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Items: 1 to 50 of 149


Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.

Koppers M, Cagnetta R, Shigeoka T, Wunderlich LC, Vallejo-Ramirez P, Qiaojin Lin J, Zhao S, Jakobs MA, Dwivedy A, Minett MS, Bellon A, Kaminski CF, Harris WA, Flanagan JG, Holt CE.

Elife. 2019 Nov 20;8. pii: e48718. doi: 10.7554/eLife.48718.


Local translation in neurons: visualization and function.

Holt CE, Martin KC, Schuman EM.

Nat Struct Mol Biol. 2019 Jul;26(7):557-566. doi: 10.1038/s41594-019-0263-5. Epub 2019 Jul 3. Review.


Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain.

Thompson AJ, Pillai EK, Dimov IB, Foster SK, Holt CE, Franze K.

Elife. 2019 Jan 15;8. pii: e39356. doi: 10.7554/eLife.39356.


Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.

Cioni JM, Lin JQ, Holtermann AV, Koppers M, Jakobs MAH, Azizi A, Turner-Bridger B, Shigeoka T, Franze K, Harris WA, Holt CE.

Cell. 2019 Jan 10;176(1-2):56-72.e15. doi: 10.1016/j.cell.2018.11.030. Epub 2019 Jan 3.


Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring.

Cagnetta R, Wong HH, Frese CK, Mallucci GR, Krijgsveld J, Holt CE.

Mol Cell. 2019 Feb 7;73(3):474-489.e5. doi: 10.1016/j.molcel.2018.11.013. Epub 2018 Dec 27.


Growth Cone Tctp Is Dynamically Regulated by Guidance Cues.

Gouveia Roque C, Holt CE.

Front Mol Neurosci. 2018 Nov 6;11:399. doi: 10.3389/fnmol.2018.00399. eCollection 2018.


Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons.

Turner-Bridger B, Jakobs M, Muresan L, Wong HH, Franze K, Harris WA, Holt CE.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9697-E9706. doi: 10.1073/pnas.1806189115. Epub 2018 Sep 25.


Cue-Polarized Transport of β-actin mRNA Depends on 3'UTR and Microtubules in Live Growth Cones.

Leung KM, Lu B, Wong HH, Lin JQ, Turner-Bridger B, Holt CE.

Front Cell Neurosci. 2018 Sep 10;12:300. doi: 10.3389/fncel.2018.00300. eCollection 2018.


Targeted Electroporation in the CNS in Xenopus Embryos.

Wong HH, Holt CE.

Methods Mol Biol. 2018;1865:119-131. doi: 10.1007/978-1-4939-8784-9_9.


Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome.

Cagnetta R, Frese CK, Shigeoka T, Krijgsveld J, Holt CE.

Neuron. 2018 Jul 11;99(1):29-46.e4. doi: 10.1016/j.neuron.2018.06.004. Epub 2018 Jun 28.


FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, Kaminski Schierle GS, Kaminski CF, Holt CE, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P.

Cell. 2018 Apr 19;173(3):720-734.e15. doi: 10.1016/j.cell.2018.03.056.


Molecular control of local translation in axon development and maintenance.

Cioni JM, Koppers M, Holt CE.

Curr Opin Neurobiol. 2018 Aug;51:86-94. doi: 10.1016/j.conb.2018.02.025. Epub 2018 Mar 14. Review.


Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function.

Cioni JM, Wong HH, Bressan D, Kodama L, Harris WA, Holt CE.

Neuron. 2018 Mar 7;97(5):1078-1093.e6. doi: 10.1016/j.neuron.2018.01.027.


Tctp in Neuronal Circuitry Assembly.

Roque CG, Holt CE.

Results Probl Cell Differ. 2017;64:201-215. doi: 10.1007/978-3-319-67591-6_10.


Axon-TRAP-RiboTag: Affinity Purification of Translated mRNAs from Neuronal Axons in Mouse In Vivo.

Shigeoka T, Jung J, Holt CE, Jung H.

Methods Mol Biol. 2018;1649:85-94. doi: 10.1007/978-1-4939-7213-5_5.


Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells.

Ströhl F, Wong HHW, Holt CE, Kaminski CF.

Methods Appl Fluoresc. 2017 Dec 19;6(1):014004. doi: 10.1088/2050-6120/aa872e.


RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo.

Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE.

Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3.


Filopodyan: An open-source pipeline for the analysis of filopodia.

Urbančič V, Butler R, Richier B, Peter M, Mason J, Livesey FJ, Holt CE, Gallop JL.

