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Items: 1 to 50 of 125

1.

Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome.

Paananen RO, Javanainen M, Holopainen JM, Vattulainen I.

J Phys Chem Lett. 2019 Jul 18;10(14):3893-3898. doi: 10.1021/acs.jpclett.9b01187. Epub 2019 Jul 1.

2.

Ocular trauma in the Finnish elderly - Helsinki Ocular Trauma Study.

Sahraravand A, Haavisto AK, Holopainen JM, Leivo T.

Acta Ophthalmol. 2018 Sep;96(6):616-622. doi: 10.1111/aos.13714. Epub 2018 Apr 16.

PMID:
29659145
3.

Matrix regeneration agents improve wound healing in non-stressed human corneal epithelial cells.

Robciuc A, Arvola RPJ, Jauhiainen M, Holopainen JM.

Eye (Lond). 2018 Apr;32(4):813-819. doi: 10.1038/eye.2017.277. Epub 2017 Dec 22.

4.

Relevance of Lipid-Based Products in the Management of Dry Eye Disease.

Garrigue JS, Amrane M, Faure MO, Holopainen JM, Tong L.

J Ocul Pharmacol Ther. 2017 Nov;33(9):647-661. doi: 10.1089/jop.2017.0052. Epub 2017 Sep 28. Review.

5.

Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes.

Robciuc A, Witos J, Ruokonen SK, Rantamäki AH, Pisella PJ, Wiedmer SK, Holopainen JM.

Cornea. 2017 Oct;36(10):1249-1255. doi: 10.1097/ICO.0000000000001322.

PMID:
28825921
6.

TFOS DEWS II Tear Film Report.

Willcox MDP, Argüeso P, Georgiev GA, Holopainen JM, Laurie GW, Millar TJ, Papas EB, Rolland JP, Schmidt TA, Stahl U, Suarez T, Subbaraman LN, Uçakhan OÖ, Jones L.

Ocul Surf. 2017 Jul;15(3):366-403. doi: 10.1016/j.jtos.2017.03.006. Epub 2017 Jul 20. Review.

7.

The Effect of Phospholipids on Tear Film Lipid Layer Surface Activity.

Rantamäki AH, Holopainen JM.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):149-154. doi: 10.1167/iovs.16-20468.

PMID:
28114572
8.

Paediatric eye injuries in Finland - Helsinki eye trauma study.

Haavisto AK, Sahraravand A, Holopainen JM, Leivo T.

Acta Ophthalmol. 2017 Jun;95(4):392-399. doi: 10.1111/aos.13327. Epub 2016 Dec 14.

9.

Distribution of local anesthetics between aqueous and liposome phases.

Ruokonen SK, Duša F, Rantamäki AH, Robciuc A, Holma P, Holopainen JM, Abdel-Rehim M, Wiedmer SK.

J Chromatogr A. 2017 Jan 6;1479:194-203. doi: 10.1016/j.chroma.2016.12.005. Epub 2016 Dec 3.

PMID:
27955893
10.

Ocular traumas in working age adults in Finland - Helsinki Ocular Trauma Study.

Sahraravand A, Haavisto AK, Holopainen JM, Leivo T.

Acta Ophthalmol. 2017 May;95(3):288-294. doi: 10.1111/aos.13313. Epub 2016 Dec 9.

11.

Bilateral Ectasia After Femtosecond Laser-Assisted Small Incision Lenticule Extraction (SMILE).

Mattila JS, Holopainen JM.

J Refract Surg. 2016 Jul 1;32(7):497-500. doi: 10.3928/1081597X-20160502-03.

PMID:
27400083
12.

Matrix Regeneration Therapy: A Case Series of Corneal Neurotrophic Ulcers.

Arvola RP, Robciuc A, Holopainen JM.

Cornea. 2016 Apr;35(4):451-5. doi: 10.1097/ICO.0000000000000759.

PMID:
26845313
13.

The Effect of Ambient Ozone on Unsaturated Tear Film Wax Esters.

Paananen RO, Rantamäki AH, Parshintsev J, Holopainen JM.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8054-62. doi: 10.1167/iovs.15-18398.

PMID:
26720456
14.

