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Items: 1 to 50 of 219

1.

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets.

Conway A, Mendel M, Kim K, McGovern K, Boyko A, Zhang L, Miller JC, DeKelver RC, Paschon DE, Mui BL, Lin PJC, Tam YK, Barbosa C, Redelmeier T, Holmes MC, Lee G.

Mol Ther. 2019 Apr 10;27(4):866-877. doi: 10.1016/j.ymthe.2019.03.003. Epub 2019 Mar 7.

PMID:
30902585
2.

The Role of 11β-Hydroxy Steroid Dehydrogenase Type 2 in Glucocorticoid Programming of Affective and Cognitive Behaviours.

Shearer FJG, Wyrwoll CS, Holmes MC.

Neuroendocrinology. 2019;109(3):257-265. doi: 10.1159/000499660. Epub 2019 Mar 19. Review.

3.

Diversifying the structure of zinc finger nucleases for high-precision genome editing.

Paschon DE, Lussier S, Wangzor T, Xia DF, Li PW, Hinkley SJ, Scarlott NA, Lam SC, Waite AJ, Truong LN, Gandhi N, Kadam BN, Patil DP, Shivak DA, Lee GK, Holmes MC, Zhang L, Miller JC, Rebar EJ.

Nat Commun. 2019 Mar 8;10(1):1133. doi: 10.1038/s41467-019-08867-x.

4.

Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells.

Llewellyn GN, Seclén E, Wietgrefe S, Liu S, Chateau M, Pei H, Perkey K, Marsden MD, Hinkley SJ, Paschon DE, Holmes MC, Zack JA, Louie SG, Haase AT, Cannon PM.

J Virol. 2019 May 1;93(10). pii: e02086-18. doi: 10.1128/JVI.02086-18. Print 2019 May 15.

PMID:
30842333
5.

BDNF+/- rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders.

Martis LS, Wiborg O, Holmes MC, Harris AP.

Genes Brain Behav. 2019 Feb;18(2):e12546. doi: 10.1111/gbb.12546. Epub 2019 Jan 2.

PMID:
30548775
6.

ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome.

Ou L, DeKelver RC, Rohde M, Tom S, Radeke R, St Martin SJ, Santiago Y, Sproul S, Przybilla MJ, Koniar BL, Podetz-Pedersen KM, Laoharawee K, Cooksley RD, Meyer KE, Holmes MC, McIvor RS, Wechsler T, Whitley CB.

Mol Ther. 2019 Jan 2;27(1):178-187. doi: 10.1016/j.ymthe.2018.10.018. Epub 2018 Nov 1.

7.

Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major.

Psatha N, Reik A, Phelps S, Zhou Y, Dalas D, Yannaki E, Levasseur DN, Urnov FD, Holmes MC, Papayannopoulou T.

Mol Ther Methods Clin Dev. 2018 Aug 14;10:313-326. doi: 10.1016/j.omtm.2018.08.003. eCollection 2018 Sep 21.

8.

Resilient and depressive-like rats show distinct cognitive impairments in the touchscreen paired-associates learning (PAL) task.

Martis LS, Brision C, Holmes MC, Wiborg O.

Neurobiol Learn Mem. 2018 Nov;155:287-296. doi: 10.1016/j.nlm.2018.08.014. Epub 2018 Aug 21.

PMID:
30138691
9.

Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency.

Abdul-Razak HH, Rocca CJ, Howe SJ, Alonso-Ferrero ME, Wang J, Gabriel R, Bartholomae CC, Gan CHV, Garín MI, Roberts A, Blundell MP, Prakash V, Molina-Estevez FJ, Pantoglou J, Guenechea G, Holmes MC, Gregory PD, Kinnon C, von Kalle C, Schmidt M, Bueren JA, Thrasher AJ, Yáñez-Muñoz RJ.

Sci Rep. 2018 May 29;8(1):8214. doi: 10.1038/s41598-018-26439-9.

10.

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy.

