Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 92

1.

Increasing the Expression Level of ChR2 Enhances the Optogenetic Excitability of Cochlear Neurons.

Meng X, Murali S, Cheng Y, Lu J, Hight AE, Kanumuri VV, Brown MC, Holt JR, Lee DJ, Edge ASB.

J Neurophysiol. 2019 Sep 18. doi: 10.1152/jn.00828.2018. [Epub ahead of print]

PMID:
31533018
2.

Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR.

Nat Biotechnol. 2019 Sep;37(9):1091. doi: 10.1038/s41587-019-0253-5.

PMID:
31406330
3.

Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers.

Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM.

Commun Biol. 2019 Aug 7;2:298. doi: 10.1038/s42003-019-0514-3. eCollection 2019.

4.

Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR.

Nat Biotechnol. 2019 Sep;37(9):1070-1079. doi: 10.1038/s41587-019-0193-0. Epub 2019 Jul 22. Erratum in: Nat Biotechnol. 2019 Aug 12;:.

PMID:
31332326
5.

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP.

Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3.

PMID:
31270503
6.

Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR.

Nat Commun. 2019 Feb 8;10(1):734. doi: 10.1038/s41467-019-08716-x.

7.

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR.

Nat Commun. 2019 Jan 22;10(1):236. doi: 10.1038/s41467-018-08264-w. Erratum in: Nat Commun. 2019 Feb 8;10(1):734.

8.

Split otoferlins reunited.

Holt JR, Geleoc GS.

EMBO Mol Med. 2019 Jan;11(1). pii: e9995. doi: 10.15252/emmm.201809995. No abstract available.

9.

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.

Corey DP, Akyuz N, Holt JR.

Cold Spring Harb Perspect Med. 2019 Oct 1;9(10). pii: a033506. doi: 10.1101/cshperspect.a033506. Review.

10.

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.

Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR.

Neuron. 2018 Aug 22;99(4):736-753.e6. doi: 10.1016/j.neuron.2018.07.033.

11.

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.

Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG.

Sci Rep. 2018 Aug 14;8(1):12124. doi: 10.1038/s41598-018-28958-x.

12.

Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.

Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald TS, Géléoc GS, Holt JR, Griffith AJ.

Sci Rep. 2018 Aug 14;8(1):12125. doi: 10.1038/s41598-018-29709-8.

13.

Regenerating hair cells in vestibular sensory epithelia from humans.

Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A.

Elife. 2018 Jul 18;7. pii: e34817. doi: 10.7554/eLife.34817.

14.

Suppressing tawny crazy ant (Nylanderia fulva) by RNAi technology.

Meng J, Lei J, Davitt A, Holt JR, Huang J, Gold R, Vargo EL, Tarone AM, Zhu-Salzman K.

Insect Sci. 2020 Feb;27(1):113-121. doi: 10.1111/1744-7917.12604. Epub 2018 Jun 28.

PMID:
29790281
15.

Invasion of sorghum in the Americas by a new sugarcane aphid (Melanaphis sacchari) superclone.

Nibouche S, Costet L, Holt JR, Jacobson A, Pekarcik A, Sadeyen J, Armstrong JS, Peterson GC, McLaren N, Medina RF.

PLoS One. 2018 Apr 25;13(4):e0196124. doi: 10.1371/journal.pone.0196124. eCollection 2018.

16.

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR.

Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20.

17.

Emerging Gene Therapies for Genetic Hearing Loss.

Ahmed H, Shubina-Oleinik O, Holt JR.

J Assoc Res Otolaryngol. 2017 Oct;18(5):649-670. doi: 10.1007/s10162-017-0634-8. Epub 2017 Aug 16. Review.

18.

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.

Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E.

Nat Biotechnol. 2017 Jun;35(6):583-589. doi: 10.1038/nbt.3840. Epub 2017 May 1.

19.

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS.

Nat Biotechnol. 2017 Mar;35(3):264-272. doi: 10.1038/nbt.3801. Epub 2017 Feb 6.

20.

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH.

Nat Biotechnol. 2017 Mar;35(3):280-284. doi: 10.1038/nbt.3781. Epub 2017 Feb 6.

21.

High-resolution three-dimensional structural microscopy by single-angle Bragg ptychography.

Hruszkewycz SO, Allain M, Holt MV, Murray CE, Holt JR, Fuoss PH, Chamard V.

Nat Mater. 2017 Feb;16(2):244-251. doi: 10.1038/nmat4798. Epub 2016 Nov 21.

22.

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

Corey DP, Holt JR.

J Neurosci. 2016 Oct 26;36(43):10921-10926.

23.

RNA Interference Prevents Autosomal-Dominant Hearing Loss.

Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJH.

Am J Hum Genet. 2016 Jun 2;98(6):1101-1113. doi: 10.1016/j.ajhg.2016.03.028. Epub 2016 May 26.

24.

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.

Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR.

Nat Commun. 2016 May 24;7:11508. doi: 10.1038/ncomms11508.

25.

Plug-N-Play: Mechanotransduction Goes Modular.

Akyuz N, Holt JR.

Neuron. 2016 Mar 16;89(6):1128-1130. doi: 10.1016/j.neuron.2016.02.041.

