Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 29

1.

Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective.

Rahman MR, Islam T, Zaman T, Shahjaman M, Karim MR, Huq F, Quinn JMW, Holsinger RMD, Gov E, Moni MA.

Genomics. 2019 Aug 1. pii: S0888-7543(19)30184-3. doi: 10.1016/j.ygeno.2019.07.018. [Epub ahead of print]

PMID:
31377428
2.

Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer's dementia.

Wang R, Holsinger RMD.

Ageing Res Rev. 2018 Dec;48:109-121. doi: 10.1016/j.arr.2018.10.002. Epub 2018 Oct 13. Review.

PMID:
30326283
3.

HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus.

Porto RR, Dutra FD, Crestani AP, Holsinger RMD, Quillfeldt JA, Homem de Bittencourt PI Jr, de Oliveira Alvares L.

Neuroscience. 2018 Apr 1;375:108-118. doi: 10.1016/j.neuroscience.2018.01.028. Epub 2018 Jan 31.

PMID:
29374537
4.

Calcium-axonemal microtubuli interactions underlie mechanism(s) of primary cilia morphological changes.

Buljan VA, Graeber MB, Holsinger RMD, Brown D, Hambly BD, Delikatny EJ, Vuletic VR, Krebs XN, Tomas IB, Bohorquez-Florez JJ, Liu GJ, Banati RB.

J Biol Phys. 2018 Mar;44(1):53-80. doi: 10.1007/s10867-017-9475-2. Epub 2017 Oct 31.

5.

Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Kosaraju J, Holsinger RMD, Guo L, Tam KY.

Mol Neurobiol. 2017 Oct;54(8):6074-6084. doi: 10.1007/s12035-016-0125-7. Epub 2016 Oct 3.

PMID:
27699599
6.

Unraveling the mechanistic complexity of Alzheimer's disease through systems biology.

Rollo JL, Banihashemi N, Vafaee F, Crawford JW, Kuncic Z, Holsinger RM.

Alzheimers Dement. 2016 Jun;12(6):708-18. doi: 10.1016/j.jalz.2015.10.010. Epub 2015 Dec 17. Review.

PMID:
26703952
7.

A novel segmentation-based algorithm for the quantification of magnified cells.

Thompson GC, Ireland TA, Larkin XE, Arnold J, Holsinger RM.

J Cell Biochem. 2014 Nov;115(11):1849-54. doi: 10.1002/jcb.24882. Erratum in: J Cell Biochem. 2015 Jan;116(1):203. Larkin, Xanthe C [corrected to Larkin, Xanthe E].

PMID:
25043374
8.

Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping.

Sajjan S, Holsinger RM, Fok S, Ebrahimkhani S, Rollo JL, Banati RB, Graeber MB.

Neuroscience. 2014 Aug 22;274:331-40. doi: 10.1016/j.neuroscience.2014.05.052. Epub 2014 Jun 4.

PMID:
24907602
9.

The potential for genetically altered microglia to influence glioma treatment.

Li W, Holsinger RM, Kruse CA, Fl├╝gel A, Graeber MB.

CNS Neurol Disord Drug Targets. 2013 Sep;12(6):750-62. Review.

10.

Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology.

Buljan VA, Holsinger RM, Brown D, Bohorquez-Florez JJ, Hambly BD, Delikatny EJ, Ivanova EP, Banati RB.

Chaos. 2013 Jun;23(2):023120. doi: 10.1063/1.4807909.

PMID:
23822485
11.

Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease.

Kosaraju J, Gali CC, Khatwal RB, Dubala A, Chinni S, Holsinger RM, Madhunapantula VS, Muthureddy Nataraj SK, Basavan D.

Neuropharmacology. 2013 Sep;72:291-300. doi: 10.1016/j.neuropharm.2013.04.008. Epub 2013 Apr 17.

PMID:
23603201
12.

Splice variants of the Alzheimer's disease beta-secretase, BACE1.