Peterson CW, Wang J, Deleage C, Reddy S, Kaur J, Polacino P, Reik A, Huang ML, Jerome KR, Hu SL, Holmes MC, Estes JD, Kiem HP.

PLoS Pathog. 2018 Apr 19;14(4):e1006956. doi: 10.1371/journal.ppat.1006956. eCollection 2018 Apr.

11.

Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing.

Laoharawee K, DeKelver RC, Podetz-Pedersen KM, Rohde M, Sproul S, Nguyen HO, Nguyen T, St Martin SJ, Ou L, Tom S, Radeke R, Meyer KE, Holmes MC, Whitley CB, Wechsler T, McIvor RS.

Mol Ther. 2018 Apr 4;26(4):1127-1136. doi: 10.1016/j.ymthe.2018.03.002. Epub 2018 Mar 10.

12.

11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.

Verma M, Kipari TMJ, Zhang Z, Man TY, Forster T, Homer NZM, Seckl JR, Holmes MC, Chapman KE.

Brain Behav Immun. 2018 Mar;69:223-234. doi: 10.1016/j.bbi.2017.11.015. Epub 2017 Nov 21.

13.

The effect of rat strain and stress exposure on performance in touchscreen tasks.

Martis LS, Krog S, Tran TP, Bouzinova E, Christiansen SL, Møller A, Holmes MC, Wiborg O.

Physiol Behav. 2018 Feb 1;184:83-90. doi: 10.1016/j.physbeh.2017.11.010. Epub 2017 Nov 10.

PMID:
29129610
14.

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.

Leibman RS, Richardson MW, Ellebrecht CT, Maldini CR, Glover JA, Secreto AJ, Kulikovskaya I, Lacey SF, Akkina SR, Yi Y, Shaheen F, Wang J, Dufendach KA, Holmes MC, Collman RG, Payne AS, Riley JL.

PLoS Pathog. 2017 Oct 12;13(10):e1006613. doi: 10.1371/journal.ppat.1006613. eCollection 2017 Oct.

15.

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, Plati T, Castiello MC, Sanvito F, Gennery AR, Bovolenta C, Palchaudhuri R, Scadden DT, Holmes MC, Villa A, Sitia G, Lombardo A, Genovese P, Naldini L.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan0820. doi: 10.1126/scitranslmed.aan0820.

PMID:
29021165
16.

Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients.

Diez B, Genovese P, Roman-Rodriguez FJ, Alvarez L, Schiroli G, Ugalde L, Rodriguez-Perales S, Sevilla J, Diaz de Heredia C, Holmes MC, Lombardo A, Naldini L, Bueren JA, Rio P.

EMBO Mol Med. 2017 Nov;9(11):1574-1588. doi: 10.15252/emmm.201707540.

17.

Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy.

Milani M, Annoni A, Bartolaccini S, Biffi M, Russo F, Di Tomaso T, Raimondi A, Lengler J, Holmes MC, Scheiflinger F, Lombardo A, Cantore A, Naldini L.

EMBO Mol Med. 2017 Nov;9(11):1558-1573. doi: 10.15252/emmm.201708148.

18.

NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease.

Mastaglio S, Genovese P, Magnani Z, Ruggiero E, Landoni E, Camisa B, Schiroli G, Provasi E, Lombardo A, Reik A, Cieri N, Rocchi M, Oliveira G, Escobar G, Casucci M, Gentner B, Spinelli A, Mondino A, Bondanza A, Vago L, Ponzoni M, Ciceri F, Holmes MC, Naldini L, Bonini C.

Blood. 2017 Aug 3;130(5):606-618. doi: 10.1182/blood-2016-08-732636. Epub 2017 Jun 21.

PMID:
28637663
19.

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells.

Chang KH, Smith SE, Sullivan T, Chen K, Zhou Q, West JA, Liu M, Liu Y, Vieira BF, Sun C, Hong VP, Zhang M, Yang X, Reik A, Urnov FD, Rebar EJ, Holmes MC, Danos O, Jiang H, Tan S.

