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Items: 1 to 50 of 119

1.

Human Genetics and Drug Development.

Holmes MV.

N Engl J Med. 2019 Mar 14;380(11):1076-1079. doi: 10.1056/NEJMe1901565. No abstract available.

PMID:
30865805
2.

Meta-Analysis and Mendelian randomization: A review.

Bowden J, Holmes MV.

Res Synth Methods. 2019 Mar 12. doi: 10.1002/jrsm.1346. [Epub ahead of print] Review.

PMID:
30861319
3.

A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.

Wiberg A, Ng M, Schmid AB, Smillie RW, Baskozos G, Holmes MV, Künnapuu K, Mägi R, Bennett DL, Furniss D.

Nat Commun. 2019 Mar 4;10(1):1030. doi: 10.1038/s41467-019-08993-6.

4.

Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events: JACC Review Topic of the Week.

Armitage J, Holmes MV, Preiss D.

J Am Coll Cardiol. 2019 Feb 5;73(4):477-487. doi: 10.1016/j.jacc.2018.10.072. Review.

5.

What is 'LDL cholesterol'?

Holmes MV, Ala-Korpela M.

Nat Rev Cardiol. 2019 Apr;16(4):197-198. doi: 10.1038/s41569-019-0157-6. No abstract available.

PMID:
30700860
6.

Adiposity in relation to risks of fatty liver, cirrhosis and liver cancer: a prospective study of 0.5 million Chinese adults.

Pang Y, Kartsonaki C, Turnbull I, Guo Y, Chen Y, Clarke R, Bian Z, Bragg F, Millwood IY, Yang L, Huang Y, Yang Y, Zhang X, Chen J, Li L, Holmes MV, Chen Z.

Sci Rep. 2019 Jan 28;9(1):785. doi: 10.1038/s41598-018-36460-7.

7.

Can Mendelian Randomization Shift into Reverse Gear?

Holmes MV, Davey Smith G.

Clin Chem. 2019 Mar;65(3):363-366. doi: 10.1373/clinchem.2018.296806. Epub 2019 Jan 28. No abstract available.

PMID:
30692117
8.

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics.

Tynkkynen T, Wang Q, Ekholm J, Anufrieva O, Ohukainen P, Vepsäläinen J, Männikkö M, Keinänen-Kiukaanniemi S, Holmes MV, Goodwin M, Ring S, Chambers JC, Kooner J, Järvelin MR, Kettunen J, Hill M, Davey Smith G, Ala-Korpela M.

Int J Epidemiol. 2019 Jan 25. doi: 10.1093/ije/dyy287. [Epub ahead of print]

PMID:
30689875
9.

Central adiposity in relation to risk of liver cancer in Chinese adults: A prospective study of 0.5 million people.

Pang Y, Kartsonaki C, Guo Y, Chen Y, Yang L, Bian Z, Bragg F, Millwood IY, Yu C, Lv J, Chen J, Li L, Holmes MV, Chen Z.

Int J Cancer. 2019 Jan 21. doi: 10.1002/ijc.32148. [Epub ahead of print]

PMID:
30665257
10.

GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.

Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, Harrison JW, Ruth KS, Beaumont RN, Jones SE, Tyrrell J, Wood AR, Weedon MN, Mägi R, Neale B, Lindgren CM, Murray A, Holmes MV.

Am J Hum Genet. 2019 Jan 3;104(1):157-163. doi: 10.1016/j.ajhg.2018.11.004. Epub 2018 Dec 21.

11.

A review of lifestyle, metabolic risk factors, and blood-based biomarkers for early diagnosis of pancreatic ductal adenocarcinoma.

Pang Y, Holmes MV, Chen Z, Kartsonaki C.

J Gastroenterol Hepatol. 2019 Feb;34(2):330-345. doi: 10.1111/jgh.14576. Epub 2019 Jan 17. Review.

12.

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood IY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Davey Smith G, Sattar N, Butterworth A, Würtz P.

Circulation. 2018 Nov 27;138(22):2499-2512. doi: 10.1161/CIRCULATIONAHA.118.034942. Epub 2018 Aug 15.

PMID:
30524137
13.

