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Items: 42

1.

Rational Design of Toxoid Vaccine Candidates for Staphylococcus aureus Leukocidin AB (LukAB).

Kailasan S, Kort T, Mukherjee I, Liao GC, Kanipakala T, Williston N, Ganjbaksh N, Venkatasubramaniam A, Holtsberg FW, Karauzum H, Adhikari RP, Aman MJ.

Toxins (Basel). 2019 Jun 14;11(6). pii: E339. doi: 10.3390/toxins11060339.

2.

Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor.

Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, Sidhu SS.

J Mol Biol. 2019 Mar 27. pii: S0022-2836(19)30148-2. doi: 10.1016/j.jmb.2019.03.017. [Epub ahead of print]

PMID:
30928493
3.

TBA225, a fusion toxoid vaccine for protection and broad neutralization of staphylococcal superantigens.

Venkatasubramaniam A, Adhikari RP, Kort T, Liao GC, Conley S, Abaandou L, Kailasan S, Onodera Y, Krishnan S, Djagbare DM, Holtsberg FW, Karauzum H, Aman MJ.

Sci Rep. 2019 Mar 1;9(1):3279. doi: 10.1038/s41598-019-39890-z.

4.

Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates.

Brannan JM, He S, Howell KA, Prugar LI, Zhu W, Vu H, Shulenin S, Kailasan S, Raina H, Wong G, Rahim MN, Banadyga L, Tierney K, Zhao X, Li Y, Holtsberg FW, Dye JM, Qiu X, Aman MJ.

Nat Commun. 2019 Jan 10;10(1):105. doi: 10.1038/s41467-018-08040-w.

5.

Efficacy of Ebola Glycoprotein-Specific Equine Polyclonal Antibody Product Against Lethal Ebola Virus Infection in Guinea Pigs.

Chan M, Holtsberg FW, Vu H, Howell KA, Leung A, Van der Hart E, Walz PH, Aman MJ, Kodihalli S, Kobasa D.

J Infect Dis. 2018 Nov 22;218(suppl_5):S603-S611. doi: 10.1093/infdis/jiy329.

PMID:
29955852
6.

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms.

Warfield KL, Howell KA, Vu H, Geisbert J, Wong G, Shulenin S, Sproule S, Holtsberg FW, Leung DW, Amarasinghe GK, Swenson DL, Bavari S, Kobinger GP, Geisbert TW, Aman MJ.

J Infect Dis. 2018 Nov 22;218(suppl_5):S553-S564. doi: 10.1093/infdis/jiy316.

PMID:
29939318
7.

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.

Zhao X, Howell KA, He S, Brannan JM, Wec AZ, Davidson E, Turner HL, Chiang CI, Lei L, Fels JM, Vu H, Shulenin S, Turonis AN, Kuehne AI, Liu G, Ta M, Wang Y, Sundling C, Xiao Y, Spence JS, Doranz BJ, Holtsberg FW, Ward AB, Chandran K, Dye JM, Qiu X, Li Y, Aman MJ.

Cell. 2017 May 18;169(5):891-904.e15. doi: 10.1016/j.cell.2017.04.038.

8.

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus.

Howell KA, Brannan JM, Bryan C, McNeal A, Davidson E, Turner HL, Vu H, Shulenin S, He S, Kuehne A, Herbert AS, Qiu X, Doranz BJ, Holtsberg FW, Ward AB, Dye JM, Aman MJ.

Cell Rep. 2017 Apr 11;19(2):413-424. doi: 10.1016/j.celrep.2017.03.049.

9.

Safety and Immunogenicity of a Parenterally Administered, Structure-Based Rationally Modified Recombinant Staphylococcal Enterotoxin B Protein Vaccine, STEBVax.

Chen WH, Pasetti MF, Adhikari RP, Baughman H, Douglas R, El-Khorazaty J, Greenberg N, Holtsberg FW, Liao GC, Reymann MK, Wang X, Warfield KL, Aman MJ.

Clin Vaccine Immunol. 2016 Dec 5;23(12):918-925. Print 2016 Dec.

10.

Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.

Keck ZY, Wang Y, Lau P, Lund G, Rangarajan S, Fauvelle C, Liao GC, Holtsberg FW, Warfield KL, Aman MJ, Pierce BG, Fuerst TR, Bailey JR, Baumert TF, Mariuzza RA, Kneteman NM, Foung SK.

Hepatology. 2016 Dec;64(6):1922-1933. doi: 10.1002/hep.28850. Epub 2016 Oct 28.

11.