Mol Ther Methods Clin Dev. 2017 Jan 11;4:137-148. doi: 10.1016/j.omtm.2016.12.009. eCollection 2017 Mar 17.

20.

Viscosity and haemodynamics in a late gestation rat feto-placental arterial network.

Bappoo N, Kelsey LJ, Parker L, Crough T, Moran CM, Thomson A, Holmes MC, Wyrwoll CS, Doyle BJ.

Biomech Model Mechanobiol. 2017 Aug;16(4):1361-1372. doi: 10.1007/s10237-017-0892-8. Epub 2017 Mar 3.

PMID:
28258413
21.

What's the Worry with Social Anxiety? Comparing Cognitive Processes in Children with Generalized Anxiety Disorder and Social Anxiety Disorder.

Hearn CS, Donovan CL, Spence SH, March S, Holmes MC.

Child Psychiatry Hum Dev. 2017 Oct;48(5):786-795. doi: 10.1007/s10578-016-0703-y.

PMID:
27917455
22.

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells.

DiGiusto DL, Cannon PM, Holmes MC, Li L, Rao A, Wang J, Lee G, Gregory PD, Kim KA, Hayward SB, Meyer K, Exline C, Lopez E, Henley J, Gonzalez N, Bedell V, Stan R, Zaia JA.

Mol Ther Methods Clin Dev. 2016 Nov 9;3:16067. eCollection 2016.

23.

Modifiable Healthy Lifestyle Behaviors: 10-Year Health Outcomes From a Health Promotion Program.

Byrne DW, Rolando LA, Aliyu MH, McGown PW, Connor LR, Awalt BM, Holmes MC, Wang L, Yarbrough MI.

Am J Prev Med. 2016 Dec;51(6):1027-1037. doi: 10.1016/j.amepre.2016.09.012.

PMID:
27866595
25.

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.

Leslie GJ, Wang J, Richardson MW, Haggarty BS, Hua KL, Duong J, Secreto AJ, Jordon AP, Romano J, Kumar KE, DeClercq JJ, Gregory PD, June CH, Root MJ, Riley JL, Holmes MC, Hoxie JA.

PLoS Pathog. 2016 Nov 17;12(11):e1005983. doi: 10.1371/journal.ppat.1005983. eCollection 2016 Nov.

26.

Thinking about worry: Investigation of the cognitive components of worry in children.

Donovan CL, Holmes MC, Farrell LJ, Hearn CS.

J Affect Disord. 2017 Jan 15;208:230-237. doi: 10.1016/j.jad.2016.09.061. Epub 2016 Oct 15.

PMID:
27792968
27.

Engineering hematopoietic stem cells toward a functional cure of human immunodeficiency virus infection.

Wang J, Holmes MC.

Cytotherapy. 2016 Nov;18(11):1370-1381. doi: 10.1016/j.jcyt.2016.07.007. Review.

PMID:
27745602
28.

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.

Solano ME, Holmes MC, Mittelstadt PR, Chapman KE, Tolosa E.

Semin Immunopathol. 2016 Nov;38(6):739-763. Epub 2016 Jul 28. Review.

PMID:
27465226
29.

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

Laskowski TJ, Van Caeneghem Y, Pourebrahim R, Ma C, Ni Z, Garate Z, Crane AM, Li XS, Liao W, Gonzalez-Garay M, Segovia JC, Paschon DE, Rebar EJ, Holmes MC, Kaufman D, Vandekerckhove B, Davis BR.

Stem Cell Reports. 2016 Aug 9;7(2):139-48. doi: 10.1016/j.stemcr.2016.06.003. Epub 2016 Jul 7.

30.

Early-life glucocorticoids programme behaviour and metabolism in adulthood in zebrafish.

Wilson KS, Tucker CS, Al-Dujaili EA, Holmes MC, Hadoke PW, Kenyon CJ, Denvir MA.

J Endocrinol. 2016 Jul;230(1):125-42. doi: 10.1530/JOE-15-0376.

