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Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.

Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D.

PLoS Genet. 2015 Dec 22;11(12):e1005735. doi: 10.1371/journal.pgen.1005735. eCollection 2015 Dec.


A mutational analysis of residues in cholera toxin A1 necessary for interaction with its substrate, the stimulatory G protein Gsα.

Jobling MG, Gotow LF, Yang Z, Holmes RK.

Toxins (Basel). 2015 Mar 18;7(3):919-35. doi: 10.3390/toxins7030919.


Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis.

Day CA, Baetz NW, Copeland CA, Kraft LJ, Han B, Tiwari A, Drake KR, De Luca H, Chinnapen DJ, Davidson MW, Holmes RK, Jobling MG, Schroer TA, Lencer WI, Kenworthy AK.

Traffic. 2015 Jun;16(6):572-90. doi: 10.1111/tra.12269. Epub 2015 Apr 27.


Immunizing adult female mice with a TcpA-A2-CTB chimera provides a high level of protection for their pups in the infant mouse model of cholera.

Price GA, Holmes RK.

PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3356. doi: 10.1371/journal.pntd.0003356. eCollection 2014 Dec.


ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide.

Banerjee T, Taylor M, Jobling MG, Burress H, Yang Z, Serrano A, Holmes RK, Tatulian SA, Teter K.

Mol Microbiol. 2014 Nov;94(4):898-912. doi: 10.1111/mmi.12807. Epub 2014 Oct 16.


Immunization with cholera toxin B subunit induces high-level protection in the suckling mouse model of cholera.

Price GA, McFann K, Holmes RK.

PLoS One. 2013;8(2):e57269. doi: 10.1371/journal.pone.0057269. Epub 2013 Feb 28.


Leptin in whales: validation and measurement of mRNA expression by absolute quantitative real-time PCR.

Ball HC, Holmes RK, Londraville RL, Thewissen JG, Duff RJ.

PLoS One. 2013;8(1):e54277. doi: 10.1371/journal.pone.0054277. Epub 2013 Jan 16.


A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.

Jobling MG, Yang Z, Kam WR, Lencer WI, Holmes RK.

MBio. 2012 Oct 30;3(6). pii: e00401-12. doi: 10.1128/mBio.00401-12.


Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera.

Arifuzzaman M, Rashu R, Leung DT, Hosen MI, Bhuiyan TR, Bhuiyan MS, Rahman MA, Khanam F, Saha A, Charles RC, LaRocque RC, Weil AA, Clements JD, Holmes RK, Calderwood SB, Harris JB, Ryan ET, Qadri F.

Clin Vaccine Immunol. 2012 Aug;19(8):1304-11. doi: 10.1128/CVI.00196-12. Epub 2012 Jun 27.


Purification and structural characterization of siderophore (corynebactin) from Corynebacterium diphtheriae.

Zajdowicz S, Haller JC, Krafft AE, Hunsucker SW, Mant CT, Duncan MW, Hodges RS, Jones DN, Holmes RK.

PLoS One. 2012;7(4):e34591. doi: 10.1371/journal.pone.0034591. Epub 2012 Apr 13.


Evaluation of heat-labile enterotoxins type IIa and type IIb in the pathogenicity of enterotoxigenic Escherichia coli for neonatal pigs.

Casey TA, Connell TD, Holmes RK, Whipp SC.

Vet Microbiol. 2012 Sep 14;159(1-2):83-9. doi: 10.1016/j.vetmic.2012.03.018. Epub 2012 Mar 16.


Characterization of OxyR as a negative transcriptional regulator that represses catalase production in Corynebacterium diphtheriae.

Kim JS, Holmes RK.

PLoS One. 2012;7(3):e31709. doi: 10.1371/journal.pone.0031709. Epub 2012 Mar 16.


The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.

Fehrholz M, Kendl S, Prifert C, Weissbrich B, Lemon K, Rennick L, Duprex PW, Rima BK, Koning FA, Holmes RK, Malim MH, Schneider-Schaulies J.

J Gen Virol. 2012 Mar;93(Pt 3):565-76. doi: 10.1099/vir.0.038919-0. Epub 2011 Dec 14.


Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.

Korotkov KV, Johnson TL, Jobling MG, Pruneda J, Pardon E, Héroux A, Turley S, Steyaert J, Holmes RK, Sandkvist M, Hol WG.

PLoS Pathog. 2011 Sep;7(9):e1002228. doi: 10.1371/journal.ppat.1002228. Epub 2011 Sep 8.


Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker.

Zajdowicz SL, Jones-Carson J, Vazquez-Torres A, Jobling MG, Gill RE, Holmes RK.

PLoS One. 2011;6(6):e21523. doi: 10.1371/journal.pone.0021523. Epub 2011 Jun 24.



Holmes RK, Jobling MG.

In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 5.


Contribution of subdomain structure to the thermal stability of the cholera toxin A1 subunit.

Banerjee T, Pande A, Jobling MG, Taylor M, Massey S, Holmes RK, Tatulian SA, Teter K.

Biochemistry. 2010 Oct 19;49(41):8839-46. doi: 10.1021/bi101201c.


Development and use of a selectable, broad-host-range reporter transposon for identifying environmentally regulated promoters in bacteria.

Spinler JK, Zajdowicz SL, Haller JC, Oram DM, Gill RE, Holmes RK.

