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Items: 1 to 50 of 96

1.

The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes.

Arif E, Solanki AK, Srivastava P, Rahman B, Tash BR, Holzman LB, Janech MG, Martin R, Knölker HJ, Fitzgibbon WR, Deng P, Budisavljevic MN, Syn WK, Wang C, Lipschutz JH, Kwon SH, Nihalani D.

Kidney Int. 2019 Mar 4. pii: S0085-2538(19)30266-2. doi: 10.1016/j.kint.2019.02.014. [Epub ahead of print]

PMID:
31097328
2.

Health-related quality of life in glomerular disease.

Canetta PA, Troost JP, Mahoney S, Kogon AJ, Carlozzi N, Bartosh SM, Cai Y, Davis TK, Fernandez H, Fornoni A, Gbadegesin RA, Herreshoff E, Mahan JD, Nachman PH, Selewski DT, Sethna CB, Srivastava T, Tuttle KR, Wang CS, Falk RJ, Gharavi AG, Gillespie BW, Greenbaum LA, Holzman LB, Kretzler M, Robinson BM, Smoyer WE, Guay-Woodford LM, Reeve B, Gipson DS; CureGN Consortium.

Kidney Int. 2019 May;95(5):1209-1224. doi: 10.1016/j.kint.2018.12.018. Epub 2019 Feb 27.

PMID:
30898342
3.

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Selewski DT, Ambruzs JM, Appel GB, Bomback AS, Matar RB, Cai Y, Cattran DC, Chishti AS, D'Agati VD, D'Alessandri-Silva CJ, Gbadegesin RA, Hogan JJ, Iragorri S, Jennette JC, Julian BA, Khalid M, Lafayette RA, Liapis H, Lugani F, Mansfield SA, Mason S, Nachman PH, Nast CC, Nester CM, Noone DG, Novak J, O'Shaughnessy MM, Reich HN, Rheault MN, Rizk DV, Saha MK, Sanghani NS, Sperati CJ, Sreedharan R, Srivastava T, Swiatecka-Urban A, Twombley K, Vasylyeva TL, Weaver DJ, Yin H, Zee J, Falk RJ, Gharavi AG, Gillespie BW, Gipson DS, Greenbaum LA, Holzman LB, Kretzler M, Robinson BM, Smoyer WE, Flessner M, Guay-Woodford LM, Kiryluk K; CureGN Consortium.

Kidney Int Rep. 2018 Aug 3;3(6):1373-1384. doi: 10.1016/j.ekir.2018.07.021. eCollection 2018 Nov.

4.

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Mariani LH, Bomback AS, Canetta PA, Flessner MF, Helmuth M, Hladunewich MA, Hogan JJ, Kiryluk K, Nachman PH, Nast CC, Rheault MN, Rizk DV, Trachtman H, Wenderfer SE, Bowers C, Hill-Callahan P, Marasa M, Poulton CJ, Revell A, Vento S, Barisoni L, Cattran D, D'Agati V, Jennette JC, Klein JB, Laurin LP, Twombley K, Falk RJ, Gharavi AG, Gillespie BW, Gipson DS, Greenbaum LA, Holzman LB, Kretzler M, Robinson B, Smoyer WE, Guay-Woodford LM; CureGN Consortium.

Am J Kidney Dis. 2019 Feb;73(2):218-229. doi: 10.1053/j.ajkd.2018.07.020. Epub 2018 Nov 9.

PMID:
30420158
5.

Reproducibility and Feasibility of Strategies for Morphologic Assessment of Renal Biopsies Using the Nephrotic Syndrome Study Network Digital Pathology Scoring System.

Zee J, Hodgin JB, Mariani LH, Gaut JP, Palmer MB, Bagnasco SM, Rosenberg AZ, Hewitt SM, Holzman LB, Gillespie BW, Barisoni L.

Arch Pathol Lab Med. 2018 May;142(5):613-625. doi: 10.5858/arpa.2017-0181-OA. Epub 2018 Feb 19.

6.

ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics.

Lin JS, Jeon JS, Fan Q, Wong HN, Palmer MB, Holzman LB.