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.

Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE Jr, Aman MJ, Dye JM, Lai JR, Chandran K.

Science. 2016 Oct 21;354(6310):350-354. Epub 2016 Sep 8.

12.

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site.

Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, Kroeker A, Vu H, Herbert AS, Fusco ML, Nyakatura EK, Lai JR, Keck ZY, Foung SKH, Saphire EO, Zeitlin L, Ward AB, Chandran K, Doranz BJ, Kobinger GP, Dye JM, Aman MJ.

Cell Rep. 2016 May 17;15(7):1514-1526. doi: 10.1016/j.celrep.2016.04.026. Epub 2016 May 5.

13.

Development of a novel multiplex electrochemiluminescent-based immunoassay for quantification of human serum IgG against 10 Staphylococcus aureus toxins.

Adhikari RP, Haudenschild C, Sterba PM, Sahandi S, Enterlein S, Holtsberg FW, Aman MJ.

J Immunol Methods. 2016 Mar;430:33-42. doi: 10.1016/j.jim.2016.01.013. Epub 2016 Jan 27.

PMID:
26826278
14.

Quantitative serology assays for determination of antibody responses to Ebola virus glycoprotein and matrix protein in nonhuman primates and humans.

Vu H, Shulenin S, Grolla A, Audet J, He S, Kobinger G, Unfer RC, Warfield KL, Aman MJ, Holtsberg FW.

Antiviral Res. 2016 Feb;126:55-61. doi: 10.1016/j.antiviral.2015.11.012. Epub 2015 Dec 8.

15.

Correction: Antibodies to S. aureus LukS-PV Attenuated Subunit Vaccine Neutralize a Broad Spectrum of Canonical and Non-Canonical Bicomponent Leukotoxin Pairs.

Adhikari RP, Kort T, Shulenin S, Kanipakala T, Ganjbaksh N, Roghmann MC, Holtsberg FW, Aman MJ.

PLoS One. 2015 Nov 16;10(11):e0143493. doi: 10.1371/journal.pone.0143493. eCollection 2015. No abstract available.

16.

Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses.

Holtsberg FW, Shulenin S, Vu H, Howell KA, Patel SJ, Gunn B, Karim M, Lai JR, Frei JC, Nyakatura EK, Zeitlin L, Douglas R, Fusco ML, Froude JW, Saphire EO, Herbert AS, Wirchnianski AS, Lear-Rooney CM, Alter G, Dye JM, Glass PJ, Warfield KL, Aman MJ.

J Virol. 2015 Oct 14;90(1):266-78. doi: 10.1128/JVI.02171-15. Print 2016 Jan 1.

17.

Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.

Keck ZY, Enterlein SG, Howell KA, Vu H, Shulenin S, Warfield KL, Froude JW, Araghi N, Douglas R, Biggins J, Lear-Rooney CM, Wirchnianski AS, Lau P, Wang Y, Herbert AS, Dye JM, Glass PJ, Holtsberg FW, Foung SK, Aman MJ.

J Virol. 2015 Oct 14;90(1):279-91. doi: 10.1128/JVI.02172-15. Print 2016 Jan 1.

18.

Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs.

Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, Nykiforuk C, Aman MJ, Berry JD, Saphire EO.

PLoS Pathog. 2015 Oct 9;11(10):e1005212. doi: 10.1371/journal.ppat.1005212. eCollection 2015 Oct. No abstract available.

19.

Antibodies to S. aureus LukS-PV Attenuated Subunit Vaccine Neutralize a Broad Spectrum of Canonical and Non-Canonical Bicomponent Leukotoxin Pairs.

Adhikari RP, Kort T, Shulenin S, Kanipakala T, Ganjbaksh N, Roghmann MC, Holtsberg FW, Aman MJ.

PLoS One. 2015 Sep 14;10(9):e0137874. doi: 10.1371/journal.pone.0137874. eCollection 2015. Erratum in: PLoS One. 2015;10(11):e0143493.

20.

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs.

Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, Nykiforuk C, Aman MJ, Berry JD, Saphire EO.

PLoS Pathog. 2015 Jun 26;11(6):e1005016. doi: 10.1371/journal.ppat.1005016. eCollection 2015 Jun. Erratum in: PLoS Pathog. 2015 Oct;11(10):e1005212. Berry, Jody [corrected to Berry, Jody D].

21.

Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles.

Warfield KL, Dye JM, Wells JB, Unfer RC, Holtsberg FW, Shulenin S, Vu H, Swenson DL, Bavari S, Aman MJ.