31.

Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess.

Wyrwoll CS, Noble J, Thomson A, Tesic D, Miller MR, Rog-Zielinska EA, Moran CM, Seckl JR, Chapman KE, Holmes MC.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6265-70. doi: 10.1073/pnas.1520356113. Epub 2016 May 16.

32.

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates.

Peterson CW, Wang J, Norman KK, Norgaard ZK, Humbert O, Tse CK, Yan JJ, Trimble RG, Shivak DA, Rebar EJ, Gregory PD, Holmes MC, Kiem HP.

Blood. 2016 May 19;127(20):2416-26. doi: 10.1182/blood-2015-09-672337. Epub 2016 Mar 15.

33.

Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.

Evans LC, Ivy JR, Wyrwoll C, McNairn JA, Menzies RI, Christensen TH, Al-Dujaili EA, Kenyon CJ, Mullins JJ, Seckl JR, Holmes MC, Bailey MA.

Circulation. 2016 Apr 5;133(14):1360-70. doi: 10.1161/CIRCULATIONAHA.115.019341. Epub 2016 Mar 7.

34.

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application.

Torikai H, Mi T, Gragert L, Maiers M, Najjar A, Ang S, Maiti S, Dai J, Switzer KC, Huls H, Dulay GP, Reik A, Rebar EJ, Holmes MC, Gregory PD, Champlin RE, Shpall EJ, Cooper LJ.

Sci Rep. 2016 Feb 23;6:21757. doi: 10.1038/srep21757.

35.

Investigation of the cognitive variables associated with worry in children with Generalised Anxiety Disorder and their parents.

Donovan CL, Holmes MC, Farrell LJ.

J Affect Disord. 2016 Mar 1;192:1-7. doi: 10.1016/j.jad.2015.12.003. Epub 2015 Dec 10.

PMID:
26702733
36.

The role of brain-derived neurotrophic factor in learned fear processing: an awake rat fMRI study.

Harris AP, Lennen RJ, Brydges NM, Jansen MA, Pernet CR, Whalley HC, Marshall I, Baker S, Basso AM, Day M, Holmes MC, Hall J.

Genes Brain Behav. 2016 Feb;15(2):221-30. doi: 10.1111/gbb.12277. Epub 2016 Jan 5.

37.

Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.

Wang J, Exline CM, DeClercq JJ, Llewellyn GN, Hayward SB, Li PW, Shivak DA, Surosky RT, Gregory PD, Holmes MC, Cannon PM.

Nat Biotechnol. 2015 Dec;33(12):1256-1263. doi: 10.1038/nbt.3408. Epub 2015 Nov 9.

38.

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.

Wang J, DeClercq JJ, Hayward SB, Li PW, Shivak DA, Gregory PD, Lee G, Holmes MC.

Nucleic Acids Res. 2016 Feb 18;44(3):e30. doi: 10.1093/nar/gkv1121. Epub 2015 Nov 2.

39.

Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model.

Toscano MG, Muñoz P, Sánchez-Gilabert A, Cobo M, Benabdellah K, Anderson P, Ramos-Mejía V, Real PJ, Neth O, Molinos-Quintana A, Gregory PD, Holmes MC, Martin F.

Mol Ther. 2016 Feb;24(2):342-353. doi: 10.1038/mt.2015.196. Epub 2015 Oct 27.

40.

Functional footprinting of regulatory DNA.

Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, Bauer DE, Holmes MC, Orkin SH, Papayannopoulou T, Stamatoyannopoulos G, Rebar EJ, Gregory PD, Urnov FD, Stamatoyannopoulos JA.

Nat Methods. 2015 Oct;12(10):927-30. doi: 10.1038/nmeth.3554. Epub 2015 Aug 31.

41.

In vivo genome editing of the albumin locus as a platform for protein replacement therapy.

Sharma R, Anguela XM, Doyon Y, Wechsler T, DeKelver RC, Sproul S, Paschon DE, Miller JC, Davidson RJ, Shivak D, Zhou S, Rieders J, Gregory PD, Holmes MC, Rebar EJ, High KA.