PLoS One. 2017 Sep 7;12(9):e0184575. doi: 10.1371/journal.pone.0184575. eCollection 2017.

7.

Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology.

Barisoni L, Gimpel C, Kain R, Laurinavicius A, Bueno G, Zeng C, Liu Z, Schaefer F, Kretzler M, Holzman LB, Hewitt SM.

Clin Kidney J. 2017 Apr;10(2):176-187. doi: 10.1093/ckj/sfw129. Epub 2017 Feb 18.

8.

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.

Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B.

Sci Rep. 2016 Aug 11;6:31482. doi: 10.1038/srep31482.

9.

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.

Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman LB, Giger RJ, DiAntonio A, Collins C.

Elife. 2016 Jun 7;5. pii: e14048. doi: 10.7554/eLife.14048.

10.

Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1.

Arif E, Sharma P, Solanki A, Mallik L, Rathore YS, Twal WO, Nath SK, Gandhi D, Holzman LB, Ostap EM, Ashish, Nihalani D.

Mol Cell Biol. 2016 May 16;36(11):1639-54. doi: 10.1128/MCB.00020-16. Print 2016 Jun 1.

11.

FAT1 mutations cause a glomerulotubular nephropathy.

Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F.

Nat Commun. 2016 Feb 24;7:10822. doi: 10.1038/ncomms10822.

12.

Complete Remission in the Nephrotic Syndrome Study Network.

Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson PJ, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova O, Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley KV, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, Mokrzycki MH, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M.

Clin J Am Soc Nephrol. 2016 Jan 7;11(1):81-9. doi: 10.2215/CJN.02560315. Epub 2015 Dec 10.

13.

Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys.

Li X, Chuang PY, D'Agati VD, Dai Y, Yacoub R, Fu J, Xu J, Taku O, Premsrirut PK, Holzman LB, He JC.

J Am Soc Nephrol. 2015 Oct;26(10):2361-77. doi: 10.1681/ASN.2014040405. Epub 2015 Feb 2.

14.

Ret is critical for podocyte survival following glomerular injury in vivo.

Hou G, Wu V, Singh G, Holzman LB, Tsui CC.

Am J Physiol Renal Physiol. 2015 Apr 1;308(7):F774-83. doi: 10.1152/ajprenal.00483.2014. Epub 2015 Jan 13.

15.

A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease.

Spinale JM, Mariani LH, Kapoor S, Zhang J, Weyant R, Song PX, Wong HN, Troost JP, Gadegbeku CA, Gipson DS, Kretzler M, Nihalani D, Holzman LB; Nephrotic Syndrome Study Network.

Kidney Int. 2015 Mar;87(3):564-74. doi: 10.1038/ki.2014.346. Epub 2014 Oct 29.

16.

The kidney research national dialogue: gearing up to move forward.

Bonventre JV, Boulware LE, Dember LM, Freedman BI, Furth SL, Holzman LB, Ketchum CJ, Little MH, Mehrotra R, Moe SM, Sands JM, Sedor JR, Somlo S, Star RA, Rys-Sikora KE; Kidney Research National Dialogue (KRND).

Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1806-11. doi: 10.2215/CJN.07310714. Epub 2014 Sep 15. Review.

17.

Glomerular disease: looking beyond pathology.

Wiggins RC, Alpers CE, Holzman LB, He JC, Salant DJ, Chugh SS, Natarajan R, Trachtman H, Brasile L, Star RA, Rys-Sikora KE, Moxey-Mims MM, Flessner MF; Kidney Research National Dialogue.

Clin J Am Soc Nephrol. 2014 Jun 6;9(6):1138-40. doi: 10.2215/CJN.01450214. Epub 2014 Apr 3.

18.

Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury.

Arif E, Rathore YS, Kumari B, Ashish F, Wong HN, Holzman LB, Nihalani D.

J Biol Chem. 2014 Apr 4;289(14):9502-18. doi: 10.1074/jbc.M113.505743. Epub 2014 Feb 19.

19.

Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S.

J Clin Invest. 2014 Mar;124(3):1098-113. doi: 10.1172/JCI69778. Epub 2014 Feb 17. Erratum in: J Clin Invest. 2015 Feb;125(2):882.

