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Items: 1 to 50 of 1671

1.

GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men.

Skov-Jeppesen K, Svane MS, Martinussen C, Gabe MBN, Gasbjerg LS, Veedfald S, Bojsen-Møller KN, Madsbad S, Holst JJ, Rosenkilde MM, Hartmann B.

Bone. 2019 May 14. pii: S8756-3282(19)30189-9. doi: 10.1016/j.bone.2019.05.014. [Epub ahead of print]

PMID:
31100534
2.

From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy.

Holst JJ.

Front Endocrinol (Lausanne). 2019 Apr 26;10:260. doi: 10.3389/fendo.2019.00260. eCollection 2019. Review.

3.

Sacubitril/valsartan augments postprandial plasma concentrations of active GLP-1 when combined with sitagliptin in men.

Wewer Albrechtsen NJ, Mark PD, Terzic D, Hansen LH, Andersen UØ, Hartmann B, Carr RD, Gustafsson F, Deacon CF, Holst JJ, Goetze JP, Plomgaard P.

J Clin Endocrinol Metab. 2019 May 10. pii: jc.2019-00515. doi: 10.1210/jc.2019-00515. [Epub ahead of print]

PMID:
31074791
4.

Glucagon Receptor Signaling and Lipid Metabolism.

Galsgaard KD, Pedersen J, Knop FK, Holst JJ, Wewer Albrechtsen NJ.

Front Physiol. 2019 Apr 24;10:413. doi: 10.3389/fphys.2019.00413. eCollection 2019.

5.

GIP-induced vasodilation in human adipose tissue involves capillary recruitment.

Asmar M, Asmar A, Simonsen L, Dela F, Holst JJ, Bülow J.

Endocr Connect. 2019 May 1. pii: EC-19-0144.R1. doi: 10.1530/EC-19-0144. [Epub ahead of print]

6.

Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women.

Otten J, Ryberg M, Mellberg C, Andersson T, Chorell E, Lindahl B, Larsson C, Holst JJ, Olsson T.

Eur J Endocrinol. 2019 Jun 1;180(6):417-427. doi: 10.1530/EJE-19-0082.

PMID:
31042670
7.

Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes.

Hansen CS, Frandsen CS, Fleischer J, Vistisen D, Holst JJ, Tarnow L, Knop FK, Madsbad S, Andersen HU, Dejgaard TF.

Front Endocrinol (Lausanne). 2019 Apr 12;10:242. doi: 10.3389/fendo.2019.00242. eCollection 2019.

8.

The incretin system in healthy humans: the role of GIP and GLP-1.

Holst JJ.

Metabolism. 2019 Apr 25. pii: S0026-0495(19)30086-1. doi: 10.1016/j.metabol.2019.04.014. [Epub ahead of print]

9.
10.

Long-acting glucagon-like peptide-1 receptor agonist-status December 2018.

Holst JJ.

Ann Transl Med. 2019 Mar;7(5):83. doi: 10.21037/atm.2019.01.09. No abstract available.

11.

Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.

Mulla CM, Goldfine AB, Dreyfuss JM, Houten S, Pan H, Pober DM, Wewer Albrechtsen NJ, Svane MS, Schmidt JB, Holst JJ, Craig CM, McLaughlin TL, Patti ME.

Obes Surg. 2019 Apr 11. doi: 10.1007/s11695-019-03845-0. [Epub ahead of print]

PMID:
30976983
12.

The liver-alpha cell axis and type 2 diabetes.

Wewer Albrechtsen NJ, Pedersen J, Galsgaard KD, Winther-Sørensen M, Suppli MP, Janah L, Gromada J, Vilstrup H, Knop FK, Holst JJ.

Endocr Rev. 2019 Mar 28. pii: er.2018-00251. doi: 10.1210/er.2018-00251. [Epub ahead of print]

PMID:
30920583
13.

Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model.

Lin S, Stoll B, Robinson J, Pastor JJ, Marini JC, Ipharraguerre IR, Hartmann B, Holst JJ, Cruz S, Lau P, Olutoye O, Fang Z, Burrin DG.

Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G641-G652. doi: 10.1152/ajpgi.00360.2018. Epub 2019 Mar 28.

PMID:
30920308
14.

No direct effect of SGLT2 activity on glucagon secretion.

Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ.

Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22.

PMID:
30903205
15.

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine.

Kuhre RE, Holst JJ.

J Vis Exp. 2019 Feb 26;(144). doi: 10.3791/58533.

PMID:
30882791
16.

Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: a randomised phase 2 trial.

