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Items: 1 to 50 of 87

1.

A Knee Size-Independent Parameter for Malalignment of the Distal Patellofemoral Joint in Children.

Wagner F, Maderbacher G, Matussek J, Holzapfel BM, Kammer B, Hubertus J, Anders S, Winkler S, Grifka J, Keshmiri A.

Adv Orthop. 2019 Sep 15;2019:3496936. doi: 10.1155/2019/3496936. eCollection 2019.

2.

Recombinant Human Bone Morphogenetic Protein 7 Exerts Osteo-Catabolic Effects on Bone Grafts That Outweigh Its Osteo-Anabolic Capacity.

Lahr CA, Wagner F, Shafiee A, Rudert M, Hutmacher DW, Holzapfel BM.

Calcif Tissue Int. 2019 Sep;105(3):331-340. doi: 10.1007/s00223-019-00574-5. Epub 2019 Jun 18.

PMID:
31214730
3.

A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma.

Wagner F, Holzapfel BM, Martine LC, McGovern J, Lahr CA, Boxberg M, Prodinger PM, Grässel S, Loessner D, Hutmacher DW.

Acta Biomater. 2019 Apr 15;89:372-381. doi: 10.1016/j.actbio.2019.02.051. Epub 2019 Mar 2.

PMID:
30836200
4.

Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone.

McGovern JA, Shafiee A, Wagner F, Lahr CA, Landgraf M, Meinert C, Williams ED, Russell PJ, Clements JA, Loessner D, Holzapfel BM, Risbridger GP, Hutmacher DW.

Cancers (Basel). 2018 Nov 13;10(11). pii: E438. doi: 10.3390/cancers10110438.

5.

A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

Loessner D, Rockstroh A, Shokoohmand A, Holzapfel BM, Wagner F, Baldwin J, Boxberg M, Schmalfeldt B, Lengyel E, Clements JA, Hutmacher DW.

Biomaterials. 2019 Jan;190-191:63-75. doi: 10.1016/j.biomaterials.2018.10.014. Epub 2018 Oct 16.

PMID:
30396040
6.

Evaluation of implant fit and frontal plane alignment after bi-compartmental knee arthroplasty using patient-specific instruments and implants.

Arnholdt J, Kamawal Y, Holzapfel BM, Ripp A, Rudert M, Steinert AF.

Arch Med Sci. 2018 Oct;14(6):1424-1431. doi: 10.5114/aoms.2018.79007. Epub 2018 Oct 23.

7.

Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone.

Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P.

Sci Transl Med. 2018 Aug 1;10(452). pii: eaao5726. doi: 10.1126/scitranslmed.aao5726.

8.

Revision knee arthroplasty with rotating hinge systems in patients with gross ligament instability.

Boelch SP, Arnholdt J, Holzapfel BM, Jakuscheit A, Rudert M, Hoberg M.

Int Orthop. 2018 Dec;42(12):2825-2833. doi: 10.1007/s00264-018-3982-z. Epub 2018 May 22.

PMID:
29789904
9.

Effects of single and combined low frequency electromagnetic fields and simulated microgravity on gene expression of human mesenchymal stem cells during chondrogenesis.

Mayer-Wagner S, Hammerschmid F, Blum H, Krebs S, Redeker JI, Holzapfel BM, Jansson V, Müller PE.

Arch Med Sci. 2018 Apr;14(3):608-616. doi: 10.5114/aoms.2016.59894. Epub 2016 May 16.

10.

Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma.

Wagner F, Holzapfel BM, McGovern JA, Shafiee A, Baldwin JG, Martine LC, Lahr CA, Wunner FM, Friis T, Bas O, Boxberg M, Prodinger PM, Shokoohmand A, Moi D, Mazzieri R, Loessner D, Hutmacher DW.

Biomaterials. 2018 Jul;171:230-246. doi: 10.1016/j.biomaterials.2018.04.030. Epub 2018 Apr 16.

PMID:
29705656
11.

Fetal Bone Marrow-Derived Mesenchymal Stem/Stromal Cells Enhance Humanization and Bone Formation of BMP7 Loaded Scaffolds.

Shafiee A, Baldwin JG, Patel J, Holzapfel BM, Fisk NM, Khosrotehrani K, Hutmacher DW.

Biotechnol J. 2017 Dec;12(12). doi: 10.1002/biot.201700414. Epub 2017 Sep 25.

PMID:
28862380
12.

High Prevalence of Vitamin D Deficiency in Patients with Bone Tumors.

Horas K, Maier G, Jakob F, Maus U, Kurth A, Jakuscheit A, Rudert M, Holzapfel BM.

