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Items: 49


Radiosynthesis and validation of [5-cyano-N-(4-(4-[11 C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl) furan-2-carboxamide] ([11 C]CPPC), a PET radiotracer for imaging CSF1R, a microglia-specific marker.

Mathews WB, Wu Y, Horti AG, Naik R, Hall AW, Holt DP, Dannals RF.

J Labelled Comp Radiopharm. 2019 Sep 16. doi: 10.1002/jlcr.3806. [Epub ahead of print]


Erratum for DeMarco et al., "Determination of [11C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging".

DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhang Z, Tonge PJ, Dannals RF, Holt DP, Lee CKK, Weinstein EA, Dartois V, Dooley KE, Jain SK.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e01368-19. doi: 10.1128/AAC.01368-19. Print 2019 Sep. No abstract available.


Effect of STN DBS on vesicular monoamine transporter 2 and glucose metabolism in Parkinson's disease.

Smith GS, Mills KA, Pontone GM, Anderson WS, Perepezko KM, Brasic J, Zhou Y, Brandt J, Butson CR, Holt DP, Mathews WB, Dannals RF, Wong DF, Mari Z.

Parkinsonism Relat Disord. 2019 Jul;64:235-241. doi: 10.1016/j.parkreldis.2019.04.006. Epub 2019 Apr 16.


Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis.

Tucker EW, Guglieri-Lopez B, Ordonez AA, Ritchie B, Klunk MH, Sharma R, Chang YS, Sanchez-Bautista J, Frey S, Lodge MA, Rowe SP, Holt DP, Gobburu JVS, Peloquin CA, Mathews WB, Dannals RF, Pardo CA, Kannan S, Ivaturi VD, Jain SK.

Sci Transl Med. 2018 Dec 5;10(470). pii: eaau0965. doi: 10.1126/scitranslmed.aau0965.


Radiosynthesis and validation of [Carboxy-11 C]4-Aminobenzoic acid ([11 C]PABA), a PET radiotracer for imaging bacterial infections.

Holt DP, Kalinda AS, Bambarger LE, Jain SK, Dannals RF.

J Labelled Comp Radiopharm. 2019 Jan;62(1):28-33. doi: 10.1002/jlcr.3674. Epub 2018 Aug 29.


An optimized radiosynthesis of [18 F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH).

Azad BB, Holt DP, Ravert HT, Horti AG, Dannals RF.

J Labelled Comp Radiopharm. 2018 Jun 15;61(7):567-572. doi: 10.1002/jlcr.3620. Epub 2018 May 7.


Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia.

Wong DF, Kuwabara H, Horti AG, Roberts JM, Nandi A, Cascella N, Brasic J, Weerts EM, Kitzmiller K, Phan JA, Gapasin L, Sawa A, Valentine H, Wand G, Mishra C, George N, McDonald M, Lesniak W, Holt DP, Azad BB, Dannals RF, Kem W, Freedman R, Gjedde A.

Int J Neuropsychopharmacol. 2018 Jul 1;21(7):656-667. doi: 10.1093/ijnp/pyy021.


Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

Gobbi LC, Knust H, Körner M, Honer M, Czech C, Belli S, Muri D, Edelmann MR, Hartung T, Erbsmehl I, Grall-Ulsemer S, Koblet A, Rueher M, Steiner S, Ravert HT, Mathews WB, Holt DP, Kuwabara H, Valentine H, Dannals RF, Wong DF, Borroni E.

J Med Chem. 2017 Sep 14;60(17):7350-7370. doi: 10.1021/acs.jmedchem.7b00632. Epub 2017 Jul 12.


An improved synthesis of the radiolabeled prostate-specific membrane antigen inhibitor, [(18) F]DCFPyL.

Ravert HT, Holt DP, Chen Y, Mease RC, Fan H, Pomper MG, Dannals RF.

J Labelled Comp Radiopharm. 2016 Sep;59(11):439-50. doi: 10.1002/jlcr.3430. Epub 2016 Jul 29.