FEMS Microbiol Lett. 2009 Feb;291(2):143-50. doi: 10.1111/j.1574-6968.2008.01430.x.


An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei.

Hamad MA, Zajdowicz SL, Holmes RK, Voskuil MI.

Gene. 2009 Feb 1;430(1-2):123-31. doi: 10.1016/j.gene.2008.10.011. Epub 2008 Oct 28.


Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins.

Gallois-Montbrun S, Holmes RK, Swanson CM, Fernández-Ocaña M, Byers HL, Ward MA, Malim MH.

J Virol. 2008 Jun;82(11):5636-42. doi: 10.1128/JVI.00287-08. Epub 2008 Mar 26.


Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.

Wolf AA, Jobling MG, Saslowsky DE, Kern E, Drake KR, Kenworthy AK, Holmes RK, Lencer WI.

Infect Immun. 2008 Apr;76(4):1476-84. doi: 10.1128/IAI.01286-07. Epub 2008 Jan 22.


Conformational instability of the cholera toxin A1 polypeptide.

Pande AH, Scaglione P, Taylor M, Nemec KN, Tuthill S, Moe D, Holmes RK, Tatulian SA, Teter K.

J Mol Biol. 2007 Dec 7;374(4):1114-28. Epub 2007 Oct 16.


Molecular characterization of Rab11-FIP3 binding to ARF GTPases.

Schonteich E, Pilli M, Simon GC, Matern HT, Junutula JR, Sentz D, Holmes RK, Prekeris R.

Eur J Cell Biol. 2007 Aug;86(8):417-31. Epub 2007 Jul 12.


APOBEC-mediated viral restriction: not simply editing?

Holmes RK, Malim MH, Bishop KN.

Trends Biochem Sci. 2007 Mar;32(3):118-28. Epub 2007 Feb 15. Review.


Bacteriophage-based vectors for site-specific insertion of DNA in the chromosome of Corynebacteria.

Oram M, Woolston JE, Jacobson AD, Holmes RK, Oram DM.

Gene. 2007 Apr 15;391(1-2):53-62. Epub 2006 Dec 14.


Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis.

Wisedchaisri G, Chou CJ, Wu M, Roach C, Rice AE, Holmes RK, Beeson C, Hol WG.

Biochemistry. 2007 Jan 16;46(2):436-47.


APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.

Holmes RK, Koning FA, Bishop KN, Malim MH.

J Biol Chem. 2007 Jan 26;282(4):2587-95. Epub 2006 Nov 22.


Dissection of the fusion machine of SARS-coronavirus.

Howard MW, Tripet B, Jobling MG, Holmes RK, Holmes KV, Hodges RS.

Adv Exp Med Biol. 2006;581:319-22. No abstract available.


Antiviral potency of APOBEC proteins does not correlate with cytidine deamination.

Bishop KN, Holmes RK, Malim MH.

J Virol. 2006 Sep;80(17):8450-8.


Heat-Labile Enterotoxins.

Jobling MG, Holmes RK.

EcoSal Plus. 2006 Jan;2(1). doi: 10.1128/ecosalplus.8.7.5.


Structural basis for the activation of cholera toxin by human ARF6-GTP.

O'Neal CJ, Jobling MG, Holmes RK, Hol WG.

Science. 2005 Aug 12;309(5737):1093-6.


Cellular internalization of cytolethal distending toxin: a new end to a known pathway.

Guerra L, Teter K, Lilley BN, Stenerlöw B, Holmes RK, Ploegh HL, Sandvig K, Thelestam M, Frisan T.

Cell Microbiol. 2005 Jul;7(7):921-34.


Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity.

Newman EN, Holmes RK, Craig HM, Klein KC, Lingappa JR, Malim MH, Sheehy AM.

Curr Biol. 2005 Jan 26;15(2):166-70.


Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles.

Gorbea C, Goellner GM, Teter K, Holmes RK, Rechsteiner M.

J Biol Chem. 2004 Dec 24;279(52):54849-61. Epub 2004 Oct 20.


Functional studies of the Mycobacterium tuberculosis iron-dependent regulator.

Chou CJ, Wisedchaisri G, Monfeli RR, Oram DM, Holmes RK, Hol WG, Beeson C.

J Biol Chem. 2004 Dec 17;279(51):53554-61. Epub 2004 Sep 29.


Cytidine deamination of retroviral DNA by diverse APOBEC proteins.

Bishop KN, Holmes RK, Sheehy AM, Davidson NO, Cho SJ, Malim MH.

Curr Biol. 2004 Aug 10;14(15):1392-6.


APOBEC-mediated editing of viral RNA.

Bishop KN, Holmes RK, Sheehy AM, Malim MH.

Science. 2004 Jul 30;305(5684):645.


Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism.

O'Neal CJ, Amaya EI, Jobling MG, Holmes RK, Hol WG.

Biochemistry. 2004 Apr 6;43(13):3772-82.


Structural characterization of the SARS-coronavirus spike S fusion protein core.

Tripet B, Howard MW, Jobling M, Holmes RK, Holmes KV, Hodges RS.

J Biol Chem. 2004 May 14;279(20):20836-49. Epub 2004 Mar 2.


Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.

Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI.

Mol Biol Cell. 2003 Dec;14(12):4783-93. Epub 2003 Sep 17.

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