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Items: 1 to 50 of 380

1.

RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS.

Seibold M, Stühmer T, Kremer N, Mottok A, Scholz CJ, Schlosser A, Leich E, Holzgrabe U, Brünnert D, Barrio S, Kortüm KM, Solimando AG, Chatterjee M, Einsele H, Rosenwald A, Bargou RC, Steinbrunn T.

Haematologica. 2019 Oct 10. pii: haematol.2019.223024. doi: 10.3324/haematol.2019.223024. [Epub ahead of print]

2.

Regulatory framework in Pakistan: situation analysis of medicine quality and future recommendations.

Rasheed H, Hoellein L, Bukhari KS, Holzgrabe U.

J Pharm Policy Pract. 2019 Sep 11;12:23. doi: 10.1186/s40545-019-0184-z. eCollection 2019. Review.

3.

Quo Vadis qNMR?

Diehl B, Holzgrabe U, Monakhova Y, Schönberger T.

J Pharm Biomed Anal. 2020 Jan 5;177:112847. doi: 10.1016/j.jpba.2019.112847. Epub 2019 Aug 30. Review.

PMID:
31505431
4.

Investigation of tryptophan-related yellowing in parenteral amino acid solution: Development of a stability-indicating method and assessment of degradation products in pharmaceutical formulations.

Unger N, Ferraro A, Holzgrabe U.

J Pharm Biomed Anal. 2020 Jan 5;177:112839. doi: 10.1016/j.jpba.2019.112839. Epub 2019 Aug 27.

PMID:
31505430
5.

11-Aminostrychnine and N-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors.

Zlotos DP, Mohsen AMY, Mandour YM, Marzouk MA, Breitinger U, Villmann C, Breitinger HG, Sotriffer C, Jensen AA, Holzgrabe U.

J Nat Prod. 2019 Aug 23;82(8):2332-2336. doi: 10.1021/acs.jnatprod.9b00180. Epub 2019 Aug 6.

PMID:
31385511
6.

Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics.

Bulitta JB, Jiao Y, Landersdorfer CB, Sutaria DS, Tao X, Shin E, Höhl R, Holzgrabe U, Stephan U, Sörgel F.

Pharmaceutics. 2019 Jul 10;11(7). pii: E323. doi: 10.3390/pharmaceutics11070323.

7.

Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs.

Hasan M, Marzouk MA, Adhikari S, Wright TD, Miller BP, Matossian MD, Elliott S, Wright M, Alzoubi M, Collins-Burow BM, Burow ME, Holzgrabe U, Zlotos DP, Stratford RE, Witt-Enderby PA.

Mol Pharmacol. 2019 Aug;96(2):272-296. doi: 10.1124/mol.119.116202. Epub 2019 Jun 20.

PMID:
31221824
8.

Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding.

Shah NR, Bulitta JB, Kinzig M, Landersdorfer CB, Jiao Y, Sutaria DS, Tao X, Höhl R, Holzgrabe U, Kees F, Stephan U, Sörgel F.

Pharmaceutics. 2019 Jun 18;11(6). pii: E286. doi: 10.3390/pharmaceutics11060286.

9.

The contamination of valsartan and other sartans, part 1: New findings.

Sörgel F, Kinzig M, Abdel-Tawab M, Bidmon C, Schreiber A, Ermel S, Wohlfart J, Besa A, Scherf-Clavel O, Holzgrabe U.

J Pharm Biomed Anal. 2019 Aug 5;172:395-405. doi: 10.1016/j.jpba.2019.05.022. Epub 2019 May 11.

PMID:
31122801
10.

The contamination of valsartan and other sartans, Part 2: Untargeted screening reveals contamination with amides additionally to known nitrosamine impurities.

Scherf-Clavel O, Kinzig M, Besa A, Schreiber A, Bidmon C, Abdel-Tawab M, Wohlfart J, Sörgel F, Holzgrabe U.

J Pharm Biomed Anal. 2019 Aug 5;172:278-284. doi: 10.1016/j.jpba.2019.04.035. Epub 2019 Apr 16.

PMID:
31078064
11.

Enantioseparation by Capillary Electrophoresis Using Cyclodextrins in an Amino Acid-Based Ionic Liquid Running Buffer.

Wahl J, Holzgrabe U.

Methods Mol Biol. 2019;1985:365-371. doi: 10.1007/978-1-4939-9438-0_20.

PMID:
31069745
12.

Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist.

Riefolo F, Matera C, Garrido-Charles A, Gomila AMJ, Sortino R, Agnetta L, Claro E, Masgrau R, Holzgrabe U, Batlle M, Decker M, Guasch E, Gorostiza P.

J Am Chem Soc. 2019 May 8;141(18):7628-7636. doi: 10.1021/jacs.9b03505. Epub 2019 Apr 26.