Synthesis and quality control of [(18) F]T807 for tau PET imaging.

Holt DP, Ravert HT, Dannals RF.

J Labelled Comp Radiopharm. 2016 Aug;59(10):411-5. doi: 10.1002/jlcr.3425. Epub 2016 Jul 17.


Comparison of Prostate-Specific Membrane Antigen-Based 18F-DCFBC PET/CT to Conventional Imaging Modalities for Detection of Hormone-Naïve and Castration-Resistant Metastatic Prostate Cancer.

Rowe SP, Macura KJ, Ciarallo A, Mena E, Blackford A, Nadal R, Antonarakis ES, Eisenberger MA, Carducci MA, Ross AE, Kantoff PW, Holt DP, Dannals RF, Mease RC, Pomper MG, Cho SY.

J Nucl Med. 2016 Jan;57(1):46-53. doi: 10.2967/jnumed.115.163782. Epub 2015 Oct 22.


Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation.

Bravo PE, Lautamäki R, Carter D, Holt DP, Nekolla SG, Dannals RF, Russell SD, Bengel FM.

Circ Cardiovasc Imaging. 2015 Aug;8(8):e003507. doi: 10.1161/CIRCIMAGING.115.003507.


Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging.

DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhuo Z, Tonge PJ, Dannals RF, Holt DP, Lee CK, Weinstein EA, Dartois V, Dooley KE, Jain SK.

Antimicrob Agents Chemother. 2015 Sep;59(9):5768-74. doi: 10.1128/AAC.01146-15. Epub 2015 Jul 13. Erratum in: Antimicrob Agents Chemother. 2019 Aug 23;63(9):.


Performance assessment of a NaI(Tl) gamma counter for PET applications with methods for improved quantitative accuracy and greater standardization.

Lodge MA, Holt DP, Kinahan PE, Wong DF, Wahl RL.

EJNMMI Phys. 2015 May;2. pii: 11. doi: 10.1186/s40658-015-0114-3.


Microwave-assisted radiosynthesis of [(18) F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist.

Ravert HT, Holt DP, Gao Y, Horti AG, Dannals RF.

J Labelled Comp Radiopharm. 2015 Apr;58(4):180-2. doi: 10.1002/jlcr.3275. Epub 2015 Feb 26.


Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone.

Lautamaki R, Sasano T, Higuchi T, Nekolla SG, Lardo AC, Holt DP, Dannals RF, Abraham MR, Bengel FM.

J Nucl Med. 2015 Mar;56(3):457-63. doi: 10.2967/jnumed.114.149971. Epub 2015 Jan 29.


A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.

Ravert HT, Holt DP, Dannals RF.

J Labelled Comp Radiopharm. 2014 Oct;57(12):695-8. doi: 10.1002/jlcr.3241. Epub 2014 Oct 20.


Quantitative Multi-modal Brain Autoradiography of Glutamatergic, Dopaminergic, Cannabinoid, and Nicotinic Receptors in Mutant Disrupted-In-Schizophrenia-1 (DISC1) Mice.

Kim J, Horti AG, Mathews WB, Pogorelov V, Valentine H, Brasic JR, Holt DP, Ravert HT, Dannals RF, Zhou L, Jedynak B, Kamiya A, Pletnikov MV, Wong DF.

Mol Imaging Biol. 2015 Jun;17(3):355-63. doi: 10.1007/s11307-014-0786-4.


Human brain imaging of α7 nAChR with [(18)F]ASEM: a new PET radiotracer for neuropsychiatry and determination of drug occupancy.

Wong DF, Kuwabara H, Pomper M, Holt DP, Brasic JR, George N, Frolov B, Willis W, Gao Y, Valentine H, Nandi A, Gapasin L, Dannals RF, Horti AG.

Mol Imaging Biol. 2014 Oct;16(5):730-8. doi: 10.1007/s11307-014-0779-3.


