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Items: 50


Ancestral reconstruction reveals mechanisms of ERK regulatory evolution.

Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt LJ.

Elife. 2019 Aug 13;8. pii: e38805. doi: 10.7554/eLife.38805.


How to say "no" most effectively: Evaluating resistance strategies for prescription stimulant diversion to inform preventive interventions.

Holt LJ, Schepis TS, Looby A, Marsh E, Marut P, Feinn R.

J Am Coll Health. 2019 Jun 26:1-11. doi: 10.1080/07448481.2019.1626861. [Epub ahead of print]


Synthetic-Evolution Reveals Narrow Paths to Regulation of the Saccharomyces cerevisiae Mitotic Kinesin-5 Cin8.

Goldstein A, Goldman D, Valk E, Loog M, Holt LJ, Gheber L.

Int J Biol Sci. 2019 May 2;15(6):1125-1138. doi: 10.7150/ijbs.30543. eCollection 2019.


Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.

Read C, Yang P, Kuc RE, Nyimanu D, Williams TL, Glen RC, Holt LJ, Arulanantham H, Smart A, Davenport AP, Maguire JJ.

Basic Clin Pharmacol Toxicol. 2019 Mar 22. doi: 10.1111/bcpt.13227. [Epub ahead of print]


Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence.

Neurohr GE, Terry RL, Lengefeld J, Bonney M, Brittingham GP, Moretto F, Miettinen TP, Vaites LP, Soares LM, Paulo JA, Harper JW, Buratowski S, Manalis S, van Werven FJ, Holt LJ, Amon A.

Cell. 2019 Feb 21;176(5):1083-1097.e18. doi: 10.1016/j.cell.2019.01.018. Epub 2019 Feb 7.


Mechano-chemostats to study the effects of compressive stress on yeast.

Holt LJ, Hallatschek O, Delarue M.

Methods Cell Biol. 2018;147:215-231. doi: 10.1016/bs.mcb.2018.06.010. Epub 2018 Jul 19.


mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding.

Delarue M, Brittingham GP, Pfeffer S, Surovtsev IV, Pinglay S, Kennedy KJ, Schaffer M, Gutierrez JI, Sang D, Poterewicz G, Chung JK, Plitzko JM, Groves JT, Jacobs-Wagner C, Engel BD, Holt LJ.

Cell. 2018 Jul 12;174(2):338-349.e20. doi: 10.1016/j.cell.2018.05.042. Epub 2018 Jun 21.


CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.

Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR.

Cell Rep. 2018 Jan 23;22(4):885-894. doi: 10.1016/j.celrep.2017.12.083. Epub 2018 Jan 28.


Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice.

Holt LJ, Brandon AE, Small L, Suryana E, Preston E, Wilks D, Mokbel N, Coles CA, White JD, Turner N, Daly RJ, Cooney GJ.

Endocrinology. 2018 Mar 1;159(3):1339-1351. doi: 10.1210/en.2017-00851.


Factors that Differentiate Prescription Stimulant Misusers from those At-Risk for Misuse: Expectancies, Perceived Safety, and Diversion.

Holt LJ, Looby A.

Subst Use Misuse. 2018 Jun 7;53(7):1068-1075. doi: 10.1080/10826084.2017.1392984. Epub 2017 Dec 8.


Pursued for their prescription: Exposure to compliance-gaining strategies predicts stimulant diversion in emerging adults.

Holt LJ, Marut PN, Schepis TS.

Psychol Addict Behav. 2018 Feb;32(1):122-131. doi: 10.1037/adb0000331. Epub 2017 Nov 16.


A glucose-starvation response regulates the diffusion of macromolecules.

Joyner RP, Tang JH, Helenius J, Dultz E, Brune C, Holt LJ, Huet S, Müller DJ, Weis K.

Elife. 2016 Mar 22;5. pii: e09376. doi: 10.7554/eLife.09376.


Correlates of smoking status among women experiencing intimate partner violence: Substance use, posttraumatic stress, and coping.

Sullivan TP, Flanagan JC, Dudley DN, Holt LJ, Mazure CM, McKee SA.

Am J Addict. 2015 Sep;24(6):546-53. doi: 10.1111/ajad.12261. Epub 2015 Aug 6.


Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity.

Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ.

Elife. 2014 Oct 13;3. doi: 10.7554/eLife.04126.


Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation.