PLoS One. 2015 Mar 20;10(3):e0118881. doi: 10.1371/journal.pone.0118881. eCollection 2015.

22.

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

Sully EK, Whaley K, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly M, Velasco J, Holtsberg FW, Stavale E, Aman MJ, Tangudu C, Uzal FA, Mantis NJ, Zeitlin L.

Toxicon. 2014 Dec 15;92:36-41. doi: 10.1016/j.toxicon.2014.09.006. Epub 2014 Sep 28.

23.

Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies.

Ascierto PA, Scala S, Castello G, Daponte A, Simeone E, Ottaiano A, Beneduce G, De Rosa V, Izzo F, Melucci MT, Ensor CM, Prestayko AW, Holtsberg FW, Bomalaski JS, Clark MA, Savaraj N, Feun LG, Logan TF.

J Clin Oncol. 2005 Oct 20;23(30):7660-8. Erratum in: J Clin Oncol. 2006 Aug 20;24(24):4047.

PMID:
16234528
24.

Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies.

Izzo F, Marra P, Beneduce G, Castello G, Vallone P, De Rosa V, Cremona F, Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA, Ng C, Curley SA.

J Clin Oncol. 2004 May 15;22(10):1815-22.

PMID:
15143074
25.

Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation.

Dillon BJ, Prieto VG, Curley SA, Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA.

Cancer. 2004 Feb 15;100(4):826-33.

26.

Regression of hepatocellular cancer in a patient treated with arginine deiminase.

Curley SA, Bomalaski JS, Ensor CM, Holtsberg FW, Clark MA.

Hepatogastroenterology. 2003 Sep-Oct;50(53):1214-6.

PMID:
14571701
27.
28.

Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies.

Bomalaski JS, Holtsberg FW, Ensor CM, Clark MA.

J Rheumatol. 2002 Sep;29(9):1942-9.

PMID:
12233890
29.

Biochemical characterization of the arginine degrading enzymes arginase and arginine deiminase and their effect on nitric oxide production.

Dillon BJ, Holtsberg FW, Ensor CM, Bomalaski JS, Clark MA.

Med Sci Monit. 2002 Jul;8(7):BR248-53.

PMID:
12118186
31.

Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties.

Holtsberg FW, Ensor CM, Steiner MR, Bomalaski JS, Clark MA.

J Control Release. 2002 Apr 23;80(1-3):259-71.

PMID:
11943403
32.

Lysophosphatidic acid induction of neuronal apoptosis and necrosis.

Steiner MR, Holtsberg FW, Keller JN, Mattson MP, Steiner SM.

Ann N Y Acad Sci. 2000 Apr;905:132-41.

PMID:
10818449
33.

Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD.

Bruce-Keller AJ, Geddes JW, Knapp PE, McFall RW, Keller JN, Holtsberg FW, Parthasarathy S, Steiner SM, Mattson MP.

J Neuroimmunol. 1999 Jan 1;93(1-2):53-71.

PMID:
10378869
34.

Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.

Guo Q, Fu W, Holtsberg FW, Steiner SM, Mattson MP.

J Neurosci Res. 1999 Jun 1;56(5):457-70.

PMID:
10369213
35.

Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells.

Holtsberg FW, Steiner MR, Bruce-Keller AJ, Keller JN, Mattson MP, Moyers JC, Steiner SM.

J Neurosci Res. 1998 Sep 15;53(6):685-96.

PMID:
9753197
37.

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, Mattson MP.

J Neurosci. 1998 Jan 15;18(2):687-97.

38.

Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons.

Holtsberg FW, Steiner MR, Keller JN, Mark RJ, Mattson MP, Steiner SM.

J Neurochem. 1998 Jan;70(1):66-76.

39.

Lysophosphatidic acid-induced proliferation-related signals in astrocytes.

Keller JN, Steiner MR, Holtsberg FW, Mattson MP, Steiner SM.

J Neurochem. 1997 Sep;69(3):1073-84.

40.

Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.

Holtsberg FW, Steiner MR, Furukawa K, Keller JN, Mattson MP, Steiner SM.

J Neurochem. 1997 Jul;69(1):68-75.

41.

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors.

Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP.

Nat Med. 1996 Jul;2(7):788-94.

PMID:
8673925
42.

Presence in human eosinophils of a lysophospholipase similar to that found in the pancreas.

Holtsberg FW, Ozgur LE, Garsetti DE, Myers J, Egan RW, Clark MA.

Biochem J. 1995 Jul 1;309 ( Pt 1):141-4.

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