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Items: 1 to 50 of 53

1.

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells.

Reuter S, Lemmermann NAW, Maxeiner J, Podlech J, Beckert H, Freitag K, Teschner D, Ries F, Taube C, Buhl R, Reddehase MJ, Holtappels R.

PLoS Pathog. 2019 Mar 7;15(3):e1007595. doi: 10.1371/journal.ppat.1007595. eCollection 2019 Mar.

2.

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M, Meyer C, Lemmermann NA, Holtappels R, Arens R, Klenerman P, Früh K, Reddehase MJ, Riemer AB, Cicin-Sain L.

PLoS Pathog. 2016 Dec 15;12(12):e1006072. doi: 10.1371/journal.ppat.1006072. eCollection 2016 Dec.

3.

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.

Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán-Garrote AL, Bäuerlein CA, Brede C, Ribechini E, Fick A, Seher A, Polz J, Ottmüller KJ, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Müller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H, Beilhack A.

J Exp Med. 2016 Aug 22;213(9):1881-900. doi: 10.1084/jem.20151563. Epub 2016 Aug 15.

4.

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

Holtappels R, Lemmermann NA, Podlech J, Ebert S, Reddehase MJ.

Front Immunol. 2016 Jun 14;7:232. doi: 10.3389/fimmu.2016.00232. eCollection 2016.

5.

Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

Holtappels R, Podlech J, Lemmermann NA, Schmitt E, Reddehase MJ.

Cell Immunol. 2016 Oct;308:44-56. doi: 10.1016/j.cellimm.2015.12.004. Epub 2015 Dec 17.

PMID:
26717854
6.

Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.

Holtappels R, Lemmermann NA, Thomas D, Renzaho A, Reddehase MJ.

Med Microbiol Immunol. 2015 Jun;204(3):317-26. doi: 10.1007/s00430-015-0404-3. Epub 2015 Mar 25.

PMID:
25805564
7.

Control of murine cytomegalovirus infection by γδ T cells.

Sell S, Dietz M, Schneider A, Holtappels R, Mach M, Winkler TH.

PLoS Pathog. 2015 Feb 6;11(2):e1004481. doi: 10.1371/journal.ppat.1004481. eCollection 2015 Feb.

8.

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.

Ebert S, Becker M, Lemmermann NA, Büttner JK, Michel A, Taube C, Podlech J, Böhm V, Freitag K, Thomas D, Holtappels R, Reddehase MJ, Stassen M.

PLoS Pathog. 2014 Apr 24;10(4):e1004100. doi: 10.1371/journal.ppat.1004100. eCollection 2014 Apr.

9.

Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

Fink A, Büttner JK, Thomas D, Holtappels R, Reddehase MJ, Lemmermann NA.

Viruses. 2014 Feb 14;6(2):808-31. doi: 10.3390/v6020808.

10.

Spatial distribution and structural arrangement of a murine cytomegalovirus glycoprotein detected by SPDM localization microscopy.

Müller P, Lemmermann NA, Kaufmann R, Gunkel M, Paech D, Hildenbrand G, Holtappels R, Cremer C, Hausmann M.

Histochem Cell Biol. 2014 Jul;142(1):61-7. doi: 10.1007/s00418-014-1185-2. Epub 2014 Feb 7.

PMID:
24504601
11.

TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer.

Nauerth M, Weißbrich B, Knall R, Franz T, Dössinger G, Bet J, Paszkiewicz PJ, Pfeifer L, Bunse M, Uckert W, Holtappels R, Gillert-Marien D, Neuenhahn M, Krackhardt A, Reddehase MJ, Riddell SR, Busch DH.

Sci Transl Med. 2013 Jul 3;5(192):192ra87. doi: 10.1126/scitranslmed.3005958.

12.

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells.

Ebert S, Lemmermann NA, Thomas D, Renzaho A, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2012 Nov;201(4):541-50. doi: 10.1007/s00430-012-0268-8. Epub 2012 Sep 14.

PMID:
22976556
13.

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.

Ebert S, Podlech J, Gillert-Marien D, Gergely KM, Büttner JK, Fink A, Freitag K, Thomas D, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2012 Nov;201(4):527-39. doi: 10.1007/s00430-012-0258-x. Epub 2012 Sep 13. Review.

PMID:
22972232
14.

Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions.

Lemmermann NA, Fink A, Podlech J, Ebert S, Wilhelmi V, Böhm V, Holtappels R, Reddehase MJ.

