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Systems biology and big data in asthma and allergy - recent discoveries and emerging challenges.

Tang HHF, Sly PD, Holt PG, Holt KE, Inouye M.

Eur Respir J. 2019 Oct 16. pii: 1900844. doi: 10.1183/13993003.00844-2019. [Epub ahead of print]


Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles.

Jones AC, Anderson D, Galbraith S, Fantino E, Cardenas DG, Read JF, Serralha M, Holt BJ, Strickland DH, Sly PD, Bosco A, Holt PG.

J Allergy Clin Immunol. 2019 Aug 19. pii: S0091-6749(19)31047-4. doi: 10.1016/j.jaci.2019.07.043. [Epub ahead of print] No abstract available.


Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study.

Guo J, Zhu W, Wang H, Holt PG, Zhang G, Liu C.

Allergy Asthma Clin Immunol. 2019 Jun 18;15:38. doi: 10.1186/s13223-019-0351-4. eCollection 2019.


Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM-85.

Sly PD, Galbraith S, Islam Z, Holt B, Troy N, Holt PG.

J Allergy Clin Immunol. 2019 Sep;144(3):870-872.e11. doi: 10.1016/j.jaci.2019.05.032. Epub 2019 Jun 8. No abstract available.


Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

Leffler J, Read JF, Jones AC, Mok D, Hollams EM, Laing IA, Le Souef PN, Sly PD, Kusel MMH, de Klerk NH, Bosco A, Holt PG, Strickland DH.

Pediatr Allergy Immunol. 2019 Sep;30(6):646-653. doi: 10.1111/pai.13063. Epub 2019 May 22.


Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection: Mechanistic Insight Using Mouse Models.

Lauzon-Joset JF, Scott NM, Mincham KT, Stumbles PA, Holt PG, Strickland DH.

J Infect Dis. 2019 May 5;219(11):1823-1831. doi: 10.1093/infdis/jiy732.


Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis.

Jones AC, Anderson D, Galbraith S, Fantino E, Gutierrez Cardenas D, Read JF, Serralha M, Holt BJ, Strickland DH, Sly PD, Bosco A, Holt PG.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1537-1549. doi: 10.1164/rccm.201804-0715OC.


Trajectories of childhood immune development and respiratory health relevant to asthma and allergy.

Tang HH, Teo SM, Belgrave DC, Evans MD, Jackson DJ, Brozynska M, Kusel MM, Johnston SL, Gern JE, Lemanske RF, Simpson A, Custovic A, Sly PD, Holt PG, Holt KE, Inouye M.

Elife. 2018 Oct 15;7. pii: e35856. doi: 10.7554/eLife.35856.


Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development.

Holt PG, Mok D, Panda D, Renn L, Fabozzi G, deKlerk NH, Kusel MMH, Serralha M, Hollams EM, Holt BJ, Sly PD, Rabin RL.

J Allergy Clin Immunol. 2019 Mar;143(3):1176-1182.e5. doi: 10.1016/j.jaci.2018.08.035. Epub 2018 Sep 12.


Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.

Teo SM, Tang HHF, Mok D, Judd LM, Watts SC, Pham K, Holt BJ, Kusel M, Serralha M, Troy N, Bochkov YA, Grindle K, Lemanske RF Jr, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE, Inouye M.

Cell Host Microbe. 2018 Sep 12;24(3):341-352.e5. doi: 10.1016/j.chom.2018.08.005.


Predicting steroid responsiveness in asthmatic children: Are we there yet?

Sly PD, Holt PG.

J Allergy Clin Immunol. 2019 Mar;143(3):927-928. doi: 10.1016/j.jaci.2018.07.035. Epub 2018 Aug 28. No abstract available.


Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation.

Mincham KT, Scott NM, Lauzon-Joset JF, Leffler J, Larcombe AN, Stumbles PA, Robertson SA, Pasquali C, Holt PG, Strickland DH.

J Clin Invest. 2018 Nov 1;128(11):4856-4869. doi: 10.1172/JCI122631. Epub 2018 Oct 2.


Atopy-Dependent and Independent Immune Responses in the Heightened Severity of Atopics to Respiratory Viral Infections: Rat Model Studies.

Lauzon-Joset JF, Jones AC, Mincham KT, Thomas JA, Rosenthal LA, Bosco A, Holt PG, Strickland DH.

Front Immunol. 2018 Aug 13;9:1805. doi: 10.3389/fimmu.2018.01805. eCollection 2018.


Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.

Leffler J, Jones AC, Hollams EM, Prastanti F, Le Souëf PN, Holt PG, Bosco A, Laing IA, Strickland DH.

J Allergy Clin Immunol. 2018 Nov;142(5):1639-1641.e5. doi: 10.1016/j.jaci.2018.07.003. Epub 2018 Jul 21. No abstract available.


A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment.

Saiganesh A, Hales BJ, Li Y, Holt PG, Le Souëf PN, Zhang G.

Allergy. 2018 Oct;73(10):2092-2094. doi: 10.1111/all.13531. Epub 2018 Jul 11. No abstract available.


Pollution, climate change, and childhood asthma in Australia.