GWAS identifies 14 loci for device-measured physical activity and sleep duration.

Doherty A, Smith-Byrne K, Ferreira T, Holmes MV, Holmes C, Pulit SL, Lindgren CM.

Nat Commun. 2018 Dec 10;9(1):5257. doi: 10.1038/s41467-018-07743-4.

14.

Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood LY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Smith GD, Sattar N, Butterworth A, Würtz P.

Circulation. 2018 Nov 27;138(22):2499–2512.

15.

Research digest: genetics in cardiometabolic disease.

Sattar N, Holmes MV, Preiss D.

Lancet Diabetes Endocrinol. 2018 Dec;6(12):922. doi: 10.1016/S2213-8587(18)30318-8. No abstract available.

PMID:
30470341
16.

Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort.

Stefler D, Malyutina S, Maximov V, Orlov P, Ivanoschuk D, Nikitin Y, Gafarov V, Ryabikov A, Voevoda M, Bobak M, Holmes MV.

Sci Rep. 2018 Nov 9;8(1):16627. doi: 10.1038/s41598-018-35122-y.

17.

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study.

Bell JA, Carslake D, Wade KH, Richmond RC, Langdon RJ, Vincent EE, Holmes MV, Timpson NJ, Davey Smith G.

PLoS Med. 2018 Aug 28;15(8):e1002641. doi: 10.1371/journal.pmed.1002641. eCollection 2018 Aug.

18.

Metabolic and lifestyle risk factors for acute pancreatitis in Chinese adults: A prospective cohort study of 0.5 million people.

Pang Y, Kartsonaki C, Turnbull I, Guo Y, Yang L, Bian Z, Chen Y, Millwood IY, Bragg F, Gong W, Xu Q, Kang Q, Chen J, Li L, Holmes MV, Chen Z.

PLoS Med. 2018 Aug 1;15(8):e1002618. doi: 10.1371/journal.pmed.1002618. eCollection 2018 Aug.

19.

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.

Davies NM, Holmes MV, Davey Smith G.

BMJ. 2018 Jul 12;362:k601. doi: 10.1136/bmj.k601. No abstract available.

20.

Diabetes, plasma glucose and incidence of colorectal cancer in Chinese adults: a prospective study of 0.5 million people.

Pang Y, Kartsonaki C, Guo Y, Chen Y, Yang L, Bian Z, Bragg F, Millwood IY, Shen L, Zhou S, Liu J, Chen J, Li L, Holmes MV, Chen Z.

J Epidemiol Community Health. 2018 Oct;72(10):919-925. doi: 10.1136/jech-2018-210651. Epub 2018 Jul 3.

21.

Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people.

Pang Y, Kartsonaki C, Guo Y, Chen Y, Yang L, Bian Z, Bragg F, Millwood IY, Mao E, Li Y, Shi L, Chen J, Li L, Holmes MV, Chen Z.

Br J Cancer. 2018 Jul;119(2):248-250. doi: 10.1038/s41416-018-0124-8. Epub 2018 Jun 6.

PMID:
29872150
22.

Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study.

Chen Z, Iona A, Parish S, Chen Y, Guo Y, Bragg F, Yang L, Bian Z, Holmes MV, Lewington S, Lacey B, Gao R, Liu F, Zhang Z, Chen J, Walters RG, Collins R, Clarke R, Peto R, Li L; China Kadoorie Biobank collaborative group.

Lancet Glob Health. 2018 Jun;6(6):e630-e640. doi: 10.1016/S2214-109X(18)30216-X.

23.

Diabetes, Plasma Glucose, and Incidence of Fatty Liver, Cirrhosis, and Liver Cancer: A Prospective Study of 0.5 Million People.

Pang Y, Kartsonaki C, Turnbull I, Guo Y, Clarke R, Chen Y, Bragg F, Yang L, Bian Z, Millwood IY, Hao J, Han X, Zang Y, Chen J, Li L, Holmes MV, Chen Z.

Hepatology. 2018 Oct;68(4):1308-1318. doi: 10.1002/hep.30083.

24.

Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults.

