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Items: 1 to 50 of 81

1.

ToxA Is Present in the U.S. Bipolaris sorokiniana Population and Is a Significant Virulence Factor on Wheat Harboring Tsn1.

Friesen TL, Holmes DJ, Bowden RL, Faris JD.

Plant Dis. 2018 Dec;102(12):2446-2452. doi: 10.1094/PDIS-03-18-0521-RE. Epub 2018 Sep 24.

PMID:
30252627
2.

Left Atrial Appendage Closure and Systemic Homeostasis: The LAA HOMEOSTASIS Study.

Lakkireddy D, Turagam M, Afzal MR, Rajasingh J, Atkins D, Dawn B, Di Biase L, Bartus K, Kar S, Natale A, Holmes DJ Jr.

J Am Coll Cardiol. 2018 Jan 16;71(2):135-144. doi: 10.1016/j.jacc.2017.10.092. Erratum in: J Am Coll Cardiol. 2018 Feb 6;71(5):590.

3.

Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo.

Čipčić Paljetak H, Verbanac D, Padovan J, Dominis-Kramarić M, Kelnerić Ž, Perić M, Banjanac M, Ergović G, Simon N, Broskey J, Holmes DJ, Eraković Haber V.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5337-48. doi: 10.1128/AAC.00524-16. Print 2016 Sep.

4.

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models.

Rajpal DK, Klein JL, Mayhew D, Boucheron J, Spivak AT, Kumar V, Ingraham K, Paulik M, Chen L, Van Horn S, Thomas E, Sathe G, Livi GP, Holmes DJ, Brown JR.

PLoS One. 2015 Dec 28;10(12):e0145499. doi: 10.1371/journal.pone.0145499. eCollection 2015.

5.

Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.

Min S, Ingraham K, Huang J, McCloskey L, Rilling S, Windau A, Pizzollo J, Butler D, Aubart K, Miller LA, Zalacain M, Holmes DJ, O'Dwyer K.

Antimicrob Agents Chemother. 2015 Aug;59(8):4644-52. doi: 10.1128/AAC.00484-15. Epub 2015 May 26.

6.

Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase.

Arat S, Spivak A, Van Horn S, Thomas E, Traini C, Sathe G, Livi GP, Ingraham K, Jones L, Aubart K, Holmes DJ, Naderer O, Brown JR.

Antimicrob Agents Chemother. 2015 Feb;59(2):1182-92. doi: 10.1128/AAC.04506-14. Epub 2014 Dec 8.

7.

Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.

O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR.

Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27.

8.

Necrotrophic effector-triggered susceptibility (NETS) underlies the barley-Pyrenophora teres f. teres interaction specific to chromosome 6H.

Liu Z, Holmes DJ, Faris JD, Chao S, Brueggeman RS, Edwards MC, Friesen TL.

Mol Plant Pathol. 2015 Feb;16(2):188-200. doi: 10.1111/mpp.12172. Epub 2014 Aug 24.

9.

Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase.

Howard S, Amin N, Benowitz AB, Chiarparin E, Cui H, Deng X, Heightman TD, Holmes DJ, Hopkins A, Huang J, Jin Q, Kreatsoulas C, Martin AC, Massey F, McCloskey L, Mortenson PN, Pathuri P, Tisi D, Williams PA.

ACS Med Chem Lett. 2013 Oct 18;4(12):1208-12. doi: 10.1021/ml4003277. eCollection 2013 Dec 12.

10.

Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity.

Kapić S, Cipčić Paljetak H, Palej Jakopović I, Fajdetić A, Ilijaš M, Stimac V, Brajša K, Holmes DJ, Berge J, Alihodžić S.

Bioorg Med Chem. 2011 Dec 1;19(23):7281-98. doi: 10.1016/j.bmc.2011.07.010. Epub 2011 Jul 21.

PMID:
22047805
11.

Synthesis and activity of new macrolones: conjugates between 6(7)-(2'-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2'-hydroxyethyl) amides and 4″-propenoyl-azithromycin.

Kapić S, Fajdetić A, Koštrun S, Cikoš A, Paljetak HČ, Antolović R, Holmes DJ, Alihodžić S.

Bioorg Med Chem. 2011 Dec 1;19(23):7270-80. doi: 10.1016/j.bmc.2011.07.011. Epub 2011 Jul 21.

PMID:
22041174
12.

Orientation masking and cross-orientation suppression (XOS): implications for estimates of filter bandwidth.

Meese TS, Holmes DJ.

J Vis. 2010 Oct 1;10(12):9. doi: 10.1167/10.12.9.

PMID:
21047741
13.

Ovarian aging in developmental and evolutionary contexts.

Finch CE, Holmes DJ.

Ann N Y Acad Sci. 2010 Aug;1204:82-94. doi: 10.1111/j.1749-6632.2010.05610.x.