Naimi RM, Hvistendahl M, Enevoldsen LH, Madsen JL, Fuglsang S, Poulsen SS, Kissow H, Pedersen J, Nerup N, Ambrus R, Achiam MP, Svendsen LB, Holst JJ, Hartmann B, Hansen SH, Dragsted LO, Steensberg A, Mouritzen U, Hansen MB, Jeppesen PB.

Lancet Gastroenterol Hepatol. 2019 May;4(5):354-363. doi: 10.1016/S2468-1253(19)30077-9. Epub 2019 Mar 15.

PMID:
30880176
17.

Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis.

Mezza T, Moffa S, Ferraro PM, Quero G, Capece U, Carfì A, Cefalo CMA, Cinti F, Sorice GP, Impronta F, Mari A, Pontecorvi A, Alfieri S, Holst JJ, Giaccari A.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2685-2694. doi: 10.1210/jc.2018-02804.

PMID:
30874733
18.

Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment.

Schiellerup SP, Skov-Jeppesen K, Windeløv JA, Svane MS, Holst JJ, Hartmann B, Rosenkilde MM.

Front Endocrinol (Lausanne). 2019 Feb 26;10:75. doi: 10.3389/fendo.2019.00075. eCollection 2019. Review.

19.

Bariatric surgery-which procedure is the optimal choice?

Madsbad S, Holst JJ.

Lancet. 2019 Mar 30;393(10178):1263-1264. doi: 10.1016/S0140-6736(19)30489-1. Epub 2019 Mar 6. No abstract available.

PMID:
30851878
20.

Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men without Diabetes.

Bergmann NC, Lund A, Gasbjerg LS, Jørgensen NR, Jessen L, Hartmann B, Holst JJ, Christensen MB, Vilsbøll T, Knop FK.

J Clin Endocrinol Metab. 2019 Mar 8. pii: jc.2019-00008. doi: 10.1210/jc.2019-00008. [Epub ahead of print]

PMID:
30848791
21.

Augmented GLP-1 secretion as seen after gastric bypass may be obtained by delaying carbohydrate digestion.

Martinussen C, Bojsen-Møller KN, Dirksen C, Svane MS, Kristiansen VB, Hartmann B, Holst JJ, Madsbad S.

J Clin Endocrinol Metab. 2019 Mar 7. pii: jc.2018-02661. doi: 10.1210/jc.2018-02661. [Epub ahead of print]

PMID:
30844053
22.

Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1-Renal Axis in Man.

Asmar A, Cramon PK, Simonsen L, Asmar M, Sorensen CM, Madsbad S, Moro C, Hartmann B, Jensen BL, Holst JJ, Bülow J.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2509-2519. doi: 10.1210/jc.2019-00004.

PMID:
30835273
23.

Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Niu L, Geyer PE, Wewer Albrechtsen NJ, Gluud LL, Santos A, Doll S, Treit PV, Holst JJ, Knop FK, Vilsbøll T, Junker A, Sachs S, Stemmer K, Müller TD, Tschöp MH, Hofmann SM, Mann M.

Mol Syst Biol. 2019 Mar 1;15(3):e8793. doi: 10.15252/msb.20188793.

24.

Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling.

Galsgaard KD, Winther-Sørensen M, Pedersen J, Kjeldsen SAS, Rosenkilde MM, Wewer Albrechtsen NJ, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E660-E673. doi: 10.1152/ajpendo.00410.2018. Epub 2019 Feb 26.

PMID:
30807215
25.

Effect of liraglutide on body weight and microvascular function in non-diabetic overweight women with coronary microvascular dysfunction.

Suhrs HE, Raft KF, Bové K, Madsbad S, Holst JJ, Zander M, Prescott E.

Int J Cardiol. 2019 May 15;283:28-34. doi: 10.1016/j.ijcard.2018.12.005. Epub 2019 Jan 2.

PMID:
30773266
26.

Functional Magnetic Resonance Imaging (fMRI) of Neural Responses to Visual and Auditory Food Stimuli Pre and Post Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG).

Baboumian S, Pantazatos SP, Kothari S, McGinty J, Holst J, Geliebter A.

Neuroscience. 2019 Feb 12. pii: S0306-4522(19)30088-0. doi: 10.1016/j.neuroscience.2019.01.061. [Epub ahead of print]

PMID:
30769095
27.

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents.

Christiansen CB, Trammell SAJ, Wewer Albrechtsen NJ, Schoonjans K, Albrechtsen R, Gillum MP, Kuhre RE, Holst JJ.

Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G574-G584. doi: 10.1152/ajpgi.00010.2019. Epub 2019 Feb 15.

PMID:
30767682
28.

Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.

