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Author Correction: The choroid plexus is an important circadian clock component.

Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T.

Nat Commun. 2019 Nov 20;10(1):5253. doi: 10.1038/s41467-019-13101-9.


A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice.

Sodhi CP, Nguyen J, Yamaguchi Y, Werts AD, Lu P, Ladd MR, Fulton WB, Kovler ML, Wang S, Prindle T Jr, Zhang Y, Lazartigues ED, Holtzman MJ, Alcorn JF, Hackam DJ, Jia H.

J Immunol. 2019 Dec 1;203(11):3000-3012. doi: 10.4049/jimmunol.1900579. Epub 2019 Oct 23.


Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost.

Zhang Y, Mao D, Keeler SP, Wang X, Wu K, Gerovac BJ, Shornick LL, Agapov EV, Holtzman MJ.

J Immunol. 2019 Apr 15;202(8):2332-2347. doi: 10.4049/jimmunol.1801491. Epub 2019 Feb 25.


Epithelial-Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease.

Keeler SP, Gerovac BJ, Wu K, Wang X, Chartock JR, Byers DE, Romero AG, Holtzman MJ.

Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S260-S265. doi: 10.1513/AnnalsATS.201808-531MG. Review.


Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants.

Keeler SP, Agapov EV, Hinojosa ME, Letvin AN, Wu K, Holtzman MJ.

J Immunol. 2018 Oct 15;201(8):2354-2368. doi: 10.4049/jimmunol.1800671. Epub 2018 Sep 12.


Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.

Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS.

J Clin Invest. 2018 Nov 1;128(11):5110-5122. doi: 10.1172/JCI120453. Epub 2018 Oct 15.


The choroid plexus is an important circadian clock component.

Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T.

Nat Commun. 2018 Mar 14;9(1):1062. doi: 10.1038/s41467-018-03507-2. Erratum in: Nat Commun. 2019 Nov 20;10(1):5253.


Recurrent wheezing in children following human metapneumovirus infection.

Coverstone AM, Wilson B, Burgdorf D, Schechtman KB, Storch GA, Holtzman MJ, Castro M, Bacharier LB, Sumino K.

J Allergy Clin Immunol. 2018 Jul;142(1):297-301.e2. doi: 10.1016/j.jaci.2018.02.008. Epub 2018 Mar 2. No abstract available.


Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.

Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI.

PLoS Genet. 2017 Dec 15;13(12):e1007128. doi: 10.1371/journal.pgen.1007128. eCollection 2017 Dec.


Triggering Receptor Expressed on Myeloid Cells-2 Expression Tracks With M2-Like Macrophage Activity and Disease Severity in COPD.

Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ.

Chest. 2018 Jan;153(1):77-86. doi: 10.1016/j.chest.2017.09.044. Epub 2017 Oct 7.


Epithelial Chloride Transport by CFTR Requires TMEM16A.

Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K.

Sci Rep. 2017 Sep 29;7(1):12397. doi: 10.1038/s41598-017-10910-0.


The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS.

Science. 2017 Aug 4;357(6350):498-502. doi: 10.1126/science.aam5336.


Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW.

Nat Microbiol. 2017 Jun 30;2:17101. doi: 10.1038/nmicrobiol.2017.101.


American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.

Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):375-381. doi: 10.1164/rccm.201705-0973WS.


BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.

Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA.

Mucosal Immunol. 2018 Jan;11(1):97-111. doi: 10.1038/mi.2017.24. Epub 2017 Apr 12.


Estrogen receptor α is required for oviductal transport of embryos.

Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W.

FASEB J. 2017 Apr;31(4):1595-1607. doi: 10.1096/fj.201601128R. Epub 2017 Jan 12.


PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.

Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL.

Radiology. 2017 Jun;283(3):758-768. doi: 10.1148/radiol.2016161409. Epub 2017 Jan 3.


Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.

Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ.

Elife. 2016 Dec 20;5. pii: e20391. doi: 10.7554/eLife.20391.


Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA.

Mol Cell Neurosci. 2016 Dec;77:47-52. doi: 10.1016/j.mcn.2016.10.004. Epub 2016 Oct 14.


Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression.

Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD.

Cell Host Microbe. 2016 Jul 13;20(1):72-82. doi: 10.1016/j.chom.2016.06.006.


First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.

Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2335-2344. doi: 10.1016/j.bbagen.2016.06.023. Epub 2016 Jun 29.


Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW.

Cell Host Microbe. 2016 Jan 13;19(1):102-13. doi: 10.1016/j.chom.2015.12.011.


PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.

Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ.

Nat Immunol. 2015 Dec;16(12):1215-27. doi: 10.1038/ni.3279. Epub 2015 Oct 19.


STAT1 modification improves therapeutic effects of interferons on lung cancer cells.

Chen J, Zhao J, Chen L, Dong N, Ying Z, Cai Z, Ji D, Zhang Y, Dong L, Li Y, Jiang L, Holtzman MJ, Chen C.

J Transl Med. 2015 Sep 8;13:293. doi: 10.1186/s12967-015-0656-0.


An acoustofluidic sputum liquefier.

Huang PH, Ren L, Nama N, Li S, Li P, Yao X, Cuento RA, Wei CH, Chen Y, Xie Y, Nawaz AA, Alevy YG, Holtzman MJ, McCoy JP, Levine SJ, Huang TJ.

Lab Chip. 2015 Aug 7;15(15):3125-31. doi: 10.1039/c5lc00539f.


IL13 activates autophagy to regulate secretion in airway epithelial cells.

Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL.

Autophagy. 2016;12(2):397-409. doi: 10.1080/15548627.2015.1056967. Epub 2015 Jun 10.


TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.

Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ.

J Exp Med. 2015 May 4;212(5):681-97. doi: 10.1084/jem.20141732. Epub 2015 Apr 20.