Severe Ocular Cowpox in a Human, Finland.

Kinnunen PM, Holopainen JM, Hemmilä H, Piiparinen H, Sironen T, Kivelä T, Virtanen J, Niemimaa J, Nikkari S, Järvinen A, Vapalahti O.

Emerg Infect Dis. 2015 Dec;21(12):2261-3. doi: 10.3201/eid2112.150621. No abstract available.

15.

Femtosecond Laser-Assisted Intrastromal Relaxing Incisions After Penetrating Keratoplasty: Effect of Incision Depth.

Wetterstrand O, Holopainen JM, Krootila K.

J Refract Surg. 2015 Jul;31(7):474-9. doi: 10.3928/1081597X-20150623-06.

PMID:
26158928
16.

The genetic variant rs4073 A→T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration.

Hautamäki A, Seitsonen S, Holopainen JM, Moilanen JA, Kivioja J, Onkamo P, Järvelä I, Immonen I.

Acta Ophthalmol. 2015 Dec;93(8):726-33. doi: 10.1111/aos.12799. Epub 2015 Jul 8.

17.

Traffic and Criminal Behavior of Adults with Attention Deficit-Hyperactivity with a Prospective Follow-Up from Birth to the Age of 40 Years.

Koisaari T, Michelsson K, Holopainen JM, Maksimainen R, Päivänsalo J, Rantala K, Tervo T.

Traffic Inj Prev. 2015;16(8):824-30. doi: 10.1080/15389588.2015.1029068. Epub 2015 Apr 2.

PMID:
25837647
18.

Climatic droplet keratopathy: an old disease in new clothes.

Serra HM, Holopainen JM, Beuerman R, Kaarniranta K, Suárez MF, Urrets-Zavalía JA.

Acta Ophthalmol. 2015 Sep;93(6):496-504. doi: 10.1111/aos.12628. Epub 2015 Jan 28. Review.

19.

Impact of amphiphilic biomass-dissolving ionic liquids on biological cells and liposomes.

Mikkola SK, Robciuc A, Lokajová J, Holding AJ, Lämmerhofer M, Kilpeläinen I, Holopainen JM, King AW, Wiedmer SK.

Environ Sci Technol. 2015 Feb 3;49(3):1870-8. doi: 10.1021/es505725g. Epub 2015 Jan 21.

PMID:
25581350
20.

Penetrating keratoplasty for corneal amyloidosis in familial amyloidosis, Finnish type.

Mattila JS, Krootila K, Kivelä T, Holopainen JM.

Ophthalmology. 2015 Mar;122(3):457-63. doi: 10.1016/j.ophtha.2014.09.035. Epub 2014 Nov 13.

PMID:
25444639
21.

Surface properties of artificial tear film lipid layers: effects of wax esters.

Kulovesi P, Rantamäki AH, Holopainen JM.

Invest Ophthalmol Vis Sci. 2014 May 29;55(7):4448-54. doi: 10.1167/iovs.14-14122.

PMID:
24876287
22.

Antievaporative mechanism of wax esters: implications for the function of tear fluid.

Paananen RO, Rantamäki AH, Holopainen JM.

Langmuir. 2014 May 27;30(20):5897-902. doi: 10.1021/la501678t. Epub 2014 May 12.

PMID:
24784703
23.

Atopic dermatitis is a risk factor for intracorneal ring segment extrusion.

Neira W, Krootila K, Holopainen JM.

Acta Ophthalmol. 2014 Sep;92(6):e491-2. doi: 10.1111/aos.12377. Epub 2014 Apr 13. No abstract available.

24.

Peripheral hypertrophic subepithelial corneal degeneration - clinical and histopathological features.

Järventausta PJ, Tervo TM, Kivelä T, Holopainen JM.

Acta Ophthalmol. 2014 Dec;92(8):774-82. doi: 10.1111/aos.12394. Epub 2014 Mar 21.

25.

Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response.

Robciuc A, Rantamäki AH, Jauhiainen M, Holopainen JM.

Invest Ophthalmol Vis Sci. 2014 Jan 2;55(1):16-24. doi: 10.1167/iovs.13-12577.