Lu L, Bennett DA, Millwood IY, Parish S, McCarthy MI, Mahajan A, Lin X, Bragg F, Guo Y, Holmes MV, Afzal S, Nordestgaard BG, Bian Z, Hill M, Walters RG, Li L, Chen Z, Clarke R.

PLoS Med. 2018 May 2;15(5):e1002566. doi: 10.1371/journal.pmed.1002566. eCollection 2018 May.

25.

Problems in interpreting and using GWAS of conditional phenotypes illustrated by 'alcohol GWAS'.

Holmes MV, Davey Smith G.

Mol Psychiatry. 2019 Feb;24(2):167-168. doi: 10.1038/s41380-018-0037-1. Epub 2018 Mar 8. No abstract available.

26.

Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke.

Holmes MV, Millwood IY, Kartsonaki C, Hill MR, Bennett DA, Boxall R, Guo Y, Xu X, Bian Z, Hu R, Walters RG, Chen J, Ala-Korpela M, Parish S, Clarke RJ, Peto R, Collins R, Li L, Chen Z; China Kadoorie Biobank Collaborative Group.

J Am Coll Cardiol. 2018 Feb 13;71(6):620-632. doi: 10.1016/j.jacc.2017.12.006.

27.

Challenges in Interpreting Multivariable Mendelian Randomization: Might "Good Cholesterol" Be Good After All?

Holmes MV, Davey Smith G.

Am J Kidney Dis. 2018 Feb;71(2):149-153. doi: 10.1053/j.ajkd.2017.10.006. No abstract available.

PMID:
29389382
28.

Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women.

Bragg F, Tang K, Guo Y, Iona A, Du H, Holmes MV, Bian Z, Kartsonaki C, Chen Y, Yang L, Sun Q, Dong C, Chen J, Collins R, Peto R, Li L, Chen Z; China Kadoorie Biobank (CKB) Collaborative Group.

Diabetes Care. 2018 Mar;41(3):494-502. doi: 10.2337/dc17-1852. Epub 2018 Jan 3.

PMID:
29298802
29.

Smoking, alcohol, and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people.

Pang Y, Holmes MV, Guo Y, Yang L, Bian Z, Chen Y, Iona A, Millwood IY, Bragg F, Chen J, Li L, Kartsonaki C, Chen Z.

Cancer Med. 2018 Jan;7(1):229-239. doi: 10.1002/cam4.1261. Epub 2017 Dec 22.

30.

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.

Harrison SC, Holmes MV, Burgess S, Asselbergs FW, Jones GT, Baas AF, van 't Hof FN, de Bakker PIW, Blankensteijn JD, Powell JT, Saratzis A, de Borst GJ, Swerdlow DI, van der Graaf Y, van Rij AM, Carey DJ, Elmore JR, Tromp G, Kuivaniemi H, Sayers RD, Samani NJ, Bown MJ, Humphries SE.

JAMA Cardiol. 2018 Jan 1;3(1):26-33. doi: 10.1001/jamacardio.2017.4293.

31.

Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.

Millwood IY, Bennett DA, Holmes MV, Boxall R, Guo Y, Bian Z, Yang L, Sansome S, Chen Y, Du H, Yu C, Hacker A, Reilly DF, Tan Y, Hill MR, Chen J, Peto R, Shen H, Collins R, Clarke R, Li L, Walters RG, Chen Z; China Kadoorie Biobank Collaborative Group.

JAMA Cardiol. 2018 Jan 1;3(1):34-43. doi: 10.1001/jamacardio.2017.4177.

32.

Correcting the Standard Errors of 2-Stage Residual Inclusion Estimators for Mendelian Randomization Studies.

Palmer TM, Holmes MV, Keating BJ, Sheehan NA.

Am J Epidemiol. 2017 Nov 1;186(9):1104-1114. doi: 10.1093/aje/kwx175.

33.

Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.

Wang Q, Holmes MV, Davey Smith G, Ala-Korpela M.

Diabetes Care. 2017 Dec;40(12):1779-1786. doi: 10.2337/dc17-1642. Epub 2017 Oct 18.

34.

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study.

