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Items: 32

1.

Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration.

Fahey JW, Wade KL, Stephenson KK, Panjwani AA, Liu H, Cornblatt G, Cornblatt BS, Ownby SL, Fuchs E, Holtzclaw WD, Cheskin LJ.

Nutrients. 2019 Jun 29;11(7). pii: E1489. doi: 10.3390/nu11071489.

2.

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.

Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT.

PLoS One. 2019 Mar 13;14(3):e0213095. doi: 10.1371/journal.pone.0213095. eCollection 2019.

3.

Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency.

Fahey JW, Wade KL, Wehage SL, Holtzclaw WD, Liu H, Talalay P, Fuchs E, Stephenson KK.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600766. Epub 2017 Feb 8.

PMID:
27935214
4.

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase.

Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P.

PLoS One. 2015 Nov 2;10(11):e0140963. doi: 10.1371/journal.pone.0140963. eCollection 2015.

5.

Purification of active myrosinase from plants by aqueous two-phase counter-current chromatography.

Wade KL, Ito Y, Ramarathnam A, Holtzclaw WD, Fahey JW.

Phytochem Anal. 2015 Jan-Feb;26(1):47-53. doi: 10.1002/pca.2535. Epub 2014 Aug 7.

6.

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P.

Cancer Prev Res (Phila). 2012 Apr;5(4):603-11. doi: 10.1158/1940-6207.CAPR-11-0538. Epub 2012 Feb 7.

7.

Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.

Healy ZR, Liu H, Holtzclaw WD, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1516-23. doi: 10.1158/1055-9965.EPI-11-0279. Epub 2011 May 20.

8.

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.

Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T.

J Biol Chem. 2010 Oct 29;285(44):33747-55. doi: 10.1074/jbc.M110.163485. Epub 2010 Aug 26.

9.

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

Shapiro TA, Fahey JW, Dinkova-Kostova AT, Holtzclaw WD, Stephenson KK, Wade KL, Ye L, Talalay P.

Nutr Cancer. 2006;55(1):53-62.

PMID:
16965241
10.

The role of Keap1 in cellular protective responses.

Dinkova-Kostova AT, Holtzclaw WD, Kensler TW.

Chem Res Toxicol. 2005 Dec;18(12):1779-91. Review. No abstract available.

PMID:
16359168
11.

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

Dinkova-Kostova AT, Holtzclaw WD, Wakabayashi N.

Biochemistry. 2005 May 10;44(18):6889-99.

PMID:
15865434
12.

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. Epub 2005 Mar 14.

13.

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

Holtzclaw WD, Dinkova-Kostova AT, Talalay P.

Adv Enzyme Regul. 2004;44:335-67. Review. No abstract available.

PMID:
15581500
14.

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. Epub 2004 Feb 5.

15.

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.

Talalay P, Dinkova-Kostova AT, Holtzclaw WD.

Adv Enzyme Regul. 2003;43:121-34. Review. No abstract available.

PMID:
12791387
16.

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.

Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13. Epub 2002 Aug 22.

17.
18.

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

Zhao Q, Yang XL, Holtzclaw WD, Talalay P.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1669-74. Erratum in: Proc Natl Acad Sci U S A 1997 May 27;94(11):5979.

19.

Comprehensive chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates.

Prestera T, Fahey JW, Holtzclaw WD, Abeygunawardana C, Kachinski JL, Talalay P.

Anal Biochem. 1996 Aug 1;239(2):168-79.

PMID:
8811902
20.

Chemoprotection against cancer by phase 2 enzyme induction.

Talalay P, Fahey JW, Holtzclaw WD, Prestera T, Zhang Y.

Toxicol Lett. 1995 Dec;82-83:173-9. Review.

PMID:
8597048
21.

Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes.

Putzer RR, Zhang Y, Prestera T, Holtzclaw WD, Wade KL, Talalay P.

Chem Res Toxicol. 1995 Jan-Feb;8(1):103-10.

PMID:
7703353
22.

Chemical and molecular regulation of enzymes that detoxify carcinogens.

Prestera T, Holtzclaw WD, Zhang Y, Talalay P.

Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2965-9.

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28.

A new assay for transaminase C.

Holtzclaw WD, Chapman LF.

Anal Biochem. 1977 Nov;83(1):162-7. No abstract available.

PMID:
411384
29.

Properties of some norvaline-resistant mutants of Bacillus subtilis.

Holtzclaw WD, Chapman LF.

J Gen Microbiol. 1975 Jun;88(2):289-94.

PMID:
807681
30.
31.

Indentification of a pH 6.5 acetohydroxyacid synthetase in Bacillus subtilis.

Holtzclaw WD, Chapman LF.

Arch Microbiol. 1974 Mar 7;96(3):267-70. No abstract available.

PMID:
4209299
32.

Some regulatory properties of phospho-2-keto-3-deoxyheptonate aldolase from the blue-green alga Anacystis nidulans.

Holtzclaw WD, Chapman LF, Gowans CS.

Biochim Biophys Acta. 1972 May 12;268(2):562-72. No abstract available.

PMID:
4623708

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