The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.

Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):790-9. doi: 10.1107/S1399004715001212. Epub 2015 Mar 26.


Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.

Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, Sestan N, Steen H, Monuki ES, Lehtinen MK.

J Neurosci. 2015 Mar 25;35(12):4903-16. doi: 10.1523/JNEUROSCI.3081-14.2015. Erratum in: J Neurosci. 2015 Jun 3;35(22):8686. Adelita, Tai [corrected to Adelita, Tais].


The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa.

Kim HJ, Kim CH, Kim MJ, Ryu JH, Seong SY, Kim S, Lim SJ, Holtzman MJ, Yoon JH.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):525-35. doi: 10.1165/rcmb.2014-0334OC.


OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.

Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M.

J Immunol. 2015 Apr 1;194(7):3317-26. doi: 10.4049/jimmunol.1402289. Epub 2015 Feb 25.


Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells.

Holtzman MJ, Byers DE, Brett JA, Patel AC, Agapov E, Jin X, Wu K.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S287-91. doi: 10.1513/AnnalsATS.201402-056AW. Review.


Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.

Gowdy KM, Martinu T, Nugent JL, Manzo ND, Zhang HL, Kelly FL, Holtzman MJ, Palmer SM.

Transpl Immunol. 2015 Jan;32(1):51-60. doi: 10.1016/j.trim.2014.10.005. Epub 2014 Nov 5.


Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.

Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ.

J Virol. 2015 Jan;89(1):337-49. doi: 10.1128/JVI.02110-14. Epub 2014 Oct 15.


The role of airway epithelial cells and innate immune cells in chronic respiratory disease.

Holtzman MJ, Byers DE, Alexander-Brett J, Wang X.

Nat Rev Immunol. 2014 Oct;14(10):686-98. doi: 10.1038/nri3739. Epub 2014 Sep 19. Review.


Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.

Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS Jr, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ.

J Allergy Clin Immunol. 2014 Dec;134(6):1402-1412.e7. doi: 10.1016/j.jaci.2014.07.013. Epub 2014 Sep 9.


Myb permits multilineage airway epithelial cell differentiation.

Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL.

Stem Cells. 2014 Dec;32(12):3245-56. doi: 10.1002/stem.1814.


Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis.

Ebbinghaus M, Gajda M, Holtzman MJ, Schulz S, Schaible HG.

Neurosci Lett. 2014 Jul 25;576:40-4. doi: 10.1016/j.neulet.2014.05.051. Epub 2014 Jun 4.


Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.

Philippot Q, Deslée G, Adair-Kirk TL, Woods JC, Byers D, Conradi S, Dury S, Perotin JM, Lebargy F, Cassan C, Le Naour R, Holtzman MJ, Pierce RA.

PLoS One. 2014 May 1;9(5):e96285. doi: 10.1371/journal.pone.0096285. eCollection 2014.


The Red journal at 25 years. Looking back and looking ahead.

Adler KB, Shapiro SD, Holtzman MJ, McDonald JA.

Am J Respir Cell Mol Biol. 2014 May;50(5):839-40. doi: 10.1165/rcmb.2014-0104ED. No abstract available.


Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.

Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ.

Protein Expr Purif. 2014 Apr;96:32-8. doi: 10.1016/j.pep.2014.01.015. Epub 2014 Feb 7.


Chemosensory functions for pulmonary neuroendocrine cells.

Gu X, Karp PH, Brody SL, Pierce RA, Welsh MJ, Holtzman MJ, Ben-Shahar Y.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):637-46. doi: 10.1165/rcmb.2013-0199OC.


Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.

Byers DE, Alexander-Brett J, Patel AC, Agapov E, Dang-Vu G, Jin X, Wu K, You Y, Alevy Y, Girard JP, Stappenbeck TS, Patterson GA, Pierce RA, Brody SL, Holtzman MJ.

J Clin Invest. 2013 Sep;123(9):3967-82. doi: 10.1172/JCI65570. Epub 2013 Aug 15. Erratum in: J Clin Invest. 2013 Dec 2;123(12):5410.


High-throughput screening normalized to biological response: application to antiviral drug discovery.

Patel DA, Patel AC, Nolan WC, Huang G, Romero AG, Charlton N, Agapov E, Zhang Y, Holtzman MJ.

J Biomol Screen. 2014 Jan;19(1):119-30. doi: 10.1177/1087057113496848. Epub 2013 Jul 16.


Reactive oxygen species induce antiviral innate immune response through IFN-λ regulation in human nasal epithelial cells.

Kim HJ, Kim CH, Ryu JH, Kim MJ, Park CY, Lee JM, Holtzman MJ, Yoon JH.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):855-65. doi: 10.1165/rcmb.2013-0003OC.


IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.

Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ.

J Clin Invest. 2012 Dec;122(12):4555-68. doi: 10.1172/JCI64896. Epub 2012 Nov 26.


Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.

Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ.

J Biol Chem. 2012 Dec 7;287(50):42138-49. doi: 10.1074/jbc.M112.410282. Epub 2012 Oct 30.


Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection.

Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman MJ, Hennighausen L, Frieman M.

J Virol. 2012 Dec;86(24):13334-49. doi: 10.1128/JVI.01689-12. Epub 2012 Sep 26.


Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens.

Holtzman MJ.

J Clin Invest. 2012 Aug;122(8):2741-8. doi: 10.1172/JCI60325. Epub 2012 Aug 1. Review.


P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception.

Brown SM, Campbell SD, Crafford A, Regina KJ, Holtzman MJ, Kharasch ED.

J Pharmacol Exp Ther. 2012 Oct;343(1):53-61. doi: 10.1124/jpet.112.193433. Epub 2012 Jun 27.

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