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Baseline predictors of negative and incomplete pleural cytology in patients with suspected pleural malignancy - Data supporting 'Direct to LAT' in selected groups.

Tsim S, Paterson S, Cartwright D, Fong CJ, Alexander L, Kelly C, Holme J, Evison M, Blyth KG.

Lung Cancer. 2019 Jul;133:123-129. doi: 10.1016/j.lungcan.2019.05.017. Epub 2019 May 16.


Pro-inflammatory responses induced by A. fumigatus and A. versicolor in various human macrophage models.

Øya E, Solhaug A, Bølling AK, Øvstebø R, Steensen TB, Afanou AKJ, Holme JA.

J Toxicol Environ Health A. 2019;82(8):483-501. doi: 10.1080/15287394.2019.1619114. Epub 2019 May 22.


Combustion Particle-Induced Changes in Calcium Homeostasis: A Contributing Factor to Vascular Disease?

Holme JA, Brinchmann BC, Le Ferrec E, Lagadic-Gossmann D, Øvrevik J.

Cardiovasc Toxicol. 2019 Jun;19(3):198-209. doi: 10.1007/s12012-019-09518-9. Review.


Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds.

Øya E, Becher R, Ekeren L, Afanou AKJ, Øvrevik J, Holme JA.

Int J Environ Res Public Health. 2019 Mar 26;16(6). pii: E1085. doi: 10.3390/ijerph16061085.


Organic chemicals from diesel exhaust particles affects intracellular calcium, inflammation and β-adrenoceptors in endothelial cells.

Brinchmann BC, Le Ferrec E, Podechard N, Lagadic-Gossmann D, Holme JA, Øvrevik J.

Toxicol Lett. 2019 Mar 1;302:18-27. doi: 10.1016/j.toxlet.2018.11.009. Epub 2018 Nov 29.


Hyphae fragments from A. fumigatus sensitize lung cells to silica particles (Min-U-Sil): Increased release of IL-1β.

Øya E, Zegeye FD, Bølling AK, Øvstebø R, Afanou AKJ, Øvrevik J, Refsnes M, Holme JA.

Toxicol In Vitro. 2019 Mar;55:1-10. doi: 10.1016/j.tiv.2018.11.002. Epub 2018 Nov 8.


Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene.

Brinchmann BC, Le Ferrec E, Bisson WH, Podechard N, Huitfeldt HS, Gallais I, Sergent O, Holme JA, Lagadic-Gossmann D, Øvrevik J.

Biochem Pharmacol. 2018 Dec;158:1-12. doi: 10.1016/j.bcp.2018.09.023. Epub 2018 Sep 22.


Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARγ.

Grytting VS, Olderbø BP, Holme JA, Samuelsen JT, Solhaug A, Becher R, Bølling AK.

Toxicol In Vitro. 2019 Feb;54:168-177. doi: 10.1016/j.tiv.2018.09.004. Epub 2018 Sep 12.


Milan winter fine particulate matter (wPM2.5) induces IL-6 and IL-8 synthesis in human bronchial BEAS-2B cells, but specifically impairs IL-8 release.

Longhin E, Holme JA, Gualtieri M, Camatini M, Øvrevik J.

Toxicol In Vitro. 2018 Oct;52:365-373. doi: 10.1016/j.tiv.2018.07.016. Epub 2018 Jul 23.


In Vitro Transformation of Human Bronchial Epithelial Cells by Diesel Exhaust Particles: Gene Expression Profiling and Early Toxic Responses.

Rynning I, Neca J, Vrbova K, Libalova H, Rossner P Jr, Holme JA, Gützkow KB, Afanou AKJ, Arnoldussen YJ, Hruba E, Skare Ø, Haugen A, Topinka J, Machala M, Mollerup S.

Toxicol Sci. 2018 Nov 1;166(1):51-64. doi: 10.1093/toxsci/kfy183.


Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s).

Brinchmann BC, Skuland T, Rambøl MH, Szoke K, Brinchmann JE, Gutleb AC, Moschini E, Kubátová A, Kukowski K, Le Ferrec E, Lagadic-Gossmann D, Schwarze PE, Låg M, Refsnes M, Øvrevik J, Holme JA.

Part Fibre Toxicol. 2018 May 11;15(1):21. doi: 10.1186/s12989-018-0257-1.


Lipophilic Chemicals from Diesel Exhaust Particles Trigger Calcium Response in Human Endothelial Cells via Aryl Hydrocarbon Receptor Non-Genomic Signalling.

