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Correction: Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.

Chepurny OG, Matsuokas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG.

J Biol Chem. 2019 May 31;294(22):8714. doi: 10.1074/jbc.AAC119.009193. No abstract available.


"A-kinase" regulator runs amok to provide a paradigm shift in cAMP signaling.

Holz GG, Chepurny OG, Leech CA.

J Biol Chem. 2019 Feb 15;294(7):2247-2248. doi: 10.1074/jbc.H119.007622.


Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.

Chepurny OG, Matsoukas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG.

J Biol Chem. 2019 Mar 8;294(10):3514-3531. doi: 10.1074/jbc.RA118.005682. Epub 2019 Jan 8. Erratum in: J Biol Chem. 2019 May 31;294(22):8714.


α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells.

Wang D, Meng Q, Leech CA, Yepuri N, Zhang L, Holz GG, Wang C, Cooney RN.

Endocrinology. 2018 Sep 1;159(9):3132-3142. doi: 10.1210/en.2018-00433.


Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.

Veluthakal R, Chepurny OG, Leech CA, Schwede F, Holz GG, Thurmond DC.

Diabetes. 2018 Oct;67(10):1999-2011. doi: 10.2337/db17-1174. Epub 2018 Jul 9.


Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG.

Sci Rep. 2018 Apr 13;8(1):6192. doi: 10.1038/s41598-018-24359-2.


Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG.

Sci Rep. 2018 Feb 28;8(1):3749. doi: 10.1038/s41598-018-22106-1. Erratum in: Sci Rep. 2018 Apr 13;8(1):6192.


A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents.

Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, Reiner DJ, Koch-Laskowski K, McGrath LE, Lhamo R, Stein LM, De Jonghe BC, Holz GG, Roth CL, Doyle RP, Hayes MR.

Diabetes Obes Metab. 2018 May;20(5):1223-1234. doi: 10.1111/dom.13222. Epub 2018 Feb 20.


PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE.

Mol Metab. 2016 May 11;5(7):459-471. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul.


Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy.

Chepurny OG, Leech CA, Tomanik M, DiPoto MC, Li H, Han X, Meng Q, Cooney RN, Wu J, Holz GG.

Sci Rep. 2016 Jun 29;6:28934. doi: 10.1038/srep28934.


GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.

Chepurny OG, Holz GG, Roe MW, Leech CA.

Mol Endocrinol. 2016 Jun;30(6):614-29. doi: 10.1210/me.2015-1306. Epub 2016 Apr 15.


Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3-36).

Henry KE, Kerwood DJ, Allis DG, Workinger JL, Bonaccorso RL, Holz GG, Roth CL, Zubieta J, Doyle RP.

ChemMedChem. 2016 May 6;11(9):1015-21. doi: 10.1002/cmdc.201600073. Epub 2016 Mar 30.


Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells.

Takeda Y, Shimayoshi T, Holz GG, Noma A.

Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C337-47. doi: 10.1152/ajpcell.00234.2015. Epub 2015 Nov 25.


Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4.

Bonaccorso RL, Chepurny OG, Becker-Pauly C, Holz GG, Doyle RP.

Mol Pharm. 2015 Sep 8;12(9):3502-6. doi: 10.1021/acs.molpharmaceut.5b00390. Epub 2015 Aug 11.


Follow-up barium study after a negative water-soluble contrast examination for suspected esophageal leak: is it necessary?

Sanchez TR, Holz GS, Corwin MT, Wood RJ, Wootton-Gorges SL.

Emerg Radiol. 2015 Oct;22(5):539-42. doi: 10.1007/s10140-015-1329-2. Epub 2015 Jun 16.


Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.


Ischemic colitis due to a mesenteric arteriovenous malformation in a patient with a connective tissue disorder.

Poullos PD, Thompson AC, Holz G, Edelman LA, Jeffrey RB.

J Radiol Case Rep. 2014 Dec 31;8(12):9-21. doi: 10.3941/jrcr.v8i12.1843. eCollection 2014 Dec.


Novel mechanism of arenavirus-induced liver pathology.

Beier JI, Jokinen JD, Holz GE, Whang PS, Martin AM, Warner NL, Arteel GE, Lukashevich IS.

PLoS One. 2015 Mar 30;10(3):e0122839. doi: 10.1371/journal.pone.0122839. eCollection 2015.


Vitamin B12 conjugation of peptide-YY(3-36) decreases food intake compared to native peptide-YY(3-36) upon subcutaneous administration in male rats.

Henry KE, Elfers CT, Burke RM, Chepurny OG, Holz GG, Blevins JE, Roth CL, Doyle RP.

Endocrinology. 2015 May;156(5):1739-49. doi: 10.1210/en.2014-1825. Epub 2015 Feb 6.


New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice.

Holz GG, Leech CA, Chepurny OG.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2593-600. doi: 10.1016/j.bbadis.2014.06.023. Epub 2014 Jun 27. Review.