Cancer Invest. 2017 Sep 14;35(8):562-568. doi: 10.1080/07357907.2017.1351985. Epub 2017 Aug 11.

PMID:
28799812
13.

[Scaffold-based Bone Tissue Engineering].

Holzapfel BM, Rudert M, Hutmacher DW.

Orthopade. 2017 Aug;46(8):701-710. doi: 10.1007/s00132-017-3444-0. Review. German.

PMID:
28725934
14.

Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load.

Holzapfel NP, Shokoohmand A, Wagner F, Landgraf M, Champ S, Holzapfel BM, Clements JA, Hutmacher DW, Loessner D.

Am J Cancer Res. 2017 Jun 1;7(6):1322-1336. eCollection 2017.

15.

Engineering a humanized bone organ model in mice to study bone metastases.

Martine LC, Holzapfel BM, McGovern JA, Wagner F, Quent VM, Hesami P, Wunner FM, Vaquette C, De-Juan-Pardo EM, Brown TD, Nowlan B, Wu DJ, Hutmacher CO, Moi D, Oussenko T, Piccinini E, Zandstra PW, Mazzieri R, Lévesque JP, Dalton PD, Taubenberger AV, Hutmacher DW.

Nat Protoc. 2017 Apr;12(4):639-663. doi: 10.1038/nprot.2017.002. Epub 2017 Mar 2.

PMID:
28253234
16.

[Acetabular revision arthroplasty : Current concepts and new developments].

Holzapfel BM, Rudert M.

Orthopade. 2017 Feb;46(2):111-113. doi: 10.1007/s00132-016-3374-2. German. No abstract available.

PMID:
28168418
17.

[Individualized unicondylar knee replacement : Use of patient-specific implants and instruments].

Arnholdt J, Holzapfel BM, Sefrin L, Rudert M, Beckmann J, Steinert AF.

Oper Orthop Traumatol. 2017 Feb;29(1):31-39. doi: 10.1007/s00064-017-0485-9. Epub 2017 Jan 31. German.

PMID:
28144717
18.

Bicompartmental individualized knee replacement : Use of patient-specific implants and instruments (iDuo™).

Steinert AF, Beckmann J, Holzapfel BM, Rudert M, Arnholdt J.

Oper Orthop Traumatol. 2017 Feb;29(1):51-58. doi: 10.1007/s00064-017-0484-x. Epub 2017 Jan 31.

PMID:
28144716
19.

Periosteum tissue engineering in an orthotopic in vivo platform.

Baldwin JG, Wagner F, Martine LC, Holzapfel BM, Theodoropoulos C, Bas O, Savi FM, Werner C, De-Juan-Pardo EM, Hutmacher DW.

Biomaterials. 2017 Mar;121:193-204. doi: 10.1016/j.biomaterials.2016.11.016. Epub 2016 Nov 20.

PMID:
28092776
20.

Acetabular defect classification in times of 3D imaging and patient-specific treatment protocols.

Horas K, Arnholdt J, Steinert AF, Hoberg M, Rudert M, Holzapfel BM.

Orthopade. 2017 Feb;46(2):168-178. doi: 10.1007/s00132-016-3378-y. Review.

PMID:
28078371
21.

[Treatment of acetabular bone defects in revision hip arthroplasty using the Revisio-System].

Hoberg M, Holzapfel BM, Steinert AF, Kratzer F, Walcher M, Rudert M.

Orthopade. 2017 Feb;46(2):126-132. doi: 10.1007/s00132-016-3375-1. German.

PMID:
28012061
22.

Tissue engineering and regenerative medicine in musculoskeletal oncology.

Holzapfel BM, Wagner F, Martine LC, Reppenhagen S, Rudert M, Schuetz M, Denham J, Schantz JT, Hutmacher DW.

Cancer Metastasis Rev. 2016 Sep;35(3):475-87. doi: 10.1007/s10555-016-9635-z. Review.

PMID:
27566370
23.

Does Anticoagulant Medication Alter Fracture-Healing? A Morphological and Biomechanical Evaluation of the Possible Effects of Rivaroxaban and Enoxaparin Using a Rat Closed Fracture Model.

Prodinger PM, Burgkart R, Kreutzer K, Liska F, Pilge H, Schmitt A, Knödler M, Holzapfel BM, Hapfelmeier A, Tischer T, Bissinger O.

PLoS One. 2016 Jul 25;11(7):e0159669. doi: 10.1371/journal.pone.0159669. eCollection 2016.

24.

Case report - calcification of the medial collateral ligament of the knee with simultaneous calcifying tendinitis of the rotator cuff.

Kamawal Y, Steinert AF, Holzapfel BM, Rudert M, Barthel T.