J Cell Biol. 2017 Oct 2;216(10):3405-3422. doi: 10.1083/jcb.201705113. Epub 2017 Jul 31.


Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons.

Ströhl F, Lin JQ, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF.

Sci Rep. 2017 Apr 6;7(1):709. doi: 10.1038/s41598-017-00695-7.


miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA.

Bellon A, Iyer A, Bridi S, Lee FCY, Ovando-Vázquez C, Corradi E, Longhi S, Roccuzzo M, Strohbuecker S, Naik S, Sarkies P, Miska E, Abreu-Goodger C, Holt CE, Baudet ML.

Cell Rep. 2017 Jan 31;18(5):1171-1186. doi: 10.1016/j.celrep.2016.12.093.


Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1.

Hörnberg H, Cioni JM, Harris WA, Holt CE.

J Neurosci. 2016 Dec 14;36(50):12697-12706. Epub 2016 Nov 9.


Mechanosensing is critical for axon growth in the developing brain.

Koser DE, Thompson AJ, Foster SK, Dwivedy A, Pillai EK, Sheridan GK, Svoboda H, Viana M, Costa LD, Guck J, Holt CE, Franze K.

Nat Neurosci. 2016 Dec;19(12):1592-1598. doi: 10.1038/nn.4394. Epub 2016 Sep 19.


Dynamic Axonal Translation in Developing and Mature Visual Circuits.

Shigeoka T, Jung H, Jung J, Turner-Bridger B, Ohk J, Lin JQ, Amieux PS, Holt CE.

Cell. 2016 Jun 30;166(1):181-92. doi: 10.1016/j.cell.2016.05.029. Epub 2016 Jun 16.


ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.

Konopacki FA, Wong HH, Dwivedy A, Bellon A, Blower MD, Holt CE.

Open Biol. 2016 Apr;6(4):150218. doi: 10.1098/rsob.150218. Epub 2016 Apr 20.


Tumor protein Tctp regulates axon development in the embryonic visual system.

Roque CG, Wong HH, Lin JQ, Holt CE.

Development. 2016 Apr 1;143(7):1134-48. doi: 10.1242/dev.131060. Epub 2016 Feb 22.


Observation of Cationic Transition Metal-Alkane Complexes with Moderate Stability in Hydrofluorocarbon Solution.

Yau HM, McKay AI, Hesse H, Xu R, He M, Holt CE, Ball GE.

J Am Chem Soc. 2016 Jan 13;138(1):281-8. doi: 10.1021/jacs.5b10583. Epub 2015 Dec 22.


NF-Protocadherin Regulates Retinal Ganglion Cell Axon Behaviour in the Developing Visual System.

Leung LC, Harris WA, Holt CE, Piper M.

PLoS One. 2015 Oct 21;10(10):e0141290. doi: 10.1371/journal.pone.0141290. eCollection 2015.


Erratum to: Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones.

Piper M, Lee AC, van Horck FP, McNeilly H, Lu TB, Harris WA, Holt CE.

Neural Dev. 2015 Jun 19;10:16. doi: 10.1186/s13064-015-0043-9. No abstract available.


Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones.

Piper M, Lee AC, van Horck FP, McNeilly H, Lu TB, Harris WA, Holt CE.

Neural Dev. 2015 Feb 25;10:3. doi: 10.1186/s13064-015-0031-0. Erratum in: Neural Dev. 2015;10:16.


Remote control of gene function by local translation.

Jung H, Gkogkas CG, Sonenberg N, Holt CE.

Cell. 2014 Mar 27;157(1):26-40. doi: 10.1016/j.cell.2014.03.005. Review.


Rab5 and Rab4 regulate axon elongation in the Xenopus visual system.

Falk J, Konopacki FA, Zivraj KH, Holt CE.

J Neurosci. 2014 Jan 8;34(2):373-91. doi: 10.1523/JNEUROSCI.0876-13.2014.


Introduction to the special issue on local protein synthesis in axons.

Sotelo-Silveira JR, Holt CE.

Dev Neurobiol. 2014 Mar;74(3):207-9. doi: 10.1002/dneu.22163. Epub 2014 Jan 28. No abstract available.


The central dogma decentralized: new perspectives on RNA function and local translation in neurons.

Holt CE, Schuman EM.

Neuron. 2013 Oct 30;80(3):648-57. doi: 10.1016/j.neuron.2013.10.036. Review.