Mokbel N, Hoffman NJ, Girgis CM, Small L, Turner N, Daly RJ, Cooney GJ, Holt LJ.

J Cell Physiol. 2014 Nov;229(11):1753-64. doi: 10.1002/jcp.24628.


Cell-cycle regulation of formin-mediated actin cable assembly.

Miao Y, Wong CC, Mennella V, Michelot A, Agard DA, Holt LJ, Yates JR 3rd, Drubin DG.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4446-55. doi: 10.1073/pnas.1314000110. Epub 2013 Oct 16.


Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat.

Bao W, Holt LJ, Prince RD, Jones GX, Aravindhan K, Szapacs M, Barbour AM, Jolivette LJ, Lepore JJ, Willette RN, DeAngelis E, Jucker BM.

Cardiovasc Diabetol. 2013 Oct 14;12:148. doi: 10.1186/1475-2840-12-148.


A person-centered approach to understanding negative reinforcement drinking among first year college students.

Holt LJ, Armeli S, Tennen H, Austad CS, Raskin SA, Fallahi CR, Wood R, Rosen RI, Ginley MK, Pearlson GD.

Addict Behav. 2013 Dec;38(12):2937-44. doi: 10.1016/j.addbeh.2013.08.015. Epub 2013 Sep 1.


The Giardia cell cycle progresses independently of the anaphase-promoting complex.

Gourguechon S, Holt LJ, Cande WZ.

J Cell Sci. 2013 May 15;126(Pt 10):2246-55. doi: 10.1242/jcs.121632. Epub 2013 Mar 22.


Methods for determining the PK parameters of AlbudAbs™ and of long serum half-life drugs made using the AlbudAb™ technology.

Rycroft D, Holt LJ.

Methods Mol Biol. 2012;911:457-73. doi: 10.1007/978-1-61779-968-6_28.


Regulatory modules: Coupling protein stability to phopshoregulation during cell division.

Holt LJ.

FEBS Lett. 2012 Aug 14;586(17):2773-7. doi: 10.1016/j.febslet.2012.05.045. Epub 2012 Jun 1. Review.


Grb10 regulates the development of fiber number in skeletal muscle.

Holt LJ, Turner N, Mokbel N, Trefely S, Kanzleiter T, Kaplan W, Ormandy CJ, Daly RJ, Cooney GJ.

FASEB J. 2012 Sep;26(9):3658-69. doi: 10.1096/fj.11-199349. Epub 2012 May 23.


Phase transitions in biogenic amorphous calcium carbonate.

Gong YU, Killian CE, Olson IC, Appathurai NP, Amasino AL, Martin MC, Holt LJ, Wilt FH, Gilbert PU.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6088-93. doi: 10.1073/pnas.1118085109. Epub 2012 Apr 4.


Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells.

Berg JS, Lin KK, Sonnet C, Boles NC, Weksberg DC, Nguyen H, Holt LJ, Rickwood D, Daly RJ, Goodell MA.

PLoS One. 2011;6(10):e26410. doi: 10.1371/journal.pone.0026410. Epub 2011 Oct 19.


Prospective analysis of early lapse to drinking and smoking among individuals in concurrent alcohol and tobacco treatment.

Holt LJ, Litt MD, Cooney NL.

Psychol Addict Behav. 2012 Sep;26(3):561-72. doi: 10.1037/a0026039. Epub 2011 Oct 24.


Anti-serum albumin domain antibodies in the development of highly potent, efficacious and long-acting interferon.

Walker A, Dunlevy G, Rycroft D, Topley P, Holt LJ, Herbert T, Davies M, Cook F, Holmes S, Jespers L, Herring C.

Protein Eng Des Sel. 2010 Apr;23(4):271-8. doi: 10.1093/protein/gzp091. Epub 2010 Jan 21.


Does the inclusion criterion of women's aggression as opposed to their victimization result in samples that differ on key dimensions of intimate partner violence?

Sullivan TP, Titus JA, Holt LJ, Swan SC, Fisher BS, Snow DL.

Violence Against Women. 2010 Jan;16(1):84-98. doi: 10.1177/1077801209353575.


Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO.

Science. 2009 Sep 25;325(5948):1682-6. doi: 10.1126/science.1172867.


Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis.

Holt LJ, Lyons RJ, Ryan AS, Beale SM, Ward A, Cooney GJ, Daly RJ.

Mol Endocrinol. 2009 Sep;23(9):1406-14. doi: 10.1210/me.2008-0386. Epub 2009 Jun 18.


