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Items: 1 to 50 of 371

1.

The contamination of valsartan and other sartans, Part 2: Untargeted screening reveals contamination with amides additionally to known nitrosamine impurities.

Scherf-Clavel O, Kinzig M, Besa A, Schreiber A, Bidmon C, Abdel-Tawab M, Wohlfart J, Sörgel F, Holzgrabe U.

J Pharm Biomed Anal. 2019 Apr 16;172:278-284. doi: 10.1016/j.jpba.2019.04.035. [Epub ahead of print]

PMID:
31078064
2.

Enantioseparation by Capillary Electrophoresis Using Cyclodextrins in an Amino Acid-Based Ionic Liquid Running Buffer.

Wahl J, Holzgrabe U.

Methods Mol Biol. 2019;1985:365-371. doi: 10.1007/978-1-4939-9438-0_20.

PMID:
31069745
3.

Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist.

Riefolo F, Matera C, Garrido-Charles A, Gomila AMJ, Sortino R, Agnetta L, Claro E, Masgrau R, Holzgrabe U, Batlle M, Decker M, Guasch E, Gorostiza P.

J Am Chem Soc. 2019 May 8;141(18):7628-7636. doi: 10.1021/jacs.9b03505. Epub 2019 Apr 26.

PMID:
31010281
4.

Reply to "Requirements for accurate 1H NMR quantification of mineral oil hydrocarbons (paraffins) for pharmaceutical or cosmetic use".

Urlaub J, Norwig J, Schollmayer C, Holzgrabe U.

J Pharm Biomed Anal. 2019 Jul 15;171:235-237. doi: 10.1016/j.jpba.2019.04.020. Epub 2019 Apr 10. No abstract available.

PMID:
31003701
5.

A long-time stability study of 50 drug substances representing common drug classes of pharmaceutical use.

Zilker M, Sörgel F, Holzgrabe U.

Drug Test Anal. 2019 Mar 25. doi: 10.1002/dta.2593. [Epub ahead of print]

PMID:
30912309
6.

Quantitative structure-property relationship modeling of polar analytes lacking UV chromophores to charged aerosol detector response.

Schilling K, Krmar J, Maljurić N, Pawellek R, Protić A, Holzgrabe U.

Anal Bioanal Chem. 2019 May;411(13):2945-2959. doi: 10.1007/s00216-019-01744-y. Epub 2019 Mar 26.

PMID:
30911799
7.

1H NMR analytical characterization of mineral oil hydrocarbons (PARAFFINS) for pharmaceutical use.

Urlaub J, Norwig J, Schollmayer C, Holzgrabe U.

J Pharm Biomed Anal. 2019 May 30;169:41-48. doi: 10.1016/j.jpba.2019.01.036. Epub 2019 Feb 21.

PMID:
30831451
8.

Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties.

Agnetta L, Bermudez M, Riefolo F, Matera C, Claro E, Messerer R, Littmann T, Wolber G, Holzgrabe U, Decker M.

J Med Chem. 2019 Mar 28;62(6):3009-3020. doi: 10.1021/acs.jmedchem.8b01822. Epub 2019 Mar 19.

PMID:
30827105
9.

A systematic review of the stability of finished pharmaceutical products and drug substances beyond their labeled expiry dates.

Zilker M, Sörgel F, Holzgrabe U.

J Pharm Biomed Anal. 2019 Mar 20;166:222-235. doi: 10.1016/j.jpba.2019.01.016. Epub 2019 Jan 11. Review.

PMID:
30660807
10.

Zwitterionic-hydrophilic interaction liquid chromatography for l-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy.

Xu X, Urlaub J, Woźniczka M, Wynendaele E, Herman K, Schollmayer C, Diehl B, Van Calenbergh S, Holzgrabe U, De Spiegeleer B.

J Pharm Biomed Anal. 2019 Feb 20;165:338-345. doi: 10.1016/j.jpba.2018.12.010. Epub 2018 Dec 7.

PMID:
30579234
11.

Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer's Disease.

Volpato D, Holzgrabe U.

Molecules. 2018 Dec 7;23(12). pii: E3230. doi: 10.3390/molecules23123230. Review.

12.

Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones.

Parlar S, Sayar G, Tarikogullari AH, Karadagli SS, Alptuzun V, Erciyas E, Holzgrabe U.

Bioorg Chem. 2018 Nov 28. pii: S0045-2068(18)30889-7. doi: 10.1016/j.bioorg.2018.11.051. [Epub ahead of print]

PMID:
30538051
13.

Determination of plasma protein binding for sympathomimetic drugs by means of ultrafiltration.

Volpp M, Holzgrabe U.

Eur J Pharm Sci. 2019 Jan 15;127:175-184. doi: 10.1016/j.ejps.2018.10.027. Epub 2018 Oct 31.

