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Autophagy and mitophagy in ALS.

Evans CS, Holzbaur ELF.

Neurobiol Dis. 2018 Jul 5. pii: S0969-9961(18)30214-6. doi: 10.1016/j.nbd.2018.07.005. [Epub ahead of print] Review.


Motor Proteins.

Sweeney HL, Holzbaur ELF.

Cold Spring Harb Perspect Biol. 2018 May 1;10(5). pii: a021931. doi: 10.1101/cshperspect.a021931. Review.


Axonal autophagy: Mini-review for autophagy in the CNS.

Stavoe AKH, Holzbaur ELF.

Neurosci Lett. 2018 Mar 13. pii: S0304-3940(18)30194-0. doi: 10.1016/j.neulet.2018.03.025. [Epub ahead of print] Review.


A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity.

Lee IG, Olenick MA, Boczkowska M, Franzini-Armstrong C, Holzbaur ELF, Dominguez R.

Nat Commun. 2018 Mar 7;9(1):986. doi: 10.1038/s41467-018-03412-8.


Opposing Kinesin and Myosin-I Motors Drive Membrane Deformation and Tubulation along Engineered Cytoskeletal Networks.

McIntosh BB, Pyrpassopoulos S, Holzbaur ELF, Ostap EM.

Curr Biol. 2018 Jan 22;28(2):236-248.e5. doi: 10.1016/j.cub.2017.12.007. Epub 2018 Jan 11.


CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons.

Klinman E, Tokito M, Holzbaur ELF.

Traffic. 2017 Dec;18(12):808-824. doi: 10.1111/tra.12529.


Huntingtin Fibrils Poke Membranes.

Guedes-Dias P, Holzbaur ELF.

Cell. 2017 Sep 21;171(1):32-33. doi: 10.1016/j.cell.2017.09.009.


The impact of cytoskeletal organization on the local regulation of neuronal transport.

Nirschl JJ, Ghiretti AE, Holzbaur ELF.

Nat Rev Neurosci. 2017 Oct;18(10):585-597. doi: 10.1038/nrn.2017.100. Epub 2017 Aug 31. Review.


Dynein efficiently navigates the dendritic cytoskeleton to drive the retrograde trafficking of BDNF/TrkB signaling endosomes.

Ayloo S, Guedes-Dias P, Ghiretti AE, Holzbaur ELF.

Mol Biol Cell. 2017 Sep 15;28(19):2543-2554. doi: 10.1091/mbc.E17-01-0068. Epub 2017 Jul 18.


Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.

Lippert LG, Dadosh T, Hadden JA, Karnawat V, Diroll BT, Murray CB, Holzbaur ELF, Schulten K, Reck-Peterson SL, Goldman YE.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4564-E4573. doi: 10.1073/pnas.1620149114. Epub 2017 May 22.


Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.

Gopal PP, Nirschl JJ, Klinman E, Holzbaur EL.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2466-E2475. doi: 10.1073/pnas.1614462114. Epub 2017 Mar 6.


Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur ELF.

Neuron. 2016 Nov 23;92(4):857-872. doi: 10.1016/j.neuron.2016.10.003. Epub 2016 Nov 3.


Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission-fusion balance within mitochondrial networks.

Moore AS, Wong YC, Simpson CL, Holzbaur EL.

Nat Commun. 2016 Sep 30;7:12886. doi: 10.1038/ncomms12886.


Spatiotemporal dynamics of autophagy receptors in selective mitophagy.

Moore AS, Holzbaur EL.

Autophagy. 2016 Oct 2;12(10):1956-1957. Epub 2016 Aug 2.


Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.

Olenick MA, Tokito M, Boczkowska M, Dominguez R, Holzbaur EL.

J Biol Chem. 2016 Aug 26;291(35):18239-51. doi: 10.1074/jbc.M116.738211. Epub 2016 Jun 30.