Brinchmann BC, Le Ferrec E, Podechard N, Lagadic-Gossmann D, Shoji KF, Penna A, Kukowski K, Kubátová A, Holme JA, Øvrevik J.

Int J Mol Sci. 2018 May 10;19(5). pii: E1429. doi: 10.3390/ijms19051429.


Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion.

Bhatnagar R, Keenan EK, Morley AJ, Kahan BC, Stanton AE, Haris M, Harrison RN, Mustafa RA, Bishop LJ, Ahmed L, West A, Holme J, Evison M, Munavvar M, Sivasothy P, Herre J, Cooper D, Roberts M, Guhan A, Hooper C, Walters J, Saba TS, Chakrabarti B, Gunatilake S, Psallidas I, Walker SP, Bibby AC, Smith S, Stadon LJ, Zahan-Evans NJ, Lee YCG, Harvey JE, Rahman NM, Miller RF, Maskell NA.

N Engl J Med. 2018 Apr 5;378(14):1313-1322. doi: 10.1056/NEJMoa1716883.


Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and causalities.

Myhre O, Låg M, Villanger GD, Oftedal B, Øvrevik J, Holme JA, Aase H, Paulsen RE, Bal-Price A, Dirven H.

Toxicol Appl Pharmacol. 2018 Sep 1;354:196-214. doi: 10.1016/j.taap.2018.03.015. Epub 2018 Mar 14. Review.


Decreased macrophage phagocytic function due to xenobiotic exposures in vitro, difference in sensitivity between various macrophage models.

Berntsen HF, Bølling AK, Bjørklund CG, Zimmer K, Ropstad E, Zienolddiny S, Becher R, Holme JA, Dirven H, Nygaard UC, Bodin J.

Food Chem Toxicol. 2018 Feb;112:86-96. doi: 10.1016/j.fct.2017.12.024. Epub 2017 Dec 16.


Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species.

Øya E, Afanou AKJ, Malla N, Uhlig S, Rolen E, Skaar I, Straumfors A, Winberg JO, Bang BE, Schwarze PE, Eduard W, Holme JA.

Indoor Air. 2018 Jan;28(1):28-39. doi: 10.1111/ina.12426. Epub 2017 Oct 3.


Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function.

Weldingh NM, Jørgensen-Kaur L, Becher R, Holme JA, Bodin J, Nygaard UC, Bølling AK.

Biomed Res Int. 2017;2017:4614379. doi: 10.1155/2017/4614379. Epub 2017 Feb 13.


The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione.

Bolling AK, Solhaug A, Morisbak E, Holme JA, Samuelsen JT.

Toxicol Lett. 2017 Mar 15;270:25-33. doi: 10.1016/j.toxlet.2017.02.007. Epub 2017 Feb 7.


Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism.

Hardonnière K, Huc L, Sergent O, Holme JA, Lagadic-Gossmann D.

Semin Cancer Biol. 2017 Apr;43:49-65. doi: 10.1016/j.semcancer.2017.01.001. Epub 2017 Jan 11. Review.


Triggering Mechanisms and Inflammatory Effects of Combustion Exhaust Particles with Implication for Carcinogenesis.

Øvrevik J, Refsnes M, Låg M, Brinchmann BC, Schwarze PE, Holme JA.

Basic Clin Pharmacol Toxicol. 2017 Sep;121 Suppl 3:55-62. doi: 10.1111/bcpt.12746. Epub 2017 Mar 15. Review.


Bagpipe lung; a new type of interstitial lung disease?

King J, Richardson M, Quinn AM, Holme J, Chaudhuri N.

Thorax. 2017 Apr;72(4):380-382. doi: 10.1136/thoraxjnl-2016-208751. Epub 2016 Aug 22. No abstract available.


Immunomodulatory effects of individual and combined mycotoxins in the THP-1 cell line.

Solhaug A, Karlsøen LM, Holme JA, Kristoffersen AB, Eriksen GS.

Toxicol In Vitro. 2016 Oct;36:120-132. doi: 10.1016/j.tiv.2016.07.012. Epub 2016 Jul 21.


Air pollution-related metals induce differential cytokine responses in bronchial epithelial cells.

Låg M, Øvrevik J, Totlandsdal AI, Lilleaas EM, Thormodsæter A, Holme JA, Schwarze PE, Refsnes M.

