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Items: 1 to 50 of 67

1.

β-Catenin maintains lung epithelial progenitors after lung specification.

Ostrin EJ, Little DR, Gerner-Mauro KN, Sumner EA, Ríos-Corzo R, Ambrosio E, Holt SE, Forcioli-Conti N, Akiyama H, Hanash SM, Kimura S, Huang SXL, Chen J.

Development. 2018 Mar 9;145(5). pii: dev160788. doi: 10.1242/dev.160788.

2.

Mesenchymal stem cells in mammary adipose tissue stimulate progression of breast cancer resembling the basal-type.

Zhao M, Sachs PC, Wang X, Dumur CI, Idowu MO, Robila V, Francis MP, Ware J, Beckman M, Rizki A, Holt SE, Elmore LW.

Cancer Biol Ther. 2012 Jul;13(9):782-92. Epub 2012 Jun 6.

3.

Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites.

Sachs PC, Francis MP, Zhao M, Brumelle J, Rao RR, Elmore LW, Holt SE.

Cell Tissue Res. 2012 Aug;349(2):505-15. doi: 10.1007/s00441-012-1423-7. Epub 2012 May 25.

4.

Electrospinning adipose tissue-derived extracellular matrix for adipose stem cell culture.

Francis MP, Sachs PC, Madurantakam PA, Sell SA, Elmore LW, Bowlin GL, Holt SE.

J Biomed Mater Res A. 2012 Jul;100(7):1716-24. doi: 10.1002/jbm.a.34126. Epub 2012 Mar 23.

PMID:
22447769
5.

Multipotent adipose stromal cells and breast cancer development: Think globally, act locally.

Zhao M, Dumur CI, Holt SE, Beckman MJ, Elmore LW.

Mol Carcinog. 2010 Nov;49(11):923-7. doi: 10.1002/mc.20675.

6.

Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression.

Chen MY, Clark AJ, Chan DC, Ware JL, Holt SE, Chidambaram A, Fillmore HL, Broaddus WC.

J Neurooncol. 2011 May;103(1):87-102. doi: 10.1007/s11060-010-0374-7. Epub 2010 Sep 4.

7.

Elevated TRF2 in advanced breast cancers with short telomeres.

Diehl MC, Idowu MO, Kimmelshue KN, York TP, Jackson-Cook CK, Turner KC, Holt SE, Elmore LW.

Breast Cancer Res Treat. 2011 Jun;127(3):623-30. doi: 10.1007/s10549-010-0988-7. Epub 2010 Jul 13.

8.

Isolating adipose-derived mesenchymal stem cells from lipoaspirate blood and saline fraction.

Francis MP, Sachs PC, Elmore LW, Holt SE.

Organogenesis. 2010 Jan-Mar;6(1):11-4.

9.

CD4+ T cells inhibit the neu-specific CD8+ T-cell exhaustion during the priming phase of immune responses against breast cancer.

Kmieciak M, Worschech A, Nikizad H, Gowda M, Habibi M, Depcrynski A, Wang E, Godder K, Holt SE, Marincola FM, Manjili MH.

Breast Cancer Res Treat. 2011 Apr;126(2):385-94. doi: 10.1007/s10549-010-0942-8. Epub 2010 May 18.

10.

Mechanism of dominant-negative telomerase function.

Nguyen BN, Elmore LW, Holt SE.

Cell Cycle. 2009 Oct 1;8(19):3227-33. Epub 2009 Oct 11.

PMID:
19738429
11.

Elevated expression of nuclear Hsp90 in invasive breast tumors.

Diehl MC, Idowu MO, Kimmelshue K, York TP, Elmore LW, Holt SE.

Cancer Biol Ther. 2009 Oct;8(20):1952-61. Epub 2009 Oct 27.

PMID:
19738418
12.

Genetic inhibition of telomerase results in sensitization and recovery of breast tumor cells.

Poynter KR, Sachs PC, Bright AT, Breed MS, Nguyen BN, Elmore LW, Holt SE.

Mol Cancer Ther. 2009 May;8(5):1319-27. doi: 10.1158/1535-7163.MCT-08-0849. Epub 2009 May 5.

13.

Japanese medaka: a new vertebrate model for studying telomere and telomerase biology.

Au DW, Mok HO, Elmore LW, Holt SE.

Comp Biochem Physiol C Toxicol Pharmacol. 2009 Mar;149(2):161-7. doi: 10.1016/j.cbpc.2008.08.005. Epub 2008 Aug 27.