Compartment-Specific Regulation of Autophagy in Primary Neurons.

Maday S, Holzbaur EL.

J Neurosci. 2016 Jun 1;36(22):5933-45. doi: 10.1523/JNEUROSCI.4401-15.2016.


Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy.

Moore AS, Holzbaur EL.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3349-58. doi: 10.1073/pnas.1523810113. Epub 2016 May 31.


The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1.

Twelvetrees AE, Pernigo S, Sanger A, Guedes-Dias P, Schiavo G, Steiner RA, Dodding MP, Holzbaur EL.

Neuron. 2016 Jun 1;90(5):1000-15. doi: 10.1016/j.neuron.2016.04.046. Epub 2016 May 19.


Methods for Assessing Nuclear Rotation and Nuclear Positioning in Developing Skeletal Muscle Cells.

Wilson MH, Bray MG, Holzbaur EL.

Methods Mol Biol. 2016;1411:269-90. doi: 10.1007/978-1-4939-3530-7_18.


The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory.

Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur ELF, Kneussel M.

Cell Rep. 2016 May 3;15(5):968-977. doi: 10.1016/j.celrep.2016.03.086. Epub 2016 Apr 21.


Lipid Rafts Assemble Dynein Ensembles.

Nirschl JJ, Ghiretti AE, Holzbaur ELF.

Trends Biochem Sci. 2016 May;41(5):393-394. doi: 10.1016/j.tibs.2016.03.005. Epub 2016 Apr 6.


α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons.

Nirschl JJ, Magiera MM, Lazarus JE, Janke C, Holzbaur EL.

Cell Rep. 2016 Mar 22;14(11):2637-52. doi: 10.1016/j.celrep.2016.02.046. Epub 2016 Mar 10.


Comparative analysis of axonal transport markers in primary mammalian neurons.

Klinman E, Holzbaur EL.

Methods Cell Biol. 2016;131:409-24. doi: 10.1016/bs.mcb.2015.06.011. Epub 2015 Sep 2.


Live-cell imaging of retrograde transport initiation in primary neurons.

Nirschl JJ, Holzbaur EL.

Methods Cell Biol. 2016;131:269-76. doi: 10.1016/bs.mcb.2015.06.002. Epub 2015 Sep 2.


Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.

Klinman E, Holzbaur EL.

Cell Rep. 2015 Jul 21;12(3):462-73. doi: 10.1016/j.celrep.2015.06.032. Epub 2015 Jul 9.


WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism.

Kast DJ, Zajac AL, Holzbaur EL, Ostap EM, Dominguez R.

Curr Biol. 2015 Jun 29;25(13):1791-7. doi: 10.1016/j.cub.2015.05.042. Epub 2015 Jun 18.


Reconstitution of microtubule-based motility using cell extracts.

Ayloo S, Holzbaur EL.

Methods Cell Biol. 2015;128:57-68. doi: 10.1016/bs.mcb.2015.02.002. Epub 2015 Apr 8.


Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization.

Ballister ER, Ayloo S, Chenoweth DM, Lampson MA, Holzbaur ELF.

Curr Biol. 2015 May 18;25(10):R407-R408. doi: 10.1016/j.cub.2015.03.056. No abstract available.


Autophagosome dynamics in neurodegeneration at a glance.

Wong YC, Holzbaur EL.

J Cell Sci. 2015 Apr 1;128(7):1259-67. doi: 10.1242/jcs.161216. Review.


Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria.

Wong YC, Holzbaur EL.

Autophagy. 2015;11(2):422-4. doi: 10.1080/15548627.2015.1009792.


Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.

McIntosh BB, Holzbaur EL, Ostap EM.

Curr Biol. 2015 Feb 16;25(4):523-9. doi: 10.1016/j.cub.2014.12.008. Epub 2015 Feb 5.


Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

Wilson MH, Holzbaur EL.

Development. 2015 Jan 1;142(1):218-28. doi: 10.1242/dev.114769.


MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons.

Fu MM, Holzbaur EL.

Autophagy. 2014;10(11):2079-81. doi: 10.4161/auto.34451. Epub 2014 Oct 30.


Axonal transport: cargo-specific mechanisms of motility and regulation.

Maday S, Twelvetrees AE, Moughamian AJ, Holzbaur EL.

Neuron. 2014 Oct 22;84(2):292-309. doi: 10.1016/j.neuron.2014.10.019. Epub 2014 Oct 22. Review.


TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation.

Mantegazza AR, Zajac AL, Twelvetrees A, Holzbaur EL, Amigorena S, Marks MS.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15508-13. doi: 10.1073/pnas.1412998111. Epub 2014 Oct 13.


Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.

Wong YC, Holzbaur EL.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48. doi: 10.1073/pnas.1405752111. Epub 2014 Oct 7.


Trim58 degrades Dynein and regulates terminal erythropoiesis.

Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ.

Dev Cell. 2014 Sep 29;30(6):688-700. doi: 10.1016/j.devcel.2014.07.021. Epub 2014 Sep 18.


Dynactin functions as both a dynamic tether and brake during dynein-driven motility.

Ayloo S, Lazarus JE, Dodda A, Tokito M, Ostap EM, Holzbaur EL.

Nat Commun. 2014 Sep 4;5:4807. doi: 10.1038/ncomms5807.


Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.

Maday S, Holzbaur EL.

Dev Cell. 2014 Jul 14;30(1):71-85. doi: 10.1016/j.devcel.2014.06.001.


Navigating the cell: how motors function in vivo.

De La Cruz EM, Holzbaur EL.

J Cell Sci. 2014 Jul 15;127(Pt 14):2997-8. doi: 10.1242/jcs.156414.


Integrated regulation of motor-driven organelle transport by scaffolding proteins.

Fu MM, Holzbaur EL.

Trends Cell Biol. 2014 Oct;24(10):564-74. doi: 10.1016/j.tcb.2014.05.002. Epub 2014 Jun 18. Review.


LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.

Fu MM, Nirschl JJ, Holzbaur ELF.

Dev Cell. 2014 Jun 9;29(5):577-590. doi: 10.1016/j.devcel.2014.04.015.


Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport.

Castle MJ, Gershenson ZT, Giles AR, Holzbaur EL, Wolfe JH.

Hum Gene Ther. 2014 Aug;25(8):705-20. doi: 10.1089/hum.2013.189. Epub 2014 May 2.


Reconstituting the motility of isolated intracellular cargoes.

Hendricks AG, Goldman YE, Holzbaur EL.

Methods Enzymol. 2014;540:249-62. doi: 10.1016/B978-0-12-397924-7.00014-5.


Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.

Castle MJ, Perlson E, Holzbaur EL, Wolfe JH.

Mol Ther. 2014 Mar;22(3):554-566. doi: 10.1038/mt.2013.237. Epub 2013 Oct 8.


Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.

Drivas TG, Holzbaur EL, Bennett J.

J Clin Invest. 2013 Oct;123(10):4525-39. doi: 10.1172/JCI69448. Epub 2013 Sep 24.


Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.

Perlson E, Hendricks AG, Lazarus JE, Ben-Yaakov K, Gradus T, Tokito M, Holzbaur EL.

J Biol Chem. 2013 Sep 27;288(39):27812-24. doi: 10.1074/jbc.M113.465088. Epub 2013 Aug 19.


Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport.

Moughamian AJ, Osborn GE, Lazarus JE, Maday S, Holzbaur EL.

J Neurosci. 2013 Aug 7;33(32):13190-203. doi: 10.1523/JNEUROSCI.0935-13.2013.


JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.

Fu MM, Holzbaur EL.

J Cell Biol. 2013 Aug 5;202(3):495-508. doi: 10.1083/jcb.201302078. Epub 2013 Jul 29.

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