Holsinger RM, Goense N, Bohorquez J, Strappe P.

Neurogenetics. 2013 Feb;14(1):1-9. doi: 10.1007/s10048-012-0348-3. Epub 2012 Nov 11. Review.

PMID:
23142975
13.

Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians.

Holsinger RM, Brown R, Richmond R, Kay-Lambkin F, Law J, Kirby AC, Chan DK.

J Am Geriatr Soc. 2012 Sep;60(9):1786-8. doi: 10.1111/j.1532-5415.2012.04127.x. No abstract available.

PMID:
22985157
14.

A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.

George AJ, Gordon L, Beissbarth T, Koukoulas I, Holsinger RM, Perreau V, Cappai R, Tan SS, Masters CL, Scott HS, Li QX.

Neurotox Res. 2010 May;17(4):360-79. doi: 10.1007/s12640-009-9112-3. Epub 2009 Sep 16.

PMID:
19760337
15.

Challenges in molecular imaging of Parkinson's disease: a brief overview.

Kassiou M, Banati R, Holsinger RM, Meikle S.

Brain Res Bull. 2009 Feb 16;78(2-3):105-8. doi: 10.1016/j.brainresbull.2008.08.006. Epub 2008 Nov 12. Review.

PMID:
18790022
16.

CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias.

Holsinger RM, Lee JS, Boyd A, Masters CL, Collins SJ.

Neurology. 2006 Aug 22;67(4):710-2. Erratum in: Neurology. 2006 Sep 26;67(6):1105.

PMID:
16924032
17.

Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.

Beckman M, Holsinger RM, Small DH.

Biochemistry. 2006 May 30;45(21):6703-14.

PMID:
16716081
18.

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.

White AR, Du T, Laughton KM, Volitakis I, Sharples RA, Xilinas ME, Hoke DE, Holsinger RM, Evin G, Cherny RA, Hill AF, Barnham KJ, Li QX, Bush AI, Masters CL.

J Biol Chem. 2006 Jun 30;281(26):17670-80. Epub 2006 Apr 28.

19.

Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease.

George AJ, Holsinger RM, McLean CA, Tan SS, Scott HS, Cardamone T, Cappai R, Masters CL, Li QX.

Neurobiol Aging. 2006 Apr;27(4):614-23. Epub 2005 Jun 6.

PMID:
15941609
20.

APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease.

George AJ, Holsinger RM, McLean CA, Laughton KM, Beyreuther K, Evin G, Masters CL, Li QX.

Neurobiol Dis. 2004 Jun;16(1):124-32.

PMID:
15207269
21.

Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

Holsinger RM, McLean CA, Collins SJ, Masters CL, Evin G.

Ann Neurol. 2004 Jun;55(6):898-9. No abstract available.

PMID:
15174031
22.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
23.

Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?

Fahnestock M, Garzon D, Holsinger RM, Michalski B.

J Neural Transm Suppl. 2002;(62):241-52.

PMID:
12456067
24.

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease.

Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G.

Ann Neurol. 2002 Jun;51(6):783-6.

PMID:
12112088
25.

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL.

Biochemistry. 2001 Jul 27;40(28):8359-68.

PMID:
11444983
26.

Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease.

Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M.

Brain Res Mol Brain Res. 2000 Mar 29;76(2):347-54.

PMID:
10762711
27.
28.

Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures.

Ikeda-Douglas CJ, Head E, Holsinger RM, Tremblay L, Racine R, Milgram NW.

Epilepsy Res. 1998 Jul;31(2):143-52.

PMID:
9714506
29.

Effects of extended electrical kindling on exploratory behavior and spatial learning.

Cammisuli S, Murphy MP, Ikeda-Douglas CJ, Balkissoon V, Holsinger RM, Head E, Michael M, Racine RJ, Milgram NW.

Behav Brain Res. 1997 Dec;89(1-2):179-90.

PMID:
9475625

Supplemental Content

Loading ...
Support Center