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Dynamic Relationship of the SNARE Complex with a Membrane.

Holz RW, Zimmerberg J.

Biophys J. 2019 Aug 20;117(4):627-630. doi: 10.1016/j.bpj.2019.07.010. Epub 2019 Jul 16. Review.


Identification of β-synuclein on secretory granules in chromaffin cells and the effects of α- and β-synuclein on post-fusion BDNF discharge and fusion pore expansion.

Abbineni PS, Bohannon KP, Bittner MA, Axelrod D, Holz RW.

Neurosci Lett. 2019 Apr 23;699:134-139. doi: 10.1016/j.neulet.2019.01.056. Epub 2019 Jan 31.


Chromogranin A, the major lumenal protein in chromaffin granules, controls fusion pore expansion.

Abbineni PS, Bittner MA, Axelrod D, Holz RW.

J Gen Physiol. 2019 Feb 4;151(2):118-130. doi: 10.1085/jgp.201812182. Epub 2018 Nov 30.


Visualization of expanding fusion pores in secretory cells.

Abbineni PS, Axelrod D, Holz RW.

J Gen Physiol. 2018 Dec 3;150(12):1640-1646. doi: 10.1085/jgp.201812186. Epub 2018 Nov 23. Review. No abstract available.


Refractive Index Imaging of Cells with Variable-Angle Near-Total Internal Reflection (TIR) Microscopy.

Bohannon KP, Holz RW, Axelrod D.

Microsc Microanal. 2017 Oct;23(5):978-988. doi: 10.1017/S1431927617012570. Epub 2017 Sep 18.


Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo.

Bohannon KP, Bittner MA, Lawrence DA, Axelrod D, Holz RW.

J Gen Physiol. 2017 Oct 2;149(10):921-934. doi: 10.1085/jgp.201711842. Epub 2017 Sep 7.


Food deprivation induces presynaptic plasticity in the autonomic nervous system.

Holz RW, Anantharam A.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5766-7. doi: 10.1073/pnas.1605618113. Epub 2016 May 13. No abstract available.


Lumenal protein within secretory granules affects fusion pore expansion.

Weiss AN, Anantharam A, Bittner MA, Axelrod D, Holz RW.

Biophys J. 2014 Jul 1;107(1):26-33. doi: 10.1016/j.bpj.2014.04.064.


Protein mobility within secretory granules.

Weiss AN, Bittner MA, Holz RW, Axelrod D.

Biophys J. 2014 Jul 1;107(1):16-25. doi: 10.1016/j.bpj.2014.04.063.


Cell biology. Dynamin flexibility drives fission.

Holz RW.

Science. 2013 Mar 22;339(6126):1392-3. doi: 10.1126/science.1236005. No abstract available.


A nibbling mechanism for clathrin-mediated retrieval of secretory granule membrane after exocytosis.

Bittner MA, Aikman RL, Holz RW.

J Biol Chem. 2013 Mar 29;288(13):9177-88. doi: 10.1074/jbc.M113.450361. Epub 2013 Feb 5.


Peptide ordering within nuclear pores in living cells.

Holz RW.

Biophys J. 2013 Jan 8;104(1):6-7. doi: 10.1016/j.bpj.2012.11.3824. Epub 2013 Jan 8. No abstract available.


Real-time imaging of plasma membrane deformations reveals pre-fusion membrane curvature changes and a role for dynamin in the regulation of fusion pore expansion.

Anantharam A, Axelrod D, Holz RW.

J Neurochem. 2012 Aug;122(4):661-71. doi: 10.1111/j.1471-4159.2012.07816.x. Epub 2012 Jun 27. Review.


Subunit-dependent axonal trafficking of distinct alpha heteromeric potassium channel complexes.

Jenkins PM, McIntyre JC, Zhang L, Anantharam A, Vesely ED, Arendt KL, Carruthers CJ, Kerppola TK, Iñiguez-Lluhí JA, Holz RW, Sutton MA, Martens JR.

J Neurosci. 2011 Sep 14;31(37):13224-35. doi: 10.1523/JNEUROSCI.0976-11.2011.


A new role for the dynamin GTPase in the regulation of fusion pore expansion.

Anantharam A, Bittner MA, Aikman RL, Stuenkel EL, Schmid SL, Axelrod D, Holz RW.

Mol Biol Cell. 2011 Jun 1;22(11):1907-18. doi: 10.1091/mbc.E11-02-0101. Epub 2011 Apr 1.


Polarized TIRFM reveals changes in plasma membrane topology before and during granule fusion.

Anantharam A, Axelrod D, Holz RW.

Cell Mol Neurobiol. 2010 Nov;30(8):1343-9. doi: 10.1007/s10571-010-9590-0.


Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM.

Anantharam A, Onoa B, Edwards RH, Holz RW, Axelrod D.

J Cell Biol. 2010 Feb 8;188(3):415-28. doi: 10.1083/jcb.200908010.


Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.

Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, Adams A, Liu L, Arvan P.

J Biol Chem. 2010 Jan 1;285(1):685-94. doi: 10.1074/jbc.M109.038042. Epub 2009 Oct 30.


Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy.

Furman CA, Chen R, Guptaroy B, Zhang M, Holz RW, Gnegy M.

J Neurosci. 2009 Mar 11;29(10):3328-36. doi: 10.1523/JNEUROSCI.5386-08.2009.


The structural and functional implications of linked SNARE motifs in SNAP25.

Wang L, Bittner MA, Axelrod D, Holz RW.

Mol Biol Cell. 2008 Sep;19(9):3944-55. doi: 10.1091/mbc.E08-04-0344. Epub 2008 Jul 2.


Increased motion and travel, rather than stable docking, characterize the last moments before secretory granule fusion.

Degtyar VE, Allersma MW, Axelrod D, Holz RW.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15929-34. Epub 2007 Sep 24.


Analysis of the late steps of exocytosis: biochemical and total internal reflection fluorescence microscopy (TIRFM) studies.

Holz RW.

Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):439-47. Epub 2006 Apr 20. Review.


Motion matters: secretory granule motion adjacent to the plasma membrane and exocytosis.

Allersma MW, Bittner MA, Axelrod D, Holz RW.

Mol Biol Cell. 2006 May;17(5):2424-38. Epub 2006 Mar 1.


Phosphatidylinositol-4,5-bisphosphate: actin dynamics and the regulation of ATP-dependent and -independent secretion.

Bittner MA, Holz RW.

Mol Pharmacol. 2005 Apr;67(4):1089-98. Epub 2005 Jan 5.


Visualization of regulated exocytosis with a granule-membrane probe using total internal reflection microscopy.

Allersma MW, Wang L, Axelrod D, Holz RW.

Mol Biol Cell. 2004 Oct;15(10):4658-68. Epub 2004 Jul 28.


Retrograde regulation of synaptic vesicle endocytosis and recycling.

Micheva KD, Buchanan J, Holz RW, Smith SJ.

Nat Neurosci. 2003 Sep;6(9):925-32.


Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.

Sun L, Bittner MA, Holz RW.

J Biol Chem. 2003 Oct 3;278(40):38301-9. Epub 2003 Jul 18.


Facilitation of Ca(2+)-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells.

Li Q, Ho CS, Marinescu V, Bhatti H, Bokoch GM, Ernst SA, Holz RW, Stuenkel EL.

J Physiol. 2003 Jul 15;550(Pt 2):431-45. Epub 2003 May 16.


Exocytosis: the chromaffin cell as a model system.

Bader MF, Holz RW, Kumakura K, Vitale N.

Ann N Y Acad Sci. 2002 Oct;971:178-83. Review.


Protein-tyrosine phosphatase-sigma is a novel member of the functional family of alpha-latrotoxin receptors.

Krasnoperov V, Bittner MA, Mo W, Buryanovsky L, Neubert TA, Holz RW, Ichtchenko K, Petrenko AG.

J Biol Chem. 2002 Sep 27;277(39):35887-95. Epub 2002 Jul 10.


Regulation of presynaptic phosphatidylinositol 4,5-biphosphate by neuronal activity.

Micheva KD, Holz RW, Smith SJ.

J Cell Biol. 2001 Jul 23;154(2):355-68.


Restriction of secretory granule motion near the plasma membrane of chromaffin cells.

Johns LM, Levitan ES, Shelden EA, Holz RW, Axelrod D.

J Cell Biol. 2001 Apr 2;153(1):177-90.


Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells.

Sun L, Bittner MA, Holz RW.

J Biol Chem. 2001 Apr 20;276(16):12911-7. Epub 2001 Jan 26.


Calcium-independent receptor for alpha-latrotoxin and neurexin 1alpha [corrected] facilitate toxin-induced channel formation: evidence that channel formation results from tethering of toxin to membrane.

Hlubek MD, Stuenkel EL, Krasnoperov VG, Petrenko AG, Holz RW.

Mol Pharmacol. 2000 Mar;57(3):519-28. Erratum in: Mol Pharmacol 2000 Apr;57(4):832.


A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors.

Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG.

J Biol Chem. 1999 Feb 26;274(9):5491-8.


A Ca2+-independent receptor for alpha-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms.

Bittner MA, Krasnoperov VG, Stuenkel EL, Petrenko AG, Holz RW.

J Neurosci. 1998 Apr 15;18(8):2914-22.


alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor.

Krasnoperov VG, Bittner MA, Beavis R, Kuang Y, Salnikow KV, Chepurny OG, Little AR, Plotnikov AN, Wu D, Holz RW, Petrenko AG.

Neuron. 1997 Jun;18(6):925-37.


Evidence that syntaxin 1A is involved in storage in the secretory pathway.

Bittner MA, Bennett MK, Holz RW.

J Biol Chem. 1996 May 10;271(19):11214-21.


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