Med Microbiol Immunol. 2012 Nov;201(4):497-512. doi: 10.1007/s00430-012-0257-y. Epub 2012 Sep 9. Review.

PMID:
22961127
15.

Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells.

Fink A, Lemmermann NA, Gillert-Marien D, Thomas D, Freitag K, Böhm V, Wilhelmi V, Reifenberg K, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2012 Nov;201(4):513-25. doi: 10.1007/s00430-012-0256-z. Epub 2012 Sep 9.

PMID:
22961126
16.

Superresolution imaging of biological nanostructures by spectral precision distance microscopy.

Cremer C, Kaufmann R, Gunkel M, Pres S, Weiland Y, Müller P, Ruckelshausen T, Lemmer P, Geiger F, Degenhard S, Wege C, Lemmermann NA, Holtappels R, Strickfaden H, Hausmann M.

Biotechnol J. 2011 Sep;6(9):1037-51. doi: 10.1002/biot.201100031. Review.

PMID:
21910256
17.

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

Seckert CK, Schader SI, Ebert S, Thomas D, Freitag K, Renzaho A, Podlech J, Reddehase MJ, Holtappels R.

J Gen Virol. 2011 Sep;92(Pt 9):1994-2005. doi: 10.1099/vir.0.031815-0. Epub 2011 Jun 1.

PMID:
21632567
18.

Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation.

Schubert K, Polte T, Bönisch U, Schader S, Holtappels R, Hildebrandt G, Lehmann J, Simon JC, Anderegg U, Saalbach A.

Eur J Immunol. 2011 Mar;41(3):645-56. doi: 10.1002/eji.201041117. Epub 2011 Jan 25.

19.

In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.

Lemmermann NA, Böhm V, Holtappels R, Reddehase MJ.

Virus Res. 2011 May;157(2):161-74. doi: 10.1016/j.virusres.2010.09.022. Epub 2010 Oct 8. Review.

PMID:
20933556
20.

Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity.

Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase MJ, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle PA.

Gastroenterology. 2010 Jan;138(1):336-46. doi: 10.1053/j.gastro.2009.08.057. Epub 2009 Sep 6.

PMID:
19737567
21.

Immune evasion proteins enhance cytomegalovirus latency in the lungs.

Böhm V, Seckert CK, Simon CO, Thomas D, Renzaho A, Gendig D, Holtappels R, Reddehase MJ.

J Virol. 2009 Oct;83(19):10293-8. doi: 10.1128/JVI.01143-09. Epub 2009 Jul 15.

22.

The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.

Holtappels R, Thomas D, Reddehase MJ.

J Virol. 2009 Sep;83(18):9611-5. doi: 10.1128/JVI.00936-09. Epub 2009 Jun 24.

23.

The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.

Böhm V, Simon CO, Podlech J, Seckert CK, Gendig D, Deegen P, Gillert-Marien D, Lemmermann NA, Holtappels R, Reddehase MJ.

J Virol. 2008 Dec;82(23):11637-50. doi: 10.1128/JVI.01510-08. Epub 2008 Sep 24.

24.

Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination.

Holtappels R, Simon CO, Munks MW, Thomas D, Deegen P, Kühnapfel B, Däubner T, Emde SF, Podlech J, Grzimek NK, Oehrlein-Karpi SA, Hill AB, Reddehase MJ.

J Virol. 2008 Jun;82(12):5781-96. doi: 10.1128/JVI.00155-08. Epub 2008 Mar 26.

25.

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues.

Wirtz N, Schader SI, Holtappels R, Simon CO, Lemmermann NA, Reddehase MJ, Podlech J.

Med Microbiol Immunol. 2008 Jun;197(2):151-8. doi: 10.1007/s00430-008-0095-0. Epub 2008 Mar 26.

PMID:
18365251
26.

CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model.

Holtappels R, Böhm V, Podlech J, Reddehase MJ.

Med Microbiol Immunol. 2008 Jun;197(2):125-34. doi: 10.1007/s00430-008-0093-2. Epub 2008 Mar 15. Review.

PMID:
18343947
27.

Correlation of dendritic cell maturation and the formation of aggregates of poly-ubiquitinated proteins in the cytosol.

Fassbender M, Herter S, Holtappels R, Schild H.

Med Microbiol Immunol. 2008 Jun;197(2):185-9. doi: 10.1007/s00430-008-0091-4. Epub 2008 Mar 14. Review.

PMID:
18340462
28.

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy.