PMID:
30391401
14.

Influence of charged aerosol detector instrument settings on the ultra-high-performance liquid chromatography analysis of fatty acids in polysorbate 80.

Schilling K, Pawellek R, Lovejoy K, Muellner T, Holzgrabe U.

J Chromatogr A. 2018 Nov 16;1576:58-66. doi: 10.1016/j.chroma.2018.09.031. Epub 2018 Sep 18.

PMID:
30245073
15.

Future Information Technology Tools for Fighting Substandard and Falsified Medicines in Low- and Middle-Income Countries.

Rasheed H, Höllein L, Holzgrabe U.

Front Pharmacol. 2018 Aug 31;9:995. doi: 10.3389/fphar.2018.00995. eCollection 2018. Review.

16.

Diffusion ordered NMR spectroscopy measurements as screening method of potential reactions of API and excipients in drug formulations.

Becht A, Schollmayer C, Wiest J, Heller D, Baumann W, Buschmann H, Holzgrabe U.

J Pharm Biomed Anal. 2019 Jan 5;162:41-46. doi: 10.1016/j.jpba.2018.09.020. Epub 2018 Sep 8.

PMID:
30219598
17.

Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids.

Wiest J, Saedtler M, Böttcher B, Grüne M, Reggane M, Galli B, Holzgrabe U, Meinel L.

Mol Pharm. 2018 Oct 1;15(10):4470-4480. doi: 10.1021/acs.molpharmaceut.8b00469. Epub 2018 Aug 28.

PMID:
30111113
18.

Novel lead compounds in pre-clinical development against African sleeping sickness.

Berninger M, Schmidt I, Ponte-Sucre A, Holzgrabe U.

Medchemcomm. 2017 Jul 31;8(10):1872-1890. doi: 10.1039/c7md00280g. eCollection 2017 Oct 1. Review.

19.

Characterization of polydisperse macrogols and macrogol-based excipients via HPLC and charged aerosol detection.

Theiss C, Holzgrabe U.

J Pharm Biomed Anal. 2018 Oct 25;160:212-221. doi: 10.1016/j.jpba.2018.07.043. Epub 2018 Jul 27.

PMID:
30099293
20.

First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers.

Jiao Y, Kim TH, Tao X, Kinzig M, Landersdorfer CB, Drescher SK, Sutaria DS, Moya B, Holzgrabe U, Sörgel F, Bulitta JB.

Eur J Pharm Sci. 2018 Oct 15;123:416-428. doi: 10.1016/j.ejps.2018.07.054. Epub 2018 Aug 1.

PMID:
30076955
21.

A New Bioactive Compound From the Marine Sponge-Derived Streptomyces sp. SBT348 Inhibits Staphylococcal Growth and Biofilm Formation.

Balasubramanian S, Skaf J, Holzgrabe U, Bharti R, Förstner KU, Ziebuhr W, Humeida UH, Abdelmohsen UR, Oelschlaeger TA.

Front Microbiol. 2018 Jul 11;9:1473. doi: 10.3389/fmicb.2018.01473. eCollection 2018.

22.

Quantification of Hydrochlorothiazide and Ramipril/Ramiprilate in Blood Serum and Cerebrospinal Fluid: A Pharmacokinetic Assessment of Central Nervous System Adverse Effects.

Sigaroudi A, Kinzig M, Wahl O, Stelzer C, Schroeter M, Fuhr U, Holzgrabe U, Sörgel F.

Pharmacology. 2018;102(3-4):133-137. doi: 10.1159/000489999. Epub 2018 Jul 6.

PMID:
29982257
23.

Quality of the antimalarial medicine artemether - lumefantrine in 8 cities of the Democratic Republic of the Congo.

Mufusama JP, Ndjoko Ioset K, Feineis D, Hoellein L, Holzgrabe U, Bringmann G.

Drug Test Anal. 2018 Oct;10(10):1599-1606. doi: 10.1002/dta.2420. Epub 2018 Jul 18.

PMID:
29896850
24.

Capillary zone electrophoresis for the determination of amodiaquine and three of its synthetic impurities in pharmaceutical formulations.

Mufusama JP, Hoellein L, Feineis D, Holzgrabe U, Bringmann G.

Electrophoresis. 2018 Oct;39(20):2530-2539. doi: 10.1002/elps.201800170. Epub 2018 Jun 13.

PMID:
29809275
25.

Fluorine walk: The impact of fluorine in quinolone amides on their activity against African sleeping sickness.

Berninger M, Erk C, Fuß A, Skaf J, Al-Momani E, Israel I, Raschig M, Güntzel P, Samnick S, Holzgrabe U.

Eur J Med Chem. 2018 May 25;152:377-391. doi: 10.1016/j.ejmech.2018.04.055. Epub 2018 Apr 30.