Blood. 2015 Oct 8;126(15):1777-84. doi: 10.1182/blood-2014-12-615492. Epub 2015 Aug 21.

42.

Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation.

Saydaminova K, Ye X, Wang H, Richter M, Ho M, Chen H, Xu N, Kim JS, Papapetrou E, Holmes MC, Gregory PD, Palmer D, Ng P, Ehrhardt A, Lieber A.

Mol Ther Methods Clin Dev. 2015 Jan 14;1:14057. doi: 10.1038/mtm.2014.57. eCollection 2015.

43.

Fetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice.

Wyrwoll C, Keith M, Noble J, Stevenson PL, Bombail V, Crombie S, Evans LC, Bailey MA, Wood E, Seckl JR, Holmes MC.

Psychoneuroendocrinology. 2015 Sep;59:59-70. doi: 10.1016/j.psyneuen.2015.05.003. Epub 2015 May 18.

44.

Early life stress produces compulsive-like, but not impulsive, behavior in females.

Brydges NM, Holmes MC, Harris AP, Cardinal RN, Hall J.

Behav Neurosci. 2015 Jun;129(3):300-8. doi: 10.1037/bne0000059.

45.

Imaging learned fear circuitry in awake mice using fMRI.

Harris AP, Lennen RJ, Marshall I, Jansen MA, Pernet CR, Brydges NM, Duguid IC, Holmes MC.

Eur J Neurosci. 2015 Sep;42(5):2125-34. doi: 10.1111/ejn.12939. Epub 2015 Jun 6.

46.

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

Beane JD, Lee G, Zheng Z, Mendel M, Abate-Daga D, Bharathan M, Black M, Gandhi N, Yu Z, Chandran S, Giedlin M, Ando D, Miller J, Paschon D, Guschin D, Rebar EJ, Reik A, Holmes MC, Gregory PD, Restifo NP, Rosenberg SA, Morgan RA, Feldman SA.

Mol Ther. 2015 Aug;23(8):1380-1390. doi: 10.1038/mt.2015.71. Epub 2015 May 5.

47.

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.

Crane AM, Kramer P, Bui JH, Chung WJ, Li XS, Gonzalez-Garay ML, Hawkins F, Liao W, Mora D, Choi S, Wang J, Sun HC, Paschon DE, Guschin DY, Gregory PD, Kotton DN, Holmes MC, Sorscher EJ, Davis BR.

Stem Cell Reports. 2015 Apr 14;4(4):569-77. doi: 10.1016/j.stemcr.2015.02.005. Epub 2015 Mar 12.

48.

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Hoban MD, Cost GJ, Mendel MC, Romero Z, Kaufman ML, Joglekar AV, Ho M, Lumaquin D, Gray D, Lill GR, Cooper AR, Urbinati F, Senadheera S, Zhu A, Liu PQ, Paschon DE, Zhang L, Rebar EJ, Wilber A, Wang X, Gregory PD, Holmes MC, Reik A, Hollis RP, Kohn DB.

Blood. 2015 Apr 23;125(17):2597-604. doi: 10.1182/blood-2014-12-615948. Epub 2015 Mar 2.

49.

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice.

Wheelan N, Webster SP, Kenyon CJ, Caughey S, Walker BR, Holmes MC, Seckl JR, Yau JL.

Neuropharmacology. 2015 Apr;91:71-6. doi: 10.1016/j.neuropharm.2014.12.005. Epub 2014 Dec 11.

50.

Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.

Rog-Zielinska EA, Craig MA, Manning JR, Richardson RV, Gowans GJ, Dunbar DR, Gharbi K, Kenyon CJ, Holmes MC, Hardie DG, Smith GL, Chapman KE.

Cell Death Differ. 2015 Jul;22(7):1106-16. doi: 10.1038/cdd.2014.181. Epub 2014 Oct 31.

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