18F-ASEM, a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET.

Horti AG, Gao Y, Kuwabara H, Wang Y, Abazyan S, Yasuda RP, Tran T, Xiao Y, Sahibzada N, Holt DP, Kellar KJ, Pletnikov MV, Pomper MG, Wong DF, Dannals RF.

J Nucl Med. 2014 Apr;55(4):672-7. doi: 10.2967/jnumed.113.132068. Epub 2014 Feb 20.


Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors.

Horti AG, Kuwabara H, Holt DP, Dannals RF, Wong DF.

J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):159-66. doi: 10.1002/jlcr.3020. Review.


Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: an agonist probe for the α7 nicotinic acetylcholine receptor.

Ravert HT, Dorff P, Foss CA, Mease RC, Fan H, Holmquist CR, Phillips E, McCarthy DJ, Heys JR, Holt DP, Wang Y, Endres CJ, Dannals RF, Pomper MG.

Nucl Med Biol. 2013 Aug;40(6):731-9. doi: 10.1016/j.nucmedbio.2013.04.005. Epub 2013 May 13.


18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry.

Wong DF, Waterhouse R, Kuwabara H, Kim J, Brašić JR, Chamroonrat W, Stabins M, Holt DP, Dannals RF, Hamill TG, Mozley PD.

J Nucl Med. 2013 Mar;54(3):388-96. doi: 10.2967/jnumed.112.107995. Epub 2013 Feb 12.


Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors.

Horti AG, Ravert HT, Gao Y, Holt DP, Bunnelle WH, Schrimpf MR, Li T, Ji J, Valentine H, Scheffel U, Kuwabara H, Wong DF, Dannals RF.

Nucl Med Biol. 2013 Apr;40(3):395-402. doi: 10.1016/j.nucmedbio.2012.11.013. Epub 2013 Jan 5.


Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancer.

Cho SY, Gage KL, Mease RC, Senthamizhchelvan S, Holt DP, Jeffrey-Kwanisai A, Endres CJ, Dannals RF, Sgouros G, Lodge M, Eisenberger MA, Rodriguez R, Carducci MA, Rojas C, Slusher BS, Kozikowski AP, Pomper MG.

J Nucl Med. 2012 Dec;53(12):1883-91. doi: 10.2967/jnumed.112.104661.


PET Imaging of nicotinic acetylcholine receptors in baboons with 18F-AZAN, a radioligand with improved brain kinetics.

Kuwabara H, Wong DF, Gao Y, Valentine H, Holt DP, Ravert HT, Dannals RF, Horti AG.

J Nucl Med. 2012 Jan;53(1):121-9. doi: 10.2967/jnumed.111.092338. Epub 2011 Dec 15.


Stable delineation of the ischemic area by the PET perfusion tracer 18F-fluorobenzyl triphenyl phosphonium after transient coronary occlusion.

Higuchi T, Fukushima K, Rischpler C, Isoda T, Javadi MS, Ravert H, Holt DP, Dannals RF, Madar I, Bengel FM.

J Nucl Med. 2011 Jun;52(6):965-9. doi: 10.2967/jnumed.110.085993. Epub 2011 May 13.


Synthesis and in vivo evaluation of (S)-6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one, a potential PET tracer for growth hormone secretagogue receptor (GHSR).

Potter R, Horti AG, Ravert HT, Holt DP, Finley P, Scheffel U, Dannals RF, Wahl RL.

Bioorg Med Chem. 2011 Apr 1;19(7):2368-72. doi: 10.1016/j.bmc.2011.02.021. Epub 2011 Feb 16.


Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB.

Resnick SM, Sojkova J, Zhou Y, An Y, Ye W, Holt DP, Dannals RF, Mathis CA, Klunk WE, Ferrucci L, Kraut MA, Wong DF.

Neurology. 2010 Mar 9;74(10):807-15. doi: 10.1212/WNL.0b013e3181d3e3e9. Epub 2010 Feb 10.


Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.

Gao Y, Ravert HT, Kuwabara H, Xiao Y, Endres CJ, Hilton J, Holt DP, Kumar A, Alexander M, Wong DF, Dannals RF, Horti AG.

Bioorg Med Chem. 2009 Jul 1;17(13):4367-77. doi: 10.1016/j.bmc.2009.05.021. Epub 2009 May 15.


New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3'-iodo-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors.

Gao Y, Horti AG, Kuwabara H, Ravert HT, Holt DP, Kumar A, Alexander M, Wong DF, Dannals RF.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6168-70. doi: 10.1016/j.bmcl.2008.10.012. Epub 2008 Oct 7.


In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat.

Tipre DN, Fox JJ, Holt DP, Green G, Yu J, Pomper M, Dannals RF, Bengel FM.

J Nucl Med. 2008 Jul;49(7):1189-95. doi: 10.2967/jnumed.107.050252. Epub 2008 Jun 13.


Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction.

Sasano T, Abraham MR, Chang KC, Ashikaga H, Mills KJ, Holt DP, Hilton J, Nekolla SG, Dong J, Lardo AC, Halperin H, Dannals RF, Marbán E, Bengel FM.

J Am Coll Cardiol. 2008 Jun 10;51(23):2266-75. doi: 10.1016/j.jacc.2008.02.062.


Derivatives of (-)-7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane are potential ligands for positron emission tomography imaging of extrathalamic nicotinic acetylcholine receptors.

Gao Y, Horti AG, Kuwabara H, Ravert HT, Hilton J, Holt DP, Kumar A, Alexander M, Endres CJ, Wong DF, Dannals RF.

J Med Chem. 2007 Aug 9;50(16):3814-24. Epub 2007 Jul 13.


Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease.

Zhou Y, Resnick SM, Ye W, Fan H, Holt DP, Klunk WE, Mathis CA, Dannals R, Wong DF.

Neuroimage. 2007 Jun;36(2):298-312. Epub 2007 Mar 16.


11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors.

Horti AG, Fan H, Kuwabara H, Hilton J, Ravert HT, Holt DP, Alexander M, Kumar A, Rahmim A, Scheffel U, Wong DF, Dannals RF.

J Nucl Med. 2006 Oct;47(10):1689-96.


Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, Debnath ML, Holt DP, Huang GF, Shao L, DeKosky ST, Price JC, Mathis CA.

J Neurosci. 2005 Nov 16;25(46):10598-606.


Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.

Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, DeKosky ST, Mathis CA.

J Cereb Blood Flow Metab. 2005 Nov;25(11):1528-47.


Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease.

Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.

J Mol Neurosci. 2004;24(1):55-62.


Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.

Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B.

Ann Neurol. 2004 Mar;55(3):306-19.


Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives.

Wang Y, Mathis CA, Huang GF, Debnath ML, Holt DP, Shao L, Klunk WE.

J Mol Neurosci. 2003;20(3):255-60.


Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE.

J Med Chem. 2003 Jun 19;46(13):2740-54.


The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA.

J Neurosci. 2003 Mar 15;23(6):2086-92.


Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.

Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.

J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805.


Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease.

Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, Mathis CA.

J Mol Neurosci. 2002 Aug-Oct;19(1-2):11-6.


A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):295-8.


Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA.

Life Sci. 2001 Aug 17;69(13):1471-84.


Analyses of [(18)F]altanserin bolus injection PET data. II: consideration of radiolabeled metabolites in humans.

Price JC, Lopresti BJ, Meltzer CC, Smith GS, Mason NS, Huang Y, Holt DP, Gunn RN, Mathis CA.

Synapse. 2001 Jul;41(1):11-21.


Analyses of [(18)F] altanserin bolus injection PET data. I: consideration of radiolabeled metabolites in baboons.

Price JC, Lopresti BJ, Mason NS, Holt DP, Huang Y, Mathis CA.

Synapse. 2001 Jul;41(1):1-10.


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