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Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal.

Mignolet J, Cerckel G, Damoczi J, Ledesma-Garcia L, Sass A, Coenye T, Nessler S, Hols P.

Elife. 2019 Aug 21;8. pii: e47139. doi: 10.7554/eLife.47139.


Distinct and Specific Role of NlpC/P60 Endopeptidases LytA and LytB in Cell Elongation and Division of Lactobacillus plantarum.

Duchêne MC, Rolain T, Knoops A, Courtin P, Chapot-Chartier MP, Dufrêne YF, Hallet BF, Hols P.

Front Microbiol. 2019 Apr 12;10:713. doi: 10.3389/fmicb.2019.00713. eCollection 2019.


Mobilization of Microbiota Commensals and Their Bacteriocins for Therapeutics.

Hols P, Ledesma-García L, Gabant P, Mignolet J.

Trends Microbiol. 2019 Aug;27(8):690-702. doi: 10.1016/j.tim.2019.03.007. Epub 2019 Apr 12. Review.


Intensive targeting of regulatory competence genes by transposable elements in streptococci.

Fléchard M, Lucchetti-Miganeh C, Hallet B, Hols P, Gilot P.

Mol Genet Genomics. 2019 Jun;294(3):531-548. doi: 10.1007/s00438-018-1507-5. Epub 2018 Nov 7.


Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.

Desguin B, Fellner M, Riant O, Hu J, Hausinger RP, Hols P, Soumillion P.

J Biol Chem. 2018 Aug 10;293(32):12303-12317. doi: 10.1074/jbc.RA118.003741. Epub 2018 Jun 10.


PBP2b plays a key role in both peripheral growth and septum positioning in Lactococcus lactis.

David B, Duchêne MC, Haustenne GL, Pérez-Núñez D, Chapot-Chartier MP, De Bolle X, Guédon E, Hols P, Hallet B.

PLoS One. 2018 May 23;13(5):e0198014. doi: 10.1371/journal.pone.0198014. eCollection 2018.


Role of cell surface composition and lysis in static biofilm formation by Lactobacillus plantarum WCFS1.

Fernández Ramírez MD, Nierop Groot MN, Smid EJ, Hols P, Kleerebezem M, Abee T.

Int J Food Microbiol. 2018 Apr 20;271:15-23. doi: 10.1016/j.ijfoodmicro.2018.02.013. Epub 2018 Feb 21.


Circuitry Rewiring Directly Couples Competence to Predation in the Gut Dweller Streptococcus salivarius.

Mignolet J, Fontaine L, Sass A, Nannan C, Mahillon J, Coenye T, Hols P.

Cell Rep. 2018 Feb 13;22(7):1627-1638. doi: 10.1016/j.celrep.2018.01.055.


Unexpected complexity in the lactate racemization system of lactic acid bacteria.

Desguin B, Soumillion P, Hausinger RP, Hols P.

FEMS Microbiol Rev. 2017 Aug 1;41(Supp_1):S71-S83. doi: 10.1093/femsre/fux021. Review.


Natural DNA Transformation Is Functional in Lactococcus lactis subsp. cremoris KW2.

David B, Radziejwoski A, Toussaint F, Fontaine L, de Frahan MH, Patout C, van Dillen S, Boyaval P, Horvath P, Fremaux C, Hols P.

Appl Environ Microbiol. 2017 Aug 1;83(16). pii: e01074-17. doi: 10.1128/AEM.01074-17. Print 2017 Aug 15.


Correction: Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.

Talagas A, Fontaine L, Ledesma-García L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna G, Hols P, Nessler S.

PLoS Pathog. 2017 Feb 14;13(2):e1006208. doi: 10.1371/journal.ppat.1006208. eCollection 2017 Feb.


Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.

Talagas A, Fontaine L, Ledesma-García L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna G, Hols P, Nessler S.

PLoS Pathog. 2016 Dec 1;12(12):e1005980. doi: 10.1371/journal.ppat.1005980. eCollection 2016 Dec. Erratum in: PLoS Pathog. 2017 Feb 14;13(2):e1006208.


Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.

Desguin B, Soumillion P, Hols P, Hausinger RP.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5598-603. doi: 10.1073/pnas.1600486113. Epub 2016 Apr 25.


Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation.

Colinet AS, Sengottaiyan P, Deschamps A, Colsoul ML, Thines L, Demaegd D, Duchêne MC, Foulquier F, Hols P, Morsomme P.