Böhm V, Podlech J, Thomas D, Deegen P, Pahl-Seibert MF, Lemmermann NA, Grzimek NK, Oehrlein-Karpi SA, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2008 Jun;197(2):135-44. doi: 10.1007/s00430-008-0092-3. Epub 2008 Mar 14.

PMID:
18340461
29.

Refinement of strategies for the development of a human cytomegalovirus dense body vaccine.

Mersseman V, Böhm V, Holtappels R, Deegen P, Wolfrum U, Plachter B, Reyda S.

Med Microbiol Immunol. 2008 Jun;197(2):97-107. doi: 10.1007/s00430-008-0085-2. Epub 2008 Mar 5.

PMID:
18320219
30.

Adoptive CD8 T cell control of pathogens cannot be improved by combining protective epitope specificities.

Holtappels R, Janda J, Thomas D, Schenk S, Reddehase MJ, Geginat G.

J Infect Dis. 2008 Feb 15;197(4):622-9. doi: 10.1086/526791.

PMID:
18240950
31.

CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation.

Simon CO, Holtappels R, Tervo HM, Böhm V, Däubner T, Oehrlein-Karpi SA, Kühnapfel B, Renzaho A, Strand D, Podlech J, Reddehase MJ, Grzimek NK.

J Virol. 2006 Nov;80(21):10436-56. Epub 2006 Aug 23.

32.

Cytomegalovirus encodes a positive regulator of antigen presentation.

Holtappels R, Gillert-Marien D, Thomas D, Podlech J, Deegen P, Herter S, Oehrlein-Karpi SA, Strand D, Wagner M, Reddehase MJ.

J Virol. 2006 Aug;80(15):7613-24.

33.

Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting.

Pahl-Seibert MF, Juelch M, Podlech J, Thomas D, Deegen P, Reddehase MJ, Holtappels R.

J Virol. 2005 May;79(9):5400-13.

34.

Stalemating a clever opportunist: lessons from murine cytomegalovirus.

Reddehase MJ, Simon CO, Podlech J, Holtappels R.

Hum Immunol. 2004 May;65(5):446-55. Review.

PMID:
15172444
35.

Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues.

Holtappels R, Podlech J, Pahl-Seibert MF, Jülch M, Thomas D, Simon CO, Wagner M, Reddehase MJ.

J Exp Med. 2004 Jan 5;199(1):131-6. Epub 2003 Dec 29.

36.
37.

Early gene m18, a novel player in the immune response to murine cytomegalovirus.

Holtappels R, Grzimek NK, Thomas D, Reddehase MJ.

J Gen Virol. 2002 Feb;83(Pt 2):311-6.

PMID:
11807223
38.
39.

Reconstitution of the complement function in C1q-deficient (C1qa-/-) mice with wild-type bone marrow cells.

Petry F, Botto M, Holtappels R, Walport MJ, Loos M.

J Immunol. 2001 Oct 1;167(7):4033-7.

40.

Dynamic antigen presentation patterns of Listeria monocytogenes-derived CD8 T cell epitopes in vivo.

Skoberne M, Holtappels R, Hof H, Geginat G.

J Immunol. 2001 Aug 15;167(4):2209-18.

43.

Identification of a K(d)-restricted antigenic peptide encoded by murine cytomegalovirus early gene M84.

Holtappels R, Thomas D, Reddehase MJ.

J Gen Virol. 2000 Dec;81(Pt 12):3037-42.

PMID:
11086134
44.

Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus.

Hengel H, Reusch U, Geginat G, Holtappels R, Ruppert T, Hellebrand E, Koszinowski UH.

J Virol. 2000 Sep;74(17):7861-8.

46.
47.

In vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirus.

Grzimek NK, Podlech J, Steffens HP, Holtappels R, Schmalz S, Reddehase MJ.

J Virol. 1999 Jun;73(6):5043-55.

48.

Proliferation and MHC-unrestricted bystander lysis by virus-specific cytotoxic T cells following antigen self-presentation.

Staege MS, Holtappels R, Thomas D, Reddehase MJ, Reske-Kunz AB.

Med Microbiol Immunol. 1998 Jun;187(1):17-21.

PMID:
9749979
49.

Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation.

Podlech J, Holtappels R, Wirtz N, Steffens HP, Reddehase MJ.

J Gen Virol. 1998 Sep;79 ( Pt 9):2099-104.

PMID:
9747717
50.

Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cells.

Alterio de Goss M, Holtappels R, Steffens HP, Podlech J, Angele P, Dreher L, Thomas D, Reddehase MJ.

J Virol. 1998 Oct;72(10):7733-44.

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