Sly PD, Holt PG.

Med J Aust. 2018 Apr 16;208(7):297-298. No abstract available.


Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics.

Jones AC, Troy NM, White E, Hollams EM, Gout AM, Ling KM, Kicic A, Stick SM, Sly PD, Holt PG, Hall GL, Bosco A.

Sci Rep. 2018 Jan 24;8(1):1511. doi: 10.1038/s41598-018-19837-6.


Functional differences in airway dendritic cells determine susceptibility to IgE-sensitization.

Leffler J, Mincham KT, Mok D, Blank F, Holt PG, Stumbles PA, Strickland DH.

Immunol Cell Biol. 2018 Mar;96(3):316-329. doi: 10.1111/imcb.12005. Epub 2018 Feb 2.


Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.

Brealey JC, Chappell KJ, Galbraith S, Fantino E, Gaydon J, Tozer S, Young PR, Holt PG, Sly PD.

Respirology. 2018 Feb;23(2):220-227. doi: 10.1111/resp.13179. Epub 2017 Sep 15.


After asthma: redefining airways diseases.

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A.

Lancet. 2018 Jan 27;391(10118):350-400. doi: 10.1016/S0140-6736(17)30879-6. Epub 2017 Sep 11. Review. No abstract available.


An exposome perspective: Early-life events and immune development in a changing world.

Renz H, Holt PG, Inouye M, Logan AC, Prescott SL, Sly PD.

J Allergy Clin Immunol. 2017 Jul;140(1):24-40. doi: 10.1016/j.jaci.2017.05.015. Review.


CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis.

Tarique AA, Sly PD, Holt PG, Bosco A, Ware RS, Logan J, Bell SC, Wainwright CE, Fantino E.

J Cyst Fibros. 2017 Jul;16(4):475-482. doi: 10.1016/j.jcf.2017.03.011. Epub 2017 Apr 17.


Low dose treatment of mice with bacterial extract (OM-85) for attenuation of experimental atopic asthma in mice.

Holt PG, Strickland DH.

Allergol Immunopathol (Madr). 2017 May - Jun;45(3):310-311. doi: 10.1016/j.aller.2016.12.002. Epub 2017 Feb 22. No abstract available.


Mannitol challenge testing for asthma in a community cohort of young adults.

White EC, de Klerk N, Hantos Z, Priston M, Hollams EM, James A, Sly PD, Holt PG, Hall GL.

Respirology. 2017 May;22(4):678-683. doi: 10.1111/resp.12955. Epub 2016 Dec 5.


Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea.

Francis JP, Richmond PC, Strickland D, Prescott SL, Pomat WS, Michael A, Nadal-Sims MA, Edwards-Devitt CJ, Holt PG, Lehmann D, van den Biggelaar AH.

Clin Exp Immunol. 2017 Mar;187(3):408-417. doi: 10.1111/cei.12902. Epub 2016 Dec 18.


Identification and Characterization of a Dendritic Cell Precursor in Parenchymal Lung Tissue.

von Garnier C, Blank F, Rothen-Rutishauser B, Goethert JR, Holt PG, Stumbles PA, Strickland DH.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):353-361. doi: 10.1165/rcmb.2016-0058OC.


Childhood atopy and mental health: a prospective, longitudinal investigation.

Goodwin RD, Robinson M, Sly PD, Holt PG.

Psychol Med. 2017 Jan;47(2):317-325. doi: 10.1017/S0033291716001896. Epub 2016 Oct 20.


Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator.

Scott NM, Lauzon-Joset JF, Jones AC, Mincham KT, Troy NM, Leffler J, Serralha M, Prescott SL, Robertson SA, Pasquali C, Bosco A, Holt PG, Strickland DH.

Mucosal Immunol. 2017 May;10(3):789-801. doi: 10.1038/mi.2016.85. Epub 2016 Oct 19.


Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.

Sly PD, Varghese J, Noor F, Tang ML, Laing I, Oo S, Prastanti F, LeSouef PN, Holt PG.

J Allergy Clin Immunol. 2017 Feb;139(2):703-705.e4. doi: 10.1016/j.jaci.2016.07.035. Epub 2016 Sep 13. No abstract available.


Vitamin D over the first decade and susceptibility to childhood allergy and asthma.

Hollams EM, Teo SM, Kusel M, Holt BJ, Holt KE, Inouye M, De Klerk NH, Zhang G, Sly PD, Hart PH, Holt PG.

J Allergy Clin Immunol. 2017 Feb;139(2):472-481.e9. doi: 10.1016/j.jaci.2016.07.032. Epub 2016 Oct 7.


Transiently increased IgE responses in infants and pre-schoolers receiving only acellular Diphtheria-Pertussis-Tetanus (DTaP) vaccines compared to those initially receiving at least one dose of cellular vaccine (DTwP) - Immunological curiosity or canary in the mine?

Holt PG, Snelling T, White OJ, Sly PD, DeKlerk N, Carapetis J, Biggelaar AVD, Wood N, McIntyre P, Gold M.

Vaccine. 2016 Jul 29;34(35):4257-4262. doi: 10.1016/j.vaccine.2016.05.048. Epub 2016 Jun 11.


Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults.

Black LJ, Burrows S, Lucas RM, Marshall CE, Huang RC, Chan She Ping-Delfos W, Beilin LJ, Holt PG, Hart PH, Oddy WH, Mori TA.

Br J Nutr. 2016 Jun;115(11):1994-2002. doi: 10.1017/S0007114516001185.


Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.

Troy NM, Hollams EM, Holt PG, Bosco A.

BMC Med Genomics. 2016 Feb 27;9:9. doi: 10.1186/s12920-016-0171-z.


Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects.

Eguíluz-Gracia I, Bosco A, Dollner R, Melum GR, Lexberg MH, Jones AC, Dheyauldeen SA, Holt PG, Bækkevold ES, Jahnsen FL.

J Allergy Clin Immunol. 2016 Jun;137(6):1872-1881.e12. doi: 10.1016/j.jaci.2015.11.025. Epub 2016 Feb 4.


Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age.

Kiraly N, Koplin JJ, Crawford NW, Bannister S, Flanagan KL, Holt PG, Gurrin LC, Lowe AJ, Tang ML, Wake M, Ponsonby AL, Dharmage SC, Allen KJ.

Allergy. 2016 Apr;71(4):541-9. doi: 10.1111/all.12830. Epub 2016 Feb 8.


Environmental Microbial Exposure and Protection against Asthma.

Holt PG, Sly PD.

N Engl J Med. 2015 Dec 24;373(26):2576-8. doi: 10.1056/NEJMcibr1511291. No abstract available.


Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spycher BD, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S, Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun-Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster-Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell CE, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MAR, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA.

Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804.


Distinguishing benign from pathologic TH2 immunity in atopic children.

Holt PG, Strickland D, Bosco A, Belgrave D, Hales B, Simpson A, Hollams E, Holt B, Kusel M, Ahlstedt S, Sly PD, Custovic A.

J Allergy Clin Immunol. 2016 Feb;137(2):379-87. doi: 10.1016/j.jaci.2015.08.044. Epub 2015 Oct 27.


The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage.

Holt PG.

J Allergy Clin Immunol. 2015 Jul;136(1):15-22. doi: 10.1016/j.jaci.2015.05.011. Review.


Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts.

Wu J, Prosperi MC, Simpson A, Hollams EM, Sly PD, Custovic A, Holt PG.

Clin Exp Allergy. 2015 Dec;45(12):1801-11. doi: 10.1111/cea.12579.


Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

Tarique AA, Logan J, Thomas E, Holt PG, Sly PD, Fantino E.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):676-88. doi: 10.1165/rcmb.2015-0012OC.


The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development.

Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, Holt BJ, Hales BJ, Walker ML, Hollams E, Bochkov YA, Grindle K, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE, Inouye M.

Cell Host Microbe. 2015 May 13;17(5):704-15. doi: 10.1016/j.chom.2015.03.008. Epub 2015 Apr 9.


Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.

Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X.

Nat Commun. 2015 Feb 24;6:6304. doi: 10.1038/ncomms7304.


Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.

Strickland DH, Fear V, Shenton S, Wikstrom ME, Zosky G, Larcombe AN, Holt PG, Berry C, von Garnier C, Stumbles PA.

PLoS One. 2014 Nov 14;9(11):e111520. doi: 10.1371/journal.pone.0111520. eCollection 2014.


Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy.

Walker ML, Holt KE, Anderson GP, Teo SM, Sly PD, Holt PG, Inouye M.

Front Immunol. 2014 Sep 23;5:447. doi: 10.3389/fimmu.2014.00447. eCollection 2014. Review.


Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood.

Zhang G, Lai CT, Hartmann P, Oddy WH, Kusel MM, Sly PD, Holt PG.

Pediatr Allergy Immunol. 2014 Oct;25(6):544-51. doi: 10.1111/pai.12265.


Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.

Anderson D, Holt BJ, Pennell CE, Holt PG, Hart PH, Blackwell JM.

Genes Immun. 2014 Dec;15(8):578-83. doi: 10.1038/gene.2014.52. Epub 2014 Sep 11.


Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents.

Black LJ, Burrows SA, Jacoby P, Oddy WH, Beilin LJ, Chan She Ping-Delfos W, Marshall CE, Holt PG, Hart PH, Mori TA.

Br J Nutr. 2014 Oct 14;112(7):1154-62. doi: 10.1017/S000711451400186X. Epub 2014 Aug 19.


Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition.

Hartwig IR, Sly PD, Schmidt LA, van Lieshout RJ, Bienenstock J, Holt PG, Arck PC.

J Allergy Clin Immunol. 2014 Jul;134(1):160-9. doi: 10.1016/j.jaci.2014.01.033. Epub 2014 Mar 21.


Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms.

Robinson M, Whitehouse AJ, Newnham JP, Gorman S, Jacoby P, Holt BJ, Serralha M, Tearne JE, Holt PG, Hart PH, Kusel MM.

Arch Womens Ment Health. 2014 Jun;17(3):213-9. doi: 10.1007/s00737-014-0422-y. Epub 2014 Mar 25.

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