BMC Musculoskelet Disord. 2016 Jul 13;17:283. doi: 10.1186/s12891-016-1147-z.

25.

A Validated Preclinical Animal Model for Primary Bone Tumor Research.

Wagner F, Holzapfel BM, Thibaudeau L, Straub M, Ling MT, Grifka J, Loessner D, Lévesque JP, Hutmacher DW.

J Bone Joint Surg Am. 2016 Jun 1;98(11):916-25. doi: 10.2106/JBJS.15.00920.

PMID:
27252436
26.

Data for accelerated degradation of calcium phosphate surface-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds.

Poh PS, Hutmacher DW, Holzapfel BM, Solanki AK, Woodruff MA.

Data Brief. 2016 Jan 22;7:923-6. doi: 10.1016/j.dib.2016.01.023. eCollection 2016 Jun.

27.

[Total knee arthroplasty. Patient-specific instruments and implants].

Steinert AF, Holzapfel BM, Sefrin L, Arnholdt J, Hoberg M, Rudert M.

Orthopade. 2016 Apr;45(4):331-40. doi: 10.1007/s00132-016-3246-9. Review. German.

PMID:
27025870
28.

Lycopene's Effects on Cancer Cell Functions within Monolayer and Spheroid Cultures.

Holzapfel NP, Holzapfel BM, Theodoropoulos C, Kaemmerer E, Rausch T, Feldthusen J, Champ S, Clements JA, Hutmacher DW, Loessner D.

Nutr Cancer. 2016;68(2):350-63. doi: 10.1080/01635581.2016.1150498. Epub 2016 Mar 25.

PMID:
27015041
29.

The Wuerzburg procedure: the tensor fasciae latae perforator is a reliable anatomical landmark to clearly identify the Hueter interval when using the minimally-invasive direct anterior approach to the hip joint.

Rudert M, Horas K, Hoberg M, Steinert A, Holzapfel DE, Hübner S, Holzapfel BM.

BMC Musculoskelet Disord. 2016 Feb 3;17:57. doi: 10.1186/s12891-016-0908-z.

30.

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy.

Dondossola E, Holzapfel BM, Alexander S, Filippini S, Hutmacher DW, Friedl P.

Nat Biomed Eng. 2016;1. pii: 0007. doi: 10.1038/s41551-016-0007. Epub 2016 Dec 19.

31.

In vitro and in vivo bone formation potential of surface calcium phosphate-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds.

Poh PSP, Hutmacher DW, Holzapfel BM, Solanki AK, Stevens MM, Woodruff MA.

Acta Biomater. 2016 Jan;30:319-333. doi: 10.1016/j.actbio.2015.11.012. Epub 2015 Nov 10.

PMID:
26563472
32.

Function of the extensor mechanism of the knee after using the 'patellar-loop technique' to reconstruct the patellar tendon when replacing the proximal tibia for tumour.

Pilge H, Holzapfel BM, Rechl H, Prodinger PM, Lampe R, Saur U, Eisenhart-Rothe R, Gollwitzer H.

Bone Joint J. 2015 Aug;97-B(8):1063-9. doi: 10.1302/0301-620X.97B8.35440.

PMID:
26224822
33.

Humanized mice models for primary bone tumor and bone metastasis research.

Thibaudeau L, Holzapfel BM, Hutmacher DW.

Cell Cycle. 2015;14(14):2191-2. doi: 10.1080/15384101.2015.1062327. No abstract available.

34.

Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance.

Hutmacher DW, Holzapfel BM, De-Juan-Pardo EM, Pereira BA, Ellem SJ, Loessner D, Risbridger GP.

Curr Opin Biotechnol. 2015 Dec;35:127-32. doi: 10.1016/j.copbio.2015.06.001. Epub 2015 Jun 26. Review.

PMID:
26121082
35.

Tissue engineered humanized bone supports human hematopoiesis in vivo.

Holzapfel BM, Hutmacher DW, Nowlan B, Barbier V, Thibaudeau L, Theodoropoulos C, Hooper JD, Loessner D, Clements JA, Russell PJ, Pettit AR, Winkler IG, Levesque JP.

Biomaterials. 2015 Aug;61:103-14. doi: 10.1016/j.biomaterials.2015.04.057. Epub 2015 May 19.

PMID:
26001075
36.

Tie-2 regulates the stemness and metastatic properties of prostate cancer cells.

Tang KD, Holzapfel BM, Liu J, Lee TK, Ma S, Jovanovic L, An J, Russell PJ, Clements JA, Hutmacher DW, Ling MT.

Oncotarget. 2016 Jan 19;7(3):2572-84. doi: 10.18632/oncotarget.3950.

37.

Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing.

Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW.

Biomaterials. 2015 Jun;52:551-60. doi: 10.1016/j.biomaterials.2015.01.025. Epub 2015 Mar 18.

PMID:
25818460
38.

Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering.

Holzapfel BM, Wagner F, Thibaudeau L, Levesque JP, Hutmacher DW.

Stem Cells. 2015 Jun;33(6):1696-704. doi: 10.1002/stem.1978. Review.

39.

Impaction bone grafting for the reconstruction of large bone defects in revision knee arthroplasty.

Rudert M, Holzapfel BM, von Rottkay E, Holzapfel DE, Noeth U.

Oper Orthop Traumatol. 2015 Feb;27(1):35-46. doi: 10.1007/s00064-014-0330-3. Epub 2015 Feb 4.

PMID:
25645323
40.

New mechanistic insights of integrin β1 in breast cancer bone colonization.

Thibaudeau L, Taubenberger AV, Theodoropoulos C, Holzapfel BM, Ramuz O, Straub M, Hutmacher DW.

Oncotarget. 2015 Jan 1;6(1):332-44.

41.

A simple technique to seal the medullary canal in cemented revision arthroplasty.

Holzapfel BM, Nöth U, Rudert M.

Eur J Orthop Surg Traumatol. 2015 Apr;25(3):601-2. doi: 10.1007/s00590-014-1530-0. Epub 2014 Sep 9. No abstract available.

PMID:
25200316
42.

Simulated microgravity affects chondrogenesis and hypertrophy of human mesenchymal stem cells.

Mayer-Wagner S, Hammerschmid F, Redeker JI, Schmitt B, Holzapfel BM, Jansson V, Betz OB, Müller PE.

Int Orthop. 2014 Dec;38(12):2615-21. doi: 10.1007/s00264-014-2454-3. Epub 2014 Jul 17.

PMID:
25030964
43.

Elastofibroma: clinical results after resection of a rare tumor entity.

Pilge H, Hesper T, Holzapfel BM, Prodinger PM, Straub M, Krauspe R.

Orthop Rev (Pavia). 2014 Jun 16;6(2):5329. doi: 10.4081/or.2014.5329. eCollection 2014 Apr 22.

44.

Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses.

Loessner D, Holzapfel BM, Clements JA.

Adv Drug Deliv Rev. 2014 Dec 15;79-80:193-213. doi: 10.1016/j.addr.2014.06.001. Epub 2014 Jun 23. Review.

PMID:
24969478
45.

Mimicking breast cancer-induced bone metastasis in vivo: current transplantation models and advanced humanized strategies.

Thibaudeau L, Quent VM, Holzapfel BM, Taubenberger AV, Straub M, Hutmacher DW.

Cancer Metastasis Rev. 2014 Sep;33(2-3):721-35. doi: 10.1007/s10555-014-9499-z. Review.

PMID:
24771149
46.

A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone.

Thibaudeau L, Taubenberger AV, Holzapfel BM, Quent VM, Fuehrmann T, Hesami P, Brown TD, Dalton PD, Power CA, Hollier BG, Hutmacher DW.

Dis Model Mech. 2014 Feb;7(2):299-309. doi: 10.1242/dmm.014076.

47.

Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours.

Holzapfel BM, Pilge H, Prodinger PM, Toepfer A, Mayer-Wagner S, Hutmacher DW, von Eisenhart-Rothe R, Rudert M, Gradinger R, Rechl H.

Int Orthop. 2014 Jul;38(7):1435-42.

48.

Gelatine methacrylamide-based hydrogels: an alternative three-dimensional cancer cell culture system.

Kaemmerer E, Melchels FP, Holzapfel BM, Meckel T, Hutmacher DW, Loessner D.

Acta Biomater. 2014 Jun;10(6):2551-62. doi: 10.1016/j.actbio.2014.02.035. Epub 2014 Feb 28.

PMID:
24590158
49.

Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.

Holzapfel BM, Wagner F, Loessner D, Holzapfel NP, Thibaudeau L, Crawford R, Ling MT, Clements JA, Russell PJ, Hutmacher DW.

Biomaterials. 2014 Apr;35(13):4108-15. doi: 10.1016/j.biomaterials.2014.01.062. Epub 2014 Feb 16.

PMID:
24534484
50.

A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone.

Hesami P, Holzapfel BM, Taubenberger A, Roudier M, Fazli L, Sieh S, Thibaudeau L, Gregory LS, Hutmacher DW, Clements JA.

Clin Exp Metastasis. 2014 Apr;31(4):435-46. doi: 10.1007/s10585-014-9638-5. Epub 2014 Feb 8.

PMID:
24510218

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