PMID:
31010281
13.

Reply to "Requirements for accurate 1H NMR quantification of mineral oil hydrocarbons (paraffins) for pharmaceutical or cosmetic use".

Urlaub J, Norwig J, Schollmayer C, Holzgrabe U.

J Pharm Biomed Anal. 2019 Jul 15;171:235-237. doi: 10.1016/j.jpba.2019.04.020. Epub 2019 Apr 10. No abstract available.

PMID:
31003701
14.

A long-time stability study of 50 drug substances representing common drug classes of pharmaceutical use.

Zilker M, Sörgel F, Holzgrabe U.

Drug Test Anal. 2019 Jul;11(7):1065-1075. doi: 10.1002/dta.2593. Epub 2019 May 2.

PMID:
30912309
15.

Quantitative structure-property relationship modeling of polar analytes lacking UV chromophores to charged aerosol detector response.

Schilling K, Krmar J, Maljurić N, Pawellek R, Protić A, Holzgrabe U.

Anal Bioanal Chem. 2019 May;411(13):2945-2959. doi: 10.1007/s00216-019-01744-y. Epub 2019 Mar 26.

PMID:
30911799
16.

1H NMR analytical characterization of mineral oil hydrocarbons (PARAFFINS) for pharmaceutical use.

Urlaub J, Norwig J, Schollmayer C, Holzgrabe U.

J Pharm Biomed Anal. 2019 May 30;169:41-48. doi: 10.1016/j.jpba.2019.01.036. Epub 2019 Feb 21.

PMID:
30831451
17.

Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties.

Agnetta L, Bermudez M, Riefolo F, Matera C, Claro E, Messerer R, Littmann T, Wolber G, Holzgrabe U, Decker M.

J Med Chem. 2019 Mar 28;62(6):3009-3020. doi: 10.1021/acs.jmedchem.8b01822. Epub 2019 Mar 19.

PMID:
30827105
18.

A systematic review of the stability of finished pharmaceutical products and drug substances beyond their labeled expiry dates.

Zilker M, Sörgel F, Holzgrabe U.

J Pharm Biomed Anal. 2019 Mar 20;166:222-235. doi: 10.1016/j.jpba.2019.01.016. Epub 2019 Jan 11.

PMID:
30660807
19.

Zwitterionic-hydrophilic interaction liquid chromatography for l-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy.

Xu X, Urlaub J, Woźniczka M, Wynendaele E, Herman K, Schollmayer C, Diehl B, Van Calenbergh S, Holzgrabe U, De Spiegeleer B.

J Pharm Biomed Anal. 2019 Feb 20;165:338-345. doi: 10.1016/j.jpba.2018.12.010. Epub 2018 Dec 7.

PMID:
30579234
20.

Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer's Disease.

Volpato D, Holzgrabe U.

Molecules. 2018 Dec 7;23(12). pii: E3230. doi: 10.3390/molecules23123230. Review.

21.

Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones.

Parlar S, Sayar G, Tarikogullari AH, Karadagli SS, Alptuzun V, Erciyas E, Holzgrabe U.

Bioorg Chem. 2019 Jun;87:888-900. doi: 10.1016/j.bioorg.2018.11.051. Epub 2018 Nov 28.

PMID:
30538051
22.

Determination of plasma protein binding for sympathomimetic drugs by means of ultrafiltration.

Volpp M, Holzgrabe U.

Eur J Pharm Sci. 2019 Jan 15;127:175-184. doi: 10.1016/j.ejps.2018.10.027. Epub 2018 Oct 31.

PMID:
30391401
23.

Influence of charged aerosol detector instrument settings on the ultra-high-performance liquid chromatography analysis of fatty acids in polysorbate 80.

Schilling K, Pawellek R, Lovejoy K, Muellner T, Holzgrabe U.

J Chromatogr A. 2018 Nov 16;1576:58-66. doi: 10.1016/j.chroma.2018.09.031. Epub 2018 Sep 18.

PMID:
30245073
24.

Future Information Technology Tools for Fighting Substandard and Falsified Medicines in Low- and Middle-Income Countries.

Rasheed H, Höllein L, Holzgrabe U.

Front Pharmacol. 2018 Aug 31;9:995. doi: 10.3389/fphar.2018.00995. eCollection 2018. Review.

25.

Diffusion ordered NMR spectroscopy measurements as screening method of potential reactions of API and excipients in drug formulations.

Becht A, Schollmayer C, Wiest J, Heller D, Baumann W, Buschmann H, Holzgrabe U.

J Pharm Biomed Anal. 2019 Jan 5;162:41-46. doi: 10.1016/j.jpba.2018.09.020. Epub 2018 Sep 8.

PMID:
30219598
26.

Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids.

