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Dietary carbohydrate rather than protein intake drives colonic microbial fermentation during weight loss.

Gratz SW, Hazim S, Richardson AJ, Scobbie L, Johnstone AM, Fyfe C, Holtrop G, Lobley GE, Russell WR.

Eur J Nutr. 2019 Apr;58(3):1147-1158. doi: 10.1007/s00394-018-1629-x. Epub 2018 Feb 20.


Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production.

Reichardt N, Vollmer M, Holtrop G, Farquharson FM, Wefers D, Bunzel M, Duncan SH, Drew JE, Williams LM, Milligan G, Preston T, Morrison D, Flint HJ, Louis P.

ISME J. 2018 Feb;12(2):610-622. doi: 10.1038/ismej.2017.196. Epub 2017 Dec 1.


Porcine Small and Large Intestinal Microbiota Rapidly Hydrolyze the Masked Mycotoxin Deoxynivalenol-3-Glucoside and Release Deoxynivalenol in Spiked Batch Cultures In Vitro.

Gratz SW, Currie V, Richardson AJ, Duncan G, Holtrop G, Farquharson F, Louis P, Pinton P, Oswald IP.

Appl Environ Microbiol. 2018 Jan 2;84(2). pii: e02106-17. doi: 10.1128/AEM.02106-17. Print 2018 Jan 15.


mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status.

Jobarteh ML, McArdle HJ, Holtrop G, Sise EA, Prentice AM, Moore SE.

J Nutr. 2017 Jul;147(7):1401-1409. doi: 10.3945/jn.116.244780. Epub 2017 May 17.


Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro.

Gratz SW, Dinesh R, Yoshinari T, Holtrop G, Richardson AJ, Duncan G, MacDonald S, Lloyd A, Tarbin J.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600680. Epub 2017 Feb 6.


Whole-body and splanchnic amino acid metabolism in sheep during an acute endotoxin challenge.

McNeil CJ, Hoskin SO, Bremner DM, Holtrop G, Lobley GE.

Br J Nutr. 2016 Jul;116(2):211-22. doi: 10.1017/S0007114516001860. Epub 2016 May 18.


Responses in whole-body amino acid kinetics to an acute, sub-clinical endotoxin challenge in lambs.

Hoskin SO, Bremner DM, Holtrop G, Lobley GE.

Br J Nutr. 2016 Feb 28;115(4):576-84. doi: 10.1017/S0007114515004894. Epub 2015 Dec 14.


Fish oil supplemented for 9 months does not improve glycaemic control or insulin sensitivity in subjects with impaired glucose regulation: a parallel randomised controlled trial.

Clark LF, Thivierge MC, Kidd CA, McGeoch SC, Abraham P, Pearson DW, Horgan GW, Holtrop G, Thies F, Lobley GE.

Br J Nutr. 2016 Jan 14;115(1):75-86. doi: 10.1017/S0007114515004274. Epub 2015 Nov 5.


Responses in gut hormones and hunger to diets with either high protein or a mixture of protein plus free amino acids supplied under weight-loss conditions.

Lobley GE, Holtrop G, Horgan GW, Bremner DM, Fyfe C, Johnstone AM.

Br J Nutr. 2015 Apr 28;113(8):1254-70. doi: 10.1017/S0007114515000069. Epub 2015 Mar 26.


Modelling the emergent dynamics and major metabolites of the human colonic microbiota.

Kettle H, Louis P, Holtrop G, Duncan SH, Flint HJ.

Environ Microbiol. 2015 May;17(5):1615-30. doi: 10.1111/1462-2920.12599. Epub 2014 Oct 7.


Annual variation of dietary deoxynivalenol exposure during years of different Fusarium prevalence: a pilot biomonitoring study.

Gratz SW, Richardson AJ, Duncan G, Holtrop G.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(9):1579-85. doi: 10.1080/19440049.2014.937772. Epub 2014 Jul 24.


Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men.

Salonen A, Lahti L, Salojärvi J, Holtrop G, Korpela K, Duncan SH, Date P, Farquharson F, Johnstone AM, Lobley GE, Louis P, Flint HJ, de Vos WM.

ISME J. 2014 Nov;8(11):2218-30. doi: 10.1038/ismej.2014.63. Epub 2014 Apr 24.


Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes.

Zhang X, McGeoch SC, Megson IL, MacRury SM, Johnstone AM, Abraham P, Pearson DW, de Roos B, Holtrop G, O'Kennedy N, Lobley GE.

Mol Nutr Food Res. 2014 Jun;58(6):1322-32. doi: 10.1002/mnfr.201300820. Epub 2014 Mar 7.


Glucose uptake by the brain on chronic high-protein weight-loss diets with either moderate or low amounts of carbohydrate.

Lobley GE, Johnstone AM, Fyfe C, Horgan GW, Holtrop G, Bremner DM, Broom I, Schweiger L, Welch A.