PMID:
20738278
14.

Synthesis and properties of macrolones characterized by two ether bonds in the linker.

Jakopović IP, Kragol G, Forrest AK, Frydrych CS, Stimac V, Kapić S, Skugor MM, Ilijas M, Paljetak HC, Jelić D, Holmes DJ, Hickey DM, Verbanac D, Eraković Haber V, Alihodzić S.

Bioorg Med Chem. 2010 Sep 1;18(17):6578-88. doi: 10.1016/j.bmc.2010.07.007. Epub 2010 Jul 14.

PMID:
20688524
15.

6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile.

Kapić S, Cipcić Paljetak H, Alihodzić S, Antolović R, Eraković Haber V, Jarvest RL, Holmes DJ, Broskey JP, Hunt E.

Bioorg Med Chem. 2010 Sep 1;18(17):6569-77. doi: 10.1016/j.bmc.2010.06.048. Epub 2010 Jul 3.

PMID:
20673633
16.

4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.

Fajdetić A, Cipcić Paljetak H, Lazarevski G, Hutinec A, Alihodzić S, Derek M, Stimac V, Andreotti D, Sunjić V, Berge JM, Mutak S, Dumić M, Lociuro S, Holmes DJ, Marsić N, Eraković Haber V, Spaventi R.

Bioorg Med Chem. 2010 Sep 1;18(17):6559-68. doi: 10.1016/j.bmc.2010.06.049. Epub 2010 Jun 22.

PMID:
20634078
17.

Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit.

Skugor MM, Stimac V, Palej I, Lugarić D, Paljetak HC, Filić D, Modrić M, Dilović I, Gembarovski D, Mutak S, Eraković Haber V, Holmes DJ, Ivezić-Schoenfeld Z, Alihodzić S.

Bioorg Med Chem. 2010 Sep 1;18(17):6547-58. doi: 10.1016/j.bmc.2010.06.050. Epub 2010 Jun 22.

PMID:
20621489
18.

Roaches, apoptosis and the ovarian clock: use it or lose it.

Holmes DJ, Lavine LC.

Heredity (Edinb). 2009 Sep;103(3):192-3. doi: 10.1038/hdy.2009.87. Epub 2009 Jul 15. No abstract available.

19.

Comparative and alternative approaches and novel animal models for aging research: introduction to special issue.

Holmes DJ, Kristan DM.

Age (Dordr). 2008 Sep;30(2-3):63-73. doi: 10.1007/s11357-008-9068-x. Epub 2008 Jul 19.

20.

Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.

Gentry DR, McCloskey L, Gwynn MN, Rittenhouse SF, Scangarella N, Shawar R, Holmes DJ.

Antimicrob Agents Chemother. 2008 Dec;52(12):4507-9. doi: 10.1128/AAC.00915-08. Epub 2008 Oct 6.

21.

Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage.

Ogburn CE, Austad SN, Holmes DJ, Kiklevich JV, Gollahon K, Rabinovitch PS, Martin GM.

J Gerontol A Biol Sci Med Sci. 1998 Jul;53(4):B287-92.

PMID:
18314559
22.

Clinical and research issues regarding chronic advanced coronary artery disease: part I: Contemporary and emerging therapies.

Jolicoeur EM, Granger CB, Henry TD, Holmes DJ, Pepine CJ, Mark D, Chaitman BR, Gersh BJ, Ohman EM; Working Group Members.

Am Heart J. 2008 Mar;155(3):418-34. doi: 10.1016/j.ahj.2007.12.004. Epub 2008 Jan 31. Review.

PMID:
18294474
23.

Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event.

Gentry DR, Holmes DJ.

Antimicrob Agents Chemother. 2008 Mar;52(3):1156-8. doi: 10.1128/AAC.00923-07. Epub 2008 Jan 14.

24.

Contextual modulation involves suppression and facilitation from the center and the surround.

Meese TS, Summers RJ, Holmes DJ, Wallis SA.

J Vis. 2007 Mar 22;7(4):7.

PMID:
17461691
25.
26.

Remote facilitation in the Fourier domain.

Meese TS, Holmes DJ, Challinor KL.

Vision Res. 2007 Apr;47(8):1112-9. Epub 2006 Dec 26.

27.

Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL.

Nat Rev Drug Discov. 2007 Jan;6(1):29-40. Epub 2006 Dec 8. Review.

PMID:
17159923
28.

Spatial and temporal dependencies of cross-orientation suppression in human vision.

Meese TS, Holmes DJ.

Proc Biol Sci. 2007 Jan 7;274(1606):127-36.

29.

Independent binocular integration for form and colour.

Holmes DJ, Hancock S, Andrews TJ.

Vision Res. 2006 Mar;46(5):665-77. Epub 2005 Jul 14.

30.

Grating and plaid masks indicate linear summation in a contrast gain pool.