PMID:
18790082
14.

Overexpression of telomerase-associated chaperone proteins in prostatic intraepithelial neoplasia and carcinomas.

Elmore LW, Forsythe R, Forsythe H, Bright AT, Nasim S, Endo K, Holt SE.

Oncol Rep. 2008 Sep;20(3):613-7.

PMID:
18695913
15.

Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation.

Gewirtz DA, Holt SE, Elmore LW.

Biochem Pharmacol. 2008 Oct 15;76(8):947-57. doi: 10.1016/j.bcp.2008.06.024. Epub 2008 Jul 9.

PMID:
18657518
16.

Recovery from stress is a function of age and telomere length.

Strub GM, Depcrynski A, Elmore LW, Holt SE.

Cell Stress Chaperones. 2008 Dec;13(4):475-82. doi: 10.1007/s12192-008-0047-z. Epub 2008 May 20.

17.

Upregulation of telomerase function during tissue regeneration.

Elmore LW, Norris MW, Sircar S, Bright AT, McChesney PA, Winn RN, Holt SE.

Exp Biol Med (Maywood). 2008 Aug;233(8):958-67. doi: 10.3181/0712-RM-345. Epub 2008 May 14.

PMID:
18480423
18.

Initiation of a zebrafish blastula cell line on rainbow trout stromal cells and subsequent development under feeder-free conditions into a cell line, ZEB2J.

Xing JG, Lee LE, Fan L, Collodi P, Holt SE, Bols NC.

Zebrafish. 2008 Spring;5(1):49-63. doi: 10.1089/zeb.2007.0512.

PMID:
18399791
19.

Vertebrate marine species as model systems for studying telomeres and telomerase.

McChesney PA, Elmore LW, Holt SE.

Zebrafish. 2005;1(4):349-55. doi: 10.1089/zeb.2005.1.349.

PMID:
18248213
20.

Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells.

Richardson RM, Nguyen B, Holt SE, Broaddus WC, Fillmore HL.

Neurosci Lett. 2007 Jun 27;421(2):168-72. Epub 2007 Jun 2.

PMID:
17566647
21.

Telomerase inhibition as an adjuvant anticancer therapy: it is more than just a waiting game.

Elmore LW, Holt SE.

Expert Opin Ther Targets. 2007 Apr;11(4):427-30.

PMID:
17373872
22.

A cell line (HEW) from embryos of haddock (Melanogrammus aeglefinius) and its capacity to tolerate environmental extremes.

Bryson SP, Joyce EM, Martell DJ, Lee LE, Holt SE, Kales SC, Fujiki K, Dixon B, Bols NC.

Mar Biotechnol (NY). 2006 Nov-Dec;8(6):641-53. Epub 2006 Aug 18.

PMID:
16909215
23.

Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells.

Compton SA, Elmore LW, Haydu K, Jackson-Cook CK, Holt SE.

Mol Cell Biol. 2006 Feb;26(4):1452-62.

24.

erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.

Lai GH, Zhang Z, Shen XN, Ward DJ, Dewitt JL, Holt SE, Rozich RA, Hixson DC, Sirica AE.

Gastroenterology. 2005 Dec;129(6):2047-57.

PMID:
16344070
25.

p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells.

Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA.

Int J Radiat Biol. 2005 Jun;81(6):445-58.

PMID:
16308915
26.

Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response.

Elmore LW, Di X, Dumur C, Holt SE, Gewirtz DA.

Clin Cancer Res. 2005 Apr 1;11(7):2637-43.

27.

Telomerase resets the homeostatic telomere length and prevents telomere dysfunction in immortalized human cells.

McChesney PA, Turner KC, Jackson-Cook C, Elmore LW, Holt SE.

DNA Cell Biol. 2004 May;23(5):293-300. No abstract available.

PMID:
15199944
28.

Telomere maintenance: at the crossroads of mismatch repair?

Nguyen B, Elmore LW, Holt SE.

Cancer Biol Ther. 2004 Mar;3(3):293-5. Epub 2004 Mar 23. Review. No abstract available.

PMID:
15004529
29.

Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity.

Wise SS, Elmore LW, Holt SE, Little JE, Antonucci PG, Bryant BH, Wise JP Sr.

Mol Cell Biochem. 2004 Jan;255(1-2):103-11.

PMID:
14971651
30.

Telomerase as a target for cancer immunotherapy.

Nguyen B, Elmore LW, Holt SE.