Gan W, Clarke RJ, Mahajan A, Kulohoma B, Kitajima H, Robertson NR, Rayner NW, Walters RG, Holmes MV, Chen Z, McCarthy MI.

Wellcome Open Res. 2017 Aug 22;2:68. doi: 10.12688/wellcomeopenres.12288.1. eCollection 2017.

35.

Impact of Selection Bias on Estimation of Subsequent Event Risk.

Hu YJ, Schmidt AF, Dudbridge F, Holmes MV, Brophy JM, Tragante V, Li Z, Liao P, Quyyumi AA, McCubrey RO, Horne BD, Hingorani AD, Asselbergs FW, Patel RS, Long Q; The GENIUS-CHD Consortium.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001616. doi: 10.1161/CIRCGENETICS.116.001616.

36.

Dyslipidaemia: Revealing the effect of CETP inhibition in cardiovascular disease.

Holmes MV, Smith GD.

Nat Rev Cardiol. 2017 Nov;14(11):635-636. doi: 10.1038/nrcardio.2017.156. Epub 2017 Oct 5. No abstract available.

37.

Genetic and epigenetic studies of adiposity and cardiometabolic disease.

Holmes MV, Pulit SL, Lindgren CM.

Genome Med. 2017 Sep 18;9(1):82. doi: 10.1186/s13073-017-0474-5. Review.

38.

Young adulthood and adulthood adiposity in relation to incidence of pancreatic cancer: a prospective study of 0.5 million Chinese adults and a meta-analysis.

Pang Y, Holmes MV, Kartsonaki C, Guo Y, Yang L, Bian Z, Chen Y, Bragg F, Iona A, Millwood IY, Chen J, Li L, Chen Z.

J Epidemiol Community Health. 2017 Nov;71(11):1059-1067. doi: 10.1136/jech-2017-208895. Epub 2017 Sep 12.

39.

Education and coronary heart disease: mendelian randomisation study.

Tillmann T, Vaucher J, Okbay A, Pikhart H, Peasey A, Kubinova R, Pajak A, Tamosiunas A, Malyutina S, Hartwig FP, Fischer K, Veronesi G, Palmer T, Bowden J, Davey Smith G, Bobak M, Holmes MV.

BMJ. 2017 Aug 30;358:j3542. doi: 10.1136/bmj.j3542.

40.

Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study.

Lyall DM, Celis-Morales C, Ward J, Iliodromiti S, Anderson JJ, Gill JMR, Smith DJ, Ntuk UE, Mackay DF, Holmes MV, Sattar N, Pell JP.

JAMA Cardiol. 2017 Aug 1;2(8):882-889. doi: 10.1001/jamacardio.2016.5804.

41.

Mendelian randomisation in cardiovascular research: an introduction for clinicians.

Bennett DA, Holmes MV.

Heart. 2017 Sep;103(18):1400-1407. doi: 10.1136/heartjnl-2016-310605. Epub 2017 Jun 8. Review.

42.

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.

Holmes MV, Ala-Korpela M, Smith GD.

Nat Rev Cardiol. 2017 Oct;14(10):577-590. doi: 10.1038/nrcardio.2017.78. Epub 2017 Jun 1. Review.

43.

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Zewinger S, Kleber ME, Tragante V, McCubrey RO, Schmidt AF, Direk K, Laufs U, Werner C, Koenig W, Rothenbacher D, Mons U, Breitling LP, Brenner H, Jennings RT, Petrakis I, Triem S, Klug M, Filips A, Blankenberg S, Waldeyer C, Sinning C, Schnabel RB, Lackner KJ, Vlachopoulou E, Nygård O, Svingen GFT, Pedersen ER, Tell GS, Sinisalo J, Nieminen MS, Laaksonen R, Trompet S, Smit RAJ, Sattar N, Jukema JW, Groesdonk HV, Delgado G, Stojakovic T, Pilbrow AP, Cameron VA, Richards AM, Doughty RN, Gong Y, Cooper-DeHoff R, Johnson J, Scholz M, Beutner F, Thiery J, Smith JG, Vilmundarson RO, McPherson R, Stewart AFR, Cresci S, Lenzini PA, Spertus JA, Olivieri O, Girelli D, Martinelli NI, Leiherer A, Saely CH, Drexel H, Mündlein A, Braund PS, Nelson CP, Samani NJ, Kofink D, Hoefer IE, Pasterkamp G, Quyyumi AA, Ko YA, Hartiala JA, Allayee H, Tang WHW, Hazen SL, Eriksson N, Held C, Hagström E, Wallentin L, Åkerblom A, Siegbahn A, Karp I, Labos C, Pilote L, Engert JC, Brophy JM, Thanassoulis G, Bogaty P, Szczeklik W, Kaczor M, Sanak M, Virani SS, Ballantyne CM, Lee VV, Boerwinkle E, Holmes MV, Horne BD, Hingorani A, Asselbergs FW, Patel RS; GENIUS-CHD consortium, Krämer BK, Scharnagl H, Fliser D, März W, Speer T.