PMID:
24302584
26.

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

Loukovaara S, Lehti K, Robciuc A, Pessi T, Holopainen JM, Koli K, Immonen I, Keski-Oja J.

Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):881-8. doi: 10.1007/s00417-013-2508-z. Epub 2013 Nov 12.

PMID:
24218041
27.

How to link pyrene to its host lipid to minimize the extent of membrane perturbations and to optimize pyrene dimer formation.

Fraňová MD, Repáková J, Holopainen JM, Vattulainen I.

Chem Phys Lipids. 2014 Jan;177:19-25. doi: 10.1016/j.chemphyslip.2013.10.004. Epub 2013 Nov 8.

PMID:
24216154
28.

Ceramides in the pathophysiology of the anterior segment of the eye.

Robciuc A, Hyötyläinen T, Jauhiainen M, Holopainen JM.

Curr Eye Res. 2013 Oct;38(10):1006-16. doi: 10.3109/02713683.2013.810273. Epub 2013 Jul 25. Review.

PMID:
23885886
29.

Treatment of Pseudomonas aeruginosa keratitis with combined corneal cross-linking and human amniotic membrane transplantation.

Mattila JS, Korsbäck A, Krootila K, Holopainen JM.

Acta Ophthalmol. 2013 Aug;91(5):e410-1. doi: 10.1111/aos.12115. No abstract available.

30.

Melting points--the key to the anti-evaporative effect of the tear film wax esters.

Rantamäki AH, Wiedmer SK, Holopainen JM.

Invest Ophthalmol Vis Sci. 2013 Aug 5;54(8):5211-7. doi: 10.1167/iovs.13-12408.

PMID:
23833062
31.

Treatment of postoperative keratoplasty astigmatism using femtosecond laser-assisted intrastromal relaxing incisions.

Wetterstrand O, Holopainen JM, Krootila K.

J Refract Surg. 2013 Jun;29(6):378-82. doi: 10.3928/1081597X-20130515-01.

PMID:
23739829
32.

Peripheral hypertrophic subepithelial corneal degeneration: characterization, treatment and association with human leucocyte antigen genes.

Järventausta PJ, Holopainen JM, Zalentein WN, Paakkanen R, Wennerström A, Seppänen M, Lokki ML, Tervo TM.

Acta Ophthalmol. 2014 Feb;92(1):71-6. doi: 10.1111/aos.12029. Epub 2013 Feb 7.

33.

Sudden death at the wheel due to a disease attack.

Tervo T, Räty E, Sulander P, Holopainen JM, Jaakkola T, Parkkari K.

Traffic Inj Prev. 2013;14(2):138-44. doi: 10.1080/15389588.2012.695827.

PMID:
23343022
34.

Comparison of lipid sinks in sequestering common intoxicating drugs.

Lokajová J, Holopainen JM, Wiedmer SK.

J Sep Sci. 2012 Nov;35(22):3106-12. doi: 10.1002/jssc.201101038.

PMID:
23175140
35.

Role of neutral lipids in tear fluid lipid layer: coarse-grained simulation study.

Telenius J, Koivuniemi A, Kulovesi P, Holopainen JM, Vattulainen I.

Langmuir. 2012 Dec 11;28(49):17092-100. doi: 10.1021/la304366d. Epub 2012 Nov 26.

PMID:
23151187
36.

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.

Loukovaara S, Robciuc A, Holopainen JM, Lehti K, Pessi T, Liinamaa J, Kukkonen KT, Jauhiainen M, Koli K, Keski-Oja J, Immonen I.

Acta Ophthalmol. 2013 Sep;91(6):531-9. doi: 10.1111/j.1755-3768.2012.02473.x. Epub 2012 Oct 26.

37.

Do lipids retard the evaporation of the tear fluid?

Rantamäki AH, Javanainen M, Vattulainen I, Holopainen JM.

Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6442-7.

PMID:
22930719
38.

Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2.

Robciuc A, Hyötyläinen T, Jauhiainen M, Holopainen JM.

J Lipid Res. 2012 Nov;53(11):2286-95. doi: 10.1194/jlr.M026732. Epub 2012 Aug 15.