Cancer Biol Ther. 2003 Mar-Apr;2(2):131-6. Review.

PMID:
12750550
31.

Telomerase protects cancer-prone human cells from chromosomal instability and spontaneous immortalization.

Elmore LW, Turner KC, Gollahon LS, Landon MR, Jackson-Cook CK, Holt SE.

Cancer Biol Ther. 2002 Jul-Aug;1(4):391-7.

PMID:
12432253
32.

Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression.

Harvey SA, Jensen KO, Elmore LW, Holt SE.

Cell Stress Chaperones. 2002 Apr;7(2):230-4. Review. No abstract available.

33.

Real-time quantitative analysis of telomerase activity in breast tumor specimens using a highly specific and sensitive fluorescent-based assay.

Elmore LW, Forsythe HL, Ferreira-Gonzalez A, Garrett CT, Clark GM, Holt SE.

Diagn Mol Pathol. 2002 Sep;11(3):177-85.

PMID:
12218458
34.

Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction.

Elmore LW, Rehder CW, Di X, McChesney PA, Jackson-Cook CK, Gewirtz DA, Holt SE.

J Biol Chem. 2002 Sep 20;277(38):35509-15. Epub 2002 Jul 5.

35.

Retroviral-mediated expression of telomerase in normal human cells provides a selective growth advantage.

Forsythe HL, Elmore LW, Jensen KO, Landon MR, Holt SE.

Int J Oncol. 2002 Jun;20(6):1137-43.

PMID:
12011990
36.

Telomerase and the benign and malignant megakaryoblastic leukemias of Down syndrome.

Holt SE, Brown EJ, Zipursky A.

J Pediatr Hematol Oncol. 2002 Jan;24(1):14-7.

PMID:
11902731
37.

Is telomerase the cure-all and end-all?

Holt SE.

Drug Discov Today. 2002 Mar 1;7(5):288. No abstract available.

PMID:
11854048
38.

A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression.

Akalin A, Elmore LW, Forsythe HL, Amaker BA, McCollum ED, Nelson PS, Ware JL, Holt SE.

Cancer Res. 2001 Jun 15;61(12):4791-6.

39.

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.

Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE.

J Biol Chem. 2001 May 11;276(19):15571-4. Epub 2001 Mar 23.

40.

Detection of telomerase by in situ hybridization and by the polymerase chain reaction-based telomerase activity assay.

Morales CP, Holt SE.

Methods Mol Med. 2001;49:43-58. doi: 10.1385/1-59259-081-0:43.

PMID:
21370132
41.

Alternative methods of extracting telomerase activity from human tumor samples.

Gollahon LS, Holt SE.

Cancer Lett. 2000 Oct 31;159(2):141-9.

PMID:
10996725
42.

Telomerase and telomere stability: a new class of tumor suppressor?

Elmore LW, Holt SE.

Mol Carcinog. 2000 May;28(1):1-4.

PMID:
10820482
43.

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase.

Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS, Shay JW, Wright WE.

J Biol Chem. 2000 Apr 7;275(14):10072-6.

44.

Clonal heterogeneity in telomerase activity and telomere length in tumor-derived cell lines.

Savre-Train I, Gollahon LS, Holt SE.

Proc Soc Exp Biol Med. 2000 Apr;223(4):379-88.

PMID:
10721008
45.

Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro.

Tesmer VM, Ford LP, Holt SE, Frank BC, Yi X, Aisner DL, Ouellette M, Shay JW, Wright WE.

Mol Cell Biol. 1999 Sep;19(9):6207-16.

46.

Resistance to apoptosis in human cells conferred by telomerase function and telomere stability.

Holt SE, Glinsky VV, Ivanova AB, Glinsky GV.

Mol Carcinog. 1999 Aug;25(4):241-8.

PMID:
10449030
47.

Role of telomerase in cellular proliferation and cancer.

Holt SE, Shay JW.

J Cell Physiol. 1999 Jul;180(1):10-8. Review.

PMID:
10362013
48.

Sadism and psychopathy in violent and sexually violent offenders.

Holt SE, Meloy JR, Strack S.

J Am Acad Psychiatry Law. 1999;27(1):23-32.

PMID:
10212024
49.

Functional requirement of p23 and Hsp90 in telomerase complexes.

Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA.

Genes Dev. 1999 Apr 1;13(7):817-26.

50.

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase.

Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE, Shay JW.

Nat Genet. 1999 Jan;21(1):115-8.

PMID:
9916803

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