Gide TN, Quek C, Menzies AM, Tasker AT, Shang P, Holst J, Madore J, Lim SY, Velickovic R, Wongchenko M, Yan Y, Lo S, Carlino MS, Guminski A, Saw RPM, Pang A, McGuire HM, Palendira U, Thompson JF, Rizos H, Silva IPD, Batten M, Scolyer RA, Long GV, Wilmott JS.

Cancer Cell. 2019 Feb 11;35(2):238-255.e6. doi: 10.1016/j.ccell.2019.01.003.

PMID:
30753825
29.

Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.

Svane MS, Bojsen-Møller KN, Martinussen C, Dirksen C, Madsen JL, Reitelseder S, Holm L, Rehfeld JF, Kristiansen VB, van Hall G, Holst JJ, Madsbad S.

Gastroenterology. 2019 May;156(6):1627-1641.e1. doi: 10.1053/j.gastro.2019.01.262. Epub 2019 Feb 8.

30.

The effect of DPP-4-protected GLP-1 (7-36) on coronary microvascular function in obese adults.

Nilsson M, Bové KB, Suhrs E, Hermann T, Madsbad S, Holst JJ, Prescott E, Zander M.

Int J Cardiol Heart Vasc. 2019 Jan 29;22:139-144. doi: 10.1016/j.ijcha.2019.01.004. eCollection 2019 Mar.

31.

Glucagon-Like Peptide-1 Is a Marker of Systemic Inflammation in Patients Treated with High-Dose Chemotherapy and Autologous Stem Cell Transplantation.

Ebbesen MS, Kissow H, Hartmann B, Grell K, Gørløv JS, Kielsen K, Holst JJ, Müller K.

Biol Blood Marrow Transplant. 2019 Feb 5. pii: S1083-8791(19)30094-1. doi: 10.1016/j.bbmt.2019.01.036. [Epub ahead of print]

PMID:
30731250
32.

Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581-2592. doi: 10.1210/jc.2018-02503.

PMID:
30726969
33.

Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study.

Bergmann NC, Lund A, Gasbjerg LS, Meessen ECE, Andersen MM, Bergmann S, Hartmann B, Holst JJ, Jessen L, Christensen MB, Vilsbøll T, Knop FK.

Diabetologia. 2019 Apr;62(4):665-675. doi: 10.1007/s00125-018-4810-0. Epub 2019 Jan 25.

PMID:
30683945
34.

Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis.

Broberg B, Madsen JL, Fuglsang S, Holst JJ, Christensen KB, Rydahl C, Idorn T, Feldt-Rasmussen B, Hornum M.

Neurogastroenterol Motil. 2019 Apr;31(4):e13554. doi: 10.1111/nmo.13554. Epub 2019 Jan 22.

PMID:
30667131
35.

Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.

Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, Hoy AJ.

Mol Cancer Res. 2019 Apr;17(4):949-962. doi: 10.1158/1541-7786.MCR-18-0347. Epub 2019 Jan 15.

PMID:
30647103
36.

Preserved glucose response to low-dose glucagon after exercise in insulin-pump-treated individuals with type 1 diabetes: a randomised crossover study.

Steineck IIK, Ranjan A, Schmidt S, Clausen TR, Holst JJ, Nørgaard K.

Diabetologia. 2019 Apr;62(4):582-592. doi: 10.1007/s00125-018-4807-8. Epub 2019 Jan 14.

PMID:
30643924
37.

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.

Bröer A, Gauthier-Coles G, Rahimi F, van Geldermalsen M, Dorsch D, Wegener A, Holst J, Bröer S.

J Biol Chem. 2019 Mar 15;294(11):4012-4026. doi: 10.1074/jbc.RA118.006378. Epub 2019 Jan 11.

PMID:
30635397
38.

Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K BRAF-Mutant Melanoma.

Pires da Silva I, Wang KYX, Wilmott JS, Holst J, Carlino MS, Park JJ, Quek C, Wongchenko M, Yan Y, Mann G, Johnson DB, McQuade JL, Rai R, Kefford RF, Rizos H, Scolyer RA, Yang JYH, Long GV, Menzies AM.

Clin Cancer Res. 2019 Feb 15;25(4):1272-1279. doi: 10.1158/1078-0432.CCR-18-1680. Epub 2019 Jan 10.

PMID:
30630828
39.

Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals.

Gasbjerg LS, Helsted MM, Hartmann B, Jensen MH, Gabe MBN, Sparre-Ulrich AH, Veedfald S, Stensen S, Lanng AR, Bergmann NC, Christensen MB, Vilsbøll T, Holst JJ, Rosenkilde MM, Knop FK.

Diabetes. 2019 May;68(5):906-917. doi: 10.2337/db18-1123. Epub 2019 Jan 9.