Toxicol In Vitro. 2016 Oct;36:53-65. doi: 10.1016/j.tiv.2016.07.004. Epub 2016 Jul 15.


Mechanisms of Action and Toxicity of the Mycotoxin Alternariol: A Review.

Solhaug A, Eriksen GS, Holme JA.

Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):533-539. doi: 10.1111/bcpt.12635. Epub 2016 Aug 10. Review.


Physico-chemical properties and biological effects of diesel and biomass particles.

Longhin E, Gualtieri M, Capasso L, Bengalli R, Mollerup S, Holme JA, Øvrevik J, Casadei S, Di Benedetto C, Parenti P, Camatini M.

Environ Pollut. 2016 Aug;215:366-375. doi: 10.1016/j.envpol.2016.05.015. Epub 2016 May 15.


The mycotoxin alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses.

Solhaug A, Wisbech C, Christoffersen TE, Hult LO, Lea T, Eriksen GS, Holme JA.

Toxicol Lett. 2015 Nov 19;239(1):9-21. doi: 10.1016/j.toxlet.2015.08.1107. Epub 2015 Sep 2.


Cytokine responses induced by diesel exhaust particles are suppressed by PAR-2 silencing and antioxidant treatment, and driven by polar and non-polar soluble constituents.

Bach N, Bølling AK, Brinchmann BC, Totlandsdal AI, Skuland T, Holme JA, Låg M, Schwarze PE, Øvrevik J.

Toxicol Lett. 2015 Oct 14;238(2):72-82. doi: 10.1016/j.toxlet.2015.07.002. Epub 2015 Jul 6.


Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanisms.

Øvrevik J, Refsnes M, Låg M, Holme JA, Schwarze PE.

Biomolecules. 2015 Jul 2;5(3):1399-440. doi: 10.3390/biom5031399. Review.


Olanzapine-induced eosinophilic pleuritis.

Evison M, Holme J, Alaloul M, Doran H, Bishop P, Booton R, Chaudhry N.

Respir Med Case Rep. 2014 Dec 16;14:24-6. doi: 10.1016/j.rmcr.2014.11.007. eCollection 2015.


Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Solhaug A, Torgersen ML, Holme JA, Lagadic-Gossmann D, Eriksen GS.

Toxicology. 2014 Dec 4;326:119-29. doi: 10.1016/j.tox.2014.10.009. Epub 2014 Oct 18.


AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells.

Øvrevik J, Låg M, Lecureur V, Gilot D, Lagadic-Gossmann D, Refsnes M, Schwarze PE, Skuland T, Becher R, Holme JA.

Cell Commun Signal. 2014 Jul 24;12:48. doi: 10.1186/s12964-014-0048-8.


Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene.

Holme JA, Nyvold HE, Tat V, Arlt VM, Bhargava A, Gutzkow KB, Solhaug A, Låg M, Becher R, Schwarze PE, Ask K, Ekeren L, Øvrevik J.

Toxicol Rep. 2014 Jul 27;1:459-473. doi: 10.1016/j.toxrep.2014.07.009. eCollection 2014.


Calcium signaling and β2-adrenergic receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS-2B cells.

Mayati A, Le Ferrec E, Holme JA, Fardel O, Lagadic-Gossmann D, Ovrevik J.

Toxicol In Vitro. 2014 Sep;28(6):1153-7. doi: 10.1016/j.tiv.2014.05.012. Epub 2014 Jun 4.


SNP genotyping: the KASP assay.

He C, Holme J, Anthony J.

Methods Mol Biol. 2014;1145:75-86. doi: 10.1007/978-1-4939-0446-4_7.


Stage distribution and performance status of newly diagnosed patients in a UK regional mesothelioma centre.

Khan S, Evison M, Alaloul M, Holme J, Booton R, Taylor P.

Lung Cancer. 2014 Jul;85(1):99-100. doi: 10.1016/j.lungcan.2014.03.024. Epub 2014 Apr 4. No abstract available.


Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved.

Longhin E, Holme JA, Gutzkow KB, Arlt VM, Kucab JE, Camatini M, Gualtieri M.

Part Fibre Toxicol. 2013 Dec 19;10:63. doi: 10.1186/1743-8977-10-63.


The occurrence of polycyclic aromatic hydrocarbons and their derivatives and the proinflammatory potential of fractionated extracts of diesel exhaust and wood smoke particles.