Wiest J, Saedtler M, Böttcher B, Grüne M, Reggane M, Galli B, Holzgrabe U, Meinel L.

Mol Pharm. 2018 Oct 1;15(10):4470-4480. doi: 10.1021/acs.molpharmaceut.8b00469. Epub 2018 Aug 28.

PMID:
30111113
27.

Novel lead compounds in pre-clinical development against African sleeping sickness.

Berninger M, Schmidt I, Ponte-Sucre A, Holzgrabe U.

Medchemcomm. 2017 Jul 31;8(10):1872-1890. doi: 10.1039/c7md00280g. eCollection 2017 Oct 1. Review.

28.

Characterization of polydisperse macrogols and macrogol-based excipients via HPLC and charged aerosol detection.

Theiss C, Holzgrabe U.

J Pharm Biomed Anal. 2018 Oct 25;160:212-221. doi: 10.1016/j.jpba.2018.07.043. Epub 2018 Jul 27.

PMID:
30099293
29.

First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers.

Jiao Y, Kim TH, Tao X, Kinzig M, Landersdorfer CB, Drescher SK, Sutaria DS, Moya B, Holzgrabe U, Sörgel F, Bulitta JB.

Eur J Pharm Sci. 2018 Oct 15;123:416-428. doi: 10.1016/j.ejps.2018.07.054. Epub 2018 Aug 1.

PMID:
30076955
30.

A New Bioactive Compound From the Marine Sponge-Derived Streptomyces sp. SBT348 Inhibits Staphylococcal Growth and Biofilm Formation.

Balasubramanian S, Skaf J, Holzgrabe U, Bharti R, Förstner KU, Ziebuhr W, Humeida UH, Abdelmohsen UR, Oelschlaeger TA.

Front Microbiol. 2018 Jul 11;9:1473. doi: 10.3389/fmicb.2018.01473. eCollection 2018.

31.

Quantification of Hydrochlorothiazide and Ramipril/Ramiprilate in Blood Serum and Cerebrospinal Fluid: A Pharmacokinetic Assessment of Central Nervous System Adverse Effects.

Sigaroudi A, Kinzig M, Wahl O, Stelzer C, Schroeter M, Fuhr U, Holzgrabe U, Sörgel F.

Pharmacology. 2018;102(3-4):133-137. doi: 10.1159/000489999. Epub 2018 Jul 6.

PMID:
29982257
32.

Quality of the antimalarial medicine artemether - lumefantrine in 8 cities of the Democratic Republic of the Congo.

Mufusama JP, Ndjoko Ioset K, Feineis D, Hoellein L, Holzgrabe U, Bringmann G.

Drug Test Anal. 2018 Oct;10(10):1599-1606. doi: 10.1002/dta.2420. Epub 2018 Jul 18.

PMID:
29896850
33.

Capillary zone electrophoresis for the determination of amodiaquine and three of its synthetic impurities in pharmaceutical formulations.

Mufusama JP, Hoellein L, Feineis D, Holzgrabe U, Bringmann G.

Electrophoresis. 2018 Oct;39(20):2530-2539. doi: 10.1002/elps.201800170. Epub 2018 Jun 13.

PMID:
29809275
34.

Fluorine walk: The impact of fluorine in quinolone amides on their activity against African sleeping sickness.

Berninger M, Erk C, Fuß A, Skaf J, Al-Momani E, Israel I, Raschig M, Güntzel P, Samnick S, Holzgrabe U.

Eur J Med Chem. 2018 May 25;152:377-391. doi: 10.1016/j.ejmech.2018.04.055. Epub 2018 Apr 30.

PMID:
29742443
35.

Bioinspired co-crystals of Imatinib providing enhanced kinetic solubility.

Reggane M, Wiest J, Saedtler M, Harlacher C, Gutmann M, Zottnick SH, Piechon P, Dix I, Müller-Buschbaum K, Holzgrabe U, Meinel L, Galli B.

Eur J Pharm Biopharm. 2018 Jul;128:290-299. doi: 10.1016/j.ejpb.2018.05.012. Epub 2018 May 4.

PMID:
29733951
36.

Azathioprine-induced reversible EBV-associated Hodgkin-like lymphoma after immunosuppressive therapy for autoimmune hepatitis
.

Munz M, Pretscher D, Wilhelm M, Holzgrabe U, Sörgel F, Birkmann J.

Int J Clin Pharmacol Ther. 2018 Mar;56)(3):142-147. doi: 10.5414/CP203106.

PMID:
29292695
37.

A stability-study of expired ampoules manufactured more than 40 years ago.

Zilker M, Sörgel F, Holzgrabe U.

J Pharm Biomed Anal. 2018 Feb 20;150:318-326. doi: 10.1016/j.jpba.2017.12.019. Epub 2017 Dec 13.

PMID:
29274583
38.