PMID:
30626611
40.

Mechanisms Preserving Insulin Action during High Dietary Fat Intake.

Lundsgaard AM, Holm JB, Sjøberg KA, Bojsen-Møller KN, Myrmel LS, Fjære E, Jensen BAH, Nicolaisen TS, Hingst JR, Hansen SL, Doll S, Geyer PE, Deshmukh AS, Holst JJ, Madsen L, Kristiansen K, Wojtaszewski JFP, Richter EA, Kiens B.

Cell Metab. 2019 Jan 8;29(1):229. doi: 10.1016/j.cmet.2018.10.002. No abstract available.

PMID:
30625306
41.

Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery.

Kandel D, Bojsen-Møller KN, Svane MS, Samkani A, Astrup A, Holst JJ, Madsbad S, Krarup T.

Am J Clin Nutr. 2019 Jan 9. doi: 10.1093/ajcn/nqy310. [Epub ahead of print]

PMID:
30624666
42.

Screening for abdominal aortic aneurysm.

Wanhainen A, Svensjö S, Holst J, Björck M, Gottsäter A; Swedish Aneurysm Screening Study group and the Swedish Society for Vascular Surgery.

Lancet. 2019 Jan 5;393(10166):27-28. doi: 10.1016/S0140-6736(18)32761-2. No abstract available.

PMID:
30614453
43.

Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity.

Quist JS, Blond MB, Gram AS, Steenholt CB, Janus C, Holst JJ, Rehfeld JF, Sjödin A, Stallknecht B, Rosenkilde M.

J Appl Physiol (1985). 2019 Apr 1;126(4):941-951. doi: 10.1152/japplphysiol.00239.2018. Epub 2019 Jan 3.

PMID:
30605397
44.

Pre-meal and postprandial lipaemia in subjects with the metabolic syndrome: effects of timing and protein quality (randomised crossover trial).

Bjørnshave A, Johansen TN, Amer B, Dalsgaard TK, Holst JJ, Hermansen K.

Br J Nutr. 2019 Jan 2:1-10. doi: 10.1017/S0007114518003264. [Epub ahead of print]

PMID:
30599817
45.

High prevalence of prediabetes and metabolic abnormalities in overweight or obese schizophrenia patients treated with clozapine or olanzapine.

Larsen JR, Svensson CK, Vedtofte L, Jakobsen ML, Jespersen HS, Jakobsen MI, Koyuncu K, Schjerning O, Nielsen J, Ekstrøm CT, Holst JJ, Correll CU, Vilsbøll T, Fink-Jensen A.

CNS Spectr. 2018 Dec 31:1-12. doi: 10.1017/S1092852918001311. [Epub ahead of print]

PMID:
30596361
46.

The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial.

Samkani A, Skytte MJ, Anholm C, Astrup A, Deacon CF, Holst JJ, Madsbad S, Boston R, Krarup T, Haugaard SB.

Lipids Health Dis. 2018 Dec 27;17(1):295. doi: 10.1186/s12944-018-0953-8.

47.

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

Guo D, Lui GYL, Lai SL, Wilmott JS, Tikoo S, Jackett LA, Quek C, Brown DL, Sharp DM, Kwan RYQ, Chacon D, Wong JH, Beck D, van Geldermalsen M, Holst J, Thompson JF, Mann GJ, Scolyer RA, Stow JL, Weninger W, Haass NK, Beaumont KA.

Int J Cancer. 2019 Jun 15;144(12):3070-3085. doi: 10.1002/ijc.32064. Epub 2019 Jan 3.

PMID:
30556600
48.

Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles.

Pereira SS, Guimarães M, Almeida R, Pereira AM, Lobato CB, Hartmann B, Hilsted L, Holst JJ, Nora M, Monteiro MP.

Int J Obes (Lond). 2018 Dec 11. doi: 10.1038/s41366-018-0282-z. [Epub ahead of print]

PMID:
30538284
49.

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery.

Wewer Albrechtsen NJ, Geyer PE, Doll S, Treit PV, Bojsen-Møller KN, Martinussen C, Jørgensen NB, Torekov SS, Meier F, Niu L, Santos A, Keilhauer EC, Holst JJ, Madsbad S, Mann M.

Cell Syst. 2018 Dec 26;7(6):601-612.e3. doi: 10.1016/j.cels.2018.10.012. Epub 2018 Dec 5.

50.

Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity.

Dirksen C, Graff J, Fuglsang S, Rehfeld JF, Holst JJ, Madsen JL.

Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G332-G337. doi: 10.1152/ajpgi.00310.2018. Epub 2018 Dec 6.

PMID:
30520691

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