Holmes DJ, Meese TS.

J Vis. 2004 Dec 22;4(12):1080-9.

PMID:
15669912
31.

Naturally long-lived animal models for the study of slow aging and longevity.

Holmes DJ.

Ann N Y Acad Sci. 2004 Jun;1019:483-5. Review.

PMID:
15247070
32.

Genomic approaches to antibacterial discovery.

Payne DJ, Gwynn MN, Holmes DJ, Rosenberg M.

Methods Mol Biol. 2004;266:231-59.

PMID:
15148422
33.

Performance data indicate summation for pictorial depth-cues in slanted surfaces.

Meese TS, Holmes DJ.

Spat Vis. 2004;17(1-2):127-51.

PMID:
15078016
34.

Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth.

O'Dwyer K, Watts JM, Biswas S, Ambrad J, Barber M, Brulé H, Petit C, Holmes DJ, Zalacain M, Holmes WM.

J Bacteriol. 2004 Apr;186(8):2346-54.

35.

A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function.

Zalacain M, Biswas S, Ingraham KA, Ambrad J, Bryant A, Chalker AF, Iordanescu S, Fan J, Fan F, Lunsford RD, O'Dwyer K, Palmer LM, So C, Sylvester D, Volker C, Warren P, McDevitt D, Brown JR, Holmes DJ, Burnham MK.

J Mol Microbiol Biotechnol. 2003;6(2):109-26.

PMID:
15044829
36.

Validation of antibacterial mechanism of action using regulated antisense RNA expression in Staphylococcus aureus.

Ji Y, Yin D, Fox B, Holmes DJ, Payne D, Rosenberg M.

FEMS Microbiol Lett. 2004 Feb 16;231(2):177-84.

37.

Birds as long-lived animal models for the study of aging.

Holmes DJ, Ottinger MA.

Exp Gerontol. 2003 Nov-Dec;38(11-12):1365-75. Review.

PMID:
14698817
38.

Identification of antimicrobial targets using a comprehensive genomic approach.

Yin D, Fox B, Lonetto ML, Etherton MR, Payne DJ, Holmes DJ, Rosenberg M, Ji Y.

Pharmacogenomics. 2004 Jan;5(1):101-13.

PMID:
14683422
39.

Is postmenopausal life-span a gift of modern health or a product of natural selection?

Holmes DJ.

Sci Aging Knowledge Environ. 2002 Feb 20;2002(7):pe3.

PMID:
14603029
40.

New benzylidenethiazolidinediones as antibacterial agents.

Heerding DA, Christmann LT, Clark TJ, Holmes DJ, Rittenhouse SF, Takata DT, Venslavsky JW.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3771-3.

PMID:
14552776
41.

Reproductive aging in female birds.

Holmes DJ, Thomson SL, Wu J, Ottinger MA.

Exp Gerontol. 2003 Jul;38(7):751-6.

PMID:
12855282
42.

Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens.

Brown JR, Gentry D, Becker JA, Ingraham K, Holmes DJ, Stanhope MJ.

EMBO Rep. 2003 Jul;4(7):692-8.

43.

Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ.

Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9.

44.

The promoter of a cold-shock-like gene has pleiotropic effects on Streptomyces antibiotic biosynthesis.

Martínez-Costa OH, Zalacaín M, Holmes DJ, Malpartida F.

FEMS Microbiol Lett. 2003 Mar 28;220(2):215-21.

45.

Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.

Chan PF, O'Dwyer KM, Palmer LM, Ambrad JD, Ingraham KA, So C, Lonetto MA, Biswas S, Rosenberg M, Holmes DJ, Zalacain M.

J Bacteriol. 2003 Mar;185(6):2051-8.

46.

Novel antibacterials: a genomics approach to drug discovery.

Chan PF, Macarron R, Payne DJ, Zalacain M, Holmes DJ.

Curr Drug Targets Infect Disord. 2002 Dec;2(4):291-308. Review.

PMID:
12570737
47.

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

Marrakchi H, Dewolf WE Jr, Quinn C, West J, Polizzi BJ, So CY, Holmes DJ, Reed SL, Heath RJ, Payne DJ, Rock CO, Wallis NG.

Biochem J. 2003 Mar 15;370(Pt 3):1055-62.

48.

Novel targets for the future development of antibacterial agents.

McDevitt D, Payne DJ, Holmes DJ, Rosenberg M.

Symp Ser Soc Appl Microbiol. 2002;(31):28S-34S. Review.

PMID:
12481826
49.

Novel targets for the future development of antibacterial agents.

McDevitt D, Payne DJ, Holmes DJ, Rosenberg M.

J Appl Microbiol. 2002;92 Suppl:28S-34S. Review.

50.

Adaptation and gain pool summation: alternative models and masking data.

Meese TS, Holmes DJ.

Vision Res. 2002 Apr;42(9):1113-25.

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