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HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology.

Berndt N, Bulik S, Wallach I, Wünsch T, König M, Stockmann M, Meierhofer D, Holzhütter HG.

Nat Commun. 2018 Jun 19;9(1):2386. doi: 10.1038/s41467-018-04720-9.


Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction.

Borchert A, Kalms J, Roth SR, Rademacher M, Schmidt A, Holzhutter HG, Kuhn H, Scheerer P.

Biochim Biophys Acta. 2018 Sep;1863(9):1095-1107. doi: 10.1016/j.bbalip.2018.06.006. Epub 2018 Jun 5.


US Time-Harmonic Elastography: Detection of Liver Fibrosis in Adolescents with Extreme Obesity with Nonalcoholic Fatty Liver Disease.

Hudert CA, Tzschätzsch H, Guo J, Rudolph B, Bläker H, Loddenkemper C, Luck W, Müller HP, Baumgart DC, Hamm B, Braun J, Holzhütter HG, Wiegand S, Sack I.

Radiology. 2018 Jul;288(1):99-106. doi: 10.1148/radiol.2018172928. Epub 2018 May 15.


Correction: The importance of membrane microdomains for bile salt-dependent biliary lipid secretion (doi:10.1242/jcs.211524).

Eckstein J, Holzhütter HG, Berndt N.

J Cell Sci. 2018 Mar 19;131(6). pii: jcs217414. doi: 10.1242/jcs.217414. No abstract available.


A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.

Berndt N, Horger MS, Bulik S, Holzhütter HG.

PLoS Comput Biol. 2018 Feb 15;14(2):e1006005. doi: 10.1371/journal.pcbi.1006005. eCollection 2018 Feb.


The importance of membrane microdomains for bile salt-dependent biliary lipid secretion.

Eckstein J, Holzhütter HG, Berndt N.

J Cell Sci. 2018 Mar 1;131(5). pii: jcs211524. doi: 10.1242/jcs.211524. Erratum in: J Cell Sci. 2018 Mar 19;131(6):.


Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.

Kürschner G, Zhang Q, Clima R, Xiao Y, Busch JF, Kilic E, Jung K, Berndt N, Bulik S, Holzhütter HG, Gasparre G, Attimonelli M, Babu M, Meierhofer D.

Oncotarget. 2017 Nov 11;8(62):105882-105904. doi: 10.18632/oncotarget.22413. eCollection 2017 Dec 1.


Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus.

Schneider J, Berndt N, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O.

J Cereb Blood Flow Metab. 2017 Jan 1:271678X17740091. doi: 10.1177/0271678X17740091. [Epub ahead of print]


A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis.

Wallstab C, Eleftheriadou D, Schulz T, Damm G, Seehofer D, Borlak J, Holzhütter HG, Berndt N.

FEBS J. 2017 Oct;284(19):3245-3261. doi: 10.1111/febs.14189. Epub 2017 Sep 6.


The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity.

Kalms J, Banthiya S, Galemou Yoga E, Hamberg M, Holzhutter HG, Kuhn H, Scheerer P.

Biochim Biophys Acta. 2017 May;1862(5):463-473. doi: 10.1016/j.bbalip.2017.01.003. Epub 2017 Jan 14.


Targeting pathogen metabolism without collateral damage to the host.

Haanstra JR, Gerding A, Dolga AM, Sorgdrager FJH, Buist-Homan M, du Toit F, Faber KN, Holzhütter HG, Szöör B, Matthews KR, Snoep JL, Westerhoff HV, Bakker BM.

Sci Rep. 2017 Jan 13;7:40406. doi: 10.1038/srep40406.


Mathematical Modeling of Cellular Metabolism.

Berndt N, Holzhütter HG.

Recent Results Cancer Res. 2016;207:221-32. doi: 10.1007/978-3-319-42118-6_10. Review.


Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice.

Abshagen K, König M, Hoppe A, Müller I, Ebert M, Weng H, Holzhütter HG, Zanger UM, Bode J, Vollmar B, Thomas M, Dooley S.

BMC Syst Biol. 2015 Nov 20;9:83. doi: 10.1186/s12918-015-0229-0.


Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes.

Liepe J, Holzhütter HG, Bellavista E, Kloetzel PM, Stumpf MP, Mishto M.

Elife. 2015 Sep 22;4:e07545. doi: 10.7554/eLife.07545.