26.

Recessive mutations of TMC1 associated with moderate to severe hearing loss.

Imtiaz A, Maqsood A, Rehman AU, Morell RJ, Holt JR, Friedman TB, Naz S.

Neurogenetics. 2016 Apr;17(2):115-123. doi: 10.1007/s10048-016-0477-1. Epub 2016 Feb 16.

27.

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.

Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B.

Cell Rep. 2015 Sep 8;12(10):1606-17. doi: 10.1016/j.celrep.2015.07.058. Epub 2015 Aug 28.

28.

The molecules that mediate sensory transduction in the mammalian inner ear.

Pan B, Holt JR.

Curr Opin Neurobiol. 2015 Oct;34:165-71. doi: 10.1016/j.conb.2015.06.013. Epub 2015 Jul 25. Review.

29.

Tmc gene therapy restores auditory function in deaf mice.

Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR.

Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996.

PMID:
26157030
30.

Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation.

Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR.

Pflugers Arch. 2015 Jan;467(1):85-94. doi: 10.1007/s00424-014-1582-3. Epub 2014 Jul 31. Review.

31.

Strain imaging of nanoscale semiconductor heterostructures with x-ray Bragg projection ptychography.

Holt MV, Hruszkewycz SO, Murray CE, Holt JR, Paskiewicz DM, Fuoss PH.

Phys Rev Lett. 2014 Apr 25;112(16):165502. Epub 2014 Apr 23.

PMID:
24815657
32.

Sound strategies for hearing restoration.

Géléoc GS, Holt JR.

Science. 2014 May 9;344(6184):1241062. doi: 10.1126/science.1241062. Review.

33.

Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.

Horwitz GC, Risner-Janiczek JR, Holt JR.

J Gen Physiol. 2014 Apr;143(4):481-97. doi: 10.1085/jgp.201311126. Epub 2014 Mar 17.

34.

TMC function in hair cell transduction.

Holt JR, Pan B, Koussa MA, Asai Y.

Hear Res. 2014 May;311:17-24. doi: 10.1016/j.heares.2014.01.001. Epub 2014 Jan 11. Review.

35.

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.

Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J.

Hum Mol Genet. 2014 May 1;23(9):2374-90. doi: 10.1093/hmg/ddt629. Epub 2013 Dec 11.

36.

A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.

Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV.

Elife. 2013 Dec 10;2:e01341. doi: 10.7554/eLife.01341.

37.

Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.

Kim YH, Holt JR.

J Gen Physiol. 2013 Sep;142(3):207-23. doi: 10.1085/jgp.201311019.

38.

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.

Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR.

Neuron. 2013 Aug 7;79(3):504-15. doi: 10.1016/j.neuron.2013.06.019. Epub 2013 Jul 18.

39.

Gene therapy for deaf mice goes viral.

Holt JR, Vandenberghe LH.

Mol Ther. 2012 Oct;20(10):1836-7. doi: 10.1038/mt.2012.196. No abstract available.

40.

The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.

Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN.

J Neurosci. 2012 Jul 11;32(28):9485-98. doi: 10.1523/JNEUROSCI.0311-12.2012.

41.

The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear.

Levin ME, Holt JR.

J Neurophysiol. 2012 Jul;108(1):175-86. doi: 10.1152/jn.00098.2012. Epub 2012 Apr 11.

42.

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.

Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della Santina CC, Holt JR, Griffith AJ.

J Clin Invest. 2011 Dec;121(12):4796-809. doi: 10.1172/JCI60405. Epub 2011 Nov 21.

43.

HCN channels expressed in the inner ear are necessary for normal balance function.

Horwitz GC, Risner-Janiczek JR, Jones SM, Holt JR.

J Neurosci. 2011 Nov 16;31(46):16814-25. doi: 10.1523/JNEUROSCI.3064-11.2011.

44.

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.

Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J.

J Neurosci. 2011 Aug 24;31(34):12241-50. doi: 10.1523/JNEUROSCI.6531-10.2011.

45.

Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human.

Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, Srisailapathy CR, Oostrik J, Admiraal RJ, Neely HR, Latoche JR, Smith RJ, Northup JK, Kremer H, Holt JR, Noben-Trauth K.

Nat Commun. 2011 Feb 15;2:201. doi: 10.1038/ncomms1200.

46.

Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15.

Lelli A, Kazmierczak P, Kawashima Y, Müller U, Holt JR.

J Neurosci. 2010 Aug 25;30(34):11259-69. doi: 10.1523/JNEUROSCI.1949-10.2010.

47.

HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.

Horwitz GC, Lelli A, Géléoc GS, Holt JR.

PLoS One. 2010 Jan 7;5(1):e8627. doi: 10.1371/journal.pone.0008627.

48.

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

Asai Y, Holt JR, Géléoc GS.

J Assoc Res Otolaryngol. 2010 Mar;11(1):27-37. doi: 10.1007/s10162-009-0193-8. Epub 2009 Oct 16.

49.

Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells.

Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS.

BMC Neurosci. 2009 Sep 24;10:122. doi: 10.1186/1471-2202-10-122.

50.

Supplemental Content

Support Center