabbe S, Laschinger M.

Blood. 2010 Sep 16;116(11):1885-94. doi: 10.1182/blood-2009-05-224428. Epub 2010 Jun 8.

PMID:
20530790
28.

TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.

Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B.

J Immunol. 2010 May 15;184(10):5842-8. doi: 10.4049/jimmunol.0902456. Epub 2010 Apr 7.

29.

Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival.

Doll D, Keller L, Maak M, Boulesteix AL, Siewert JR, Holzmann B, Janssen KP.

Int J Colorectal Dis. 2010 May;25(5):573-81. doi: 10.1007/s00384-010-0901-1. Epub 2010 Feb 17.

PMID:
20162422
31.

Intact LFA-1 deactivation promotes T-cell activation and rejection of cardiac allograft.

Hüser N, Fasan A, Semmrich M, Schmidbauer P, Holzmann B, Laschinger M.

Int Immunol. 2010 Jan;22(1):35-44. doi: 10.1093/intimm/dxp111. Epub 2009 Nov 27.

PMID:
19946016
32.

Procalcitonin can be used for monitoring sepsis in patients with medullary thyroid carcinoma.

Novotny AR, Luppa P, Rosenberg R, Schneider H, Maak M, Bartels H, Holzmann B, Friess H.

Thyroid. 2009 Nov;19(11):1287-9. doi: 10.1089/thy.2009.0093. No abstract available.

PMID:
19785521
33.

Calculated withdrawal of low-dose immunosuppression based on a detailed immunological monitoring after kidney transplantation between monocygotic twins.

Hüser N, Matevossian E, Schmidbauer P, Assfalg V, Scherberich JE, Stangl M, Holzmann B, Friess H, Laschinger M.

Transpl Immunol. 2009 Dec;22(1-2):38-43. doi: 10.1016/j.trim.2009.09.002. Epub 2009 Sep 17.

PMID:
19766188
34.

Combined immunosuppressive and antibiotic therapy improves bacterial clearance and survival of polymicrobial septic peritonitis.

Assfalg V, Hüser N, Reim D, Kaiser-Moore S, Rossmann-Bloeck T, Weighardt H, Novotny AR, Stangl MJ, Holzmann B, Emmanuel KL.

Shock. 2010 Feb;33(2):155-61. doi: 10.1097/SHK.0b013e3181ab9014.

PMID:
19487979
35.

Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer.

Anjomshoaa A, Lin YH, Black MA, McCall JL, Humar B, Song S, Fukuzawa R, Yoon HS, Holzmann B, Friederichs J, van Rij A, Thompson-Fawcett M, Reeve AE.

Br J Cancer. 2008 Sep 16;99(6):966-73.

36.

Procalcitonin ratio indicates successful surgical treatment of abdominal sepsis.

Novotny AR, Emmanuel K, Hueser N, Knebel C, Kriner M, Ulm K, Bartels H, Siewert JR, Holzmann B.

Surgery. 2009 Jan;145(1):20-6. doi: 10.1016/j.surg.2008.08.009. Epub 2008 Sep 26.

PMID:
19081471
37.

Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice.

Scheikl T, Reis B, Pfeffer K, Holzmann B, Beer S.

Mol Immunol. 2009 Feb;46(5):969-77. doi: 10.1016/j.molimm.2008.09.023. Epub 2008 Oct 31.

PMID:
18950867
38.

Informatics and medicine--from molecules to populations.

Kuhn KA, Knoll A, Mewes HW, Schwaiger M, Bode A, Broy M, Daniel H, Feussner H, Gradinger R, Hauner H, Höfler H, Holzmann B, Horsch A, Kemper A, Krcmar H, Kochs EF, Lange R, Leidl R, Mansmann U, Mayr EW, Meitinger T, Molls M, Navab N, Nüsslin F, Peschel C, Reiser M, Ring J, Rummeny EJ, Schlichter J, Schmid R, Wichmann HE, Ziegler S.

Methods Inf Med. 2008;47(4):283-95.

PMID:
18690362
39.

Role of T cells for cytokine production and outcome in a model of acute septic peritonitis.

Reim D, Westenfelder K, Kaiser-Moore S, Schlautkötter S, Holzmann B, Weighardt H.

Shock. 2009 Mar;31(3):245-50. doi: 10.1097/SHK.0b013e31817fd02c.

PMID:
18650777
40.

Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.

Sewald X, Gebert-Vogl B, Prassl S, Barwig I, Weiss E, Fabbri M, Osicka R, Schiemann M, Busch DH, Semmrich M, Holzmann B, Sebo P, Haas R.

Cell Host Microbe. 2008 Jan 17;3(1):20-9. doi: 10.1016/j.chom.2007.11.003.

41.

Role of Toll-like receptor responses for sepsis pathogenesis.

Weighardt H, Holzmann B.

Immunobiology. 2007;212(9-10):715-22. Epub 2007 Nov 26. Review.

PMID:
18086373
42.

Correlation of CK-20-positive cells in peripheral venous blood with serum CEA levels in patients with colorectal carcinoma.

Friederichs J, Gertler R, Rosenberg R, Dahm M, Nekarda H, Holzmann B, Siewert JR.

World J Surg. 2007 Dec;31(12):2329-34.

PMID:
17914651
43.

Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER.

Harzenetter MD, Novotny AR, Gais P, Molina CA, Altmayr F, Holzmann B.

J Immunol. 2007 Jul 1;179(1):607-15.

44.

Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.

Rohde F, Rimkus C, Friederichs J, Rosenberg R, Marthen C, Doll D, Holzmann B, Siewert JR, Janssen KP.

Int J Cancer. 2007 Oct 15;121(8):1717-23.

45.

Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis.

Novotny A, Emmanuel K, Matevossian E, Kriner M, Ulm K, Bartels H, Holzmann B, Weighardt H, Siewert JR.

Am J Surg. 2007 Jul;194(1):35-9.

PMID:
17560906
46.

Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome.

Novotny AR, Emmanuel K, Maier S, Westerholt A, Weighardt H, Stadler J, Bartels H, Schwaiger M, Siewert JR, Holzmann B, Heidecke CD.

Surgery. 2007 Mar;141(3):376-84. Epub 2007 Jan 22.

PMID:
17349850
47.

Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis.

Weber GF, Schlautkötter S, Kaiser-Moore S, Altmayr F, Holzmann B, Weighardt H.

Infect Immun. 2007 Apr;75(4):1690-7. Epub 2007 Jan 29.

48.

Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer.

Lin YH, Friederichs J, Black MA, Mages J, Rosenberg R, Guilford PJ, Phillips V, Thompson-Fawcett M, Kasabov N, Toro T, Merrie AE, van Rij A, Yoon HS, McCall JL, Siewert JR, Holzmann B, Reeve AE.

Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):498-507.

49.

RhoH is important for positive thymocyte selection and T-cell receptor signaling.

Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B, Klinkert WE, Straten PT, Køllgaard T, Sixt M, Brakebusch C.

Blood. 2007 Mar 15;109(6):2346-55. Epub 2006 Nov 21.

PMID:
17119112
50.

IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase.

Weber GF, Gaertner FC, Erl W, Janssen KP, Blechert B, Holzmann B, Weighardt H, Essler M.

J Immunol. 2006 Dec 1;177(11):8266-72.

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