PMID:
29742443
26.

Bioinspired co-crystals of Imatinib providing enhanced kinetic solubility.

Reggane M, Wiest J, Saedtler M, Harlacher C, Gutmann M, Zottnick SH, Piechon P, Dix I, Müller-Buschbaum K, Holzgrabe U, Meinel L, Galli B.

Eur J Pharm Biopharm. 2018 Jul;128:290-299. doi: 10.1016/j.ejpb.2018.05.012. Epub 2018 May 4.

PMID:
29733951
27.

Azathioprine-induced reversible EBV-associated Hodgkin-like lymphoma after immunosuppressive therapy for autoimmune hepatitis
.

Munz M, Pretscher D, Wilhelm M, Holzgrabe U, Sörgel F, Birkmann J.

Int J Clin Pharmacol Ther. 2018 Mar;56)(3):142-147. doi: 10.5414/CP203106.

PMID:
29292695
28.

A stability-study of expired ampoules manufactured more than 40 years ago.

Zilker M, Sörgel F, Holzgrabe U.

J Pharm Biomed Anal. 2018 Feb 20;150:318-326. doi: 10.1016/j.jpba.2017.12.019. Epub 2017 Dec 13.

PMID:
29274583
29.

Impurity profiling of N,N'-ethylenebis-l-cysteine diethyl ester (Bicisate).

Wahl O, Cleynhens J, Verbruggen AM, Holzgrabe U.

J Pharm Biomed Anal. 2018 Feb 20;150:132-136. doi: 10.1016/j.jpba.2017.11.078. Epub 2017 Dec 5.

PMID:
29223061
30.

The influence of Osmunda regalis root extract on head and neck cancer cell proliferation, invasion and gene expression.

Schmidt M, Skaf J, Gavril G, Polednik C, Roller J, Kessler M, Holzgrabe U.

BMC Complement Altern Med. 2017 Dec 4;17(1):518. doi: 10.1186/s12906-017-2009-4.

31.

A Novel Mechanism of Inactivating Antibacterial Nitro Compounds in the Human Pathogen Staphylococcus aureus by Overexpression of a NADH-Dependent Flavin Nitroreductase.

El-Hossary EM, Förstner KU, François P, Baud D, Streker K, Schrenzel J, Ohlsen K, Holzgrabe U.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01510-17. doi: 10.1128/AAC.01510-17. Print 2018 Feb.

32.

Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima.

Skaf J, Hamarsheh O, Berninger M, Balasubramanian S, Oelschlaeger TA, Holzgrabe U.

Fitoterapia. 2018 Mar;125:191-198. doi: 10.1016/j.fitote.2017.11.001. Epub 2017 Nov 3.

PMID:
29108932
33.

Mapping the pharmaceutical design space by amorphous ionic liquid strategies.

Wiest J, Saedtler M, Balk A, Merget B, Widmer T, Bruhn H, Raccuglia M, Walid E, Picard F, Stopper H, Dekant W, Lühmann T, Sotriffer C, Galli B, Holzgrabe U, Meinel L.

J Control Release. 2017 Dec 28;268:314-322. doi: 10.1016/j.jconrel.2017.10.040. Epub 2017 Oct 31.

PMID:
29097303
34.

Capillary electrophoresis separation of phenethylamine enantiomers using amino acid based ionic liquids.

Wahl J, Holzgrabe U.

J Pharm Biomed Anal. 2018 Jan 30;148:245-250. doi: 10.1016/j.jpba.2017.10.010. Epub 2017 Oct 17.

PMID:
29059613
35.

A diversity oriented synthesis of natural product inspired molecular libraries.

Chauhan J, Luthra T, Gundla R, Ferraro A, Holzgrabe U, Sen S.

Org Biomol Chem. 2017 Nov 7;15(43):9108-9120. doi: 10.1039/c7ob02230a.

PMID:
29048087
36.

Severe Drug-Induced Liver Injury as an Adverse Drug Event of Antibiotics: A Case Report and Review of the Literature.

Munz M, Grummich H, Birkmann J, Wilhelm M, Holzgrabe U, Sörgel F.

Chemotherapy. 2017;62(6):367-373. doi: 10.1159/000480399. Epub 2017 Sep 22.

PMID:
28934748
37.

Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.

Sigaroudi A, Kinzig M, Wahl O, Stelzer C, Schroeter M, Fuhr U, Holzgrabe U, Sörgel F.

Pharmacology. 2018;101(1-2):29-34. doi: 10.1159/000480091. Epub 2017 Sep 21.

38.

Isolation of a novel compound (MIMO2) from the methanolic extract of Moringa oleifera leaves: protective effects against vanadium-induced cytotoxity.