Regulation of liver metabolism by the endosomal GTPase Rab5.

Zeigerer A, Bogorad RL, Sharma K, Gilleron J, Seifert S, Sales S, Berndt N, Bulik S, Marsico G, D'Souza RCJ, Lakshmanaperumal N, Meganathan K, Natarajan K, Sachinidis A, Dahl A, Holzhütter HG, Shevchenko A, Mann M, Koteliansky V, Zerial M.

Cell Rep. 2015 May 12;11(6):884-892. doi: 10.1016/j.celrep.2015.04.018. Epub 2015 Apr 30.


Joint effect of unlinked genotypes: application to type 2 diabetes in the EPIC-Potsdam case-cohort study.

Knüppel S, Meidtner K, Arregui M, Holzhütter HG, Boeing H.

Ann Hum Genet. 2015 Jul;79(4):253-63. doi: 10.1111/ahg.12115. Epub 2015 Apr 23.


Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients.

Berndt N, Kann O, Holzhütter HG.

J Cereb Blood Flow Metab. 2015 Sep;35(9):1494-506. doi: 10.1038/jcbfm.2015.70. Epub 2015 Apr 22.


Sequential metabolic phases as a means to optimize cellular output in a constant environment.

Palinkas A, Bulik S, Bockmayr A, Holzhütter HG.

PLoS One. 2015 Mar 18;10(3):e0118347. doi: 10.1371/journal.pone.0118347. eCollection 2015.


Computer simulations suggest a key role of membranous nanodomains in biliary lipid secretion.

Eckstein J, Berndt N, Holzhütter HG.

PLoS Comput Biol. 2015 Feb 18;11(2):e1004033. doi: 10.1371/journal.pcbi.1004033. eCollection 2015 Feb.


The virtual liver: state of the art and future perspectives.

Drasdo D, Bode J, Dahmen U, Dirsch O, Dooley S, Gebhardt R, Ghallab A, Godoy P, Häussinger D, Hammad S, Hoehme S, Holzhütter HG, Klingmüller U, Kuepfer L, Timmer J, Zerial M, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2071-5. doi: 10.1007/s00204-014-1384-6. No abstract available.


Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach.

Ricken T, Werner D, Holzhütter HG, König M, Dahmen U, Dirsch O.

Biomech Model Mechanobiol. 2015 Jun;14(3):515-36. doi: 10.1007/s10237-014-0619-z. Epub 2014 Sep 19.


SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques.

Bölling C, Weidlich M, Holzhütter HG.

J Biomed Semantics. 2014 Jun 3;5(Suppl 1 Proceedings of the Bio-Ontologies Spec Interest G):S1. doi: 10.1186/2041-1480-5-S1-S1. eCollection 2014.


Modelling proteasome and proteasome regulator activities.

Liepe J, Holzhütter HG, Kloetzel PM, Stumpf MP, Mishto M.

Biomolecules. 2014 Jun 20;4(2):585-99. doi: 10.3390/biom4020585. Review.


Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.


Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test.

Holzhütter HG, Lock JF, Taheri P, Bulik S, Goede A, Stockmann M.

PLoS One. 2013 Aug 15;8(8):e70780. doi: 10.1371/journal.pone.0070780. eCollection 2013.


Rapid degradation of solid-phase bound peptides by the 20S proteasome.

Hovestädt M, Kuckelkorn U, Niewienda A, Keller C, Goede A, Ay B, Günther S, Janek K, Volkmer R, Holzhütter HG.

J Pept Sci. 2013 Sep;19(9):588-97. doi: 10.1002/psc.2536. Epub 2013 Jul 28.


Evaluation of 41 candidate gene variants for obesity in the EPIC-Potsdam cohort by multi-locus stepwise regression.

Knüppel S, Rohde K, Meidtner K, Drogan D, Holzhütter HG, Boeing H, Fisher E.

PLoS One. 2013 Jul 12;8(7):e68941. doi: 10.1371/journal.pone.0068941. Print 2013.


Metabolic gradients as key regulators in zonation of tumor energy metabolism: a tissue-scale model-based study.

König M, Holzhütter HG, Berndt N.

Biotechnol J. 2013 Sep;8(9):1058-69. doi: 10.1002/biot.201200393. Epub 2013 Jun 26.