Sci Rep. 2016 Apr 14;6:24282. doi: 10.1038/srep24282.


Regulation of Cell Wall Plasticity by Nucleotide Metabolism in Lactococcus lactis.

Solopova A, Formosa-Dague C, Courtin P, Furlan S, Veiga P, Péchoux C, Armalyte J, Sadauskas M, Kok J, Hols P, Dufrêne YF, Kuipers OP, Chapot-Chartier MP, Kulakauskas S.

J Biol Chem. 2016 May 20;291(21):11323-36. doi: 10.1074/jbc.M116.714303. Epub 2016 Mar 28.


Complete Genome Sequence of Streptococcus salivarius HSISS4, a Human Commensal Bacterium Highly Prevalent in the Digestive Tract.

Mignolet J, Fontaine L, Kleerebezem M, Hols P.

Genome Announc. 2016 Feb 4;4(1). pii: e01637-15. doi: 10.1128/genomeA.01637-15.


Modeling of the ComRS Signaling Pathway Reveals the Limiting Factors Controlling Competence in Streptococcus thermophilus.

Haustenne L, Bastin G, Hols P, Fontaine L.

Front Microbiol. 2015 Dec 22;6:1413. doi: 10.3389/fmicb.2015.01413. eCollection 2015.


METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.

Desguin B, Zhang T, Soumillion P, Hols P, Hu J, Hausinger RP.

Science. 2015 Jul 3;349(6243):66-9. doi: 10.1126/science.aab2272.


Forces in yeast flocculation.

El-Kirat-Chatel S, Beaussart A, Vincent SP, Abellán Flos M, Hols P, Lipke PN, Dufrêne YF.

Nanoscale. 2015 Feb 7;7(5):1760-7. doi: 10.1039/c4nr06315e.


Molecular mapping of the cell wall polysaccharides of the human pathogen Streptococcus agalactiae.

Beaussart A, Péchoux C, Trieu-Cuot P, Hols P, Mistou MY, Dufrêne YF.

Nanoscale. 2014 Dec 21;6(24):14820-7. doi: 10.1039/c4nr05280c. Epub 2014 Oct 31.


Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum.

Desguin B, Goffin P, Bakouche N, Diman A, Viaene E, Dandoy D, Fontaine L, Hallet B, Hols P.

J Bacteriol. 2015 Jan 1;197(1):219-30. doi: 10.1128/JB.02192-14. Epub 2014 Oct 27.


Regulation of competence for natural transformation in streptococci.

Fontaine L, Wahl A, Fléchard M, Mignolet J, Hols P.

Infect Genet Evol. 2015 Jul;33:343-60. doi: 10.1016/j.meegid.2014.09.010. Epub 2014 Sep 16. Review.


Control of natural transformation in salivarius Streptococci through specific degradation of σX by the MecA-ClpCP protease complex.

Wahl A, Servais F, Drucbert AS, Foulon C, Fontaine L, Hols P.

J Bacteriol. 2014 Aug;196(15):2807-16. doi: 10.1128/JB.01758-14. Epub 2014 May 16.


Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.

Desguin B, Goffin P, Viaene E, Kleerebezem M, Martin-Diaconescu V, Maroney MJ, Declercq JP, Soumillion P, Hols P.

Nat Commun. 2014 Apr 7;5:3615. doi: 10.1038/ncomms4615.


GtfA and GtfB are both required for protein O-glycosylation in Lactobacillus plantarum.

Lee IC, van Swam II, Tomita S, Morsomme P, Rolain T, Hols P, Kleerebezem M, Bron PA.

J Bacteriol. 2014 May;196(9):1671-82. doi: 10.1128/JB.01401-13. Epub 2014 Feb 14.


Forces driving the attachment of Staphylococcus epidermidis to fibrinogen-coated surfaces.

Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Vanzieleghem T, Foster TJ, Hols P, Mahillon J, Dufrêne YF.

Langmuir. 2013 Oct 22;29(42):13018-22. doi: 10.1021/la4029172. Epub 2013 Oct 10.


MecA protein acts as a negative regulator of genetic competence in Streptococcus mutans.

Tian XL, Dong G, Liu T, Gomez ZA, Wahl A, Hols P, Li YH.