Igado OO, Glaser J, Ramos-Tirado M, Bankoğlu EE, Atiba FA, Holzgrabe U, Stopper H, Olopade JO.

Drug Chem Toxicol. 2018 Jul;41(3):249-258. doi: 10.1080/01480545.2017.1366504. Epub 2017 Sep 19.

PMID:
28925291
39.

Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro)heteroaromatic compounds.

Hati S, Holzgrabe U, Sen S.

Beilstein J Org Chem. 2017 Aug 15;13:1670-1692. doi: 10.3762/bjoc.13.162. eCollection 2017. Review.

40.

A miniaturized peptidyl-prolyl isomerase enzyme assay.

Vivoli M, Renou J, Chevalier A, Norville IH, Diaz S, Juli C, Atkins H, Holzgrabe U, Renard PY, Sarkar-Tyson M, Harmer NJ.

Anal Biochem. 2017 Nov 1;536:59-68. doi: 10.1016/j.ab.2017.08.004. Epub 2017 Aug 11.

PMID:
28803887
41.

Stability and assessment of amino acids in parenteral nutrition solutions.

Unger N, Holzgrabe U.

J Pharm Biomed Anal. 2018 Jan 5;147:125-139. doi: 10.1016/j.jpba.2017.07.064. Epub 2017 Aug 2. Review.

PMID:
28797955
42.

Bistacrines as potential antitrypanosomal agents.

Schmidt I, Göllner S, Fuß A, Stich A, Kucharski A, Schirmeister T, Katzowitsch E, Bruhn H, Miliu A, Krauth-Siegel RL, Holzgrabe U.

Bioorg Med Chem. 2017 Aug 15;25(16):4526-4531. doi: 10.1016/j.bmc.2017.06.051. Epub 2017 Jul 1.

PMID:
28698054
43.

Interlaboratory Comparison Test as an Evaluation of Applicability of an Alternative Edible Oil Analysis by 1H NMR Spectroscopy.

Zailer E, Holzgrabe U, Diehl BWK.

J AOAC Int. 2017 Nov 1;100(6):1819-1830. doi: 10.5740/jaoacint.17-0063. Epub 2017 Jun 29.

PMID:
28664825
44.

Crystal structure of (3S*,4R*)-4-fluoro-3-(4-meth-oxy-phen-yl)-1-oxo-2-phenyl-1,2,3,4-tetra-hydro-iso-quinoline-4-carb-oxy-lic acid.

Lehmann A, Lechner L, Radacki K, Braunschweig H, Holzgrabe U.

Acta Crystallogr E Crystallogr Commun. 2017 May 23;73(Pt 6):867-870. doi: 10.1107/S2056989017007186. eCollection 2017 Jun 1.

45.

Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor.

Bermudez M, Bock A, Krebs F, Holzgrabe U, Mohr K, Lohse MJ, Wolber G.

ACS Chem Biol. 2017 Jul 21;12(7):1743-1748. doi: 10.1021/acschembio.7b00275. Epub 2017 Jun 12.

PMID:
28585805
46.

Current role and future perspectives of multivariate (chemometric) methods in NMR spectroscopic analysis of pharmaceutical products.

Monakhova YB, Holzgrabe U, Diehl BWK.

J Pharm Biomed Anal. 2018 Jan 5;147:580-589. doi: 10.1016/j.jpba.2017.05.034. Epub 2017 May 27. Review.

PMID:
28583765
47.

A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy.

Agnetta L, Kauk M, Canizal MCA, Messerer R, Holzgrabe U, Hoffmann C, Decker M.

Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7282-7287. doi: 10.1002/anie.201701524. Epub 2017 May 16.

PMID:
28510314
48.

Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells.

Bach M, Lehmann A, Brünnert D, Vanselow JT, Hartung A, Bargou RC, Holzgrabe U, Schlosser A, Chatterjee M.

J Med Chem. 2017 May 25;60(10):4147-4160. doi: 10.1021/acs.jmedchem.6b01613. Epub 2017 May 8.

PMID:
28453931
49.

Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2.

Messerer R, Dallanoce C, Matera C, Wehle S, Flammini L, Chirinda B, Bock A, Irmen M, Tränkle C, Barocelli E, Decker M, Sotriffer C, De Amici M, Holzgrabe U.

Medchemcomm. 2017 Apr 27;8(6):1346-1359. doi: 10.1039/c7md00149e. eCollection 2017 Jun 1.

50.

Opening NADPH oxidase inhibitors for in vivo translation.

Hecht N, Terveer N, Schollmayer C, Holzgrabe U, Meinel L.

Eur J Pharm Biopharm. 2017 Jun;115:206-217. doi: 10.1016/j.ejpb.2017.03.001. Epub 2017 Mar 8.

PMID:
28284727

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