The high energy demand of neuronal cells caused by passive leak currents is not a waste of energy.

Berndt N, Holzhütter HG.

Cell Biochem Biophys. 2013 Nov;67(2):527-35. doi: 10.1007/s12013-013-9538-3.


Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network.

Huchzermeyer C, Berndt N, Holzhütter HG, Kann O.

J Cereb Blood Flow Metab. 2013 Feb;33(2):263-71. doi: 10.1038/jcbfm.2012.165. Epub 2012 Nov 21.


Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy.

König M, Holzhütter HG.

J Biol Chem. 2012 Oct 26;287(44):36978-89. doi: 10.1074/jbc.M112.382069. Epub 2012 Sep 12.


Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism.

Bazzani S, Hoppe A, Holzhütter HG.

BMC Syst Biol. 2012 Aug 31;6:118. doi: 10.1186/1752-0509-6-118.


CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism.

Karlstädt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG.

BMC Syst Biol. 2012 Aug 29;6:114. doi: 10.1186/1752-0509-6-114.


CySBML: a Cytoscape plugin for SBML.

König M, Dräger A, Holzhütter HG.

Bioinformatics. 2012 Sep 15;28(18):2402-3. doi: 10.1093/bioinformatics/bts432. Epub 2012 Jul 5.


Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism.

König M, Bulik S, Holzhütter HG.

PLoS Comput Biol. 2012;8(6):e1002577. doi: 10.1371/journal.pcbi.1002577. Epub 2012 Jun 21.


A hypothetical model of cargo-selective rab recruitment during organelle maturation.

Binder B, Holzhütter HG.

Cell Biochem Biophys. 2012 May;63(1):59-71. doi: 10.1007/s12013-012-9341-6.


Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis.

Knüppel S, Esparza-Gordillo J, Marenholz I, Holzhütter HG, Bauerfeind A, Ruether A, Weidinger S, Lee YA, Rohde K.

BMC Med Genet. 2012 Jan 27;13:8. doi: 10.1186/1471-2350-13-8.


The virtual liver: a multidisciplinary, multilevel challenge for systems biology.

Holzhütter HG, Drasdo D, Preusser T, Lippert J, Henney AM.

Wiley Interdiscip Rev Syst Biol Med. 2012 May-Jun;4(3):221-35. doi: 10.1002/wsbm.1158. Epub 2012 Jan 13.


Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore .

Hoppe A, Ilkavets I, Dooley S, Holzhütter HG.

Metabolites. 2012 Nov 21;2(4):983-1003. doi: 10.3390/metabo2040983.


Metannogen: annotation of biological reaction networks.

Gille C, Hübner K, Hoppe A, Holzhütter HG.

Bioinformatics. 2011 Oct 1;27(19):2763-4. doi: 10.1093/bioinformatics/btr456. Epub 2011 Aug 8.


Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes.

Hoppe A, Richter C, Holzhütter HG.

Biosystems. 2011 Aug;105(2):122-9. doi: 10.1016/j.biosystems.2011.05.006. Epub 2011 Jun 2. No abstract available.


Enzymatic features of the glucose metabolism in tumor cells.

Herling A, König M, Bulik S, Holzhütter HG.

FEBS J. 2011 Jul;278(14):2436-59. doi: 10.1111/j.1742-4658.2011.08174.x. Epub 2011 Jun 10. Review.


The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model.

Berndt N, Hoffmann S, Benda J, Holzhütter HG.

J Theor Biol. 2011 May 7;276(1):42-9. doi: 10.1016/j.jtbi.2011.01.022. Epub 2011 Feb 2.


FASIMU: flexible software for flux-balance computation series in large metabolic networks.

Hoppe A, Hoffmann S, Gerasch A, Gille C, Holzhütter HG.

BMC Bioinformatics. 2011 Jan 22;12:28. doi: 10.1186/1471-2105-12-28.


HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology.

Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG.

Mol Syst Biol. 2010 Sep 7;6:411. doi: 10.1038/msb.2010.62.


Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

Huthmacher C, Hoppe A, Bulik S, Holzhütter HG.

BMC Syst Biol. 2010 Aug 31;4:120. doi: 10.1186/1752-0509-4-120.


Fluxviz - Cytoscape plug-in for visualization of flux distributions in networks.

König M, Holzhütter HG.

Genome Inform. 2010;24:96-103.


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