Totlandsdal AI, Øvrevik J, Cochran RE, Herseth JI, Bølling AK, Låg M, Schwarze P, Lilleaas E, Holme JA, Kubátová A.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2014;49(4):383-96. doi: 10.1080/10934529.2014.854586.


Real world experiences: pirfenidone is well tolerated in patients with idiopathic pulmonary fibrosis.

Chaudhuri N, Duck A, Frank R, Holme J, Leonard C.

Respir Med. 2014 Jan;108(1):224-6. doi: 10.1016/j.rmed.2013.11.005. Epub 2013 Nov 15.


Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway.

Dendelé B, Tekpli X, Hardonnière K, Holme JA, Debure L, Catheline D, Arlt VM, Nagy E, Phillips DH, Ovrebø S, Mollerup S, Poët M, Chevanne M, Rioux V, Dimanche-Boitrel MT, Sergent O, Lagadic-Gossmann D.

Chem Biol Interact. 2014 Jan 25;207:41-51. doi: 10.1016/j.cbi.2013.11.002. Epub 2013 Nov 15.


Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies.

Nemmar A, Holme JA, Rosas I, Schwarze PE, Alfaro-Moreno E.

Biomed Res Int. 2013;2013:279371. doi: 10.1155/2013/279371. Epub 2013 Jun 20. Review.


Inflammation-related effects of diesel engine exhaust particles: studies on lung cells in vitro.

Schwarze PE, Totlandsdal AI, Låg M, Refsnes M, Holme JA, Øvrevik J.

Biomed Res Int. 2013;2013:685142. doi: 10.1155/2013/685142. Epub 2013 Feb 14. Review.


Mechanisms of chemokine responses by polycyclic aromatic hydrocarbons in bronchial epithelial cells: sensitization through toll-like receptor-3 priming.

Øvrevik J, Refsnes M, Holme JA, Schwarze PE, Låg M.

Toxicol Lett. 2013 May 23;219(2):125-32. doi: 10.1016/j.toxlet.2013.02.014. Epub 2013 Feb 28.


Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages.

Solhaug A, Holme JA, Haglund K, Dendele B, Sergent O, Pestka J, Lagadic-Gossmann D, Eriksen GS.

Toxicol Lett. 2013 May 10;219(1):8-17. doi: 10.1016/j.toxlet.2013.02.012. Epub 2013 Feb 27.


Differential chemokine induction by 1-nitropyrene and 1-aminopyrene in bronchial epithelial cells: importance of the TACE/TGF-α/EGFR-pathway.

Øvrevik J, Holme JA, Låg M, Schwarze PE, Refsnes M.

Environ Toxicol Pharmacol. 2013 Mar;35(2):235-9. doi: 10.1016/j.etap.2012.12.011. Epub 2013 Jan 4.


Role for membrane remodeling in cell death: implication for health and disease.

Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D.

Toxicology. 2013 Feb 8;304:141-57. doi: 10.1016/j.tox.2012.12.014. Epub 2012 Dec 31. Review.


Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies.

Holme J, Stockley JA, Stockley RA.

Respir Med. 2013 Mar;107(3):387-93. doi: 10.1016/j.rmed.2012.12.003. Epub 2012 Dec 29.


Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?

Kocbach Bølling A, Holme JA, Bornehag CG, Nygaard UC, Bertelsen RJ, Nånberg E, Bodin J, Sakhi AK, Thomsen C, Becher R.

EXCLI J. 2013 Aug 20;12:733-59. eCollection 2013.


Season linked responses to fine and quasi-ultrafine Milan PM in cultured cells.

Longhin E, Pezzolato E, Mantecca P, Holme JA, Franzetti A, Camatini M, Gualtieri M.

Toxicol In Vitro. 2013 Mar;27(2):551-9. doi: 10.1016/j.tiv.2012.10.018. Epub 2012 Nov 16.


Mechanisms involved in alternariol-induced cell cycle arrest.

Solhaug A, Vines LL, Ivanova L, Spilsberg B, Holme JA, Pestka J, Collins A, Eriksen GS.

Mutat Res. 2012 Oct-Nov;738-739:1-11. doi: 10.1016/j.mrfmmm.2012.09.001. Epub 2012 Sep 29.


Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages.

Sandberg WJ, Låg M, Holme JA, Friede B, Gualtieri M, Kruszewski M, Schwarze PE, Skuland T, Refsnes M.

Part Fibre Toxicol. 2012 Aug 10;9:32. doi: 10.1186/1743-8977-9-32.

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