20.

Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.

George B, Fan Q, Dlugos CP, Soofi AA, Zhang J, Verma R, Park TJ, Wong H, Curran T, Nihalani D, Holzman LB.

Kidney Int. 2014 Jun;85(6):1382-1394. doi: 10.1038/ki.2013.556. Epub 2014 Feb 5.

21.

Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy.

Johnstone DB, Ikizler O, Zhang J, Holzman LB.

PLoS One. 2013 Jul 10;8(7):e67839. doi: 10.1371/journal.pone.0067839. Print 2013.

22.

KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis.

Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH, Somers MJ, Trachtman H, Waldman M.

Am J Kidney Dis. 2013 Sep;62(3):403-41. doi: 10.1053/j.ajkd.2013.06.002. Epub 2013 Jul 18. Review. Erratum in: Am J Kidney Dis. 2017 Mar;69(3):485.

PMID:
23871408
23.

Myo1c is an unconventional myosin required for zebrafish glomerular development.

Arif E, Kumari B, Wagner MC, Zhou W, Holzman LB, Nihalani D.

Kidney Int. 2013 Dec;84(6):1154-65. doi: 10.1038/ki.2013.201. Epub 2013 May 29.

24.

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.

Blattner SM, Hodgin JB, Nishio M, Wylie SA, Saha J, Soofi AA, Vining C, Randolph A, Herbach N, Wanke R, Atkins KB, Gyung Kang H, Henger A, Brakebusch C, Holzman LB, Kretzler M.

Kidney Int. 2013 Nov;84(5):920-30. doi: 10.1038/ki.2013.175. Epub 2013 May 15.

25.

Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach.

Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PX, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KE, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M.

Kidney Int. 2013 Apr;83(4):749-56. doi: 10.1038/ki.2012.428. Epub 2013 Jan 16.

26.

APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis.

Johnstone DB, Shegokar V, Nihalani D, Rathore YS, Mallik L, Ashish, Zare V, Ikizler HO, Powar R, Holzman LB.

PLoS One. 2012;7(12):e51546. doi: 10.1371/journal.pone.0051546. Epub 2012 Dec 26.

27.

Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.

Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S.

J Clin Invest. 2012 Dec;122(12):4401-11. doi: 10.1172/JCI65289. Epub 2012 Nov 26.

28.

Signaling from the podocyte intercellular junction to the actin cytoskeleton.

George B, Holzman LB.

Semin Nephrol. 2012 Jul;32(4):307-18. doi: 10.1016/j.semnephrol.2012.06.002. Review.

29.

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.

Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W.

Cell Rep. 2012 Jul 26;2(1):52-61. doi: 10.1016/j.celrep.2012.06.002. Epub 2012 Jul 12.

30.

Podocyte-specific knockout of myosin 1e disrupts glomerular filtration.

Chase SE, Encina CV, Stolzenburg LR, Tatum AH, Holzman LB, Krendel M.

Am J Physiol Renal Physiol. 2012 Oct;303(7):F1099-106. doi: 10.1152/ajprenal.00251.2012. Epub 2012 Jul 18.

31.

Podocytes: gaining a foothold.

Garg P, Holzman LB.

Exp Cell Res. 2012 May 15;318(9):955-63. doi: 10.1016/j.yexcr.2012.02.030. Epub 2012 Mar 7. Review.

PMID:
22421512
32.

Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS).

Mallik L, Arif E, Sharma P, Rathore YS, Wong HN, Holzman LB, Ashish, Nihalani D.

J Biol Chem. 2012 Mar 16;287(12):9441-53. doi: 10.1074/jbc.M111.284927. Epub 2012 Jan 17.

33.

Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.

George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB.

J Clin Invest. 2012 Feb;122(2):674-92. doi: 10.1172/JCI60070. Epub 2012 Jan 17.

34.

Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival.

Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K.

J Biol Chem. 2011 Jul 22;286(29):26003-15. doi: 10.1074/jbc.M111.223164. Epub 2011 May 25.

35.

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.

Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL.

J Clin Invest. 2011 Jun;121(6):2181-96. doi: 10.1172/JCI44771. Epub 2011 May 23.

36.

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.