Impurity profiling of N,N'-ethylenebis-l-cysteine diethyl ester (Bicisate).

Wahl O, Cleynhens J, Verbruggen AM, Holzgrabe U.

J Pharm Biomed Anal. 2018 Feb 20;150:132-136. doi: 10.1016/j.jpba.2017.11.078. Epub 2017 Dec 5.

PMID:
29223061
39.

The influence of Osmunda regalis root extract on head and neck cancer cell proliferation, invasion and gene expression.

Schmidt M, Skaf J, Gavril G, Polednik C, Roller J, Kessler M, Holzgrabe U.

BMC Complement Altern Med. 2017 Dec 4;17(1):518. doi: 10.1186/s12906-017-2009-4.

40.

A Novel Mechanism of Inactivating Antibacterial Nitro Compounds in the Human Pathogen Staphylococcus aureus by Overexpression of a NADH-Dependent Flavin Nitroreductase.

El-Hossary EM, Förstner KU, François P, Baud D, Streker K, Schrenzel J, Ohlsen K, Holzgrabe U.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01510-17. doi: 10.1128/AAC.01510-17. Print 2018 Feb.

41.

Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima.

Skaf J, Hamarsheh O, Berninger M, Balasubramanian S, Oelschlaeger TA, Holzgrabe U.

Fitoterapia. 2018 Mar;125:191-198. doi: 10.1016/j.fitote.2017.11.001. Epub 2017 Nov 3.

PMID:
29108932
42.

Mapping the pharmaceutical design space by amorphous ionic liquid strategies.

Wiest J, Saedtler M, Balk A, Merget B, Widmer T, Bruhn H, Raccuglia M, Walid E, Picard F, Stopper H, Dekant W, Lühmann T, Sotriffer C, Galli B, Holzgrabe U, Meinel L.

J Control Release. 2017 Dec 28;268:314-322. doi: 10.1016/j.jconrel.2017.10.040. Epub 2017 Oct 31.

PMID:
29097303
43.

Capillary electrophoresis separation of phenethylamine enantiomers using amino acid based ionic liquids.

Wahl J, Holzgrabe U.

J Pharm Biomed Anal. 2018 Jan 30;148:245-250. doi: 10.1016/j.jpba.2017.10.010. Epub 2017 Oct 17.

PMID:
29059613
44.

A diversity oriented synthesis of natural product inspired molecular libraries.

Chauhan J, Luthra T, Gundla R, Ferraro A, Holzgrabe U, Sen S.

Org Biomol Chem. 2017 Nov 7;15(43):9108-9120. doi: 10.1039/c7ob02230a.

PMID:
29048087
45.

Severe Drug-Induced Liver Injury as an Adverse Drug Event of Antibiotics: A Case Report and Review of the Literature.

Munz M, Grummich H, Birkmann J, Wilhelm M, Holzgrabe U, Sörgel F.

Chemotherapy. 2017;62(6):367-373. doi: 10.1159/000480399. Epub 2017 Sep 22.

PMID:
28934748
46.

Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.

Sigaroudi A, Kinzig M, Wahl O, Stelzer C, Schroeter M, Fuhr U, Holzgrabe U, Sörgel F.

Pharmacology. 2018;101(1-2):29-34. doi: 10.1159/000480091. Epub 2017 Sep 21.

47.

Isolation of a novel compound (MIMO2) from the methanolic extract of Moringa oleifera leaves: protective effects against vanadium-induced cytotoxity.

Igado OO, Glaser J, Ramos-Tirado M, Bankoğlu EE, Atiba FA, Holzgrabe U, Stopper H, Olopade JO.

Drug Chem Toxicol. 2018 Jul;41(3):249-258. doi: 10.1080/01480545.2017.1366504. Epub 2017 Sep 19.

PMID:
28925291
48.

Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro)heteroaromatic compounds.

Hati S, Holzgrabe U, Sen S.

Beilstein J Org Chem. 2017 Aug 15;13:1670-1692. doi: 10.3762/bjoc.13.162. eCollection 2017. Review.

49.

A miniaturized peptidyl-prolyl isomerase enzyme assay.

Vivoli M, Renou J, Chevalier A, Norville IH, Diaz S, Juli C, Atkins H, Holzgrabe U, Renard PY, Sarkar-Tyson M, Harmer NJ.

Anal Biochem. 2017 Nov 1;536:59-68. doi: 10.1016/j.ab.2017.08.004. Epub 2017 Aug 11.

PMID:
28803887
50.

Stability and assessment of amino acids in parenteral nutrition solutions.

Unger N, Holzgrabe U.

J Pharm Biomed Anal. 2018 Jan 5;147:125-139. doi: 10.1016/j.jpba.2017.07.064. Epub 2017 Aug 2. Review.

PMID:
28797955

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