Br J Nutr. 2014 Feb;111(4):586-97. doi: 10.1017/S0007114513002900.


Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status.

Zhang X, McGeoch SC, Johnstone AM, Holtrop G, Sneddon AA, MacRury SM, Megson IL, Pearson DW, Abraham P, De Roos B, Lobley GE, O'Kennedy N.

J Thromb Thrombolysis. 2014 May;37(4):455-63. doi: 10.1007/s11239-013-1000-2.


A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes.

McGeoch SC, Johnstone AM, Lobley GE, Adamson J, Hickson K, Holtrop G, Fyfe C, Clark LF, Pearson DW, Abraham P, Megson IL, MacRury SM.

Diabet Med. 2013 Nov;30(11):1314-23. doi: 10.1111/dme.12228. Epub 2013 Jun 22.


Diet composition is associated with endogenous formation of N-nitroso compounds in obese men.

Holtrop G, Johnstone AM, Fyfe C, Gratz SW.

J Nutr. 2012 Sep;142(9):1652-8. doi: 10.3945/jn.112.158824. Epub 2012 Jul 25.


Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat.

Wilson FA, Holtrop G, Calder AG, Anderson SE, Lobley GE, Rees WD.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1531-40. doi: 10.1152/ajpendo.00668.2011. Epub 2012 Mar 27.


Phylogenetic distribution of genes encoding β-glucuronidase activity in human colonic bacteria and the impact of diet on faecal glycosidase activities.

McIntosh FM, Maison N, Holtrop G, Young P, Stevens VJ, Ince J, Johnstone AM, Lobley GE, Flint HJ, Louis P.

Environ Microbiol. 2012 Aug;14(8):1876-87. doi: 10.1111/j.1462-2920.2012.02711.x. Epub 2012 Feb 24.


Food intake and dietary glycaemic index in free-living adults with and without type 2 diabetes mellitus.

McGeoch SC, Holtrop G, Fyfe C, Lobley GE, Pearson DW, Abraham P, Megson IL, Macrury SM, Johnstone AM.

Nutrients. 2011 Jun;3(6):683-93. doi: 10.3390/nu3060683. Epub 2011 Jun 9.


Is D-methionine bioavailable to the dairy cow?

Lapierre H, Holtrop G, Calder AG, Renaud J, Lobley GE.

J Dairy Sci. 2012 Jan;95(1):353-62. doi: 10.3168/jds.2011-4553.


Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach.

Tannock GW, Wilson CM, Loach D, Cook GM, Eason J, O'Toole PW, Holtrop G, Lawley B.

ISME J. 2012 May;6(5):927-38. doi: 10.1038/ismej.2011.161. Epub 2011 Nov 17.


Study of the effect of presence or absence of protozoa on rumen fermentation and microbial protein contribution to the chyme.

Belanche A, Abecia L, Holtrop G, Guada JA, Castrillo C, de la Fuente G, Balcells J.

J Anim Sci. 2011 Dec;89(12):4163-74. doi: 10.2527/jas.2010-3703. Epub 2011 Jul 1.


Bayesian analysis of non-linear differential equation models with application to a gut microbial ecosystem.

Lawson DJ, Holtrop G, Flint H.

Biom J. 2011 Jul;53(4):543-56. doi: 10.1002/bimj.201000250. Epub 2011 Jun 16.


Rates of production and utilization of lactate by microbial communities from the human colon.

Belenguer A, Holtrop G, Duncan SH, Anderson SE, Calder AG, Flint HJ, Lobley GE.

FEMS Microbiol Ecol. 2011 Jul;77(1):107-19. doi: 10.1111/j.1574-6941.2011.01086.x. Epub 2011 Apr 6.


High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health.

Russell WR, Gratz SW, Duncan SH, Holtrop G, Ince J, Scobbie L, Duncan G, Johnstone AM, Lobley GE, Wallace RJ, Duthie GG, Flint HJ.

Am J Clin Nutr. 2011 May;93(5):1062-72. doi: 10.3945/ajcn.110.002188. Epub 2011 Mar 9.


Metabolism of 2-hydroxy-4-(methylthio)butanoate (HMTBA) in lactating dairy cows.

Lapierre H, Vázquez-Añón M, Parker D, Dubreuil P, Holtrop G, Lobley GE.

J Dairy Sci. 2011 Mar;94(3):1526-35. doi: 10.3168/jds.2010-3914.


Effect of method of conservation of timothy on endogenous nitrogen flows in lactating dairy cows.

Ouellet DR, Berthiaume R, Holtrop G, Lobley GE, Martineau R, Lapierre H.

J Dairy Sci. 2010 Sep;93(9):4252-61. doi: 10.3168/jds.2010-3085.


Dominant and diet-responsive groups of bacteria within the human colonic microbiota.