Fasting therapy - an expert panel update of the 2002 consensus guidelines.

Wilhelmi de Toledo F, Buchinger A, Burggrabe H, Hölz G, Kuhn C, Lischka E, Lischka N, Lützner H, May W, Ritzmann-Widderich M, Stange R, Wessel A, Boschmann M, Peper E, Michalsen A; Medical Association for Fasting and Nutrition (Ärztegesellschaft für Heilfasten und Ernährung, ÄGHE.

Forsch Komplementmed. 2013;20(6):434-43. doi: 10.1159/000357602. Epub 2013 Dec 16.


Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.

Hösel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, Büning H.

Hepatology. 2014 Jun;59(6):2110-20. doi: 10.1002/hep.26990. Epub 2014 Apr 30.


Regulation of glucose homeostasis by GLP-1.

Nadkarni P, Chepurny OG, Holz GG.

Prog Mol Biol Transl Sci. 2014;121:23-65. doi: 10.1016/B978-0-12-800101-1.00002-8. Review.


Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?

Holz GG, Chepurny OG, Leech CA.

Islets. 2013 Sep-Dec;5(5):229-32. doi: 10.4161/isl.26958. Epub 2013 Nov 8. Review.


CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.

Zippin JH, Chen Y, Straub SG, Hess KC, Diaz A, Lee D, Tso P, Holz GG, Sharp GW, Levin LR, Buck J.

J Biol Chem. 2013 Nov 15;288(46):33283-91. doi: 10.1074/jbc.M113.510073. Epub 2013 Oct 7.


Epac2A makes a new impact in β-cell biology.

Holz GG, Chepurny OG, Leech CA.

Diabetes. 2013 Aug;62(8):2665-6. doi: 10.2337/db13-0796. No abstract available.


Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.

Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2013 Aug;27(8):1267-82. doi: 10.1210/me.2013-1029. Epub 2013 Jun 24.


Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J.

J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15.


Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

Clardy-James S, Chepurny OG, Leech CA, Holz GG, Doyle RP.

ChemMedChem. 2013 Apr;8(4):582-6. doi: 10.1002/cmdc.201200461. Epub 2012 Nov 30.


Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi: 10.1073/pnas.1210209109. Epub 2012 Oct 22.


Role of phospholipase Cε in physiological phosphoinositide signaling networks.

Smrcka AV, Brown JH, Holz GG.

Cell Signal. 2012 Jun;24(6):1333-43. doi: 10.1016/j.cellsig.2012.01.009. Epub 2012 Jan 20. Review.


Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.

Leech CA, Dzhura I, Chepurny OG, Kang G, Schwede F, Genieser HG, Holz GG.

Prog Biophys Mol Biol. 2011 Nov;107(2):236-47. doi: 10.1016/j.pbiomolbio.2011.07.005. Epub 2011 Jul 19. Review.


Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.


Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.

Islets. 2009 Nov-Dec;1(3):260-5. doi: 10.4161/isl.1.3.9645.


Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.

Leech CA, Chepurny OG, Holz GG.

Vitam Horm. 2010;84:279-302. doi: 10.1016/B978-0-12-381517-0.00010-2. Review.


Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.


Impact of climatic and soil conditions on environmental fate of atrazine used under plantation forestry in Australia.

Kookana R, Holz G, Barnes C, Bubb K, Fremlin R, Boardman B.

J Environ Manage. 2010 Dec;91(12):2649-56. doi: 10.1016/j.jenvman.2010.07.037. Epub 2010 Aug 19.


PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E622-33. doi: 10.1152/ajpendo.00630.2009. Epub 2009 Dec 15.


Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.

Peyot ML, Gray JP, Lamontagne J, Smith PJ, Holz GG, Madiraju SR, Prentki M, Heart E.

PLoS One. 2009 Jul 13;4(7):e6221. doi: 10.1371/journal.pone.0006221.


Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.

Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2009 Apr 17;284(16):10728-36. doi: 10.1074/jbc.M900166200. Epub 2009 Feb 25.


Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.

Stanojevic V, Habener JF, Holz GG, Leech CA.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):614-9. doi: 10.1016/j.bbrc.2008.01.109. Epub 2008 Feb 1.


Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells.

Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG.

J Physiol. 2008 Mar 1;586(5):1307-19. doi: 10.1113/jphysiol.2007.143818. Epub 2008 Jan 17.


Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells.

Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

Sci STKE. 2006 Sep 19;2006(353):pl6.


Cell physiology of cAMP sensor Epac.

Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG.

J Physiol. 2006 Nov 15;577(Pt 1):5-15. Epub 2006 Sep 14. Review.


cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.

Kang G, Chepurny OG, Malester B, Rindler MJ, Rehmann H, Bos JL, Schwede F, Coetzee WA, Holz GG.

J Physiol. 2006 Jun 15;573(Pt 3):595-609. Epub 2006 Apr 13.


Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

J Biol Chem. 2005 Sep 2;280(35):31294-302. Epub 2005 Jun 29.

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