Zhdanova O, Srivastava S, Di L, Li Z, Tchelebi L, Dworkin S, Johnstone DB, Zavadil J, Chong MM, Littman DR, Holzman LB, Barisoni L, Skolnik EY.

Kidney Int. 2011 Oct;80(7):719-30. doi: 10.1038/ki.2011.122. Epub 2011 May 4.

37.

Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.

Johnstone DB, Zhang J, George B, Léon C, Gachet C, Wong H, Parekh R, Holzman LB.

Mol Cell Biol. 2011 May;31(10):2162-70. doi: 10.1128/MCB.05234-11. Epub 2011 Mar 14.

38.

Deletion of von Hippel-Lindau in glomerular podocytes results in glomerular basement membrane thickening, ectopic subepithelial deposition of collagen {alpha}1{alpha}2{alpha}1(IV), expression of neuroglobin, and proteinuria.

Steenhard BM, Isom K, Stroganova L, St John PL, Zelenchuk A, Freeburg PB, Holzman LB, Abrahamson DR.

Am J Pathol. 2010 Jul;177(1):84-96. doi: 10.2353/ajpath.2010.090767. Epub 2010 Jun 3.

39.

Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture.

Garg P, Verma R, Cook L, Soofi A, Venkatareddy M, George B, Mizuno K, Gurniak C, Witke W, Holzman LB.

J Biol Chem. 2010 Jul 16;285(29):22676-88. doi: 10.1074/jbc.M110.122929. Epub 2010 May 15.

40.

Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria.

Dai C, Saleem MA, Holzman LB, Mathieson P, Liu Y.

Kidney Int. 2010 Jun;77(11):962-73. doi: 10.1038/ki.2010.40. Epub 2010 Mar 10.

41.

Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice.

Zhang H, Schin M, Saha J, Burke K, Holzman LB, Filipiak W, Saunders T, Xiang M, Heilig CW, Brosius FC 3rd.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F91-8. doi: 10.1152/ajprenal.00021.2010. Epub 2010 Apr 7.

42.

Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria.

Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y.

J Am Soc Nephrol. 2009 Sep;20(9):1997-2008. doi: 10.1681/ASN.2009010019. Epub 2009 Jul 23.

43.

Initial insight on the determinants of podocyte polarity.

Holzman LB, Garg P.

J Am Soc Nephrol. 2009 Apr;20(4):683-5. doi: 10.1681/ASN.2009020217. Epub 2009 Mar 25. No abstract available.

44.

A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype.

Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN.

Kidney Blood Press Res. 2008;31(6):421-32. doi: 10.1159/000190788. Epub 2009 Jan 14.

45.

Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1.

Wagner MC, Rhodes G, Wang E, Pruthi V, Arif E, Saleem MA, Wean SE, Garg P, Verma R, Holzman LB, Gattone V, Molitoris BA, Nihalani D.

J Biol Chem. 2008 Dec 19;283(51):35579-89. doi: 10.1074/jbc.M805507200. Epub 2008 Oct 14.

46.

Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus.

Jia Q, McDill BW, Sankarapandian B, Wu S, Liapis H, Holzman LB, Capecchi MR, Miner JH, Chen F.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1790-8. doi: 10.1152/ajprenal.90519.2008. Epub 2008 Oct 8.

47.

Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.

Shi S, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP.

J Am Soc Nephrol. 2008 Nov;19(11):2159-69. doi: 10.1681/ASN.2008030312. Epub 2008 Sep 5.

48.

Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria.

Chen S, Wassenhove-McCarthy DJ, Yamaguchi Y, Holzman LB, van Kuppevelt TH, Jenniskens GJ, Wijnhoven TJ, Woods AC, McCarthy KJ.

Kidney Int. 2008 Aug;74(3):289-99. doi: 10.1038/ki.2008.159. Epub 2008 May 14.

49.

Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity.

Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R.

Dev Biol. 2008 Apr 15;316(2):288-301. doi: 10.1016/j.ydbio.2008.01.022. Epub 2008 Jan 31.

50.

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.

Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB.

Mol Cell Biol. 2007 Dec;27(24):8698-712. Epub 2007 Oct 8.

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