Walker AW, Ince J, Duncan SH, Webster LM, Holtrop G, Ze X, Brown D, Stares MD, Scott P, Bergerat A, Louis P, McIntosh F, Johnstone AM, Lobley GE, Parkhill J, Flint HJ.

ISME J. 2011 Feb;5(2):220-30. doi: 10.1038/ismej.2010.118. Epub 2010 Aug 5.


Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene.

Louis P, Young P, Holtrop G, Flint HJ.

Environ Microbiol. 2010 Feb;12(2):304-14. doi: 10.1111/j.1462-2920.2009.02066.x. Epub 2009 Oct 5.


Fetal iron status regulates maternal iron metabolism during pregnancy in the rat.

Gambling L, Czopek A, Andersen HS, Holtrop G, Srai SK, Krejpcio Z, McArdle HJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1063-70. doi: 10.1152/ajpregu.90793.2008. Epub 2009 Jan 28.


Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline.

Wilson FA, van den Borne JJ, Calder AG, O'Kennedy N, Holtrop G, Rees WD, Lobley GE.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E702-13. doi: 10.1152/ajpendo.90670.2008. Epub 2009 Jan 13.


Human colonic microbiota associated with diet, obesity and weight loss.

Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, Louis P, Flint HJ.

Int J Obes (Lond). 2008 Nov;32(11):1720-4. doi: 10.1038/ijo.2008.155. Epub 2008 Sep 9.


The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities.

Walker AW, Duncan SH, Harmsen HJ, Holtrop G, Welling GW, Flint HJ.

Environ Microbiol. 2008 Dec;10(12):3275-83. doi: 10.1111/j.1462-2920.2008.01717.x. Epub 2008 Aug 15.


Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii.

Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P.

Br J Nutr. 2009 Feb;101(4):541-50. doi: 10.1017/S0007114508019880. Epub 2008 Jul 1.


Distribution of 15N in amino acids during 15N-leucine infusion: impact on the estimation of endogenous flows in dairy cows.

Lapierre H, Ouellet DR, Berthiaume R, Martineau R, Holtrop G, Lobley GE.

J Dairy Sci. 2008 Jul;91(7):2702-14. doi: 10.3168/jds.2007-0871.


Contribution of gut microbial lysine to liver and milk amino acids in lactating does.

Abecia L, Balcells J, Fondevila M, Belenguer A, Holtrop G, Lobley GE.

Br J Nutr. 2008 Nov;100(5):977-83. doi: 10.1017/S0007114508957986. Epub 2008 Mar 12.


Impact of pH on lactate formation and utilization by human fecal microbial communities.

Belenguer A, Duncan SH, Holtrop G, Anderson SE, Lobley GE, Flint HJ.

Appl Environ Microbiol. 2007 Oct;73(20):6526-33. Epub 2007 Aug 31.


Impact of high-protein diets with either moderate or low carbohydrate on weight loss, body composition, blood pressure and glucose tolerance in rats.

Lobley GE, Bremner DM, Holtrop G, Johnstone AM, Maloney C.

Br J Nutr. 2007 Jun;97(6):1099-108. Epub 2007 Mar 30.


Effect of dietary copper deficiency on iron metabolism in the pregnant rat.

Andersen HS, Gambling L, Holtrop G, McArdle HJ.

Br J Nutr. 2007 Feb;97(2):239-46.


Selective colonization of insoluble substrates by human faecal bacteria.

Leitch EC, Walker AW, Duncan SH, Holtrop G, Flint HJ.

Environ Microbiol. 2007 Mar;9(3):667-79.


Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces.

Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ, Lobley GE.

Appl Environ Microbiol. 2007 Feb;73(4):1073-8. Epub 2006 Dec 22.


Absorption and digestive tract metabolism of 2-hydroxy-4-methylthiobutanoic acid in lambs.

Lobley GE, Wester TJ, Holtrop G, Dibner JJ, Parker DS, Vázquez-Añón M.

J Dairy Sci. 2006 Sep;89(9):3508-21.


Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut.

Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ.

Appl Environ Microbiol. 2006 May;72(5):3593-9.


What is the true supply of amino acids for a dairy cow?

Lapierre H, Pacheco D, Berthiaume R, Ouellet DR, Schwab CG, Dubreuil P, Holtrop G, Lobley GE.

J Dairy Sci. 2006 Mar;89 Suppl 1:E1-14. Review.


Can general anaesthesia be used for the Paralytic Shellfish Poison bioassay?

Holtrop G, Petrie J, McElhiney J, Dennison N.

Toxicon. 2006 Mar;47(3):336-47. Epub 2006 Jan 20.


Contribution of acetate to butyrate formation by human faecal bacteria.

Duncan SH, Holtrop G, Lobley GE, Calder AG, Stewart CS, Flint HJ.

Br J Nutr. 2004 Jun;91(6):915-23.


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