Depressive symptoms, drinking consequences, and motivation to change in first time DWI offenders.

Holt LJ, O'Malley SS, Rounsaville BJ, Ball SA.

Am J Drug Alcohol Abuse. 2009;35(3):117-22. doi: 10.1080/00952990802585398.


Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.

Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV.

Biochemistry. 2009 Jun 23;48(24):5563-72. doi: 10.1021/bi9000062.


Molecular determinants of Grb14-mediated inhibition of insulin signaling.

Goenaga D, Hampe C, Carré N, Cailliau K, Browaeys-Poly E, Perdereau D, Holt LJ, Daly RJ, Girard J, Broutin I, Issad T, Burnol AF.

Mol Endocrinol. 2009 Jul;23(7):1043-51. doi: 10.1210/me.2008-0360. Epub 2009 Apr 9.


The class I bHLH factors E2-2A and E2-2B regulate EMT.

Sobrado VR, Moreno-Bueno G, Cubillo E, Holt LJ, Nieto MA, Portillo F, Cano A.

J Cell Sci. 2009 Apr 1;122(Pt 7):1014-24. doi: 10.1242/jcs.028241.


Positive feedback sharpens the anaphase switch.

Holt LJ, Krutchinsky AN, Morgan DO.

Nature. 2008 Jul 17;454(7202):353-7. doi: 10.1038/nature07050. Epub 2008 Jun 15.


Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs.

Holt LJ, Basran A, Jones K, Chorlton J, Jespers LS, Brewis ND, Tomlinson IM.

Protein Eng Des Sel. 2008 May;21(5):283-8. doi: 10.1093/protein/gzm067. Epub 2008 Apr 2.


Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.

Smith FM, Holt LJ, Garfield AS, Charalambous M, Koumanov F, Perry M, Bazzani R, Sheardown SA, Hegarty BD, Lyons RJ, Cooney GJ, Daly RJ, Ward A.

Mol Cell Biol. 2007 Aug;27(16):5871-86. Epub 2007 Jun 11.


Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.

Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR.

Mol Cell. 2005 Oct 28;20(2):325-33.


Adapter protein connections: the MRL and Grb7 protein families.

Holt LJ, Daly RJ.

Growth Factors. 2005 Sep;23(3):193-201. Review. No abstract available.


Grb10 and Grb14: enigmatic regulators of insulin action--and more?

Holt LJ, Siddle K.

Biochem J. 2005 Jun 1;388(Pt 2):393-406. Review.


Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis.

Tang Y, Lee KS, Yang H, Logan DW, Wang S, McKinnon ML, Holt LJ, Condie A, Luu MT, Akhurst RJ.

Genomics. 2005 Jan;85(1):60-70.


Domain antibodies: proteins for therapy.

Holt LJ, Herring C, Jespers LS, Woolven BP, Tomlinson IM.

Trends Biotechnol. 2003 Nov;21(11):484-90. Review.


Use of phage display and high-density screening for the isolation of an antibody against the 51-kDa subunit of complex I.

Rubinstein JL, Holt LJ, Walker JE, Tomlinson IM.

Anal Biochem. 2003 Mar 15;314(2):294-300.


Protein profiling comes of age.

Tomlinson IM, Holt LJ.

Genome Biol. 2001;2(2):REVIEWS1004. Epub 2001 Jan 31. Review.


Bilateral occipital lobe stroke with inferior altitudinal defects.

Holt LJ, Anderson SF.

Optometry. 2000 Nov;71(11):690-702.


The use of recombinant antibodies in proteomics.

Holt LJ, Enever C, de Wildt RM, Tomlinson IM.

Curr Opin Biotechnol. 2000 Oct;11(5):445-9. Review.


By-passing selection: direct screening for antibody-antigen interactions using protein arrays.

Holt LJ, Büssow K, Walter G, Tomlinson IM.

Nucleic Acids Res. 2000 Aug 1;28(15):E72.


Stability of trypsin immobilized on inorganic orthopedic biomaterials.

Holt LJ, Puleo DA.

Artif Cells Blood Substit Immobil Biotechnol. 1996 Nov;24(6):613-20.


The effect of heterologous antisera and rheumatoid factor on the synthesis of DNA and protein by human peripheral lymphocytes.

Holt LJ, Ling NR, Stanworth DR.

Immunochemistry. 1966 Sep;3(5):359-71. No abstract available.


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