Cell biology in neuroscience: RNA-based mechanisms underlying axon guidance.

Shigeoka T, Lu B, Holt CE.

J Cell Biol. 2013 Sep 30;202(7):991-9. doi: 10.1083/jcb.201305139. Review.


RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system.

Kalous A, Stake JI, Yisraeli JK, Holt CE.

Dev Neurobiol. 2014 Mar;74(3):303-18. doi: 10.1002/dneu.22110. Epub 2013 Sep 11.


RNA-binding protein Hermes/RBPMS inversely affects synapse density and axon arbor formation in retinal ganglion cells in vivo.

Hörnberg H, Wollerton-van Horck F, Maurus D, Zwart M, Svoboda H, Harris WA, Holt CE.

J Neurosci. 2013 Jun 19;33(25):10384-95. doi: 10.1523/JNEUROSCI.5858-12.2013.


Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation.

Leung LC, Urbančič V, Baudet ML, Dwivedy A, Bayley TG, Lee AC, Harris WA, Holt CE.

Nat Neurosci. 2013 Feb;16(2):166-73. doi: 10.1038/nn.3290. Epub 2013 Jan 6.


Role of microRNAs in Semaphorin function and neural circuit formation.

Baudet ML, Bellon A, Holt CE.

Semin Cell Dev Biol. 2013 Mar;24(3):146-55. doi: 10.1016/j.semcdb.2012.11.004. Epub 2012 Dec 5. Review.


Imaging axon pathfinding in zebrafish in vivo.

Leung L, Holt CE.

Cold Spring Harb Protoc. 2012 Sep 1;2012(9):992-7. doi: 10.1101/pdb.prot070011.


Imaging axon pathfinding in Xenopus in vivo.

Leung L, Holt CE.

Cold Spring Harb Protoc. 2012 Sep 1;2012(9):984-91. doi: 10.1101/pdb.prot070003.


Differing semaphorin 3A concentrations trigger distinct signaling mechanisms in growth cone collapse.

Manns RP, Cook GM, Holt CE, Keynes RJ.

J Neurosci. 2012 Jun 20;32(25):8554-9. doi: 10.1523/JNEUROSCI.5964-11.2012.


Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.

Jung H, Yoon BC, Holt CE.

Nat Rev Neurosci. 2012 Apr 13;13(5):308-24. doi: 10.1038/nrn3210. Review. Erratum in: Nat Rev Neurosci. 2012 Aug;13(8):597.


Local translation of extranuclear lamin B promotes axon maintenance.

Yoon BC, Jung H, Dwivedy A, O'Hare CM, Zivraj KH, Holt CE.

Cell. 2012 Feb 17;148(4):752-64. doi: 10.1016/j.cell.2011.11.064.


miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones.

Baudet ML, Zivraj KH, Abreu-Goodger C, Muldal A, Armisen J, Blenkiron C, Goldstein LD, Miska EA, Holt CE.

Nat Neurosci. 2011 Dec 4;15(1):29-38. doi: 10.1038/nn.2979.


Regulation of chemotropic guidance of nerve growth cones by microRNA.

Han L, Wen Z, Lynn RC, Baudet ML, Holt CE, Sasaki Y, Bassell GJ, Zheng JQ.

Mol Brain. 2011 Nov 3;4:40. doi: 10.1186/1756-6606-4-40.


Local translation of mRNAs in neural development.

Jung H, Holt CE.

Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):153-65. doi: 10.1002/wrna.53. Epub 2010 Oct 19. Review.


14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity.

Yoon BC, Zivraj KH, Strochlic L, Holt CE.

Dev Neurobiol. 2012 Apr;72(4):600-14. doi: 10.1002/dneu.20955.


Translational regulation in growth cones.

Jung H, O'Hare CM, Holt CE.

Curr Opin Genet Dev. 2011 Aug;21(4):458-64. doi: 10.1016/j.gde.2011.04.004. Epub 2011 Apr 27. Review.


Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization.

Gumy LF, Yeo GS, Tung YC, Zivraj KH, Willis D, Coppola G, Lam BY, Twiss JL, Holt CE, Fawcett JW.

RNA. 2011 Jan;17(1):85-98. doi: 10.1261/rna.2386111. Epub 2010 Nov 23.


Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.

Zivraj KH, Tung YC, Piper M, Gumy L, Fawcett JW, Yeo GS, Holt CE.

J Neurosci. 2010 Nov 17;30(46):15464-78. doi: 10.1523/JNEUROSCI.1800-10.2010.

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