Lancet Diabetes Endocrinol. 2017 Jul;5(7):534-543. doi: 10.1016/S2213-8587(17)30096-7. Epub 2017 May 26.

44.

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A; UCLEB Consortium; METASTROKE Consortium, Mutsert R, Noordam R, Caulfield MJ, Jukema JW, Worrall BB, Munroe PB, Menon U, Power C, Kuh D, Lawlor DA, Humphries SE, Mook-Kanamori DO, Sattar N, Kivimaki M, Price JF, Davey Smith G, Dudbridge F, Hingorani AD, Holmes MV, Casas JP.

Circulation. 2017 Jun 13;135(24):2373-2388. doi: 10.1161/CIRCULATIONAHA.116.026560. Epub 2017 May 12.

45.

Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms.

van 't Hof FN, Vaucher J, Holmes MV, de Wilde A, Baas AF, Blankensteijn JD, Hofman A, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Vermeulen SH, Rinkel GJ, de Bakker PI, Ruigrok YM.

Eur J Hum Genet. 2017 Jun;25(6):758-762. doi: 10.1038/ejhg.2017.48. Epub 2017 Apr 5.

46.

The Relationship between Body Mass Index and 10-Year Trajectories of Physical Functioning in Middle-Aged and Older Russians: Prospective Results of the Russian HAPIEE Study.

Hu Y, Malyutina S, Pikhart H, Peasey A, Holmes MV, Hubacek J, Denisova D, Nikitin Y, Bobak M.

J Nutr Health Aging. 2017;21(4):381-388. doi: 10.1007/s12603-016-0769-z.

PMID:
28346564
47.

Cannabis use and risk of schizophrenia: a Mendelian randomization study.

Vaucher J, Keating BJ, Lasserre AM, Gan W, Lyall DM, Ward J, Smith DJ, Pell JP, Sattar N, Paré G, Holmes MV.

Mol Psychiatry. 2018 May;23(5):1287-1292. doi: 10.1038/mp.2016.252. Epub 2017 Jan 24.

48.

Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China.

Bragg F, Holmes MV, Iona A, Guo Y, Du H, Chen Y, Bian Z, Yang L, Herrington W, Bennett D, Turnbull I, Liu Y, Feng S, Chen J, Clarke R, Collins R, Peto R, Li L, Chen Z; China Kadoorie Biobank Collaborative Group.

JAMA. 2017 Jan 17;317(3):280-289. doi: 10.1001/jama.2016.19720.

PMID:
28114552
49.

Diabetes, plasma glucose and incidence of pancreatic cancer: A prospective study of 0.5 million Chinese adults and a meta-analysis of 22 cohort studies.

Pang Y, Kartsonaki C, Guo Y, Bragg F, Yang L, Bian Z, Chen Y, Iona A, Millwood IY, Lv J, Yu C, Chen J, Li L, Holmes MV, Chen Z.

Int J Cancer. 2017 Apr 15;140(8):1781-1788. doi: 10.1002/ijc.30599. Epub 2017 Feb 8.

50.

Commentary: Mendelian randomization-inspired causal inference in the absence of genetic data.

Zuccolo L, Holmes MV.

Int J Epidemiol. 2017 Jun 1;46(3):962-965. doi: 10.1093/ije/dyw327.

PMID:
28025256

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