J Bacteriol. 2013 Nov;195(22):5196-206. doi: 10.1128/JB.00821-13. Epub 2013 Sep 13.


Surface proteome analysis of a natural isolate of Lactococcus lactis reveals the presence of pili able to bind human intestinal epithelial cells.

Meyrand M, Guillot A, Goin M, Furlan S, Armalyte J, Kulakauskas S, Cortes-Perez NG, Thomas G, Chat S, Péchoux C, Dupres V, Hols P, Dufrêne YF, Trugnan G, Chapot-Chartier MP.

Mol Cell Proteomics. 2013 Dec;12(12):3935-47. doi: 10.1074/mcp.M113.029066. Epub 2013 Sep 3.


Binding mechanism of the peptidoglycan hydrolase Acm2: low affinity, broad specificity.

Beaussart A, Rolain T, Duchêne MC, El-Kirat-Chatel S, Andre G, Hols P, Dufrêne YF.

Biophys J. 2013 Aug 6;105(3):620-9. doi: 10.1016/j.bpj.2013.06.035.


Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.

Bienert GP, Desguin B, Chaumont F, Hols P.

Biochem J. 2013 Sep 15;454(3):559-70. doi: 10.1042/BJ20130388.


Metabolic engineering of Lactobacillus plantarum for succinic acid production through activation of the reductive branch of the tricarboxylic acid cycle.

Tsuji A, Okada S, Hols P, Satoh E.

Enzyme Microb Technol. 2013 Jul 10;53(2):97-103. doi: 10.1016/j.enzmictec.2013.04.008. Epub 2013 May 9.


O-glycosylation as a novel control mechanism of peptidoglycan hydrolase activity.

Rolain T, Bernard E, Beaussart A, Degand H, Courtin P, Egge-Jacobsen W, Bron PA, Morsomme P, Kleerebezem M, Chapot-Chartier MP, Dufrêne YF, Hols P.

J Biol Chem. 2013 Aug 2;288(31):22233-47. doi: 10.1074/jbc.M113.470716. Epub 2013 Jun 12.


Single-cell force spectroscopy of probiotic bacteria.

Beaussart A, El-Kirat-Chatel S, Herman P, Alsteens D, Mahillon J, Hols P, Dufrêne YF.

Biophys J. 2013 May 7;104(9):1886-92. doi: 10.1016/j.bpj.2013.03.046.


Extracellular life cycle of ComS, the competence-stimulating peptide of Streptococcus thermophilus.

Gardan R, Besset C, Gitton C, Guillot A, Fontaine L, Hols P, Monnet V.

J Bacteriol. 2013 Apr;195(8):1845-55. doi: 10.1128/JB.02196-12. Epub 2013 Feb 8.


Mechanism of competence activation by the ComRS signalling system in streptococci.

Fontaine L, Goffin P, Dubout H, Delplace B, Baulard A, Lecat-Guillet N, Chambellon E, Gardan R, Hols P.

Mol Microbiol. 2013 Mar;87(6):1113-32. doi: 10.1111/mmi.12157. Epub 2013 Feb 4.


SOS response activation and competence development are antagonistic mechanisms in Streptococcus thermophilus.

Boutry C, Delplace B, Clippe A, Fontaine L, Hols P.

J Bacteriol. 2013 Feb;195(4):696-707. doi: 10.1128/JB.01605-12. Epub 2012 Nov 30.


Dual role for the O-acetyltransferase OatA in peptidoglycan modification and control of cell septation in Lactobacillus plantarum.

Bernard E, Rolain T, David B, André G, Dupres V, Dufrêne YF, Hallet B, Chapot-Chartier MP, Hols P.

PLoS One. 2012;7(10):e47893. doi: 10.1371/journal.pone.0047893. Epub 2012 Oct 26.


Identification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of Lactobacillus plantarum WCFS1.

Rolain T, Bernard E, Courtin P, Bron PA, Kleerebezem M, Chapot-Chartier MP, Hols P.

Microb Cell Fact. 2012 Oct 15;11:137. doi: 10.1186/1475-2859-11-137.


Analysis of the peptidoglycan hydrolase complement of Lactobacillus casei and characterization of the major γ-D-glutamyl-L-lysyl-endopeptidase.

Regulski K, Courtin P, Meyrand M, Claes IJ, Lebeer S, Vanderleyden J, Hols P, Guillot A, Chapot-Chartier MP.