39.

In vitro and in vivo entrapment of bupivacaine by lipid dispersions.

Litonius E, Lokajova J, Yohannes G, Neuvonen PJ, Holopainen JM, Rosenberg PH, Wiedmer SK.

J Chromatogr A. 2012 Sep 7;1254:125-31. doi: 10.1016/j.chroma.2012.07.013. Epub 2012 Jul 11.

PMID:
22832037
40.

Chromatographic lipid profiling of stress-exposed cells.

Wiedmer SK, Robciuc A, Kronholm J, Holopainen JM, Hyötyläinen T.

J Sep Sci. 2012 Aug;35(15):1845-53. doi: 10.1002/jssc.201200252. Epub 2012 May 24.

PMID:
22623480
41.

Pro-inflammatory cytokines and gelatinases in climatic droplet keratopathy.

Holopainen JM, Robciuc A, Cafaro TA, Suarez MF, Konttinen YT, Alkatan HM, Tabbara KF, Tervahartiala T, Sorsa T, Urrets-Zavalia JA, Serra HM.

Invest Ophthalmol Vis Sci. 2012 Jun 14;53(7):3527-35. doi: 10.1167/iovs.12-9441.

PMID:
22570354
42.

In vivo confocal microscopy study of climatic droplet keratopathy.

Urrets-Zavalia JA, Croxatto JO, Holopainen JM, Cafaro TA, Esposito F, Neira W, Serra HM.

Eye (Lond). 2012 Jul;26(7):1021-3. doi: 10.1038/eye.2012.79. Epub 2012 Apr 27. No abstract available.

43.

Long-term outcome of central toxic keratopathy after photorefractive keratectomy.

Neira W, Holopainen JM, Tervo TM.

Cornea. 2011 Nov;30(11):1207-12. doi: 10.1097/ICO.0b013e31821142d0.

PMID:
21926568
44.

Transient corneal thinning in eyes undergoing corneal cross-linking.

Holopainen JM, Krootila K.

Am J Ophthalmol. 2011 Oct;152(4):533-6. doi: 10.1016/j.ajo.2011.03.023. Epub 2011 Jul 2.

PMID:
21726844
45.

Human tear fluid lipidome: from composition to function.

Rantamäki AH, Seppänen-Laakso T, Oresic M, Jauhiainen M, Holopainen JM.

PLoS One. 2011 May 5;6(5):e19553. doi: 10.1371/journal.pone.0019553.

46.

Spatial distribution of glycerophospholipids in the ocular lens.

Pól J, Vidová V, Hyötyläinen T, Volný M, Novák P, Strohalm M, Kostiainen R, Havlíček V, Wiedmer SK, Holopainen JM.

PLoS One. 2011 Apr 29;6(4):e19441. doi: 10.1371/journal.pone.0019441.

47.

Dry eye symptoms are increased in mice deficient in phospholipid transfer protein (PLTP).

Setälä NL, Metso J, Jauhiainen M, Sajantila A, Holopainen JM.

Am J Pathol. 2011 May;178(5):2058-65. doi: 10.1016/j.ajpath.2011.01.027.

48.

Refractive surgery in anisometropic adult patients induce plastic changes in primary visual cortex.

Vuori E, Vanni S, Henriksson L, Tervo TM, Holopainen JM.

Acta Ophthalmol. 2012 Nov;90(7):669-76. doi: 10.1111/j.1755-3768.2011.02152.x. Epub 2011 Apr 6.

49.

Corneal sensitivity in diabetic patients subjected to retinal laser photocoagulation.

Neira-Zalentein W, Holopainen JM, Tervo TM, Borrás F, Acosta MC, Belmonte C, Gallar J.

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):6043-9. doi: 10.1167/iovs.10-7054.

PMID:
21447686
50.

Lessons from the biophysics of interfaces: lung surfactant and tear fluid.

Rantamäki AH, Telenius J, Koivuniemi A, Vattulainen I, Holopainen JM.

Prog Retin Eye Res. 2011 May;30(3):204-15. doi: 10.1016/j.preteyeres.2011.02.002. Epub 2011 Feb 23. Review.

PMID:
21352946

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