PLoS One. 2012;7(2):e32301. doi: 10.1371/journal.pone.0032301. Epub 2012 Feb 27.


Genetic and biochemical characterization of the cell wall hydrolase activity of the major secreted protein of Lactobacillus rhamnosus GG.

Claes IJ, Schoofs G, Regulski K, Courtin P, Chapot-Chartier MP, Rolain T, Hols P, von Ossowski I, Reunanen J, de Vos WM, Palva A, Vanderleyden J, De Keersmaecker SC, Lebeer S.

PLoS One. 2012;7(2):e31588. doi: 10.1371/journal.pone.0031588. Epub 2012 Feb 16.


Towards a nanoscale view of lactic acid bacteria.

Tripathi P, Beaussart A, Andre G, Rolain T, Lebeer S, Vanderleyden J, Hols P, Dufrêne YF.

Micron. 2012 Dec;43(12):1323-30. doi: 10.1016/j.micron.2012.01.001. Epub 2012 Jan 12. Review.


Adaptor protein MecA is a negative regulator of the expression of late competence genes in Streptococcus thermophilus.

Boutry C, Wahl A, Delplace B, Clippe A, Fontaine L, Hols P.

J Bacteriol. 2012 Apr;194(7):1777-88. doi: 10.1128/JB.06800-11. Epub 2012 Jan 27.


The fast milk acidifying phenotype of Streptococcus thermophilus can be acquired by natural transformation of the genomic island encoding the cell-envelope proteinase PrtS.

Dandoy D, Fremaux C, de Frahan MH, Horvath P, Boyaval P, Hols P, Fontaine L.

Microb Cell Fact. 2011 Aug 30;10 Suppl 1:S21. doi: 10.1186/1475-2859-10-S1-S21. Epub 2011 Aug 30.


Identification of the amidotransferase AsnB1 as being responsible for meso-diaminopimelic acid amidation in Lactobacillus plantarum peptidoglycan.

Bernard E, Rolain T, Courtin P, Hols P, Chapot-Chartier MP.

J Bacteriol. 2011 Nov;193(22):6323-30. doi: 10.1128/JB.05060-11. Epub 2011 Sep 23.


Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing.

Storelli G, Defaye A, Erkosar B, Hols P, Royet J, Leulier F.

Cell Metab. 2011 Sep 7;14(3):403-14. doi: 10.1016/j.cmet.2011.07.012.


Characterization of O-acetylation of N-acetylglucosamine: a novel structural variation of bacterial peptidoglycan.

Bernard E, Rolain T, Courtin P, Guillot A, Langella P, Hols P, Chapot-Chartier MP.

J Biol Chem. 2011 Jul 8;286(27):23950-8. doi: 10.1074/jbc.M111.241414. Epub 2011 May 17.


Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci.

Fleuchot B, Gitton C, Guillot A, Vidic J, Nicolas P, Besset C, Fontaine L, Hols P, Leblond-Bourget N, Monnet V, Gardan R.

Mol Microbiol. 2011 May;80(4):1102-19. doi: 10.1111/j.1365-2958.2011.07633.x. Epub 2011 Mar 30.


Inactivation of a small heat shock protein affects cell morphology and membrane fluidity in Lactobacillus plantarum WCFS1.

Capozzi V, Weidmann S, Fiocco D, Rieu A, Hols P, Guzzo J, Spano G.

Res Microbiol. 2011 May;162(4):419-25. doi: 10.1016/j.resmic.2011.02.010. Epub 2011 Feb 22.


A new morphogenesis pathway in bacteria: unbalanced activity of cell wall synthesis machineries leads to coccus-to-rod transition and filamentation in ovococci.

Pérez-Núñez D, Briandet R, David B, Gautier C, Renault P, Hallet B, Hols P, Carballido-López R, Guédon E.

Mol Microbiol. 2011 Feb;79(3):759-71. doi: 10.1111/j.1365-2958.2010.07483.x. Epub 2010 Dec 13.


Fluorescence and atomic force microscopy imaging of wall teichoic acids in Lactobacillus plantarum.

Andre G, Deghorain M, Bron PA, van Swam II, Kleerebezem M, Hols P, Dufrene YF.

ACS Chem Biol. 2011 Apr 15;6(4):366-76. doi: 10.1021/cb1003509. Epub 2011 Feb 4.


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